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Member Forum >> Heart Health Forum >> Benfotiamine
 Benfotiamine
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Posted: 1/13/2012 9:00:31 AM
 

benfotiamine Looks interesting and I plan to start a thread on it.
HB

What is the relationship between benfotiamine and diabetes?

It was not until Michael Brownlee et al’s paper (3) was published in the journal Nature Medicine in February 2003 that benfotiamine really came to the world’s attention with regard to the possibility of preventing the development and progression of diabetic complications. Brownlee and his team had discovered that benfotiamine had the ability to simultaneously inhibit three of the above mentioned major biochemical pathways implicated in the development of hyperglycemia induced vascular damage - in other words they had discovered that benfotiamine could block the damage triggered when cells are exposed to high concentrations of sugar.

They were able to demonstrate that benfotiamine prevented the development of retinopathy in diabetic rats, which raised the hope that this previously overlooked compound would be able to do the same for people.

Since then benfotiamine has undergone several studies with the main focus being the use of benfotiamine as a treatment for diabetes complications. These studies have shown that benfotiamine appears to be able to help prevent or slow the development of neuropathy, retinopathy and nephropathy by inhibiting the build-up of glucose in blood vessels.

Other uses for Benfotiamine

One of the theories behind why we age in the way that we do is based on the gradual formation of advanced glycation/glycosylation end products (or AGEs) which in turn can damage many of our body systems, organs and tissues. Glycation (sometimes called non-enzymatic glycosylation) occurs every day as part and parcel of the body’s normal metabolic processes. It is a series of chemical reactions that occur when protein molecules bind to sugar molecules. Glycation is a haphazard process - where enzymes control the process it is known as glycosylation. A whole cascade of chemical reactions occurs during glycation/glycosylation which ultimately results in the formation of advanced glycation (or glycosylation) end products (AGEs). While some AGEs are benign, the majority are extremely harmful.

Research suggests that many chronic age-related degenerative diseases such as cancer, cardiovascular disease, cataract problems and Alzheimer’s may all be associated with the havoc and destruction that a steady accumulation of AGEs over time can cause.

Take for example cardiovascular disease. AGEs can lead to the stiffening and weakening of collagen in blood vessel walls. This type of stiffening leads to high blood pressure and the weakening can result in an aneurism (a weak spot in the wall of an artery or a vein that dilates or balloons out to form a blood-filled sack or pouch). If an aneurism bursts, a massive amount of blood is released, which results in an almost instantaneous drop in blood pressure that can lead to death. If a burst occurs in the brain, it can result in a stroke. AGEs can also affect the amount of LDL (bad) cholesterol that gets deposited in blood vessel walls and in time this can also result in atherosclerosis which is the root cause of various cardiovascular diseases such as angina, heart attack and stroke.

Of course, for someone whose blood system is bathed in too much glucose, as is the case with diabetes, AGEs are formed far more quickly. Watching someone with diabetes is in effect like watching someone age in fast forward.

Treatment with benfotiamine, has however been proven to reduce tissue AGEs. This is due to the fact that benfotiamine leads to significantly increased intracellular thiamine diphosphate levels. Thiamine diphosphate is a co-factor in the enzyme transketolase and it’s transketolase that works to reduce tissue AGEs. Using thiamine (Vitamin B1) alone to increase transketolase levels does not work efficiently enough to stop AGEs from accumulating in healthy cells. But benfotiamine can increase transketolase levels by as much as 300%! The implications of this in relation to anti-aging medicine are potentially enormous.

Benfotiamine, in combination with pyridoxine hydrochloride, has also been used for a number of years by doctors in Germany to treat nerve damage and nerve pain such as sciatica.

Whilst research into benfotiamine continues, even at this stage we already know enough to understand its potential and the fact that ultimately benfotiamine may have a huge impact on the lives of so many.

Dosage

50mg doses should be taken two or three times daily. Type 1 diabetics may need to increase their doses to 100mg.

References

1. Wild S, Roglic G, Green A, Sicree R, King H. Global Prevalence of Diabetes. Estimates for the year 200 and projections for 2030. Diabetes Care 2004 27:1047–1053
2. Roglic G, Unwin N, Bennett PH, Mathers C, Tuomilheto J, Nag S, Connolly V, King H. The burden of mortality attributable to diabetes: realistic estimates for the year 2000. Diabetes Care 2005 Sep;28(9):2130-5.
3. Hammes HP, Du X, Edelstein D, Taguchi T, Matsumura T, Ju Q, Lin J, Bierhaus A, Nawroth P, Hannak D, Neumaier M, Bergfeld R, Giardino I, Brownlee M. Benfotiamine blocks three major pathways of hyperglycaemic damage and prevents experimental diabetic retinopathy. Nat Med. 2003 Mar;9(3):294-9. Epub 2003 Feb 18



http://www.antiaging-systems.com/194-benfotiamine-milgamma-mono-vitamin-b1

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Posted: 1/13/2012 11:59:23 AM
 
HB~Glad you started a different thread discussion for benfotiamine. Great stuff you have dug up here.




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Posted: 1/13/2012 2:39:15 PM
 
Thanks Pamoja.
I was unaware of that !


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Posted: 1/13/2012 8:36:51 PM
 
asataxanthin 16mg/day you can 2x it

try green coffee extract to lower BG or drink lightly roasted

stuart






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Posted: 1/13/2012 9:03:13 PM
 
Yes lots of members on Bernsteins board used it for eye protection.


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Posted: 1/17/2012 3:04:26 PM
 
Heart Builder

This is very encouraging to read.  I am happy for you.   Thanks for letting us know what supplements you are taking to help with
this condition.

Marilyn




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Posted: 1/17/2012 3:50:00 PM
 
Great news HB, that is encouraging! 


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Posted: 1/17/2012 5:17:45 PM
 
Thanks Greatly Guys.
HB




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Posted: 2/10/2012 7:51:27 PM
 
to healthnut - - - give me a call


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Posted: 2/12/2012 6:13:55 PM
 
Thanks much for that Pamoja. I didn't know that. HB


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Posted: 6/17/2012 9:03:00 PM
 
HB, Kathy,

Are you using benfotiamine or still using benfotiamine???  If so, what kind of results are you getting???

Steve


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Heart_Builder

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Posted: 6/17/2012 9:41:47 PM
 
Steve,
Yes I'm using it but my blood glucose doesn't appear to be any better but I need to do a Hba1c. Because my AGE counts maybe dropping even if my BG isn't so HbA1c may get better anyway. HB




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Posted: 6/18/2012 9:28:47 PM
 
I was using benfotiamine for the past few months and ran out a couple weeks ago.  It didn't appear to be doing much, but BG's seem to be a bit higher since I got off.  I also noticed an increase in PN symtoms off benfotiamine.


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