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Member Forum >> Heart Health Forum >> Studies on fish oil
 Studies on fish oil

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Join Date: 10/25/2010
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Posted: 6/26/2014 12:18:24 AM


  • Omega-3 Fatty Acids in the Management of Hypertriglyceridemia: New Findings and Formulations - Continuing Medical Education (CME):Princeton Media Associates, exp. 10/29/06 - "To lower TG levels, the dose of omega-3 therapy is ~4 g of EPA + DHA per day"
  • Omega-3 Fatty Acids: Recommendations for Therapeutics and Prevention - Medscape, exp. 10/19/06 -"Studies support low DHA as a risk factor for dementia. Low total n-3 fatty acids levels, EPA and DHA associate with greater risk of CVD, dietary intake and/or supplementation is supported as a secondary or tertiary prevention measure. Omega-3 fatty acids also help to prevent type 2 diabetes and the metabolic syndrome, two common precursors to CVD. There is some support for schizophrenia, depressive or aggressive disorders; however, large multi-center clinical trials have yet to be conducted. The anti-inflammatory properties of n-3 fatty acids are helpful in decreasing symptoms of rheumatoid arthritis and may possibly increase remission length in Crohn's patients"
  • Omega 3: Implications in human health and disease - PowerPak (CME course), exp. 8/1/03 - "On average, our society consumes around 35% of its caloric intake from fat, mainly as vegetable oil. The omega 6 LA comprises 7% to 9% of our daily caloric intake, while the omega 3 LNA makes up about 0.7% of energy. It is therefore estimated that the dietary ratio of LA to LNA ranges from 10 to 20:1, at which level the metabolism of LNA is strongly suppressed.2,25 Again, this is far more than the recommended ratio of 2.3:1" - See Mega Twin EPA at

General Information:

  • An Evidence-Based Medicine Approach to the Appropriate Selection of Supplementation with Omega-3 Fatty -, 6/1/07 - "Fish oils EPA and DHA appear to result in different physiologic effects than their precursor, the plant-derived ALA.12-14 Biosynthesis of EPA or DHA from ALA is limited. Although dietary consumption of ALA alone will prevent EFA deficiency, emerging scientific evidence indicates that for optimum health or body function, the fish oils EPA and DHA should also be ingested regularly, either from dietary or supplement sources. Use of ALA supplementation alone, even with high dose or long-term consumption, does not result in lowered triglyceride concentrations seen with EPA or DHA, nor does it demonstrate similar in vitro susceptibility to oxidation of LDL cholesterol"
  • The Heart-Healthy Benifits of Omega-3 Fatty Acids - John Hopkins University School of Medicine, 6/05 - "Fish-oil supplements appear to have much lower levels of toxins than fish. In a study of 5 over the-counter fish-oil preparations, levels of PCBs and organochlorines were below the detectable limit in all of the supplements ... Because consumption of this amount of fish in secondary prevention is difficult for most individuals, dietary supplementation is generally needed and should be recommended. The dose in secondary prevention should be at least 875 mg of EPA + DHA per day. This dose can generally be obtained by taking 2 capsules of concentrated fish oils (at least 50% EPA + DHA) per day. For example, such a preparation would contain 500 mg of EPA + DHA per each 1000-mg fish-oil capsule"
  • Omega 3: Implications in Human Health and Disease - - "It should be noted, however, that flaxseed or flaxseed oil does not contain EPA or DHA. Thus flaxseed and fish oil are not interchangeable sources of omega 3 fatty acids per se" - I believe the same holds true for canola oil - Ben
  • Omega 3: Implications in Human Health and Disease -"The omega 6 LA comprises 7% to 9% of our daily caloric intake, while the omega 3 LNA makes up about 0.7% of energy. It is therefore estimated that the dietary ratio of LA to LNA ranges from 10 to 20:1, at which level the metabolism of LNA is strongly suppressed. Again, this is far more than the recommended ratio of 2.3:1 ... From an evolutionary perspective, a significant change in the diet has occurred in a very short time. The diet of our ancestors in the Paleolithic period (400,000 to 45,000 years ago) was lower in fat and balanced in omega 6 and omega 3—a ratio of 1:1, or 10- to 20-fold lower than today's standard."

News & Research:

  • Omega-3 inhibits blood vessel growth in age-related macular degeneration - Science Daily, 6/17/14 - "Age-related macular degeneration (AMD), which is characterized by choroidal neovascularization (CNV), or blood vessel growth, is the primary cause of blindness in elderly individuals of industrialized countries ... the omega (ω)-3 long-chain polyunsaturated fatty acids (LCPUFAs), DHA and EPA, and their specific bioactive products derived from the cytochrome P450 (CYP) pathway, can influence choroidal neovascularization (CNV) and vascular leakage by modulating micro-environmental immune cell recruitment to the site of these lesions ... Given the prevalence of neovascular eye disease, the potential impact of this study is highly significant. We have identified unique endogenous lipid biometabolites that are able to inhibit pathologic retinal angiogenesis, a major driver of vision loss worldwide"- See fish oil supplements at
  • Diet Rich in Polyphenols Improves Glucose Metabolism - Medscape, 6/4/14 - "they randomized 45 patients to one of four diets: a standard control diet that was low in omega-3 fatty acids and polyphenols, a diet rich in omega-3 fatty acids, a diet rich in polyphenols, and a diet that included omega-3 fatty acids and polyphenols. All patients were overweight or obese, with a body-mass index > 30 ... Although individuals lost more weight on the eight-week omega-3-fatty-acid–enriched diet, there were significantly greater improvements in plasma glucose and plasma insulin levels with the polyphenol-enriched diet during an oral glucose tolerance test. The improvement in glucose metabolism was observed only in those who consumed the polyphenol-enriched diet ... this particular mechanism of action with polyphenols is similar to drugs used in the treatment of diabetes. However, rather than wait until the patient is diagnosed with the metabolic disease, a diet rich in polyphenols could be used as a preventive strategy"
  • Diet can predict cognitive decline, researchers say - Science Daily, 4/27/14 -"What is the takeaway from this research? There is growing evidence that very long chain omega-3 fatty acids are beneficial for maintaining cognitive health, and many Americans do not have an adequate intake of these nutrients" - See fish oil supplements at
  • Fatty-Fish Consumption Alters HDL-Particle Profile - Medscape, 3/7/14 - "Although total-, LDL-, and HDL-cholesterol levels did not change, for those who consumed this healthy diet rich in polyunsaturated fatty acids, the intake of fish was strongly correlated with an increased concentration of large HDL particles, including an increase in the average diameter of HDL particles and an increase in the concentrations of large HDL lipid components ... The changes that we saw in large HDL particles could be related to those parameters that are functionally related to reverse cholesterol transport ... Thus, our findings could partly explain the known protective effects of fish consumption against atherosclerosis"
  • Fish Oil Might Guard Against Loss of Brain Cells - WebMD, 1/22/14 -"The more you consume the omega-3 fatty acids found in fish oils, the less likely you are to lose as many precious brain cells as you age ... the researchers tested levels of omega-3 fatty acids in the red blood cells of more than 1,000 older women. Eight years later, the women had MRI scans that measured their brain volumes. At the time of the scans, the women were an average of 78 years old ... Participants whose omega-3 levels were twice as high had a 0.7 percent higher brain volume ... The results suggest that the effect on brain volume is the equivalent of delaying the normal loss of brain cells that comes with aging by one to two years" - [Medscape] - See fish oil supplements at
  • Fish derived serum omega-3 fatty acids help reduce risk of type 2 diabetes - Science Daily, 1/14/14 - "Ongoing at the University of Eastern Finland, the Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD) determined the serum omega-3 fatty acid concentrations of 2,212 men between 42 and 60 years of age at the onset of the study, in 1984-1989 ... follow-up of 19.3 years ... The risk of men in the highest serum omega-3 fatty acid concentration quarter to develop type 2 diabetes was 33% lower than the risk of men in the lowest quarter" - See fish oil supplements at
  • Omega-3 Dietary Supplements Pass Blood-Brain Barrier - Science Daily, 12/4/13 -"omega-3 fatty acids in dietary supplements can cross the blood brain barrier in people with Alzheimer's disease ... The findings are presented in the Journal of Internal Medicine, and strengthen the evidence that omega-3 may benefit certain forms of this seriously debilitating disease ... Thirty-three patients participated in the study, 18 of whom received a daily omega-3 supplement and 15 a placebo for six months. The results show that the first group had higher levels of both DHA and eicosapentaenoic acid (EPA, another omega-3 fatty acid) in their cerebrospinal fluid (which surrounds the CNS) and blood. No such change was seen in the placebo group ... Moreover, they also found that levels of DHA correlated directly with the degree of change in Alzheimer's disease and inflammatory markers in the cerebrospinal fluid"
  • Low-fat fish oil changes cancer tissue in prostate cancer, study shows - Science Daily, 11/18/13 - "Men with prostate cancer who ate a low-fat diet and took fish oil supplements had lower levels of pro-inflammatory substances in their blood and a lower cell cycle progression score, a measure used to predict cancer recurrence ... lowering the cell cycle progression (CCP) score may help prevent prostate cancers from becoming more aggressive ... The Western diet consisted of 40 percent of calories from fat, generally equivalent to what many Americans consume today .... The low-fat diet consisted of 15 percent of calories from fat. Additionally, the men on this diet took five grams of fish oil per day in five capsules, three with breakfast and two with dinner, to provide omega-3 fatty acids"
  • High serum fatty acid protects against brain abnormalities - Science Daily, 10/17/13 - "3,660 people aged 65 and older underwent brain scans to detect so called silent brain infarcts, or small lesions in the brain that can cause loss of thinking skills, dementia and stroke. Scans were performed again five years later on 2,313 of the participants ... silent brain infarcts, which are only detected by brain scans, are found in about 20% of otherwise healthy elderly people ... those who had high long-chain omega-3 polyunsaturated fatty acid content in blood had about 40% lower risk of having small brain infarcts compared to those with low content of these fatty acids in blood ... people who had high long-chain omega-3 polyunsaturated fatty acid content in blood also had fewer changes in the white matter in their brains"
  • Diet during pregnancy and early life may affect children's behavior and intelligence - Science Daily, 9/13/13 - "Blood samples were taken from 493 schoolchildren, aged between seven and nine years, from 74 mainstream schools in Oxfordshire. All of the children were thought to have below-average reading skills ... Analyses of their blood samples showed that, on average, just under two per cent of the children's total blood fatty acids were Omega-3 DHA (Docosahexaenoic acid) and 0.5 per cent were Omega-3 EPA (Eicosapentaenoic acid), with a total of 2.45 per cent for these long-chain Omega-3 combined. This is below the minimum of 4 per cent recommended by leading scientists to maintain cardiovascular health in adults, with 8-12 per cent regarded as optimal for a healthy heart ... levels of Omega-3 fatty acids in the blood significantly predicted a child's behaviour and ability to learn. Higher levels of Omega-3 in the blood, and DHA in particular, were associated with better reading and memory, as well as with fewer behaviour problems as rated by parents and teachers"
  • Fatty acids could aid cancer prevention and treatment - Science Daily, 8/1/13 -"new research from scientists at Queen Mary, University of London ... In vitro tests showed omega-3 fatty acids induced cell death in malignant and pre-malignant cells at doses which did not affect normal cells, suggesting they have the potential to be used in both the treatment and prevention of certain skin and oral cancers"
  • Diets lacking omega-3s lead to anxiety, hyperactivity in teens: Generational omega-3 deficiencies have worsening effects over time - Science Daily, 7/29/13 -"in a rodent model second-generation deficiencies of omega-3s caused elevated states of anxiety and hyperactivity in adolescents and affected the teens' memory and cognition ... this dietary deficiency can compromise the behavioral health of adolescents, not only because their diet is deficient but because their parents' diet was deficient as well. This is of particular concern because adolescence is a very vulnerable time for developing psychiatric disorders including schizophrenia and addiction."Diets lacking omega-3 fatty acids -- found in foods like wild fish, eggs, and grass-fed livestock -- can have worsened effects over consecutive generations, especially affecting teens"
  • Fish Oil's Link to Prostate Cancer Unproven - Medscape, 7/26/13 - "The bottom line is that we cannot determine from this study design whether the intake of omega-3 fatty acids will cause prostate cancer and raise a man's risk for high-grade disease. The media has taken this and sensationalized the risk associated with omega-3 fatty acid intake"
  • Low Omega-3 in Kids Linked to Behavior, Cognitive Deficits - Medscape, 7/23/13 -"This study formed the screening stage of a previously published randomized controlled intervention study that included 362 healthy children aged 7 to 9 years from primary schools in Oxfordshire, a large county in the UK, who had low reading scores. The DOLAB study reported that supplementation with 600 mg DHA daily for 16 weeks improved reading and behavior in children with the lowest 20% of reading scores ... The study showed that reading scores were significantly and positively associated with the omega-3 fatty acids DHA (P < .003), docosapentaenoic acid (DPA; P < .04), eicosapentaenoic acid (EPA; P < .005), and the omega-3 index (EPA+DHA; P < .04). Total omega-6 fatty acids also showed a positive correlation with reading ... Results were similar for working memory. Scores for Recall of Digits Forward were significantly and positively associated with DHA (P < .003), DPA (P < .04), EPA (P < .005), the omega-3 index (P < .001), and total omega-3 (P < .004)"
  • How a SELECTed Bad Study Became Big News - Dr. Michael Murray, 7/12/13 -"This study is not consistent with other studies (discussed below) ... There is no evidence that anybody in this study took fish oil supplements or even ate fish ... In usual circumstances, plasma levels of EPA and DHA reflect very recent intake and are considered a poor biomarker of long-term omega-3 intake ... Patients with prostate cancer may have only recently increased their fish and/or fish oil consumption ... Fish and fish oil ingestion produces a big rise in plasma omega-3 levels in about 4.5 hours and washes out around 48 hours ... The data may reflect cancer activity rather than a causative association. Without dietary history or documentation of fish oil use there is no way of knowing"
  • Experts slam omega-3 link to prostate cancer as 'scaremongering' - Nutra USA, 7/12/13 - "if the findings of the new study were true, "then prostate cancer would be rampant in any country with high seafood consumption (Scandinavia, Japan etc) and conversely, low level consumption should be protective"
  • Specific Fish Oils May Protect Against Breast Cancer - Medscape, 6/27/13 - "The consumption of higher levels of dietary marine n-3 polyunsaturated fatty acids (PUFAs) is associated with a 14% lower risk for breast cancer than lower levels of consumption ... They found that marine n-3 PUFAs were associated with a 14% reduction in the risk for breast cancer (relative risk [RR] for highest vs lowest intake, 0.86) ... no significant association was observed for exposure to alpha linolenic acid (ALA), which is contained in some nuts and in vegetable oils. About half of the studies in the meta-analysis contained data on ALA. Both ALA and n-3 PUFAs are types of omega-3 fatty acids" - [Science Daily] - See Mega Twin EPA at and Jarrow Max DHA at
  • Could a Diet High in Fish and Flax Help Prevent Broken Hips? - Science Daily, 6/27/13 - "The study showed that higher levels of omega-3 fatty acids from both plant and fish sources in those blood cells were associated with a lower likelihood of having fractured a hip ... The study also showed that as the ratio of omega-6 fatty acids to omega-3s increased, so did the risk for hip fracture ... Inflammation is associated with an increased risk of bone loss and fractures, and omega-3 fatty acids are believed to reduce inflammation ... omega-3 fatty acids have anti-inflammatory properties and omega-6 fatty acids seem to have both anti- and pro-inflammatory effects ... women who had the highest ratio of omega-6 to omega-3 fatty acids had nearly twice the risk of hip fractures compared to women with the lowest ratios. The current typical American diet contains between 15 and 17 times more omega-6 than omega-3, a ratio that previous research has suggested should be lowered to 4-to-1, or even 2-to-1, by increasing omega-3s, to improve overall health. The primary omega-6 fatty acid in the diet is linoleic acid, which composes about 99 percent of Americans' omega-6 intake and is found in corn, soybean, safflower and sunflower oils"
  • Marine n-3 Polyunsaturated Fatty Acids - Medscape, 6/11/13 - "Sarcopenia is the age-related loss of muscle mass that results in a reduction in skeletal muscle function, quality of life and an increased risk of falls. Older muscle has an 'anabolic resistance' to both nutrients and exercise, with the precise underlying mechanism still to be elucidated. The n-3 polyunsaturated fatty acids found in fish oil can be incorporated into the membranes of skeletal muscles, where they may have anti-inflammatory effects. This alteration in muscle membrane fatty acid composition may have anabolic effects in aging muscle and, thus, be useful in the treatment of sarcopenia ... The current data presented suggest that n-3 PUFAs may be of benefit in the treatment of sarcopenia"
  • Omega-3 fatty acids may help heal a broken heart - Science Daily, 5/30/13 -"The potency of these compounds corresponds to concentrations that have been measured in the blood of human subjects taking high dose fish oil supplements for short periods of time. In rabbits, researchers treated the artery with RvD at the time of the balloon angioplasty procedure by infusing the drug directly into the vessel, and found that this one-time treatment reduced inflammation and subsequent scarring of the vessel after one month"
  • Fish Oil Supplements May Help Fight Against Type 2 Diabetes - Science Daily, 5/22/13 - "Fish oil supplements, also called omega 3 fatty acid capsules, raise levels of adiponectin in the bloodstream. Adiponectin is an important hormone that has beneficial effects on metabolic processes like glucose regulation and the modulation of inflammation. In long-term human studies, higher levels of adiponectin are associated with lower risks of type 2 diabetes and coronary heart disease ... The meta-analysis reviewed and analyzed results from 14 randomized, placebo-controlled clinical trials"
  • Fish oil may help the heart beat mental stress - Science Daily, 5/22/13 -"volunteers who took fish oil supplements for several weeks had a blunted response to mental stress in several measurements of cardiovascular health, including heart rate and muscle sympathetic nerve activity (MSNA), part of the "fight or flight" response, compared to volunteers who took olive oil instead. The results may explain why taking fish oil could be beneficial to the heart and might eventually help doctors prevent heart disease in select populations"
  • Fish oil may stall effects of junk food on brain - Science Daily, 5/14/13 -"high-fat diets could disrupt neurogenesis, a process that generates new nerve cells, but diets rich in omega-3s could prevent these negative effects by stimulating the area of the brain that control feeding, learning and memory ... Excessive intake of certain macronutrients, the refined sugars and saturated fats found in junk food, can lead to weight gain, disrupt metabolism and even affect mental processing ... These changes can be seen in the brain's structure, including its ability to generate new nerve cells, potentially linking obesity to neurodegenerative diseases ... omega-3 fish oils can reverse or even prevent these effects ... omega-3s restore normal function by interfering with the production of these inflammatory molecules, suppressing triglycerides, and returning these nerve growth factors to normal ... Fish oils don't appear to have a direct impact on weight loss, but they may take the brakes off the detrimental effects of some of the processes triggered in the brain by high-fat diets. They seem to mimic the effects of calorie restrictive diets and including more oily fish or fish oil supplements in our diets could certainly be a positive step forward for those wanting to improve their general health"
  • Eating fish associated with lower risk of dying among older adults: Risk of dying from heart disease significantly lowered - Science Daily, 4/1/13 -"Older adults who have higher blood levels of omega-3 fatty acids -- found in fatty fish and seafood -- may be able to lower their overall mortality risk by as much as 27% and their mortality risk from heart disease by about 35% ... older adults who had the highest blood levels of the fatty acids found in fish lived, on average, 2.2 years longer than those with lower levels ... The researchers examined 16 years of data from about 2,700 U.S. adults aged 65 or older who participated in the Cardiovascular Health Study (CHS), a long-term study supported by the National Heart, Lung, and Blood Institute ... One type in particular -- docosahexaenoic acid, or DHA -- was most strongly related to lower risk of coronary heart disease (CHD) death (40% lower risk), especially CHD death due to arrhythmias (electrical disturbances of the heart rhythm) (45% lower risk). Of the other blood fatty acids measured -- eicosapentaenoic acid (EPA) and docosapentaenoic acid (DPA) -- DPA was most strongly associated with lower risk of stroke death, and EPA most strongly linked with lower risk of nonfatal heart attack"
  • High Intake of Dietary Long-Chain ω-3 Fatty Acids Is Associated With Lower Blood Pressure in Children Born With Low Birth Weight: NHANES 2003-2008 - Hypertension. 2013 Mar 4 - "Reduced fetal growth is associated with increased systolic blood pressure ... In the 354 participants with reduced birth weight, when compared with children with the lowest tertile of intake, those who had the highest tertile of dietary eicosapentaenoic acid and docosahexaenoic acid intake had significantly lower systolic blood pressure (-4.9 mm Hg [95% confidence interval, -9.7 to -0.1]) and pulse pressure (-7.7 mm Hg [95% confidence interval, -15.0 to -0.4])" - See Mega Twin EPA at and Jarrow Max DHA at
  • Taking omega-3 supplements may help prevent skin cancer, new study finds - Science Daily, 2/26/13 - "the study analysed the effect of taking omega-3 on 79 healthy volunteers ... taking a regular dose of fish oils boosted skin immunity to sunlight. Specifically, it also reduced sunlight-induced suppression of the immune system, known as immunosuppression, which affects the body's ability to fight skin cancer and infection ... it was the first time the research had been carried out on humans"
  • Omega-3s inhibit breast cancer tumor growth, study finds - Science Daily, 2/21/13 -"A lifelong diet rich in omega-3 fatty acids can inhibit growth of breast cancer tumours by 30 per cent ... the researchers created a novel transgenic mouse that both produces omega-3 fatty acids and develops aggressive mammary tumours. The team compared those animals to mice genetically engineered only to develop the same tumours ... Mice producing omega-3s developed only two-thirds as many tumours -- and tumours were also 30-per-cent smaller -- as compared to the control mice"
  • Fish oil may protect dialysis patients from sudden cardiac death - Science Daily, 2/6/13 - "We found that higher levels of omega-3 fatty acids in the blood of patients who were just starting hemodialysis were very strongly associated with a lower risk of sudden cardiac death over the first year of their treatment ... The five-year survival rate for patients on hemodialysis is 35 percent, with the risk of death highest in the first few months of starting treatment. The most common cause of death in these patients is sudden cardiac death, which accounts for about one out of every four deaths"
  • Omega-3-Rich Ground Beef Available Soon - Science Daily, 2/4/13 -"The U.S. currently does not have a recommended daily intake of omega-3s, though many doctors and nutritionists recommend between 1,200-1,600 milligrams daily ... A quarter-pound hamburger made of the enriched ground beef has 200 milligrams of omega-3s" - See Mega Twin EPA at which has 765 milligrams of omega-3 in one capsule. So you'd have to eat 3.825 hamburgers to get the omega-3 in one capsule. At 330 calories per hamburger, that's 1262 calories compared to 10 calories for the capsule.
  • Limiting Polyunsaturated Fatty Acid Levels in Pregnancy May Influence Body Fat of Children - Science Daily, 1/10/13 - "mothers who have higher levels of n-6 polyunsaturated fatty acids (PUFAs), which are found in cooking oils and nuts, during pregnancy have fatter children ... assessed the fat and muscle mass of 293 boys and girls at four and six years, who are part of the Southampton Women's Survey (SWS), a large prospective mother-offspring cohort ... the higher the level of n-3 the less fat and more muscle and bone in the baby ... This could suggest that a pregnancy supplementation strategy would be beneficial"
  • Association Between use of Specialty Dietary Supplements and C-Reactive Protein Concentrations - Medscape, 12/28/12 - "In summary, this study adds support to laboratory research and to some human studies which suggest that glucosamine, chondroitin, and fish oil may reduce systemic inflammation. In doing so, this study adds biologic plausibility to previous studies which have shown beneficial effects of these supplements on chronic diseases. Given the number of diseases with which inflammation is associated, such as cancer and cardiovascular disease, there is a need to find safe and effective ways to reduce inflammation. Research suggests that these 3 supplements have excellent safety profiles, [88–92] supporting their potential role in disease prevention"- Seeglucosamine products at,chondroitin sulfate at, Mega Twin EPA at and Jarrow Max DHA at
  • Glucosamine, Chondroitin, Fish Oil May Reduce Inflammation - Medscape, 11/27/12 -"Inflammation is now recognized as a factor in cancer and cardiovascular disease as well as many rheumatoid diseases ... the researchers found hs-CRP reductions of 17% (95% confidence interval [CI], 7% - 26%) with glucosamine, 22% (95% CI, 8% - 33%) with chondroitin, and 16% (95% CI, 0.3% - 29%) with fish oil compared with participants who did not take the supplements"
  • Eating more fish could reduce postpartum depression - Science Daily, 11/15/12 -"Low levels of omega-3 may be behind postpartum depression ... Because omega-3 is transferred from the mother to her fetus and later to her breastfeeding infant, maternal omega-3 levels decrease during preg