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Member Forum >> Bowel Flora and Digestive Health >> Microbial regulation of organismal energy homeostasis
 Microbial regulation of organismal energy homeostasis
Rodney D

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Posted: 12/12/2019 4:17:00 PM
 
This is not an easy read for me but seems really interesting...what I can understand anyway. Here is an example:

Bäckhed et al.12 demonstrated the role of the gut microbiota in host energy metabolism and growth by showing that germ-free mice gained less body weight and fat mass than conventionalised mice (that is, those harbouring a gut microbiota). This difference was observed despite increased food intake in germ-free mice. The same group of researchers found that the microbiota of genetic obese mice (ob/ob) harvests more energy than their lean ob/+ counterparts. In addition, this phenotype was transferred in germ-free mice transplanted with the microbiota from the obese donors11. Initially, the hypothesis was that this shift provided more SCFAs (acetate, propionate, butyrate and lactate) that could be used as metabolic substrates by the host (Fig. 1). In addition, it was suggested that the gut microbiota contributed to energy metabolism through a direct interaction with the digestive tract. Indeed, the germ-free mice exhibit a lower level of caecal SCFAs than conventionalised mice, thereby suggesting that gut bacteria directly contribute to energy absorption by providing energy substrates to the host13.

Microbial regulation of organismal energy homeostasis
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Dr. Davis

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Posted: 12/12/2019 6:49:09 PM
 
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