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Join Date: 12/5/2017 Posts Contributed: 2461 Post Likes: 277 Recommends Recd: 0 Ignores Issued: 0
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Posted: 5/30/2018 7:50:00 AM
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Originally posted by Dr. Davis on 2018-05-30
on the Wheat Belly Blog,
sourced from and currently found at: Infinite Health Blog.
PCM forum Index
of WB Blog articles.
Stay 40 years old . . . for the next 40, 50, or 60 years?

The images of the mice are
from one of the elegant MIT
studies from Poutahidis et al investigating the
effects of Lactobacillus reuteri
ATCC PTA 6475. Even if you are not a fan
of reading such detailed experimental studies, I
urge you to read these, as they are well-written,
wonderfully detailed, and written by people who
have a real understanding of the full implications
of the work they are doing.
Specifically, the above photo
shows what happens at 12 months of age in
control mice (example on left) compared to mice
fed L. reuteri in their water (example
on right). Notice that the control mouse is fat,
while the treated mouse is slender.
This and related studies
demonstrate that:
- While control mice got old—stopped playing,
lost interest in mating or grooming each other, and
got fat—L. reuteri mice stayed
slender, mated more and continued to groom each
other. In other words, L. reuteri
mice stayed youthful as they aged.
- Testicular size (specifically Leydig cell number)
and testosterone production in L. reuteri
mice was considerably greater
- Sebum production, hair density, skin thickness, and
dermal collagen were dramatically greater
- Skin healing was hugely accelerated
- Inflammatory measures (e.g., IL-10, neutrophil
blood count) were lower
- On an obesogenic diet, control mice got fat while
L. reuteri mice stayed slender
Most of these effects were
found to be mediated through increased
oxytocin blood levels, mimicking
the findings of studies in parabiosis,
in which immunologically compatible mice had their
circulatory systems combined, one old and one young:
the older mouse reverse-aged and became young again,
mediated largely via oxytocin.
Other studies in mice and in
humans have demonstrated that L. reuteri
or oxytocin are associated with:
- Marked weight loss without change in diet or exercise
- Greater bone density or less bone loss
- Increased muscle mass
- Reduced insulin resistance, reduced visceral fat
- More rapid skin healing
- Increased empathy
To put this all another way,
L. reuteri mice stayed young
and slender until death (without life extension).
More and more of the findings
in mice are being corroborated in humans. Will this
youth-preserving effect also translate to humans?
Could it mean that at, say, at age 40, you begin
to supplement with L. reuteri (as we have been
doing by amplifying bacterial counts with
prebiotic-infused yogurt making) and you can
remain 40 years old for another 40, 50, or
60 years with preservation of healthy, smooth
skin, dense bones, high levels of testosterone and
estrogen, thick hair, preservation of muscle,
prevention of visceral fat accumulation, lower levels
of inflammation, more youthful mentality, and slender?
Could it mean that you are biking, dancing, and
socializing at age 80 just as you are at 40 and
not the one driving 20 miles per hour in a
45 mile-per-hour zone or asking the sales clerk
to help you lift the gallon jug of milk?
I think that we are heading
in that direction. And, because of the anorexigenic
effect of L. reuteri/oxytocin, i.e.,
the loss of interest in food (though it still tastes
good; you are simply freed from appetite, not taste)
may lead us in the direction of caloric restriction
that, at least in several experimental models, has
been the most effective strategy to lengthen life.

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Tags: appetite,belly,Loss,oxytocin,PCM,reuteri,undoctored,WBB,Weight,wheat,yogurt
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