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Member Forum >> Heart Health General Discussion >> Pfzier terminates development of bococizumab (a PCSK9 inhibitor)
 Pfzier terminates development of bococizumab (a PCSK9 inhibitor)
Bob Niland

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Posted: 11/1/2016 8:51:32 PM
Edited: 11/10/2016 7:18:29 AM (1)
 

MPT: Morning Break: PCSK9 Drug Dropped
Pfizer said it was axing its investigational PCSK9 inhibitor bococizumab, citing trial results showing more adverse effects and less long-term efficacy than other drugs in the class.

Pfizer Press Release:
Pfizer Discontinues Global Development of Bococizumab, Its Investigational PCSK9 Inhibitor
With the completion of six bococizumab lipid-lowering studies, Pfizer has observed an emerging clinical profile that includes an unanticipated attenuation of low-density lipoprotein cholesterol (LDL-C) lowering over time, as well as a higher level of immunogenicity and higher rate of injection-site reactions with bococizumab than shown with the other agents in this class. The goal of treating elevated cholesterol is to reduce the occurrence of cardiovascular events such as heart attacks and stroke, which requires long-term effective and durable cholesterol-lowering. …

The release didn't speak of events (or all-cause mortality), but we may eventually learn of those results, because:
…Pfizer has committed to ensuring that the data will be made available to study leaders for independent analysis and prompt public presentation. …

The good news here, I suppose, is that now we won't have to learn how to pronounce "Bococizumab", although I imagine they were working on a trendy retail branding for it, perhaps "Lipidown".

___________
Bob Niland [disclosures] [topics]



Tags: bococizumab,PCSK9 inhibitor




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Posted: 11/8/2016 2:03:14 PM
 
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Bob Niland

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Posted: 11/9/2016 10:45:08 AM
 
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Tags: PCSK9 inhibitor

xtronics

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Posted: 11/14/2016 10:30:53 AM
 
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Posted: 12/18/2016 12:02:40 PM
 
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Bob Niland

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Posted: 12/18/2016 12:36:07 PM
 
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Posted: 12/18/2016 1:53:43 PM
 
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Posted: 12/19/2016 7:34:56 PM
 
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Posted: 1/6/2017 6:20:01 PM
 
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Bob Niland

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Posted: 1/7/2017 7:25:26 AM
 
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Posted: 1/7/2017 12:07:01 PM
 
The Budoff PCSK9 study group I was in recently was stopped also.


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Bob Niland

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Posted: 1/7/2017 2:13:08 PM
Edited: 3/17/2017 7:49:14 PM (4)
 
{deleted inadvertently}


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Posted: 1/7/2017 4:16:49 PM
Edited: 1/8/2017 12:08:25 AM (1)
 
Bob~I'm not sure.


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xtronics

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Posted: 1/10/2017 12:28:16 PM
 
Failed results are often never published.

Wonder if we will ever know.





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ptheut

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Posted: 1/10/2017 1:59:50 PM
 
they stated that there was no money in the product as it only worked on high HCY folks


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xtronics

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Posted: 1/13/2017 7:16:47 PM
 
@ptheut - where did you see that?





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ptheut

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Posted: 1/13/2017 9:18:06 PM
 
bloomberg


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xtronics

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Posted: 1/14/2017 11:52:34 AM
 
Not seeing anything on bloomberg?

What I do see is that it is too expensive $14,000/year and a lawsuit has killed any competition.





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Posted: 1/14/2017 11:59:27 AM
 
couple of weeks ago - - - 7 sec blurb 


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xtronics

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Posted: 1/23/2017 4:16:57 PM
 
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Bob Niland

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Posted: 3/17/2017 7:49:41 PM
 
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Posted: 3/18/2017 9:37:00 AM
 
Bob, great spin from big Pharma,  bottom line, no money in it




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Bob Niland

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Posted: 3/18/2017 10:24:01 AM
 
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Posted: 3/19/2017 5:04:14 PM
 
I agree Bob, those with FH and some other Hcy related issues are screwed. 




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Posted: 5/18/2017 10:01:40 PM
Edited: 5/18/2017 10:14:58 PM (4)
 
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