Stents, defibrillators, and other profit-making opportunities

As a practicing cardiologst, every day I receive a dozen or more magazines or newspapers targeting practicing physicians, not to mention the hundreds of letters, postcards, invitations to "talks", etc. that I receive. All of these materials share one common goal: To get the practicing cardiologist/physician to insert more of a manufacturer's stents, defibrillators, prescribe more of their drugs, etc.

This is a highly effective and profitable area. Pfizer's Lipitor, for instance, generated $12.2 billion just last year alone. This kind of money will fund an extraordinary amount of marketing.

I'm on the www.heart.org mailing list, a website for cardiologists. I'd estimate that 90% or more of their content is device-related: discussions of situations in which to insert stents, the expanding world of implantable devices, the ups and downs of various drugs. Rarely are discussions of healthy lifestyles, exercise, nutritional supplements, part of the dialogue.

How can you protect yourself from the brainwashed physician, flooded with visions of all the devices he can put in you, all the drugs that can "cure" your disease? Simple: information. Be better informed. Ask pointed questions. The idiotic lay press tells you to ask a doctor about his education. That's not generally the problem. Some of the best educated doc's I know are also the most flagrantly guilty of profiteering medicine.

Ask your doctor about his/her philosphy about the use of medications, devices, etc. If their word is God, take it or leave it, run the other way.

Will radiation kill you?

Several people have asked me lately if radiation is truly dangerous. These conversations were sparked by an editorial comment made on a column I wrote for Life Extension Magazine's April, 2006 issue on "Three ways to detect hidden heart disease".

Among the methods that were discussed in this piece was, of course, CT heart scanning. Anyone who is involved with CT heart scans Quickly recognizes the spectacular power of this test to uncover hidden, unsuspected heart disease, literally within seconds. In 2006, there's really nothing like it for the every day person to have hidden heart disease detected and precisely quantified.

Yet, the "rebuttal" to my article claimed that the broad use of heart scans was only my personal view and that, in truth, radiation kills people.

NONSENSE! If an ovarian cancer is discovered by a CT scan of the abdomen, is that unwise use of radiation? If pneumonia or lung cancer is discovered on a chest x-ray with minimal radiation exposure, have we performed a disservice. Of course not. In fact, these are often lifesaving applications of radiation.

Can radiation be used unwisely with excessive exposure? Of course. The 64 slice CT angiograms are just an example of this. Dr. Mehmet Oz announced on Oprah recently that this was a test to be used for broad screening of women for heart disease. This is wrong. The radiation required for a full 64 slice CT angiogram test is truly excessive for a screening application. You wouln't want to get breast cancer from your mammogram, would you? The radiation from a 64-slice CT angiogram is similar to that of a heart catheterization in the hospital--too much for screening. This is not to be confused with a CT heart scan for a calcium score performed on a 64 slice device. I think this can be performed with acceptable radiation exposure.

Think about what would happen, for instance, if you had your heart disease undetected, had a heart attack, and went to the hospital? During your hospitalization, you'd likely get five chest x-rays, a heart catheterization, perhaps one or more nuclear imaging tests, maybe even a full CT scan (with far more radiation than a screening heart scan). The amount of radiation of a heart scan is trivial compared to what you obtain in a hospital.

So take it all in perspective. The low level of radiation required for a simple heart scan (not an angiogram) does not by itself substantially add to your lifetime risk of radiation exposure. It may, in fact, save your life or reduce your life long exposure to radiation.

Are you using bogus supplements?

I consider nutritional supplements an important, many times a critical,part of a coronary plaque control program.

But use the wrong brand or use it in the wrong way, and you can obtain no benefit. Occasionally, you can even suffer adverse effects.

Take coenzyme Q10, for instance. (Track Your Plaque Members: A full, in-depth Special Report on coenzyme Q10 will be on the website in the next couple of weeks.) Take the wrong brand to minimize the likelihood of statin-related muscle aches, and you may find taking Lipitor, Zocor, Crestor, etc. intolerable or impossible. However, take a 100 mg preparation from a trusted manufacturer in an oil-based capsule, and you are far more likely to avoid the inevitable muscle aches. (Though, of course, consult with your doctor, for all it's worth, if you develop muscle aches on any of these prescription agents.)

Unfortunately, you and I often don't truly know for a fact if a bottle from the shelf of a health food store or drugstore is accurately labeled, pure, free of contaminants, and efficacious.

One really great service for people serious about supplements is the www.consumerlab.com website. They are a membership website (with dues very reasonable) started by a physician interested in ensuring supplement quality. Consumer Lab tests nutritional supplements to determine whether it 1) contains what the label claims, and 2) is free of contamination. (I have no reason to pitch this or any other site; it's just a great service.) They recently found a supplement with Dr. Andrew Weil's name on it to have excess quantities of lead!

What Consumer Lab does not do is determine efficacy. In other words, they do a responsible job of reporting on what clinical studies have been performed to support the use of a specific supplement. However, true claims of efficacy of supplement X to treat symptom or disease Y can only come with FDA approval. Supplements rarely will be put through the financial rigors of this process.

If you're not a serious supplement user, but just need a reliable source, we've had good experiences with:

--GNC--the national chain
--Vitamin Shoppe--also a national chain
--www.lifeextension.com or www.lef.org--A great and low-priced source, but they do charge a $75 annual membership that comes with a subscription to their magazine, Life Extension (which I frequently write for) and several free supplements that you may or may not need. Again, I'm not pitching them; they are simply a good source.
--Solgar--a major manufacturer
--Vitamin World
--Nature's Bounty
--Sundown

There are many others, as well. Unfortunately, it's only the occasional manufacturer or distributor that permits unnacceptable contamination with lead or other poisons, or inaccurately labels their supplement (e.g., contains 1000 mg of glucosamine when it really contains 200 mg). I have not come across any manufacturer/distributor who has systemtically marketed uniformly bad products.

It really helps to have someone to lean on

Among my patients are several husband and wife teams, both of whom have heart disease by some measure. Several couples, for instance, consist of a huband who's received a stent, survived a heart attack, or has some other scar of the conventional approach. The wives generally have a substantial heart scan score in the several hundred range.

There are a few couples for which the roles are reversed: wife with bypass, heart attack, etc. and husband with a substantial quantity of coronary plaque by CT heart scan.

From them all, however, I've learned the power of teamwork. When both wife and husband (or even "significant other") are committed to the effort of controlling or reversing heart disease risk, the likelihood of success is magnified many-fold. Everything is easier: shopping for and choosing foods, incorporating supplements in the budget, taking vacations with a healthy focus, following through and sticking with your program.

Several of the couples have succeeded in obtaining regression of plaque for both man and woman. Both have reduced their heart scan scores and, as a result, dramatically reduced the potential for future heart attack and procedures.

Unfortunately, I will also see the opposite situation: One spouse committed to the program but the other indifferent. They may say such things as "You can't control what happens in the future." Or, "There's no way you can get rid of risk for heart disease. My doctor says it's hereditary." Or, "I've eaten this way since I was a kid. I'm not changing now for you or for anybody else."

Such negative commentary can't help but erode your commitment to health. Most of us recognize these sorts of comments as self-fulfulling and self-defeating.

What should you do if you have an unsupportive partner? Not easy. But it really can help to seek out a supportive partner, whether it's a friend, relative, or other significant person in your life. Of course, not everybody can find such a person. Perhaps that's another way our program can help.

I'd like to hear from anyone who does obtain substantial support of someone close, or if you are struggling to do so.

Five foods that can booby trap your heart disease prevention program

There are several foods that commonly come up on people's lists of habitual foods that are truly undesirable for a heart disease prevention program. Curiously, people choose these foods because of the mis-perception that they are healthy. My patients are often shocked when I tell them that they are not healthy and are, in fact, detrimental to their program.

I'm not talking about foods that are obviously unhealthy. You know these: fried foods, greasy cheeseburgers, French fries, bacon, sausage, etc. Nearly everyone knows that the high saturated fat content, low fiber, and low nutritional value of these foods are behind heart disease, hypertension, and a variety of cancers.

I'm talking about foods that people say they eat because they view them as healthy--but they're not.

Here's the list:

1) Low-fat or non-fat salad dressings--Virtually all brands we've examined have high-fructose corn syrup as one the main ingredients. What does high fructose corn syrup do? Triggers sugar cravings, makes your triglycerides skyrocket (causing formation of abnormal lipoproteins like small LDL), and causes diabetes. The average American now ingests nearly 80 lbs of this evil sweetener per year. You're far better off with olive, canol, grapeseed, or flaxseed based salad dressings.

2) Breakfast cereals--If you've been following these discussions, you know that the majority of breakfast cereals are sugar. They may not actually contain sugar, but they contain ingredients that are converted to sugar in your body. They may be cleverly disguised as healthy--Raisin Bran, Shredded Wheat, etc.

3) Pretzels--"A low-fat snack". That's right. A low-fat snack that raises blood sugar like eating table sugar from the bowl.

4) Margarine--Forget this silly argument about which is worse, butter or margarine. Which is worse, strychnine or lead? Both are poisons to the human body. Who cares which is worse? Fortunately, there are now healthy "margarines" like Smart Balance and Benecol that lack the saturated fat or hydrogenated fat of either.

4) Bananas--Bananas are not all that intrinsically unhealthy. The problem is that people will say to me, "Oh sure, I eat fruit. Two bananas a day." What I hear is "I don't really eat fruit with high nutrient value, fiber, and reduced sugar release. I reach for only bananas which yield extreme sugar rises in my blood and are low fiber." Aren't they high in potassium? Yes, but there are better sources. Cut back if you are a banana freak.


Why the mis-perceptions? A holdover from the low-fat diet days and marketing from food manufacturers are the principal reasons. Of course, foods are meant to be enjoyed, but be informed about it. Choose foods for the right reasons, not because of some cleverly-crafted marketing campaign.

Breakfast of champions?

I spend time every day educating or reminding patients that breakfast cereals are not health foods.

I see jaws drop in shock when I tell them that, in my opinion and despite the marketing claims, Cheerios, Raisin Bran, Shredded Wheat, and the like do not yield health benefits. In fact, they do the the opposite: dramatically raise blood sugar and trigger an adverse cascade of events that eventually leads to diabetes and heart disease.

Why the health claims in advertising? Because these products contain insoluble fiber, the sort that makes your bowels regular. Yes, your bowels are important to health, too. But the benefits end there.

Breakfast cereals are a highly refined, processed food that are not good for your plaque control program. What they are is a highly profitable, multi-billion dollar business, deeply entrenched in American culture ("They'rrrre grrrrrreat!"--Tony the Tiger; "There's a whole scoop of raisins in every box of Post Raisin Bran!" Bet you remember them all.)

I find it particularly upsetting when I see the stamp of approval from the American Heart Association on some products. Gee, if the Heart Association says it's good for you, it must be true! Don't you believe it. The American Heart Association relies on corporate donations, just like any other charity.

If you must eat breakfast cereals, refer to www.glycemicindex.com for a full database of glycemic indexes. You can look up a specific product and it will list its glycemic index, or sugar-releasing properties. You should try to keep glycemic index of the foods you choose below 50.

For a revealing discussion of the influence of food marketers on our perceptions of food, see Track Your Plaque nutrition expert, Gay Riley's discussion The Marketing of Food and Diets in America at her website, www.netnutritionist.com.

In heart disease prevention, shoot for perfection

It really struck me today that it's the people who've chosen to compromise their prevention program who end up with trouble--heart procedures, heart attack, even heart failure.

Take Bob, for example. Bob is 73 years old and had a bypass operation in 2000. The procedure went well and Bob enjoyed 6 years of seemingly trouble-free life. Bob had a seriously low HDL cholesterol for which he as taken a modest dose of niacin, but was unwilling to do much more. His HDL cholesterol was thererefore "stalled" at around 40 mg. (We aim for 60 mg or greater.) We talked repeatedly about the options for increasing HDL but Bob was content with his results. After all, since his bypass operation, he'd felt well and could do all he wanted without physical limitation.

But Bob underwent a stress test for surveillance purposes (which we routinely do 5 or more years after bypass surgery). The test was markedly abnormal with two major areas of poor blood flow to his heart (signalling potential heart attack in future). Bob ended up getting 5 stents to salvage two bypass grafts, both of which showed signs of substantial degeneration.

I've seen this scenario repeatedly: A person is unwilling to go the extra mile to obtain perfection in lipid/lipoprotein patterns, lifestyle changes, and taking the basic, required supplements. Compromises eventually catch up to you in the form of another heart attack, more procedures, heart failure, physical disability, even death.

The message: Don't draw compromises in heart disease prevention. Coronary plaque is a chronic process. It will take advantage of you if you ever let your guard down.

The epidemic of small LDL

Of the patients I saw in my office yesterday, virtually EVERYONE had small LDL.

Small LDL is emerging as an extraordinarily prevalent lipoprotein pattern that drives coronary plaque growth. Previous estimates have put small LDL as affecting only 20-30% of people with coronary disease. However, in my experience in the last few years, I would estimate that greater than 80% of people with measurable coronary plaque have small LDL.

If you have a heart scan score >zero, chances are you have it, too.

I call small LDL a "modern" disease because it has skyrocketed in prevalence recently because of the great surge in inactivity in Americans.

When's the last time you walked to the grocery store and back, lugging two bags of groceries? How many years has it been since you've push-mowed your lawn? All the small conveniences of life have permeated further and further into our activities. Most of us spend the great majority of our day right where you are now--on your duff.

On the bright side, small LDL in most people is reducable by simply getting up and going. But the old teaching of 30 minutes of activity per day is now outdated. This was true when the other hours of your life included physical activities, like housework or a moderately active job. However, if the other 23 1/2 hours of your day are sedentary, then 30 minutes a day won't do it. An hour or more of activity, whether exercise or physical labor of some variety will get you better small LDL-suppressing results.

For most people with small LDL, fish oil and niacin are also necessary to fully suppress small LDL to the Track Your Plaque goal of <10 mg/dl.

A great discussion on vitamin D

If you need better convincing that vitamin D is among the most underappreciated but crucial vitamins for health, see Russell Martin's review of vitamin D and its role in cancer prevention. You'll find it in March, 2006 Life Extension Magazine or their www.LEF.org website at:

http://search.lef.org/cgi-src-bin/MsmGo.exe?grab_id=0&page_id=1308&query=vitamin%20d&hiword=VITAM%20VITAMER%20VITAMERS%20VITAMI%20VITAMINA%20VITAMINAS%20VITAMINC%20VITAMIND%20VITAMINE%20VITAMINEN%20VITAMINES%20VITAMINIC%20VITAMINK%20VITAMINS%20d%20vitamin%20

Our preliminary experience over the past year suggests that vitamin D may be the crucial missing link in many people's plaque control program. We've had a handful of people who, despite an otherwise perfect program (LDL<60, HDL>60, etc.; vigorous exercise, healthy food selection, etc.--I mean perfect)continued to show plaque growth. The rate of growth was slower than the natural expected rate of 30% per year, but still frightening rates of 14-18% per year--until we added vitamin D. All of a sudden, we saw dramatic regression of 7-25% in 6 months to a year.

This does not mean that vitamin D all by itself regresses plaque. I believe it means that vitamin D exerts a "permissive" effect, allowing all the other treatments (fish oil, LDL reduction, HDL raising, correction of small LDL, etc.) to exert their full benefit. So please don't stop everything and just take D. This will not work. However, adding vitamin D to your program on top of the basic Track Your Plaque approach--that's the best way I know of.

MSNBC Report: We need more heart procedures!

A recent headline from MSNBC by Robert Bazell reads:

NEW YORK - Angioplasty, bypass surgery and cholesterol-lowering medications are among the many interventions that have brought a sharp decrease in heart disease deaths in recent years. But, as Dr. Sharon Hayes of the Mayo Clinic points out, there is one big problem.

“The death rates in women have not declined as much as they have in men,” she says.

The piece goes on to suggest that women are getting short-ended in the diagnosis of heart symptoms and heart attack. The solution: More testing to assess the need for procedures like bypass.

This is typical of the device and medication-dominated media consciousness: More procedures, more medication, more devices. Who's paying for advertising, after all? The money at stake is huge. But is this what you want?

Don't be swayed by media reporters with limited understanding of the real issues (at best), consciousness of who's paying for advertising (at worst). Yes, heart disese is often underestimated or misdiagnosed in women. The answer is better detection earlier in life followed by efforts to halt the process--effective, safe treatments for people's benefit, not just profit.
More on aortic valve disease and vitamin D

More on aortic valve disease and vitamin D

I hope I'm not getting my hopes up prematurely, but I believe that I've seen it once again: Dramatic reversal of aortic valve disease.

This 64-year old man came to me because of a heart scan score of 212. Jack proved to have small LDL, lipoprotein(a), and pre-diabetes. But there was a wrench in the works: Because of a new murmur, we obtain an echocardiogram that revealed a mildly stiff ("stenotic") aortic valve, one of the heart valves within the heart that can develop abnormal stiffness with time.

You can think of aortic valve disease as something like arthritis--a phenomenon of "wear and tear" that progresses over time, but doesn't just go away. In fact, the usual history is that, once detected, we expect it to get worse over the next few years. The stiff aortic valve eventually causes symptoms like chest pains, breathlessness, lightheadedness, and in very severe cases, passing out. For this reason, when symptoms appear, most cardiologists recommend surgical aortic valve replacement with a mechanical or a bio-prosthetic ("pig") valve.

Now, Jack's first aortic valve area (the parameter we follow by echocardiogram representing the effective area of the valve opening when viewed end on) was 1.6 cm2. A year later: 1.4 cm2. One year later again: 1.1 cm2.

In other words, progressive deterioration and a shrinking valve area. Most people begin to develop symptoms when they drop below 1.0 cm2.

Resigned to a new valve sometime in the next year or two, Jack underwent yet another echocardiogram: Valve area 1.8 cm2.

Is this for real? I had Jack come into the office. Lo and behold, to my shock and amazement, the prominent heart murmur he had all along was now barely audible.

I'm quite excited. However, it remains too early to get carried away. I've now seen this in a handful of people, all with aortic valve disease.

Aortic valve stenosis is generally regarded as a progressive disease that must eventually be corrected with surgery--period. The only other strategy that has proven to be of any benefit is Crestor 40 mg per day, an intolerable dose in my experience.

If the vitamin D effect on aortic valve disease proves consistent in future, even in a percentage of people, then hallelujah! We will be tracking this experience in future.

Comments (22) -

  • Mike

    8/22/2007 1:19:00 PM |

    What does vitamin D have to do with the improved heart valve?

  • Richard A.

    8/22/2007 9:42:00 PM |

    Maybe a little vitamin k with the vitamin d would give even better results for aortic valve disease.

  • Dr. Davis

    8/22/2007 9:46:00 PM |

    If this is true, I can only speculate on the mechanism for vitamin D's effect. It might include anti-inflammatory effects, suppression or modification of calcium deposition, and lipid (cholesterol) effects. However, this is just my speculation.

    I also agree that adding vitamin K2 may exert an effect, particularly in view of the valve disease that develops when people take the vitamin K blocker, Coumadin.

  • Anonymous

    8/31/2007 2:48:00 PM |

    Why do you stress Vitamin D3 supplements be in gel cap form?  Many of these contain Vitamin A in addition to the D.  If capsules of D are taken after a meal containing some fat, woulden't that suffce?

  • Dr. Davis

    8/31/2007 3:25:00 PM |

    If you want consistent absorption of vitamin D, gelcaps are best. Tablets are, in my view, next to worthless because of the erratic absorption, even when taken with a fatty meal.

    You can find D without A. Go to Vitamin Shoppe or buy Carlsons'brand.

  • Jim Chinnis

    9/10/2007 2:31:00 AM |

    Dr. Davis, I think you neglected to mention vitamin D in your blog article. Take a look at what you wrote!

  • Dr. Davis

    9/10/2007 4:17:00 AM |

    Whoops!

    Yes. It was vitamin D supplementation that I presume was the factor behind the effect on valve disease.

  • Adam

    9/13/2007 12:52:00 AM |

    Dr. Davis,

    Thanks for the thoughts. And, I really like your blog.  Thanks for sharing. I'm definitely coming back!

    Cheers,

    Adam
    Adam's Heart Valve Surgery Blog

  • Anonymous

    10/2/2007 4:16:00 PM |

    Any suggestions on dosage requirements of D3 gel caps?

  • Dr. Davis

    10/2/2007 6:22:00 PM |

    We've used anywhere from 4000-8000 units per day of an oil-based gelcap to achieve this effect.
    Please see my numerous prior posts on vit D dosing, along with commentary on our website, www.trackyourplaque.com.

  • William Ball, Pharm.D.

    9/30/2008 5:38:00 AM |

    I'm 60 and just this week was diagnosed by echo as having a bicuspid aortic valve that is clacified, sclerosed and fused with a valve area of 1.1cm.  I'm asymptomatic, but my reading shows I'm headed for valve replacement within a few years at most.  I read you anecdotal reports of vitmain D apparent reversal of aortic stenosis.  However, I am aware that vitamin D can increase calcium deposition in tissues.  Are you sure this is safe for patients like me?  You are aware that nothing to date has been proven to change the natural history of this disease, so I find your blog posts to be provocative at best and perhaps rather reckless despite your medical credentials.  Do you have any recent follow-up on your initial anecdotal report?

  • Anonymous

    12/18/2008 5:11:00 PM |

    Hell of a way to ask for help, Bill!

  • William Ball

    5/5/2009 3:40:00 AM |

    Being as I see no further follow-up on this one patient back in 2007, I'll just add that I had my vitamin D levels checked in September and they were low, so I decided to try Dr. Davis's idea.  On 10K IU of D3 I achieved normal vitmain D levels.  Unfortunately, in the last 6 months my AS has progressed with my valve opening going down from 1.1 to 0.9cm.  I still am asymptomatic but will have another echo in 4 months.  My cardiologist is concerned as my left ventricle also increased in size from 5.6 to 6.8cm in 6 months. I'll give the D3 another 4 months, but so far, it appears not to be helping at best and perhaps is accelerating the progression of my AS.

  • William Ball

    7/8/2009 2:28:57 AM |

    Further follow-up on my case.  Today I just got back from Stanford where I had another echo and met with Dr. Craig Miller, Chief of Cardiothoracic Surgery, to discuss my options.  My valve has further stenosed down to 0.7cm from 0.9 only 3 months earlier.  So, despite healthy doses of vitamin D, it looks like, if anything, the calcification of my valve has accelerated. This really points out how a single anecdotal report can be rather misleading.  Although I can believe that the patient's AS in the original report may have receded, there is no way you can attribute this to vitamin D.  It could be a completely unrepeatable coincidence.  Dr, Davis, with all due respect for your good intentions and the benefit you may otherwise provide to your patients, you really ought to remove your case report until you have some more concrete, repeateable evidence.  It not only may not have helped me, but it may have harmed me.

  • Dr. William Davis

    7/8/2009 12:29:17 PM |

    William--

    Sorry to hear about your valve "progression."

    My experience is not one patient, but around 20. Most have shown either modest reversal of aortic valve stenosis or stabilization (i.e., no change); two have progressed.

    So your experience is the exception, not the rule, compared to what I am seeing. I cannot claim that vitamin D is the "cure all," but I believe this phenomenon can teach us some interesting lessons.

    By the way, your disease, I believe is just showing the natural progression. Small leaps in severity like this are not uncommon in the absence of vitamin D.

  • Anonymous

    7/28/2009 8:39:00 PM |

    There are some people who's bodies are predisposed to use vitamin d the wrong way. Here's a link to one page that can take you to the research on this subject.
    http://www.examiner.com/x-7160-Sacramento-Nutrition-Examiner~y2009m4d15-Will-taking-vitaminD3-calcify-your-aorta-if-you-have-a-certain-genetic-variation

  • Anonymous

    10/19/2009 11:41:50 AM |

    Dr. Davis,
    Following the previous post from 'anonymous' I would add this comment in support of Bills thoughts that your posts may be 'reckless'.

    There is some evidence that vitamin D can actually CAUSE aortic valve calcification, both in animal models (see The Journal of the American College of Cardiology 2003, Volume 41, Issue 7, Pages 1211-1217: Experimental aortic valve stenosis in rabbits) and in human patients (see Heart 2001, Volume 85, pages 635-638: The vitamin D receptor genotype predisposes to the development of calcific aortic valve stenosis). In this case, you should be very careful in extrapolating your observations of one patient (perhaps with unusually low LDL) to a blanket 'vitamin D restoration' model. It could cause deterioration in the health status of those who seek your expertise without a proper diagnosis.
    A good PubMed search will provide the necessary literature for you to research (rather than speculate) on the mechanism for vitamin D's effect, and may help you to follow the ongoing debate about the validity of the animal model.

  • Dr. William Davis

    10/19/2009 8:51:52 PM |

    Anon--

    I believe you are confusing two things: vitamin D at physiologic replacement levels (as we do in humans) and vitamin D at toxic, supraphysiologic levels (as in rats and mice).

    Like any hormone, too little is not good, too much is not good. We want just right to obtain the benefits.

  • Anonymous

    10/20/2009 10:12:52 AM |

    Hi again Dr. Williams,

    forgive me for pushing you on this, but I am not confusing two things at all.

    One should, of course, always be cautious when extrapolating animal studies to humans and, while the supraphysiological (toxic) levels shown in some animal models is a potential issue (though also debatable, as physiological - or nutritionally relevant - levels CAN induce valve stenosis in mice with sub-optimal lipid metabolism), the main issue is that we are beginning to understand the complexity and potential danger of untested 'nutritional supplements' because of the wide genetic variation that exists in any population (see the second reference I provided for you comparing 630 HUMAN patients). Further, there is very little data on what actually represents 'toxic' levels in humans who take complex multivitamin mixtures, regardless of geographic considerations, environmental load and preexisting baseline blood concentrations (e.g., would you advise selenium supplementation for someone living in Nebraska?).

    This is perhaps demonstrated by your own reports of "around 20" patients (the complete statistics for which I would be interested to see). What is meant by "modest reversal or stabilization in most"? Is not the "around" 10% who have regressed worthy of your interest? I would have thought that without a recovery in all of your patients, you may consider that you are indeed "getting your hopes up prematurely" and that you may be more keen to understand the biochemistry behind the failures. Perhaps you could secure funding to follow these patients in a well designed scientific study? There must be other doctors with similar experiences who would be keen to push the science forward and take it out of the realm of anecdote?

    While I absolutely agree with you that prevention is better than intervention (I saw an excellent seminar just yesterday from professor Richard Cooper [from Loyola Chicago] demonstrating how just reducing salt intake can have dramatic effects on heart health in most people, and Professor Valentin Fuster [Mount Sinai] knows how a good exercise regime can reverse coronary desease). And while I also don't like the 'statin-and-stent' mentality (do statins work at all in women??), I also believe that drug disposition and pharmacokinetics are incredibly important.

    I simply think that you should place an enormous caveat on any of your posts that suggest that supplements such as vitamin D (and perhaps K, A, E, C, selenium etc. etc.) might be a 'magic bullet'. None of them is when applied across the board. In fact, there is strong, reputable and repeatable science that demonstrates potential damage caused by some of these unregulated concoctions that are marketed as 'healthy' (the topic of another of your 'scam' posts when applied to health foods).

    You are absolutely correct that the vitamin D phenomenon "can teach us some interesting lessons", but you are not the first person to have noted this idea and it is being investigated in fairly comprehensive studies. When the results are in, perhaps we will have a better understanding of the types of patient for whom it would work (and those for whom it may be dangerous).

    As with other eminent 'web-doctors' (e.g., Dr. Mercola, who advises vitamin D instead of the flu vaccine, or those who push "vitamin B17" instead of cancer chemotherapy), I would suggest that a blog is not a good place to practice science or medicine and I would hope you would regularly advise your readers to go to a good doctor in their area who perhaps agrees with your alternative methodologies for a full and well considered diagnosis.

  • Dr. William Davis

    10/21/2009 2:15:12 AM |

    Thank you, Anonymous.

    First of all, it's Dr. Davis, not Williams.

    Second of all, I agree with one of your points: This is the Heart Scan BLOG, not the Heart Scan Journal, not the Heart Scan List of Facts. It is a BLOG--pure and simple.  

    I hope anyone coming here for my musings and thoughts realize that's all they are. If anyone is stupid enough to make more of it than that, well that's not my problem.

  • Anonymous

    10/21/2009 9:09:51 AM |

    Hi Dr. Davis (apologies for the previous mistake),

    I wanted to point out that I enjoy your Blog and I share your interest in a nutritional basis for the prevention of cardiovascular disease. However, you allude in your various blogs to several of the unanswered issues behind our understanding of a highly complex topic. Salt reduction, resveratrol, caloric restriction and the enormous array of vitamins provide clear benefits for some people and yet seem to have almost no effect (or, when combined carelessly, even a detrimental effect) on others.

    Based on your last response, I have a final comment on this "more on aortic valve disease and vitamin D" post on your 'blog - not advice'. Then you can choose to be incensed by it, or take it as it is meant - a comment from a concerned cardiovascular research scientist who would dearly like to see these alternative approaches brought into the mainstream.

    Whether you accept responsibility for it or not, it is clear that some people read your postings and act on your "musings". You are, after all, a cardiologist and seen as an expert in medical matters. Further, you and I both know that the vast majority of people neither have access to nor the potential to understand the scientific literature, so the internet has become a frequently dangerous tool by which millions get their information and advice.

    In this thread alone, there are people asking for (and receiving) specific advice on the type of vitamin D to acquire (gel caps) and the purported optimum dosage (anywhere from 4000-8000 units per day). Further, while you don't actually tell him to, William Ball was clearly following what he perceives as 'Doctor's advice' when he "decided to try Dr. Davis's idea".

    His subsequent decline was then 'diagnosed' by you as likely being a "natural progression", even though he states that his vitamin D levels were "normal". This was apparently after taking 10,000 IU per day? Perhaps Mr. Ball would have been interested to know that 10,000 IU is the figure proposed by Hathcock et al., in 2007 as being the upper tolerance limit for humans [Am. J. Clin. Nutr. 85 (1): 6–18] - and should perhaps raise alarm bells.

    There were several opportunities for you to make more clear that this is just "a blog" and should not be used as an alternative for sound medical advice. There is a lot still unknown about this topic and while "not your problem" (and to use your words) there are plenty of people "stupid enough to make more of" your post that you might wish.

    I have several friends for whom I have great concerns because they follow potentially dangerous alternative health approaches based on the "knowledge" they glean from the internet. One friend takes potentially toxic doses of the cyanide compound 'vitamin' B17 to prevent cancer. I have family members who have not vaccinated their children because they KNOW vaccines cause autism. Another refuses to use toothpaste and spends a fortune on bottled water because fluoride will reduce his IQ and give him cancer.

    Big Pharma is now seen almost universally as demonic and conspiracy theories abound. According to such theories, without the influence of doctors, scientists and pharmaceutical companies, we would already be living in a world without cancer and cardiovascular disease - but we are hiding the answers for the sake of profit. While you clearly hold some cynical views about the profitability of the 'conventional treatment' of heart disease, most doctors are doing the best they can under hugely difficult circumstances (and in the face of patients refusing to change bad behavior). We can only hope that the future is brighter as a result of the research being conducted on the alternative preventive measures to which you subscribe.

    In the meantime, as a doctor, you should perhaps be more aware of your influence and how blindly some people will follow your advice, whether you think you have given it or otherwise.

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    11/3/2010 8:43:50 PM |

    Aortic valve stenosis is generally regarded as a progressive disease that must eventually be corrected with surgery--period. The only other strategy that has proven to be of any benefit is Crestor 40 mg per day, an intolerable dose in my experience.

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