Catheterization to “define coronary anatomy”

Gary is an avid jogger. On an average day, he runs 5-6 miles at a good clip. On two occasions recently, however, Gary experienced an ache in his left shoulder at mile 4. It was a toothache-like feeling, but he kept on going without difficulty.

Gary also had a heart scan score of 370.

Upon hearing of Gary’s score and his shoulder sensation, the cardiologist who saw him advised a heart catheterization “to define coronary anatomy”. (This is a real incident.)


What exactly does that mean? Why would Gary’s cardiologist need to define it?

In my view, this is an absurd notion. No one needs to “define coronary anatomy”. This catch-all phrase is commonly used to justify heart procedures. I believe what the cardiologist is saying is that it’s the easiest (for the cardiologist) and perhaps most generously reimbursed method to determine whether Gary’s symptoms are warning of an impending heart attack or not.

The problem is that the question can also be answered quite well by doing a stress test. Though not perfect diagnostic tests, stress tests are useful when symptoms are present that are doubtful in nature. Gary’s left shoulder ache could have been related to his heart, but the likelihood was that it was not. A stress test would have answered the diagnostic question quite adequately.

Instead, this man was subjected to an invasive test that was likely unnecessary. This happens dozens, if not hundreds, of times per day just around here. Nationwide, it is an epidemic of malpractice.

There are, indeed, times when a person should proceed directly to a heart catheterization. This is commonly and appropriately performed when a person develops unstable heart symptoms, such as chest discomfort or breathlessness at rest while not doing anything physical, or if the frequency is increasing, or if a stress test shows an important abnormality. There is no question that heart procedures can be lifesaving at times.

The problem is that thousands of people every year are scared into these procedures inappropriately. Beware!
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"It's genetic"

"It's genetic"

At 53, Sam had been through the wringer with heart disease. After his first heart attack at age 50, he'd undergone four heart catheterizations, 5 stents, and, most recently, a bypass operation. He came to us to see if there was a better solution.

After hearing Sam's story, I asked,"Did your doctors suggest to you why you had heart disease?"

"Well, they said it was genetic, since my father went through the same thing in his early 50s, though he died after his second heart attack at age 54. They said it was bad luck and nothing could be done about it."

Though Sam's case is more dramatic than most, I hear this argument every day: Risk for heart disease is genetic.

It's true: There are indeed multiple reasons for inheriting causes for coronary heart disease, genes that heighten inflammatory responses, oxidative responses, modify lipoprotein particles, increase blood pressure, etc. There has even been some excitement over developing chromosomal markers for heightened risk.

That's all well and fine, but what can we do about it today?

In practical life, many inherited genetic patterns can be expressed in ways that you and I can identify--and correct. They are not chromosomal markers, but end products of genetic patterns. (Although there are indeed identifiable chromosomal markers, they have not yet led to meaningful treatments to my knowledge.)

These readily identifiable patterns include:

--Lipoprotein(a)--Clearly genetically transmitted, passed from mother or father to each child with a 50% likelihood, then you onto your children if you have it.

--Small LDL--Although small LDL is amplified by high-carbohydrate diets and obesity, it can also occur in slender people who do not indulge in carbohydrates --i.e., a genetic tendency. Or, it can be a combination of poor lifestyle magnifying the genetic tendency for small LDL.

--Low HDL--Particularly the extremes of low HDL below 30 mg/dl. (Although, interestingly, I am seeing more of these people, though not all, respond to vitamin D replacement. Perhaps an important subgroup of low HDL people are really Vitamin D Receptor (VDR) variants.)

--ApoE--Two variants are relevant: ApoE2 and ApoE4. In my experience, it's the E2 that carries far greater significance, though the data are somewhat scanty. ApoE4 people are more sensitive to the fats in their diet (greater rises in LDL with fats; thus, some people advocate a tighter saturated fat restriction with this pattern, though I am not convinced that is the best solution), while ApoE2 people are exceptionally sensitive to carbohydrates, develop extravagant increases in triglycerides, and are very diabetes-prone with even the most minimal weight gain. If two "doses" of the E2 gene are present (homozygotic), then the tendencies are very exagerrated. E4 people are also subject to greater likelihood of Alzheimer's, though it is not a certain risk in a specific individual.

--Postprandial disorders--We use the fasting intermediate-density lipoprotein (IDL) as an easy, obtainable index of the ability to clear after-eating byproducts of meals from the blood. Increased IDL has been related to increased coronary, carotid, and aortic aneurysmal disease.

--Hypertriglyceridemia-i.e., increases in triglycerides, While not all forms of high triglycerides confer risk for atherosclerosis, many do, particularly if associated with IDL, small LDL, increased LDL particle number and/or apoB.


There are more, but you get the point. There are clear-cut genetically-transmitted reasons for greater risk for cardiovascular disease. Some, like lipoprotein(a), yield very high risk. Others, like increased triglycerides, yield mixed levels of risk.

Importantly, all of these patterns--ALL--are identifiable and are treatable. Treatment may not always be the easiest thing, but they are treatable nonetheless. While lipoprotein(a), for instance, is the most difficult pattern to correct in the above list, I remind everyone that our current "record holder" for reversal of plaque and heart scan scores--63% reduction--has lipoprotein(a) that we corrected.

If you've been told that your risk for cardiovascular disease or coronary plaque is "genetic" and thereby uncorrectable and hopeless, run the other direction as fast as you can. Get another opinion from someone willing to take the modest effort to tell you precisely why.

Comments (17) -

  • steve

    11/18/2008 2:58:00 PM |

    all excellent points,but the question is: how do you find someone who will tell you why?  Most will look at advanced cholesterol testing and based on that prescribe a statin and a low fat diet.  Speaking of diet, it is unclear how much sat fat you think acceptable on a daily basis.  It is nice to say it is ok to have and we have gone overboard in its elimination, but unfair not to then say how much in your view is ok

  • Anonymous

    11/18/2008 4:25:00 PM |

    Thank you, thank you, thank you... I'm still trying to convince my dad that his lifestyle is still important after his idiot cardiologist told him it was all genetic and all he could do it take meds and hope for the best... I hate when docs downplay diet and exercise.  Ugh!

    On another note, I've been told that because I have ApoE 4 I should not consume alcohol or take fish oil.  What do you know about that?

  • vin

    11/18/2008 4:25:00 PM |

    My grandmother, who died 20 years ago at the age of 85, used to say "it is god's will" whenever someone died young (or old). It is what the modern day cardiologist now puts it down to genetics.

    That is progress over the last 100 years.

  • Jessica

    11/18/2008 7:14:00 PM |

    I think the potential that Vitamin D has relating to heart health is significant.

    Although I'm not the best at verbalizing why this is the case, when I learn a condition is "genetic" and it tends to strike later in life, I think, "but you've had that gene your entire life. Why is it that NOW it's expressing itself?"

    Genetic predispositions to conditions may explain why someone has a condition, but it doesn't explain why the condition occurs when it does.

    Could it be that identifying and correcting D deficiencies early in life will provide our cells (DNA) with the power to continue suppressing genes that should never be expressed?

  • Anonymous

    11/18/2008 7:59:00 PM |

    I think you missed one of the biggest "genetic" factors: crappy living habits: junk food, no exercise. These pass down from generation to generation too. But, like some of the others you mentioned, these conditions are treatable.

  • Anonymous

    11/19/2008 12:03:00 AM |

    www.amocare.com is a free service that has hospitals located in the U.S. that perform heart surgery for around 70% the cost of the price of the average cost. American Medical Outsourcing will help you with the entire process of the treatment. Heart bypass surgery usaly cost $45k-$55k. with AMO, the cost is around $10k-$13k. Go to www.amocare.com for more info.

  • Anonymous

    11/19/2008 4:01:00 PM |

    I'm curious as to why you approved the comment of the amocare spammer?

  • Katherine

    11/20/2011 6:08:47 PM |

    About six months ago I started eating a paleo lifestyle.  Since then I've had two cholestrol panels.  After two months, my LDL was 180.  Four months later, my LDL was 290.  HDL is 68 and Trigs are 41.  I've also lost about 10-14 pounds.  My dad has high cholesterol (LDL) and my grandmother on my mom's side had a heart attack at 66 and died.  I've recently had a FH test and I'm awaiting the results.  Now after reading this, having having a test run on the ApoE4 seems like a good idea as well.  Would the ApoE4 be appropriate?  Was the FH test a waste of time?

  • Dr. William Davis

    11/21/2011 1:38:03 PM |

    Both can be helpful, if only to confirm whether there is a genetic basis or not.

  • Katherine

    11/24/2011 2:16:31 PM |

    Dr. Davis,
    You've said "ApoE4 people are more sensitive to the fats in their diet (greater rises in LDL with fats; thus, some people advocate a tighter saturated fat restriction with this pattern, though I am not convinced that is the best solution),"  What do you think is the best solution?

  • Dr. William Davis

    11/25/2011 2:10:35 PM |

    Because the majority of apo E4 people have extravagant numbers of small LDL particles triggered by carbohydrate consumption, I still advise first eliminating wheat and slashing carbs.

  • Gene K

    11/25/2011 4:21:21 PM |

    I am apo E4/3, and I was able to bring down my small LDL particles to under 90. My daily carb consumption includes a small cup of dark berries, hummus, non-starchy vegetables (broccoli, eggplant, cauliflower, zucchini), and natto. I saw a big drop in small LDL particles after I greatly reduced consumption of oils (olive oil specifically), but I don't know whether this change alone had a role in causing the reduction of my smLDL.

  • Gene K

    11/25/2011 4:27:53 PM |

    (cont'd) As far as fats, I don't eat red meat, but plenty of fatty fish and lean poultry plus an egg every day. Tons of yellow mustard (turmeric), too.

  • Dr. William Davis

    11/27/2011 2:15:58 PM |

    HI, Gene--

    I believe the best way to view this is that oils/fats amplify LDL particles in all its forms. If in the presence of carbohydrates, oils/fats will increase small LDL because it is the dominant form.

  • Katherine

    11/28/2011 8:50:14 PM |

    I have eliminated wheat and eat about 30 total carbs a day while my LDL is 289.  I am actively losing weight which is sounds like may have influenced my numbers.  Is the Apo E4 associated only with increased LDL's or is it with elevated Trigs as well?  My Trigs are 37.

  • Ronnie

    12/13/2011 3:16:58 AM |

    My doctor tested me for ApoE without telling me and mailed me my results....I'm a 3/4.  My LDL-P was 1206, Triglycerides 115, HDL-C 72, sdLDL 37 mg/dl.  I'm 60, female, thin (5'2" 109 lbs), have exercised my entire life, non smoker, occasionally drink one glass of white wine.  Parents never had heart disease although I have a sister with CAD which I always chalked up to poor lifestyle habits (terrible diet, sedentary).  I never expected this and I'm not handling this news well at all.  While some people may want to know their ApoE genotype, I wasn't one of them.  I greatly resent my doctor doing this test without consulting me first and the way I received the results through the mail.   I have no idea what to do this information.  Do I consult with a geneticist, a cardiologist or a lipid specialist?

  • Robin Michael

    5/1/2013 5:50:50 PM |

    Dr. Davis,

    I joined TYP specifically because my Heart Diagnostics Lab results (taken before I started Wheat Belly plan) showed my to be APOE E4 3/4 genotype.  My other numbers: total cholesterol=154, LDL-C=85, HDL-C=56, Triglycerides=58. On Lipitor generic 10mg, Lisinopril 20mg and Amlodipine 5mg. I find the WB plan to be easy, but am moderately high fat diet including labne for breakfast, eggs for lunch with avocado, sour cream, and fish/chicken and salad/green vegetable for dinner. Carbs are limited to less than 50g per day. I generally cook with olive oil, and sometimes toasted sesame oil. I eat very little fruit, limited my intake to a few berries in the morning, a plum or half an apple at lunch.

    Do you recommend lowering my fat intake? Anything else?

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You mean weight loss is hazardous to your health?

You mean weight loss is hazardous to your health?

In my last Heart Scan Blog post, What is this wacky thing called weight loss?, I discussed how weight loss is associated with distortions in cholesterol and blood sugar values that can be very confusing, often leading your doctor to wrongly and unnecessarily prescribe drugs--since he/she likely rarely sees weight loss.

Blog reader, Donald K., posted his enlightening story:

I experienced this very thing.

After losing serious weight from the eliminating wheat, processed, and sugary foods (1 year in total) I lost 130 pounds. When I was nearly finished I went to see my doctor. He wanted to put me on statins. I explained to him how the data does not support application to me (no evidence of heart disease) and I got the mantra about standards of practice, etc, etc. I held my ground and decided I am much happier eating dairy, eggs, grass fed beef, wild caught fish, and as much raw foods (nuts, veggies, fruits) as my body desires to treat my health parameters.

Maintaining weight, it is easy. My BMI (23 down from 40) has remained constant for a few months now. You are right: metabolic processes definitely change. I no longer have sensations of glucose fluctuations or an uncontrolled appetite. I can only imagine the improved hormone regulation and metabolic communication going on inside my body.

The symptoms from obesity, all gone. Goodbye sleep apnea, hypertension, hemorrhoids, arrhythmias, gastroinestinal disruptions, smelly body, chaffing thighs, and others not mentioned. The positive effects are just as dramatic, but I don’t want to ramble on.

Weight loss? What is it? Getting your life back!


Brace yourself: If you are following the nutrition advice posted here and in the Track Your Plaque program, or the discussion I've initiated in Wheat Belly, then you may find yourself in the very same health predicament as Donald. Arm yourself to protect yourself against the drug-wielding ways of doctors. No, weight loss to achieve ideal weight is definitely not bad for health. But your doctor's misinterpretation of its effects can be!

Comments (11) -

  • Ari

    9/23/2011 2:11:44 PM |

    How would wheat and/or obesity and hemorrhoids relate?

  • Kent

    9/23/2011 3:25:49 PM |

    I have unique concern associated with my elimination of wheat.  I was already slim with low body fat and when I cut the wheat I dropped another 20 pounds.  I look almost unhealthy I got so skinny with the sunken cheeks, etc.  I can eat and eat the good stuff along with drinking 6 tablespoons of olive oil a day and using ample cocounut oil.  Any suggestions?

  • Tim

    9/23/2011 9:12:52 PM |

    Dr. Davis, I know this may be off-topic a bit, but what are your views of sugar alcohols like Xylitol and Sorbitol?  If you'd care not to respond here, maybe you could have it as a future blog posting.  I'm just curious as to if you have any evidence of any mal-effects it may have on the body.

    Thanks!

  • Joe

    9/24/2011 3:39:02 PM |

    Dr. Davis, Peter's got a fascinating post up...do you think these bizarre varieties of wheat are damaging our mitochondria?

    http://high-fat-nutrition.blogspot.com/2011/09/did-you-over-eat-yourself-in-to-obesity.html

  • Dr. William Davis

    9/25/2011 12:07:46 AM |

    Peter is always great for some unique perspectives.

    I'll have to reflect on this particular line of argument.

  • Dr. William Davis

    9/25/2011 12:09:30 AM |

    Hi, Tim--

    The two sugar alcohols that are pretty benign, meaning minimal to no blood sugar effects and no diarrhea or cramps, are erythritol and xylitol.

    Mannitol and sorbitol and problem sweeteners with very different effects.

  • Dr. William Davis

    9/25/2011 12:12:14 AM |

    Hi, Kent--

    Eat more!

    Eat more avocados, oils like olive, olives, vegetables, raw nuts, cheese, etc. Eat more real food.

    Note that the weight loss develops without cutting calories!

  • Dr. William Davis

    9/25/2011 12:13:13 AM |

    Hi, Ari--

    Hmmm. Not sure.

    That relationship might be a bit of a stretch.

  • Donald Kjellberg

    9/25/2011 10:18:38 PM |

    Here is how they relate: Consider the relief from having 130 pounds removed from your body while sitting. That is a lot of extra pressure on the veinous system in that area. In addition, with improved health you have a higher energy level and naturally find yourself sitting less. The end result, the factors triggering hemorrhoids have been removed and so have the hemorrhoids.

  • Dr. William Davis

    9/26/2011 12:36:08 PM |

    Excellent, Donald!

    A powerful, but indirect, connection I had forgotten about.

  • Jake Billotti

    3/13/2014 6:17:15 AM |

    Dr. aren't wheat a good source of proteins and fibre

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Why healthy can make us fat

Why healthy can make us fat


Brian Wansink, author of Mindless Eating: Why we eat more than we think (see yesterday's Heart Scan Blog post), also has a Blog. Despite the bland advice offered on much of the Prevention Magazine and website, Wansink's Food Think Blog is a winner.

In a recent post, Wansink quotes a report from Science Daily that described a study he recently published in the Journal of Consumer Research. Wansink's study describes how just applying the label "healthy" to fast food choices increased consumers' calorie intake:


"When we see a fast-food restaurant like Subway advertising its low-calorie sandwiches, we think, 'It's OK: I can eat a sandwich there and then have a high-calorie dessert,' when, in fact, some Subway sandwiches contain more calories than a Big Mac."

In one study, Chandon and Wansink had consumers guess how many calories are in sandwiches from two restaurants. They estimated that sandwiches contain 35% fewer calories when they come from restaurants claiming to be healthy than when they are from restaurants not making this claim.

The result of this calorie underestimation? Consumers then chose beverages, side dishes, and desserts containing up to 131% more calories when the main course was positioned as "healthy" compared to when it was not--even though, in the study, the "healthy" main course already contained 50% more calories than the "unhealthy" one.

"These studies help explain why the success of fast-food restaurants serving lower-calorie foods has not led to the expected reduction in total calorie intake and in obesity rates," the authors write.


Interesting. In fact, I've had many patients say that they eat at Subway or similar chains and choose the "healthy" options. "That's got to be better than a cheeseburger and fries!" Perhaps not. (Of course, you can't leave Subway or other fast food operation feasting on wheat products.)

Wansink can be counted on for some truly fascinating observations into many behaviors that are subconscious but explain at least part of the reason why we're so fat. Though his Blog has a relatively short history of posts, there's lots of great commentary.

Pierre Chandon and Brian Wansink. "The Biasing Health Halos of Fast Food Restaurant Health Claims: Lower Calorie Estimates and Higher Side-Dish Consumption Intentions" Journal of Consumer Research, October 2007.
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Warfarin is scary stuff

Warfarin is scary stuff

Gilbert is a 58-year old high school science teacher.

When I first met Gil, he'd been having bouts of atrial fibrillation and had required various medications to suppress recurrences of the rhythm. However, because his rhythm proved somewhat difficult to control, his electrophysiologist (heart rhythm specialist) prescribed warfarin to reduce the risk of stroke. With atrial fibrillation, because of blood stagnation (in the left atrial appendage) in the heart, there is a stroke risk of approximately 8% per year. Warfarin reduces this risk substantially, to about 2%.

I met Gil because he had a cholesterol disorder. In my practice, the first step in gauging the implications of a lipid or lipoprotein disorder is to obtain a heart scan. If the heart scan score is zero, great. It means that we have plenty of time to treat the disorder since risk for cardiovascular events is near zero also; it means less intensive efforts less intensive efforts are necessary. But if the heart scan score is, say, 1200, then an aggressive approach in short order is required, since the risk for heart attack may as high as 20-25% per year, even in the absence of symptoms.

Gil's heart scan score: 787--high and posing a risk for heart attack of about 5-10% per year without preventive efforts. Gil did indeed prove to have a complex lipoprotein disorder, as well as high blood pressure, vitamin D deficiency, and several other potential contributors to coronary plaque.

Gil did just about everything right: He exercised, followed the recommended diet, achieved better than the Track Your Plaque 60-60-60, lost 18 lbs of abdominal fat.

Gil's rhythm stabilized for several months, only to have atrial fibrillation break through again. So Gil's electrophysiologist re-prescribed warfarin.

18 months later, Gil's 2nd heart scan score: 1410--a near doubling. Unsettling to Gil and to us, to say the least.

How can this happen in the face of perfect lipids/lipoproteins, correction of hidden causes like lipoprotein(a) and inflammation, along with a vigorous lifestyle effort?

I fear that the culprit might be warfarin.

Warfarin, better known by its brand name, Coumadin, may have some effects that intersect with the Track Your Plaque mission of reducing coronary plaque.

It is no secret that, beyond the obvious risk of bleeding from blood thinning, warfarin also may:

--Accelerate aortic valve calcification
--Accelerate calcification of the framework of the mitral valve (the mitral "anulus")
--Accelerate osteoporosis
--Induce an artificial situation of vitamins K1 and K2 deficiency.

The vitamin K1 deficiency is the route by which blood thinning is achieved. However, the K2 deficiency may have undesirable consequences, among which are the above list of various pathologic calcifications.

I therefore wonder if warfarin dramatically accelerated the coronary calcium that we track to gauge the progression of coronary atherosclerosis. One experience is hardly sufficient reason to sound the alarm. It is also difficult to pinpoint the cause of the explosive growth in Gil's coronary calcium specifically on warfarin.

That all said, I am quite certain it was the warfarin.

Unfortunately, some people are unavoidably committed to warfarin, such as those with specific genetic blood clotting disorders, prosthetic valves, prior deep vein thromboses and pulmonary emboli, etc.--serious reasons. Until an alternative emerges, warfarin remains a necessity for some people. (No, nattokinase is NOT an alternative, at least not one that would permit survival.)

My personal policy is that warfarin be used only when absolutely necessary and the gains markedly outweight the risks--including that of possible accelerated calcification of multiple sites.

Whether we will be able to get Gil off warfarin and potentially gain control over his coronary disease/plaque/calcium remains to be seen. I sure hope so.




Caraballo PJ, Heit JA, Atkinson EJ et al. Long-term use of oral anticoagulants and the risk of fracture. Arch Intern Med 1999; 159 (15): 1750–6. PMID 10448778.

Pilon D, Castilloux AM, Dorais M, LeLorier J. Oral anticoagulants and the risk of osteoporotic fractures among elderly. Pharmacoepidemiol Drug Saf 2004;13(5): 289–294.PMID 15133779.

Gage BF, Birman-Deych E, Radford MJ, Nilasena DS, Binder EF. Risk of osteoporotic fracture in elderly patients taking warfarin: results from the National Registry of Atrial Fibrillation 2. Arch Intern Med 2004; 166(2):241–246.PMID 16432096.




Copyright 2008 William Davis, MD

Comments (16) -

  • Anonymous

    4/19/2008 1:59:00 AM |

    Interesting--a good friend of mine had an angiogram 10 years ago to check a heart irregularity. Turned out he need a valve. the angiogram showed no stenosis or detatectable CAD. He had a mechanical valve put in and went on Comudin. Five years ago he had a heart attack with significant blockages. He has since had another heart attack. Your article would explain what happened.

  • Harry35

    4/20/2008 4:28:00 AM |

    There are other references that substantiate the negative effects of warfarin on the arteries. The effect of warfarin on coronary calcium score was investigated by Koos, et. al. in a study published in the American Journal of Cardiology, Vol 96, Issue 6, page 747 entitled "Relation of Oral Anticoagulation to Cardiac Valvular and Coronary Calcium Assessed by Multislice Spiral Computed Tomography," 15 Sept 2005. They found that the coronary artery calcium Agatston score of warfarin-treated patients with calcific aortic disease was about twice as high as that of similar patients not on warfarin (1561 vs 738). They concluded that "The results of our study have demonstrated that oral anticoagulation may be associated with increased valvular and coronary calcium in patients with aortic valve disease, presumably due to decreased activation of the matrix Gla protein."

    Also, there is a study by Price et. al. in Arteriosclerosis, Thrombosis, and Vascular Biology, 1998;18 pages 1400-1407,"Warfarin Causes Rapid Calcification of the Elastic Lamellae in Rat Arteries and Heart Valves." These rats were given Vitamin K to counteract the anticoagulant effects of warfarin, but they still experienced extensive calcification.

    Hopefully some of the new anticoagulants that don't interfere with warfarin, like Rivaroxaban, will be approved soon so that people in need of long-term anticoagulation won't have to rely on warfarin.

  • Anonymous

    4/20/2008 11:07:00 AM |

    I'm glad to see you are sometimes posting references at the bottom of your blog.  It doesn't help me so much, but it might be helping  doctors become believers.  

    Two former medical doctors, one is now a salesman, the other a researcher, have not shown  interest in TYP until last week for some reason.  One is from Germany, and when he was in town on  business i talked with him in person. he only had criticism for  TYP ideas.  The other from China didn't criticize but seemed to believe the supplements recommended were to similar to Chinese herbalist.  He would tell me that he wants western drugs not vitamin supplements for heart care.

    I don't know why but both doctors seem to have changed their mind on TYP last week.  The German doctor did not talk with me, he talked with a friend about buying the right kind of vitamin D to take for the TYP program.  Same change of heart happened with the Chinese salesman, as he contacted me wanting basic information on TYP.
    The Chinese friend will hopefully read this blog posting on vitamin K, and Warfarin, which I forwarded to him. I believe this is one of the medicines he takes.        

    The two do not know each other.    I don't know what happened to cause this turn around, but something did.

  • Mike

    4/20/2008 1:37:00 PM |

    Don't aspirin and Fish oil (omega-3s) also help thin the blood?

  • Anonymous

    4/24/2008 1:27:00 AM |

    I had a-fib until it was successfully treated at the Mayo Clinic by Dr Brady. Based on my experience I'd suggest Gil see an EP at one of the large centers with lots of experience ablating a-fib. You want an operator with +500 a-fib procedures under their belt.

    Three months after treatment, I was off warfarin.

  • Dr. B G

    4/26/2008 2:38:00 AM |

    EP fails most of the time (unfortunately). However, there appear to be many theories abounding that afib is a consequence of inflammation.... (ummm... just like CAD and heart disease).

    And guess what causes inflammation?

    Excessive carbs, insulin and diabetes/metabolic syndrome!

    http://www.ncbi.nlm.nih.gov/pubmed/15240964
    Sata N et al. C-reactive protein and atrial fibrillation. Is inflammation a consequence or a cause of atrial fibrillation?
    Jpn Heart J. 2004 May;45(3):441-5.
    PMID: 15240964

    Boos CJ, Lip GY.  Inflammation and atrial fibrillation: cause or effect? Heart. 2008 Feb;94(2):133-4. No abstract available.  PMID: 18195117

    Watson T, Kakar P, Lip GY. Cardioversion for atrial fibrillation: does inflammation matter? Am J Cardiol. 2007 Jun 1;99(11):1617-8. Epub 2007 Apr 17. No abstract available.

  • Dr. B G

    4/26/2008 2:38:00 AM |

    EP fails most of the time (unfortunately). However, there appear to be many theories abounding that afib is a consequence of inflammation.... (ummm... just like CAD and heart disease).

    And guess what causes inflammation?

    Excessive carbs, insulin and diabetes/metabolic syndrome!

    http://www.ncbi.nlm.nih.gov/pubmed/15240964
    Sata N et al. C-reactive protein and atrial fibrillation. Is inflammation a consequence or a cause of atrial fibrillation?
    Jpn Heart J. 2004 May;45(3):441-5.
    PMID: 15240964

    Boos CJ, Lip GY.  Inflammation and atrial fibrillation: cause or effect? Heart. 2008 Feb;94(2):133-4. No abstract available.  PMID: 18195117

    Watson T, Kakar P, Lip GY. Cardioversion for atrial fibrillation: does inflammation matter? Am J Cardiol. 2007 Jun 1;99(11):1617-8. Epub 2007 Apr 17. No abstract available.

  • Dr. B G

    4/27/2008 5:48:00 AM |

    Dear Anonymous,

    I hope your physician friends become as enamored with TYP as you are Smile  
    This is the 'trickle up' effect!

    Thanks for your endorsements and support!

  • Dr. B G

    4/27/2008 5:48:00 AM |

    Dear Anonymous,

    I hope your physician friends become as enamored with TYP as you are Smile  
    This is the 'trickle up' effect!

    Thanks for your endorsements and support!

  • Anonymous

    7/24/2008 12:07:00 AM |

    What if Gil abstained from consuming all (plant source) vitamin K1 rich foods and supplimented with vitamin K2 at a dose that would make his INR managable?  Would that at least help stop his calcium score from going up further?

    Also, with a better than 60/60/60 lipid profile, won't the more dangerous soft "unstable" plaques and small LDL particles still remain minimized?  And if that's true, would that make Gil, and people like him, be a rare exception to the "heart scan score" being the "golden standard" to predict future heart attack risk?

  • phuli cohan

    2/20/2009 9:22:00 PM |

    Vitamin K2 deficiency can be safely corrected while on warfarin, there is an excellent article about how to do this safely ( Pharmacotherapy 2005;25:1746-1751).  There are also specialty labs that measure K2.  All cardiac patients should maintain normal levels of K2

  • buy jeans

    11/3/2010 3:46:34 PM |

    Gil's heart scan score: 787--high and posing a risk for heart attack of about 5-10% per year without preventive efforts. Gil did indeed prove to have a complex lipoprotein disorder, as well as high blood pressure, vitamin D deficiency, and several other potential contributors to coronary plaque.

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    2/22/2011 6:01:05 AM |

    wow. lastly, I found something useful for my paper to write down about. that is fascinating and helps me with extra research in the future. Glad I found this blog.Thank you. And I do hope you'll develop some of your concepts about this matter and I'll positive come again and browse it. Thanks for the effort and time.

  • Jeorjette

    6/12/2011 1:48:54 PM |

    I had open heart surgery 14 months ago to repair the mitral valve of a infection that had attached itself as a vegetation. I ended up having AF and now on warfarin. I was told you can't have this and can't have that. Rubbish. For over a year I have self medicated myself with 40mg of Vitamin K in the form of stem enhance followed with superabsorable CoQ10, gamma E, and many other high quality vitamins, lots of anti-oxidents and growth hormone releasing agents in the form of amino acids. Also L-Arginine and nician. I am doing extremely well.
    Not only that. I also mix raw cabbage, sweet potato, beetroot, celery, broc ,tumeric, carrot and more
    I am taking warfarin but the trick is balancing and consistancy and you can do extremely well regardless of the set back. Don't say no. Don't sit and die. Think beyond the square

  • Jeorjette

    6/12/2011 11:26:10 PM |

    Secondly, warfarin does do damage. Use natural products to counterbalance these. Using amino acid stacks you can also trigger your own growth hormone, not only to counterbalance the damage warfarin does but it also excel the rest of the body. Anti-oxidents should also be taken in a wide spectrum like Acai Berry, Vit C, CoQ10,gamma E, Nanoresveratrol, Calcium complex, Omega 3. Whey powder, colstrum, Stem cell enhance
    most products  www.life-enhancement.com  and www.lef.com  also look at pituiatry support to start growth hormone release

  • Hal

    4/19/2012 4:01:44 PM |

    How does Pradaxa fair in this tail?  I have AFib and recently switched from warfarin to Pradaxa.  Well on Warfarin I did (and on Pradaxa will continue to) supplement with K2 but it appears that this was at lower levels than recommended here.  I plan on increasing my K2 intake.

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