Go the distance!

How long should it take to stop or reverse coronary plaque growth? How long will it require to stop your heart scan score of, say, 350, from increasing at the expected rate of 30% per year, slow it down (we say "decelerate") to less than 30%, or stop it altogether? Or, actually reduce your score?

It can vary widely. Several simple patterns do seem to emerge, however. Our experience is that lower scores, particularly less than 100 at the start, are easier to gain control over. Scores of 50 or less, in fact, commonly can return to zero.

Higher scores, particularly those >1000, are more difficult to slow or reduce, though we've done it many times. You'll generally have to try harder and it may take longer. It's not uncommon to not stop plaque growth with a starting score this high until your 2nd or 3rd year of effort.

Sometimes it may take even longer. An occasional person requires four or five years to gain control. And there are, unfortunately, some people who never really gain complete control. They slow plaque growth compared to what it would have been with conventional efforts, but never completely halt growth. Why? Sometimes it's a matter of less than full commitment. Other times, we just don't know. Thankfully, these especially difficult cases are few and the majority enjoy substantial slowing or reversal.

Since, in some people, success may take time, you've got to stick it out. Have you ever gotten lost in a strange city only to find out later that the place you were looking for was right around the corner? It can be the same way with stopping coronary plaque growth. If you start with a score of 1000 and, after two years of effort, you've only slowed growth to 11% per year and then give up in frustration, you may have missed the opportunity to have stopped growth entirely in your third year.

All we can do is tip the scales heavily in your favor. We provide you with the best tools known. You've got to provide the commitment, the consistent effort of taking your supplements or medication, making the lifestyle changes, choosing the right foods and avoiding the wrong ones. But you've got to go the distance and not give up too easily.

What you need is an expert in health!

Where can you find an expert in health?

In my experience, they're hard--very hard--to find.

Your hospital? Certainly not the hospitals I know. The hospitals I know are experts in disease, but not in health. Hospitals are helpful when you're sick. But if you're well and would like to stay that way, there's no reason to hang around a hospital. Prevent cancer, prevent heart disease, stay well? There's no place for this conversation in a hospital.

In fact, hospital staff are among the most unhealthy people I come across. Obesity is a nationwide problem affecting millions of Americans. But it's especially a problem among people who work in hospitals. I shudder in horror when I go to a hospital cafeteria and witness the sorts of food they serve in hospitals and see what the staff eat. Should they be regarded as experts in health?

How about doctors? If you associate with physicians like the ones I know, most have lots of knowledge about disease, but little understanding of health. A rare one has insight and interest in health.

I went to a recent meeting with my cardiology colleagues. Food served: pizza, Coca-Cola, spaghetti, fried onion rings, white bread with butter. They all dug in without hesitation. Over half were miserably overweight. Several were, in fact, diabetic; several more, pre-diabetic. I know that at least several are smokers. Experts in health?

Drug companies? Well, they're interested in health only as far as it provides profits. But health for its own sake? Ask anybody from a drug manufacturer about their views on the nutritional supplement movement and watch them sneer.

Food manufacturers? You mean like Coca-Cola, Pepsi-Cola, Nabisco, and General Mills? How about fast-food operations like McDonald's, Pizza Hut, and KFC?

The message: Know where to look for genuine information on health. You won't get it from hospitals. You won't get it from drug company marketing. For the most part, you can't even get it from your physician.

Instead, you're going to witness a broad movement towards self-empowerment in health, fueled by the internet and services like ours (Track Your Plaque). These are information resources that are not driven by profit, intent on providing truth, and not afraid to reject prevailing views.

It does not mean that hospitals are unnecessary, or that food manufacturers are evil, or that fast food should be legislated out of existence. We live in a capitalistic society, driven by supply and demand. Hopefully, demand is borne from educated choices from informed consumers. That's where information that's reliable, credible, and not profit driven come in.

Lipoprotein(a) and small LDL

It's been my suspicion for some time that the combination of lipoprotein(a), or Lp(a), in combination with small LDL particles is a really bad risk for heart disease. People with this combination seem to have much higher heart scan scores for age than others. This seems to be a pattern that we'll see in the occasional woman less than 50 years old who already has a high heaert scan score. (It's unusual for women to have detectable coronary plaque before age 50.)

Very little data exists to support this idea and we are in the process of performing a small study to see whether it's true or not. My gut sense: it's among the most potent causes of coronary plaque around.

Case in point: Even though I spend a great deal of my time and energy advocating heart disease prevention, I still maintain my hospital privileges and skills. I had to cover one of the emergency rooms in town this past weekend (a requirement to maintain my hospital privileges).

One of the patients I saw was a 40-year old man--we'll call him Roland-- suffering a very large heart attack, a so-called "anterior myocardial infarction", or a heart attack involving the most important front portion of the heart. Thankfully, he came to the ER within 45 minutes after his chest pain started. The situation was immediately obvious and I was called to the ER. We quickly took him to the cardiac catheterization laboratory and put a stent in the left anterior descending artery and flow was restored. His chest pain dissipated over the next few minutes.

Nonetheless, Roland was left with a large area of reduced contraction of his heart muscle. Only time will tell how much recovery he'll have.

Roland was extremely lucky. The majority of people with closure of the artery that he'd experienced die within minutes. He did, in fact, "arrest" briefly, i.e., his heart became electrically unstable, though he recovered promptly.

Along with the multiple tubes of blood we required to run tests for his heart attack management, we had Roland's lipids and other measures sent off, as well. Wouldn't you know: Lp(a) and small LDL. This may have accounted for a heart attack at age 40.

Keep a lookout for this when you have lipoprotein testing. Conveniently, niacin can be used to treat both patterns, though higher doses are generally required for the Lp(a) part of the pattern. It's also my belief that the sort of Lp(a) measurement performed by the Liposcience laboratory (www.liposcience.com) is superior. They use a particle number based measure, not a weight-based measure. It is therefore independent of particle size, which can vary. Further work will, I believe, reveal some very important insights into the dreaded Lp(a).

"Please don't tell my doctor I had a heart scan!"

I overheard this recent conversation between a CT technologist and a 53-year old woman (who I'll call Joan) who just had a scan at a heart scan center:


CT Tech: It appears to me that you have a moderate quantity of coronary plaque. But you should know that this is a lot of plaque for a woman in your age group. A cardiologist will review your scan after it's been put through a software program that allows us to score your images.

Joan: (Sighing) I guess now I know. I've always suspected that I would have some plaque because of my mother. I just don't want to go through what she had to.

CT Tech: Then it's really important that you discuss these results with your doctor. If you wrote your doctor's name on the information sheet, we'll send him the results.

Joan: Oh, no! Don't send my doctor the results! I already asked him if I should get a scan and he said there was no reason to. He said he already knew that my cholesterol was kind of high and that was everything he needed to know. He actually got kind of irritated when I asked. So I think it's best that he doesn't get involved.


This is a conversation that I've overheard many times. (I'm not intentionally an eavesdropper; the physician reading station at the scan center where I interpret scans--Milwaukee Heart Scan--is situated so that I easily overhear conversations between the technologists and patients as they review images immediately after undergoing a scan.)

If Joan feels uncomfortable discussing her heart scan results with her doctor, where can she turn? Get another opinion? Rely on family and friends? Keep it a secret? Read up about heart disease on the internet? Ignore her heart scan?

I've seen people do all of these things. Ideally, people like Joan would simply tell their doctor about their scan and review the results. He/she would then 1) Discuss the implications of the scan, 2) Identify all concealed causes of plaque, and then 3) Help construct an effective program to gain control of plaque to halt or reverse its growth. Well, in my experience, fat chance. 98% of the time it won't happen.

I think it will happen in 10-20 years as public dissatisfaction with the limited answers provided through conventional routes grows and compels physicians to sit up and take notice that people are dying around them every day because of ignorance, misinformation, and greed.

But in 2006, if you're in a situation like Joan--your doctor is giving you lame answers to your questions or dismissing your concerns as neurotic--then PLEASE, PLEASE, PLEASE take advantage of the universe of tools in the Track Your Plaque program.

People tell me sometimes that our program is not that easy--it requires reading, thinking, follow-through, and often asking (persuading?) your doctor that some extra steps (like blood work) need to be performed. The alternative? Take Lipitor and keep your mouth shut? Just accept your fate, grin and bear it, hoping luck will hold out? To me, there's no rational choice here.

Doctor, why do I have heart disease?

I see a great many people in my practice who come for a 2nd opinion regarding their coronary disease.

When I ask patients whether they ever asked their primary doctor or cardiologist why they have heart disease in the first place, I get one of several responses:

1) My doctor said it from high cholesterol.

2) My doctor said it was "genetic" or "part of your family history" and so unidentifiable and uncorrectable. Tough luck.

3) I didn't ask and they didn't tell me.


Let's talk about each of these.

Can heart disease be only from high cholesterol and, if so, can taking a statin cholesterol drug be a "cure"? In the vast majority of cases, in my experience, cholesterol by itself is rarely the only identifiable cause of coronary disease.

Most people have a multitude of causes (e.g., small LDL, low HDL, vitamin D deficiency, concealed pre-diabetic patterns, etc.). This explains why many people with high LDL don't have heart disease and why others with low HDL do have heart disease. High LDL cholesterol is only part of the cause.

Does "genetic" or being part of your family's history also mean unidentifiable and uncorrectable? Absolutely not.

What your doctor is really saying is "I don't know enough to diagnose the causes because I haven't kept up with the scientific literature", or "I don't want to be bothered with this because it takes a lot of time and pays me very little money; I'd rather wait until you need a stent ", or "The drug representatives haven't told me about any new drugs". This is ignorance and laziness at best, greed and profiteering at worst. Don't fall for it. I hope that by now you recognize that the great majority of causes of heart disease are identifiable and correctable.

If you didn't think to ask, now you know that you should. If you and your doctor don't think about why you have coronary plaque in the first place, how can you develop a program to control it?

You need to ask. And you need to get confident answers. "I don't know" or "It's genetic" and the like are unacceptable.

Pill pushers

Have you read the latest cover story from Forbes magazine? It's entitled "Pill Pushers: How the drug industry abandoned science for salesmanship".

It's great reading. (A condensed version is available at the www.forbes.com website: http://www.forbes.com/business/forbes/2006/0508/094a.html. They require you to provide your e-mail address though it's free.)

Drug industry advertising has raised consciousness of all the prescription therapies available for us--that's good. However, they've gone so far overboard trying to squeeze more and more revenues out of drugs that they've cost this country a huge amount in increased health care costs and even lost lives. (Forbes does a great job of summarizing some of these instances.)

Drugs like Lipitor, Crestor, Zocor; diabetes agents; anti-hypertensive agents, etc., that is, medications taken chronically, a huge financial bonanzas for drug companies. Not only do they get $100-200 per month, but they get it month after month after month. That's per drug.

Now not all medications are bad or unnecessary. There are times when they can be truly necessary and beneficial. But don't rely on drug company advertising to tell us when.

Heart disease reversal is getting easier and easier

I've recently observed that more and more of our patients on the Track Your Plaque program seem to be stopping or reducing their heart scan scores. And they're doing it faster, in less time, and with larger drops in score.

I'm not entirely sure why the sudden surge in success. However, I do wonder if adding therapeutic levels of vitamin D--at least in our generally sun-deprived Wisconsin participants--is responsible. However, we've also gotten a lot smarter on how to correct the parameters that seems to have outsized effects on plaque growth, especially small LDL.

Yesterday alone, we had two people we added to our list of successes. One, an attorney, stopped his score in one year, with no change (compared to the expected increase of 30%). Another, a woman from the northeast, dropped her score 10% in one year. Her story is remarkable for beginning at a score >1000. In general, the higher your starting score, the longer it takes to stop or reduce it.

These are just two examples. It seems to be happening at an accelerating pace.

I can only hope that our surge in success (not 100%--yet!) will continue. But, every week, we're adding more and more people to our list of success stories.

A used car lot on every street corner

Imagine that, every day, a parade of used-car salesmen knock on your front door to sell you a special "deal". Day in, day out they knock, expecting you to hear about their offers openly.

Is there any doubt about their intentions or motives? Of course not. They're just trying to profit from selling you a car.

That's how it is in a medical office nowadays. Drug representatives, 5, 6, or more each and every day, promoting drugs. Except that the profits from drugs are far greater than a used automobile, and there's a third party involved in the transaction: you.

Today, a pushy representative came to my office. My staff and I tried to tell him that I was not interested in speaking to him. But he proved such a nuisance that I finally came out to tell him that I objected to the idea of drug reps just hanging around trying to hawk their wares.

He blurted, "Doctor, do you have patients with angina? Our new drug, ranolazine, is perfect. Forget about nitroglycerin, beta blockers, and all that. Here's the latest study proving it's better." He tried to shove a reprint of the study at me.

Getting to the bottom line, I asked, "What does it cost the patient?"

"Well, the co-pay is between $40 and $60. We're not yet well covered by insurance, so it'll cost patients around $200 a month."

Need I say more? Here's a drug that does little more than help relieve anginal chest pains. It doesn't reverse coronary plaque. It won't avoid heart attack, death, or procedures. It just modestly cuts back on the frequency of chest pain. And all for the cost of a single heart scan--a heart scan that could have prevented the entire cascade of symptoms/procedures/medication/hospitalization etc.

Hospitals, drug companies, medical device manufacturers. They're all businesses that thrive on your doctor's failure to detect and control your coronary plaque. Sometimes, even your doctor is part of this conspiracy to squeeze dollars out of human disease. Don't fall for it.

Heart disease reversal at age 77

I met Agnes 18 months ago after she underwent a heart scan that revealed a scary score of over 1100. Although in her mid-70s, this was still a very high score. (Recall that a score this high carries a risk for heart attack and death of 25% per year.) Poor Agnes was a wreck over this unexpected result. "I can't sleep, I can't stop thinking about it!"

She'd undergone the scan because her 44-year old son had a heart scan score of 2200! Unfortunately, he ended up with a bypass operation for very severe disease.

Despite having been seeing a cardiologist in Boston for the last 8 years for a murmur, we uncovered multiple hidden lipoprotein patterns, many of which she shared with her son. Her most notable abnormalities were a low HDL and small LDL. Nearly 100% of all LDL particles were, in fact, small. This pattern also caused her LDL cholesterol to be underestimated by over 40%.

18 months on the Track Your Plaque program and Agnes came into town to get a repeat scan. Her score was 10.2% lower. She'd learned to live with the idea that she had hidden heart disease missed by her doctor and cardiologist for many years. But knowledge of the substantial reversal she'd achieved in the 18 months on the program gave Agnes tremendous peace of mind.

Agnes left the office with a big smile.

If you need a reason to quit smoking...

If you've read Track Your Plaque, you already know my feelings about smoking and coronary plaque. Smoke, and you will lose the battle for control over coronary plaque growth--it will grow and grow until catastrophe strikes.

Nonetheless, this is not sufficiently motivating for some people.

If you need more motivation to quit smoking, just take a look at your heart scan sometime, accompanied by either one of the doctors or technicians at the scan center you choose. After you've had an opportunity to look at your coronary arteries, take a look at the lungs. The heart is in the middle and the lungs are the two large black areas on either side of the heart. (They're not really black; that's just the way the images are color-coded.)

Smokers will see large cavities in their lungs--literally, half-inch to one-inch wide holes that contain only air. Many of them. These represent remnants of lung tissue, digested away and now useless from the damage incurred through smoking.

Non-smokers should see uniform lung tissue without such cavities.

What surprised me early on in my heart scan experience was how little smoking exposure was required to generate these cavities. A 40-year old, for instance, who smoked a half-pack per day for 10 years would have them. Heavier smokers, of course, showed far more extensive cavities.

Officially, these cavities are called "emphysematous blebs", meaning the scars of the lung disease, emphysema.

When I've pointed out these cavities or emphysematous blebs to patients, 9 out of 10 times they immediately become non-smokers. Commonly, they'd exclaim, "I had no idea I was really damaging my lungs!" Most admitted that they were awaiting some bona fide evidence that they were truly doing some harm to their bodies. Well, that's it.

Give it a try if you're struggling.
To remind us what ideal body weight is: Watch an old movie!

To remind us what ideal body weight is: Watch an old movie!

Jack was skeptical. At 273 lbs, 5 ft 11 inches, he felt that he was "just right".

"I feel fine. I don't see why you think I should lose weight," he declared. "In fact, when I lost 25 lbs a couple of years ago, everyone said I was too skinny!"

I showed Jack why: He had an HDL of 35 mg/dl, small LDL (over 90% of all LDL particles), an elevated blood sugar of 123 mg/dl (diabetes is officially 126 mg/dl or greater), high blood pressure, and increased inflammation (C-reactive protein). These were all manifestations that his body weight was too much for it to handle.




So I told Jack that we've all forgotten what ideal weight should look like. Our perception of "normal" has been so utterly and dramatically distorted by the appearance of our friends, family, co-workers, and other people around us that we've all lost a sense of what a desirable weight for health should be.




So I suggested to Jack that, if he wanted to rememember what ideal weight is and what people are supposed to look like, just watch old movies.

Old movies, like the 1942 production of Casablanca, or the 1952 production of Singin' in the Rain, show the body build that was prevalent in those days. Look at Humphrey Bogart or Gene Kelly--men with average builds, weighing 140-160 lbs--that's how humans were meant to look.

A report this morning on the Today Show showed the "after" photos of several people following bariatric (weight reduction) surgery. The "after" pictures, from the perspective of ideal weight and ideal health, remain hugely overweight.

We need to readjust our perceptions of weight. The average woman in the U.S. now weighs 172 lbs(!!!). Don't confuse average with desirable.
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Is Lp(a) part of your legacy to your children?

Is Lp(a) part of your legacy to your children?

If you have lipoprotein(a), Lp(a)--the most aggressive known cause of heart disease that no one has heard of--then you need to tell your children.

Lp(a) is a "cleanly" inherited genetic pattern: If either parent has it, there's a 50% chance that you have it. If you have it, then there's a 50% likelihood that each of your children has it. (Note that each child experiences a likelihood of 50%, not 50% of your children. This is because each child is conceived as an independent statistical event. So much for romance!)

The atherogenicity (plaque-causing potential) of Lp(a) also tends to get transmitted. In other words, if your Dad had a heart attack at age 50 due to Lp(a) and you share Lp(a), then you likely share a similar magnitude of risk as your Dad. If your Mom had Lp(a), though passed quietly at age 89 without any overt evidence of heart disease, then you are likely to share the relatively benign form of Lp(a).

For most of us with Lp(a), however, it is best to assume that it has at least some potential for causing heart disease, being the most aggressive cause known. (That is, until we have the ability in everyday clinical practice to characterize Lp(a) by assessing such factors as the size of the apoprotein(a) molecule, the number of kringle "repeats" on the tail, etc. Until then, we need to rely on the crude, though helpful, observation of family history.)

At what age should you inform your children? There's no hard-and-fast rule. However, I generally suggest to patients that they talk about Lp(a) with their children when they reach their 20s or 30s, old enough to begin to understand the implications and begin to think about adopting healthier lifestyles. Is treatment required at, say, age 35? That depends on the pattern of Lp(a)-related heart disease in the family: With exceptionally aggressive forms, it might be reasonable to begin treatment at this relatively early age.

Comments (21) -

  • craig&jan

    9/15/2009 4:59:09 AM |

    Finally switched to a new PCP who says she loves lipids!  Very interested in all facets of cardiac risk, thyroid, etc.

    My father is 88 and still very active. My mom passed away at 84 following her first health event which was a stroke.  
    I have been following this blog's recommendations for supplements, diet,etc. The new dr did a lipid panel and without any rx meds, my total was 199, HDL 61, Tri 68, LDL 124.  My Lp(a) was tested by my previous dr and was 34. I was told that was high and I probably had inherited my mother's pattern and she most likely had an Lp(a)problem. The new dr says I must go on Crestor 5mg a day to lower my LDL to 100. She says that will protect me from depositing more plaque in the coming years, in effect immobilizing the Lp(a). Would you say that was a fair assessment and reason to start on a statin?  She feels the lowest dose possible is enough to benefit by lowering the LDL.  Your post is exactly the situation I'm in and adding meds are my biggest question.  I will tell my children who are in their late 20's. I'm in my mid-50's with no other health issues.  I'd love your take on it.

    Thanks.

    Jan

  • craig&jan

    9/15/2009 4:59:09 AM |

    Finally switched to a new PCP who says she loves lipids!  Very interested in all facets of cardiac risk, thyroid, etc.

    My father is 88 and still very active. My mom passed away at 84 following her first health event which was a stroke.  
    I have been following this blog's recommendations for supplements, diet,etc. The new dr did a lipid panel and without any rx meds, my total was 199, HDL 61, Tri 68, LDL 124.  My Lp(a) was tested by my previous dr and was 34. I was told that was high and I probably had inherited my mother's pattern and she most likely had an Lp(a)problem. The new dr says I must go on Crestor 5mg a day to lower my LDL to 100. She says that will protect me from depositing more plaque in the coming years, in effect immobilizing the Lp(a). Would you say that was a fair assessment and reason to start on a statin?  She feels the lowest dose possible is enough to benefit by lowering the LDL.  Your post is exactly the situation I'm in and adding meds are my biggest question.  I will tell my children who are in their late 20's. I'm in my mid-50's with no other health issues.  I'd love your take on it.

    Thanks.

    Jan

  • Dr. William Davis

    9/15/2009 11:57:55 AM |

    Hi, Jan--

    Sadly, that is the typical primary care response, someone who has minimal to no insight into Lp(a).

    So, no, I would not agree with this approach that was first popularized by a single substudy performed by Dr. Greg Brown at the University of Washington.

    I take a very different view of Lp(a) that varies depending on age. However, this is a lengthy topic either for a future post or refer to the detailed discussions in the Track Your Plaque website.

  • ABick

    9/15/2009 3:47:10 PM |

    Dr. Davis - Is any amount of Lp(a) a significant risk factor for CVD?  Or is there a relatively safe threshold that if one is below there should be limited risk?

  • steve

    9/15/2009 4:42:52 PM |

    Dr Davis:  what would you say is a high Lp(a)? The NMR range is <75nmol, and the other measurement i think is <32or 40dl.  Would a 30-40 be high on NMR, or 15-20 per dl?
    Thanks,

  • Scott Miller

    9/15/2009 8:01:37 PM |

    Dr. Davis,

    I read all of your posts, greatly admire your practice, open-mindedness, and vast knowledge.

    I have measured my Lp(a) for several years, and have kept it at a bare minimum, usually below 8, most recent a reading of 3. I do this through a paleo-like diet:

    o High-fat (avoiding polyunsaturated fats, but high in saturated fats, mono unsaturated fats, and marine omega-3's)
    o Moderate protein (mostly from animal sources)
    o Low-carb (no grains, no added sugars, absolutely no processed fructose, and eating mostly high-water-volume vegetables, which are naturally very low in actual glucose polymers)

    My primary goals:
    o Maintain ultra low inflammation
    o Maintain low insulin usage (thru maintaining low-normal blood glucose, in the 80's)

    I'm 48, in supremely great health, and look around 35-yrs-old.

    My question: I've thoroughly looked for studies linking Lp(a) to gluten consumption, but I've come up empty. Are you aware of any studies?

  • Dr. William Davis

    9/15/2009 9:17:14 PM |

    AB and Steve--

    Because there are several different methods to measure Lp(a) for which the "reference ranges" differ, it is best to consult the range offered by the lab used, which are pretty good indicators of normal vs. abnormal.

    Scott--

    I know of no data specifically relating gluten to Lp(a). Anecdotally, there may be an effect, but it is likely relatively small.

  • Scott Miller

    9/16/2009 2:14:38 AM |

    Dr. Davis, I thought you had found in your practice a link between gluten and Lp(a). Or, at least, wheat and Lp(a)?

  • Dr. William Davis

    9/16/2009 2:30:01 AM |

    Hi, Scott-

    It's difficult to separate out the effects of wheat elimination vs. carbohydrate reduction, increased fat/oil intake. So I cannot say with absolute confidence that gluten specifically affects Lp(a).

    It's an interesting concept, but I don't believe that we have an answer.

  • David

    9/16/2009 4:41:08 AM |

    Dr. Davis- Have you ever seen Lp(a) cause heart disease in the very young? Under 35 or even under 30? I know that even children can have high Lp(a), and it makes me wonder if plaque growth is going on throughout childhood in these cases or if it is rather somehow "activated" once a certain point is reached and accelerates in a very short time toward the kind of events we see in the 40s and 50s age groups.

  • Lou

    9/16/2009 4:16:09 PM |

    Dr Davis

    I found a lab in Europe that will do an Lp(a) test and also Apolipoprotein A. I want to do the Lp(a) test as you suggest.

    The lab also offers an Apolipoprotein B test. Is the Apolipoprotein B of any use value? I couldn't see much info about it on your blog/book.

    Thanks
    Lou

  • Kent

    9/16/2009 4:54:47 PM |

    I see various thoughts and studies on the effects of monounsaturated fats on LP(a). I see Scotts example of using lots of saturated and monounsaturated fats and lowering his LP(a). I see other studies where they say monounsaturateds can raise LP(a) by 10-12%. What gives?

  • Dr. William Davis

    9/17/2009 1:45:11 AM |

    Hi, David--

    Rarely will Lp(a) cause heart disease before age 35. There are always exceptions, but they are exceptionally rare.


    Lou--

    Apo B is an improvement over calculated LDL. Yes, it is worth the few extra bucks. My personal favorite, however, is NMR LDL particle number, the best measure of LDl by a long stretch. Apo B is a second best.

  • Dr. B G

    9/17/2009 2:13:23 PM |

    Kent,

    Saturated fatty acids (SFA)indeed potently control Lp(a) in the clinical trials as well as anecdotally in our TYP membership. Why? SFA are actually hormonal in action, binders of receptors just like omega-3 fatty acids which lower inflammation and raise HDLs.

    There is a study that shows if Lp(a) is = or < than HDL2, Lp(a) is effectively 'neutralized'. Some of our members had HDL2 of > 40-50 mg/dl. In fact, Lp(a) and HDL track  together and  Dr. Davis' TYP program includes every facet and strategy that raises HDL to one's genetic potential:
    --thyroid and hormone replacement
    --wheat/gluten/carb elimination
    --vitamin D

    With every 10% increase in vit D, there is a ~1% increase in HDL. Did u know Crestor raises vit D by 159%?! Of course Crestor has NASTY side effects -- Crestor raises oxLDL + Lp(a)).

    -G

  • Dr. B G

    9/17/2009 2:13:23 PM |

    Kent,

    Saturated fatty acids (SFA)indeed potently control Lp(a) in the clinical trials as well as anecdotally in our TYP membership. Why? SFA are actually hormonal in action, binders of receptors just like omega-3 fatty acids which lower inflammation and raise HDLs.

    There is a study that shows if Lp(a) is = or < than HDL2, Lp(a) is effectively 'neutralized'. Some of our members had HDL2 of > 40-50 mg/dl. In fact, Lp(a) and HDL track  together and  Dr. Davis' TYP program includes every facet and strategy that raises HDL to one's genetic potential:
    --thyroid and hormone replacement
    --wheat/gluten/carb elimination
    --vitamin D

    With every 10% increase in vit D, there is a ~1% increase in HDL. Did u know Crestor raises vit D by 159%?! Of course Crestor has NASTY side effects -- Crestor raises oxLDL + Lp(a)).

    -G

  • Anonymous

    9/17/2009 6:32:59 PM |

    My brother had a MI right after he turned 29. My parents now in sixties, do not have cholesterol related heart disease yet although my mom has some issues now due to thyroid problems. She has also developed diabetes unfortunately.

    Would this be Lp(a) related incidence?

  • Kent

    9/18/2009 5:10:58 PM |

    Dr. BG, Thanks for your response on the subject of fats. I was aware that saturated fats could substatially lower LP(a), however my area of concern has more to do with the mono unsaturated fats. Scott mentioned how he had lowered his LP(a) with a diet that included high intake of the mono unsaturated fats. Yet, I have read elsewhere that the mono unsaturated fats can raise LP(a) by 10-12%. (Vessby B et al 2002).
    So I guess my question remains do monos raise or lower LP(a)

  • Florida Butterfly

    2/9/2010 2:07:29 AM |

    I am 22 and just found out that I inherited the elevated lp(a) levels. As of now my number his higher than my dads! He just avoided a heart attack, and had stents put in just before it reached that point. Needless to say I inherited it from him.  I am starting Niacin, only 100 mg.  I will say that it is a serious struggle for me to change my lifestyle as in diet and exercise so early.   My lp(a) # was 65

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    11/4/2010 5:13:10 PM |

    (That is, until we have the ability in everyday clinical practice to characterize Lp(a) by assessing such factors as the size of the apoprotein(a) molecule, the number of kringle "repeats" on the tail, etc. Until then, we need to rely on the crude, though helpful, observation of family history.)

  • Anthony Cozzi

    11/24/2011 1:46:27 AM |

    Dear Dr. Davis
    I am 58 years old and have had three stents ( one in 2000 and two in 2008 ).  My Lp(a) is >200 according to my last Berkely Test in 2010.  I am soon having another Berkely Test and would like to know exactly what I should have tested besides my Lp(a) and particle size.  I have been taking Niaspan (1500mg daily) and Simcor 1000/20, Fish Oil and Vitamin D3 ( 6000 iu ) all daily.  Would you suggest me taking any DHEA ?  I would really appreciate hearing from you.  I live in Chicago and could visit your office. 708-925-3010.  Thank you.
    Anthony Cozzi

  • Dr. William Davis

    11/25/2011 2:12:20 PM |

    Hi, Anthony--

    Thyroid assessment is crucial in Lp(a): TSH, free T3, free T4. Also, a DHEA level. Both issues are very important.

    Sorry, but my practice is now closed to new patients, since we were booking 6 months in advance. However, much of this can be found in the Track Your Plaque website.

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