Are happy people more likely to reduce heart scan scores?

I was talking to Darryl, a patient today: 71 years old with a heart scan score of 378, as well as an enlarged aorta (4.5 cm).

We had identified numerous lipoprotein abnormalities 12 months ago and advised him on a program for correction. His patterns included small LDL, high triglycerides, sky-high IDL (VERY important when you have an enlarged aorta), and lipoprotein(a). Blood pressure was also high, another crucial fact to correct when the aorta is enlarged.

Anyway, Darryl corrected lipoproteins to perfection: basic lipids were substantially better than 60-60-60; lipoprotein(a) was reduced well into the desirable range; IDL was eliminated; blood pressure was 108/64. Repeat heart scan score: 354.

There's nothing spectacular about Darryl's story, except that, despite these issues, Darryl was a happy man. He smiled throughout our conversation. He has told me on several occasions how grateful he is for the life he has.

Darryl is not wealthy. He retired around 4 years ago and fills his day with helping his wife, walking outdoors, helping out at his church, and contributing to the care of his grandchildren. Through all this Darryl is incurably, unfailingly, and irrepressibly happy.

It made me think back through all the other people who've also had great succes in their Track Your Plaque program. It struck me that, for the most part, they too were a happy bunch: generally optimistic, happy, not overly stressed nor prone to extremely stressful responses to stressful situations. All seem to also be grateful for the good in their lives, though most had no more money than the average person and had their share of difficulties in life. In fact, I can only recall one person who reversed coronary plaque who was an angry, pessimistic personality. Just one.

Could it be that happy, optimistic people are more likely to reverse coronary plaque? It would, after all, be consistent with all the other observations that type A personalities have more heart attack, etc.

Anyway, this is just an informal observation but one that seems very consistent. Track your plaque--and be happy!

Don't overdo the vitamin D

As time passes and I advise more and more people to supplement vitamin D, I gain increasing respect for this powerful "vitamin". I am convinced that vitamin D replacement is the reason for a recent surge in our success rates in dropping CT heart scan scores. I believe it is also explains the larger drops we've been witnessing lately--20-30%.

But vitamin D can be overdone, too. Too much of a good thing . . .

Despite being labeled a "vitamin", cholecalciferol is actually a hormone. Vitamins are obtained from food and you can thereby develop deficiencies because of poor intake. Deficiency of vitamin C, for instance, arises from a lack of vegetables and fruits.

Vitamin D, on the other hand, is nearly absent from food. The only naturally-occuring source is oily fish like salmon and sardines. Milk usually has a little (100 units per 8 oz) because milk producers have been required by law to put it there to reduce the incidence of childhood rickets.

A woman came to me with a heart scan score of nearly 3800, the highest score I've every seen in a woman. (Record for a male >8,000!) She was taking vitamin D by prescription from her family doctor but at a dose of 150,000 units per week, or approximately 21,000 units per day. This had gone on for about 3-4 years. This may explain her excessive coronary calcium score. Interestingly, she had virtually no lipoprotein abnormalities identified, which by itself is curious, since most people have some degree of abnormality like small LDL. Obviously, I asked her to stop the vitamin D.

Should you be afraid of vitamin D? Of course not. If your neighbor is an alcoholic and has advanced cirrhosis, does that mean you shouldn't have a glass or two of Merlot for health and enjoyment? It's a matter of quantity. Too little vitamin D and you encourage coronary plaque growth. Too much vitamin D and you trigger "pathologic calcification", or the deposition of calcium in inappropriate places and sometimes to extreme degrees, as in this unfortunate woman.

Ideally, you should have your doctor check your 25-OH-vitamin D3 blood levels twice a year in summar and in winter. We aim for a level of 50 ng/ml, the level at which the phenemena of deficiency dissipate.

"It must have been the statin"

After four years of trying, Randy finally reduced her heart scan score. It not only dropped, it plummeted. After four previous scans that showed 25% or more increases, she'd finally dropped her score 23%. (I Blogged about Randy's case a few weeks ago.)

Randy also works for a cardiologist. When she told him that she had reversed her coronary plaque and reduced her heart scan score by 23%, he said, "It must have been the statin agent."

Randy was indeed on a statin drug at a low dose. But she also had taken great efforts in exercise, food choices, fish oil, and vitamin D. In fact, her score had progressed dramatically while she was taking the drug. Put simply, it was not the statin.

But that is the mindset of the conventionally thinking cardiologist. Stent, bypass, or statin drug--what else is there? Even with crystal clear evidence for coronary plaque regression, they refuse to acknowledge that tools that are not in their everyday consciousness could have achieved so spectacular a result.

Given a choice, 9 out of 10 cardiologists would rather put a stent in and walk away $2000 richer for an hour of work. Don't allow them to have this choice. Take control now.

Statin Drugs May Help the Healthy:
Cholesterol-Lowering Statin Drugs May Benefit People Without Heart Disease


That's the headline on WebMD, reporting the findings of a recent study published in the Archives of Internal Medicine. In reality, it wasn't really a study at all, but a re-analysis of previously published data, a so-called meta-analysis.

Nonetheless, the University of Toronto group re-analyzed the results of several studies, pooling data on 28,000 people, none of whom had known coronary disease. The results were similar to the results of the studies that were reported individually: a 29% reduction in heart attack and other "events" in people taking statin drugs.

What's surprising to me is this notion that statins, or any other treatment for that matter, prevent heart attack in people without heart disease. This is idiotic. Of course they had coronary heart disease. You can't have a heart attack in the absence of coronary disease. (There are very rare exceptions, like cocaine users, who experience coronary spasm from the drug).

What the study shows is that people with unrecognized heart disease experienced a reduction in heart attack. What it also means is that many, many people truly without heart disease were unnecessarily treated. As you'd predict, the drug manufacturers love this sort of broad, untargeted use of their drugs. It's an approach that brings in billions of dollars of revenues. The article on WebMD, in fact, was accompanied by three ads for various cholesterol drugs on this single page story.

What if only people with heart disease, as identified by CT heart scan scores, were treated? You would indeed witness an even larger reduction in heart attack risk, because the group receiving treatment both has the disease and is thereby at greater risk. Treatment should yield even greater risk reduction than treating broad groups who superficially appear to not have heart disease.

Ignore this nonsense about statin drugs reducing heart attack risk in people without heart disease. If you don't look for it, you won't know you have it. Once again, you can be lots smarter than the media. Get a heart scan and find out if your risk is worth reducing.

Heart attack guaranteed

What if you knew for a fact that your risk for heart attack was 100% by, say, age 58? This is indeed true for many people, though at age 60, 65, 70--or 45.

In other words, unless something were done about the causes of heart disease, you would inevitably suffer a heart attack at 58.

What sort of action could you take at age 45?

Obviously, not smoking is an absolute requirement. Continue and you may as well start getting your affairs together.

How about exercising and eating a generally healthy diet? Will your risk be reduced to zero? No. It might be reduced 20-30%, depending on genetic factors.

How about a statin drug? Watch TV ads during Oprah, and you might think it's a cure. But in reality, while it is a financial bonanza for the drug manufacturers, it will reduce risk for heart attack by 30%.

(Note that risk reduction by following multiple strategies is not necessarily additive. In other words, if you have a healthy lifestyle and take a statin agent, is risk reduced 60% (30 + 30)? No, because the effects may overlap.)

So, eating healthy, exercising, and taking a statin drug might reduce risk 35-40%, maybe 50% in the best case scenario. Would you be satisfied? Most would not.

Add fish oil at a truly therapeutic dose. Risk reduction by itself: 28%.

Add niacin or other strategies for correction of your individual, specific causes of heart disease: Now we're up to 90% reduction.

Throw in a tracking process to prove whether or not atherosclerotic plaque has progressed or reversed. Now we're approaching 100% if plaque reverses. The only way I know how to track plaque is through CT heart scans. What other test is readily available to you with low radiation exposure, yet is relatively inexpensive and precise? It certainly is not stress testing, heart catheterization, CT angiograms, or other techniques. Cholesterol won't tell you. Besides CT heart scans, there's nothing else I know of.

Let's fact it: For many people, uncorrected risk for heart attack is truly 100% at some age. Take action while you can.

That, in a nutshell, is the Track Your Plaque program.

Heart scan curiosities 3



This is a sample image from the heart scan of a 54-year old, 212 lb, 5 ft 2 inch woman. The heart is the whitish-gray in the center; lungs are the dark (air-filled) areas on either side of the heart. Note the massive amount of surrounding gray tissues that encircles the heart and lungs. This is fat. At this weight, the diameter of total fat exceeds the combined diameter of the heart and lungs. If we were to show the abdomen, there would be even more fat. (The image shows the body not well centered because the technologist centers the heart, since this is, after all, a heart scan.)





This is a 55-year old, 151 lb, 5 ft 4 inch woman. Note the contrast in the quantity of fat tissue surrounding the chest, a much more normal appearance. Note that this woman is still around 25 lb over ideal weight, but not to the extreme degree of the woman above.

Another curious observation: Note the more whitish streaking in the heavier woman's lungs. Heart scans are performed while holding a deep inspiration (a deep breath inwards), mostly to eliminate lung respiratory motion during image acquisition. Nonetheless, the heavier woman's lungs are not as fully expanded as the more slender woman. In other words, the heavier woman cannot inflate her lungs as effectively as the thinner woman. Ever notice how breathless heavy people are? Some of this effect is just being out of shape. But there's also the added effect of the abdominal fat exerting upwards compression on the lung tissues, and the constrictive effect of the encircling fat mass. At the beginning of inspiration, the chest fat exerts the resistance of inertia to inspiration that is absent, or less, in a slender person. With each breath, the heavy woman must move 50 lbs or so of surrounding fat mass just to inhale.

The heavier woman is, in effect, suffocating herself in fat.

The distortions to the human body incurred by extreme weight gain are both fascinating and shocking. I hope you're breathing easily.

The shameful "standard of care"

John's initial heart scan four years ago showed a score of 329. His physician prescribed Zocor for a somewhat high LDL cholesterol.

One year later, John asked for another scan. His score: 385, a 17% increase. John exercised harder and cut his fat intake.

This past fall--3 years after his last scan--John had yet another heart scan. Score: 641, a 66% increase over the last scan, all the while on Zocor.

John sought an opinion from a reputable cardiologist. He concurred with the prescription of Zocor and advised annual stress tests. That's it.

Followers of the Track Your Plaque approach know that the expected uncorrected rate of increase in heart scan score is 30% per year. On Zocor or other cholesterol reducing statin agent, a common rate of growth is between 18-24% per year--better but not great. Plaque growth is certainly not stopped.

But that is the full extent of interest and responsibility of your cardiologist. Prescribe a statin drug, perform a stress test, and the full extent of his obligation has been fulfilled. In legal terms, your physician has met the prevailing
"standard of care". No more, no less.

In other words, the prevailing standard of care falls shamefully short of what is truly possible. For the majority of the motivated and interested, coronary plaque reversal--reduction of your heart scan score--should be the standard aimed for. It's not always achievable, but it is so vastly superior to the prescribe statin, wait for heart attack approach endorsed by most cardiologists.

Heart scan curiosities 2



This is an example of a so-called "hiatal hernia", meaning the stomach has migrated through the diaphragmatic hiatus into the chest--the stomach is literally in the chest. This example is an unusually large one. Hiatal hernias can cause chest pain, indigestion, and a variety of other gastrointestinal complaints. Heart scans are reasonably useful to screen for this disorder, though very small ones could escape detection by this method.

Sometimes, you can actually hear the gurgling of stomach contents (the common "growling" stomach) by listening to the chest. Large ones like this actually crowd your heart (the gray structure above the circled hernia), irritating it and even causing abnormal rhythm disorders. The dense dark material within the hernia represents lunch.

I would not advocate CT heart scans as a principal method to make a diagnosis, but sometimes it just pops up during a heart scan and we pass it on to the person scanned.

Vitamin D: New Miracle Drug

At the meetings of the American Society of Bone and Mineral Research, Dr. Bruce Troen of the University of Miami detailed his views on the extraordinary benefits of vitamin D replacement. He also talked about the enormous problem of unrecognized vitamin deficiency.

“There’s a huge epidemic of hypovitaminosis D, and the real key here is not just that it’ll benefit you from a bone and neuromuscular standpoint, but if you correct hypovitaminosis D and the corresponding secondary hyperparathyroidism, then you’re going to decrease prostate cancer, colon cancer—actually “up to 17 different cancers, breast cancer included.”

Unfortunately, Dr. Troen did not talk much about the heart benefits of vitamin D, likely since the data is scant, nearly non-existent. However, if the Track Your Plaque experience means anything, I predict that vitamin D replacement will become among the most powerful tools you can use to gain control over coronary plaque.

Read the text of a report from the Internal Medicine World Report to read more of Dr. Troen's comments.


http://www.imwr.com/article.php?s=IMWR/2006/11&p=40

Heart disease "reversal" by stress test


Here's an interesting example of a 71-year old man who achieved "reversal" of an abnormality by a nuclear stress test.

This man underwent bypass surgery around 10 years ago, two stents three years ago. A nuclear stress test in April, 2005 showed an area of poor blood flow in the front of the heart. On the images, normal blood flow is shown by the yellow/orange areas. poor or absent blood flow is shown by the blue/purple areas within the white outline.

Now, I can tell you that this man is no paragon of health. He's only accepted limited changes in his otherwise conventional program--in other words, someone who I'd be shocked achieved true reversal of his heart disease. (I didn't have him undergo any CT heart scans because of the difficulties in scoring someone who has undergone bypass surgery and stents, and because of limited motivation. True plaque reversal is for the motivated.)This patient did, however, accept adding fish oil and niacin to his program.

Nonetheless, stress testing can be helpful as a "safety check". Here's the follow-up stress test:
You'll notice that the blue/purple areas of poor blood flow have just about disappeared. This occurred without procedures.

Does this represent "reversal"? No, it does not. It does represent reversal of this phenomenon of poor flow. It does not represent reversal of the plaque lining the artery wall. That's because improvement of flow, as in this man, can be achieved with relatively easy efforts, e.g., improvement in diet, statin drugs, blood pressure control, etc. True reversal or reduction of coronary plaque, however, is tougher.

If blood flow is improved, who cares whether plaque shrinks? Does it still matter? It does. That's because the "event" that gets us in trouble is not progressive reduction in blood flow, but "rupture" of a plaque. A reduction in plaque--genuine reversal--is what slashes risk of plaque rupture.
Vitamin D: Deficiency vs optimum level

Vitamin D: Deficiency vs optimum level

Dr. James Dowd of the Vitamin D Cure posted his insightful comments regarding the Institute of Medicine's inane evaluation of vitamin D.

Dr. Dowd hits a bullseye with this remark:

The IOM is focusing on deficiency when it should be focusing on optimal health values for vitamin D. The scientific community continues to argue about the lower limit of normal when we now have definitive pathologic data showing that an optimal vitamin D level is at or above 30 ng/mL. Moreover, if no credible toxicity has been reported for vitamin D levels below 200 ng/mL, why are we obsessing over whether our vitamin D level should be 20 ng/mL or 30 ng/mL?

Yes, indeed. Have no doubts: Vitamin D deficiency is among the greatest public health problems of our age; correction of vitamin D (using the human form of vitamin D, i.e., D3 or cholecalciferol, not the invertebrate or plant form, D2 or ergocalciferol) is among the most powerful health solutions.

I have seen everything from relief from winter "blues," to reversal of arthritis, to stopping the progression of aortic valve disease, to partial reversal of dementia by achieving 25-hydroxy vitamin D levels of 50 ng/ml or greater. (I aim for 60-70 ng/ml.)

The IOM's definition of vitamin D adequacy rests on what level of 25-hydroxy vitamin D reverses hyperparathyroidism (high PTH levels) and rickets. Surely there is more to health than that.

Dr. Dowd and vocal vitamin D advocate, Dr. John Cannell, continue to champion the vitamin D cause that, like many health issues, conradicts the "wisdom" of official organizations like the IOM.

Comments (20) -

  • Anton

    12/19/2010 2:20:07 AM |

    Thanks for your great blog, and for your interest in Vitamin D.

    Along with doctors Dowd and Cannell, add Dr. Holick as another pioneer in Vitamin D. research.

    http://www.vitamindhealth.org/

  • Anonymous

    12/19/2010 4:58:25 AM |

    I bet natural vitamin d is far superior to oral supplementation.  I think vit D absorbtion is optimized by low carb, but you also need some sunlight added into the picture.

  • Dr. William Davis

    12/19/2010 1:59:13 PM |

    Hi, Anon--

    Where I live, it's been around 10 degrees Fahrenheit for about two weeks straight. Probably too cold to lay out in a bathing suit.

    For many of us, supplementation is the only choice.

    Also, don't forget that the majority of people after age 40 have lost much of their ability to activate vit D in the skin.

  • kellgy

    12/19/2010 5:02:25 PM |

    I just added his book to my wish list and it will be my next read. I am beginning to wonder why don't we seek to reach serum vitamin D somewhere between 100-150 range. Has there been any research indicating any response to these levels? Even with all the recent research focusing on vitamin D, it would be nice to understand overall health responses at varying degrees of serum content from deficiency to toxicity. We need a wider perspective to draw from.

    BTW, an update: 110 pounds and counting . . . My BMI is about to fall into the normal range and my health has never been better!

    This is an unusual thought. Sitting in front of a very warm and soothing fire last night, I was wondering how my skin reacts to the radiation, aside from the warmth and relaxation benefits.

  • IggyDalrymple

    12/20/2010 3:07:51 AM |

    My level dropped 20 points when I reduced my intake from 10,000 iu/day to 5,000 /day.  I went back to 10,000 and now I'm at 63 ng/ml.  I'll stick with 10,000 iu unless I exceed 100 ng/ml.

  • Susanne

    12/20/2010 7:06:08 AM |

    I wonder if there is not a missing piece to the puzzle of vitamin D deficiency in relation to adequate iodine levels.  I have appended text from the website Iodine4health.  In it Dr. Vickery noticed a connection between the two:

    ”I have also noted an apparent connection between bringing sufficient iodine to a bromine plugged thyroid, and the vitamin D metabolism of the body. Although I am unaware of the exact mechanism, it seems clear that the calcitonin/parathyroid hormone/Vitamin D/calcium balance in the body changes as people on iodine loading programs often register as vitamin D deficient when they did not previously."

    I believe this to be my case.  I tested my vitamin D levels for years and they were optimal based on Dr. Mercola's recommendations and I supplemented with D in the form of cod liver oil rarely.  Then I started taking iodine and I had such a dramatic improvement in symptoms that I knew I had been iodine deficient perhaps my entire life.  After 2-3 years of iodine supplemention I am going to get my D levels tested soon.

  • Anonymous

    12/20/2010 12:10:49 PM |

    Susanne
    Please write the name of the test you underwent to find iodine deficient?Is it a routine blood test that nay primary care doc can order?Readers please chime in please

    Regards
    SMK

  • Pater_Fortunatos

    12/20/2010 1:02:01 PM |

    Published less than a month ago:

    Vitamin D deficiency in rheumatoid arthritis: prevalence, determinants and associations with disease activity and disability

    http://arthritis-research.com/content/12/6/R216

  • Anonymous

    12/20/2010 9:58:20 PM |

    "Probably too cold to lay out in a bathing suit."

    Did you try without?
    OK, couldn't resist.

  • Anonymous

    12/20/2010 10:21:05 PM |

    Just a quick question about D3 supplements. I know that dry tabs aren't ideal because they're hard for the body to absorb but what about capsulated powdered D3?

  • Anonymous

    12/21/2010 1:34:06 AM |

    Have an observation using a vitamin D light that I thought to mention.  I take vitamin D capsules and have been doing so for around 5 years.  This winter I decided that I would also use a vitamin D3 light pretty much each day in addition to taking the capsules.  I bought a light sold on Dr Cannell's sight.  I've noticed that sunlight and the artificial D3 light makes me feel warm through out the day, something D3 isn't able to do for me, at least.  And with this cold fall/winter going on right now, this 10 minutes of sunlight is a big plus!    

    Well, there might be a nice bonus from using the light.  I think I'm growing bigger, in a muscular way.  I do work out at a gym and have done so for over 1 years.  Just began the slow burn process last week.  But this muscle growth seems to have started around the time I made a conscious effort to use the indoor light or obtain some sunlight.  

    Anyway, no way to prove, and could be completely wrong about this.  Just something I've noticed as my shirts have grown tighter over the last couple months.  Weight has gone up also by a few pounds. I'm pleased.

  • Jessica

    12/22/2010 7:29:50 PM |

    SMK- the test for iodine that we order in our clinic (family practice) is an iodine loading 24 hour urine test.

    patients take 50 mg of iodoral then capture their urine for the next 24 hours to see how much is excreted.

    There is a 2 week prep, though, that helps ensure the test is accurate.

    Dr. Brownstein (?) has several books on the topic. I think he recommends the load testing method in his book, "Iodine, why we need it, why we can't live without it."

  • Chris Masterjohn

    12/23/2010 2:10:47 AM |

    I'll be posting my comments on the IOM report soon, although this sucker is 999 pages long and taking me a while to read.  I don't think it is at all true that it focuses on "deficiency" instead of "optimal levels."  I think it is quite clearly and very explicitly focused on optimal levels.  

    The IOM claims to not have found sufficient evidence to conclude that higher levels are optimal.  Now, I do believe that there is good enough evidence to act on the hypothesis that levels should be above 30 ng/mL, and my impression so far is that there is very little data supporting an argument for >50 ng/mL as some suggest.  That said, I won't be convinced that the IOM is *wrong* that definitive evidence for greater than 20 ng/mL is lacking until I finish reading the report and look at some of the primary references.

    I do think it's important, however, to exercise the freedom to act on hypotheses.  If we needed definitive evidence for everyone we do, our familial relations and whole lives would fall apart.  Still, I think the IOM had a responsibility to assess the quality of the evidence and only solidify what is definitive into recommendations, as long as those recommendations don't preclude the freedom to use higher levels.

    In any case, hopefully I can finish this bad boy in the next week and blog about it.

    Chris

  • Anonymous

    12/24/2010 3:43:54 AM |

    Isn't anyone concerned about all those studies summarized in the IOM report showing increased mortality at the highest D levels? 50 ng/ml is the highest level that I can justify targeting.

  • Lacey

    12/24/2010 3:17:52 PM |

    Off topic, but...I wish Paleo bloggers were better at spotting and stopping spam comments.

    Blogger Brooklyn said...Awesome Blog!!! blah blah blah blah

    Funny, Brooklyn had the exact same words to say over on Stephan Guyanet's blog:  http://tinyurl.com/2v25wc3

    His wonderful blog that he links back to says, among other things, "In the meantime, they recommend that all people, with or without diabetes, should have a healthy balanced diet, low in fat, salt and sugar with plenty of fruit and vegetables." It's also chock full of plagiarized text.

    Sincere paleo fan or linkspammer?  You be the judge.

  • Travis Culp

    12/25/2010 4:38:25 AM |

    Has anyone tested vitamin D levels in indigenous people? I try to dose about 30 minutes a day of sun during solar noon without a shirt on during the summer and 5000 IU a day for the rest of the year. No idea what my level would be though.

  • Peter

    12/25/2010 12:45:12 PM |

    I'm more concerned about official organizations going beyond the evidence (eat margarine! eat carbs! avoid saturated fat!) than  being over-cautious when there's not a lot of reliable research.

  • Anonymous

    1/4/2011 4:26:38 AM |

    One more comment on my apparently deleted comment - there's a possibiliy I never typed in the word verification code, but I believe I did actually post the comment. Sorry, if I did falsely accuse.

  • Brad Fallon

    3/5/2011 6:08:50 PM |

    Vitamin D Deficiency, what is the best natural source apart from sunshine to help keep the levels up?

  • Anonymous

    3/21/2011 4:15:01 PM |

    I just found my new vitamin store. The prices are the lowest I could find. They gave me a free gift of $5.00 with no minimum purchase and I got free shipping! The code I used at checkout is WIR500. Maybe it will work for you too?

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