For the sake of convenience: Commercial sources of prebiotic fibers

Our efforts to obtain prebiotic fibers/resistant starches, as discussed in the Cureality Digestive Health Track, to cultivate healthy bowel flora means recreating the eating behavior of primitive humans who dug in the dirt with sticks and bone fragments for underground roots and tubers, behaviors you can still observe in extant hunter-gatherer groups, such as the Hadza and Yanomamo. But, because this practice is inconvenient for us modern folk accustomed to sleek grocery stores, because many of us live in climates where the ground is frozen much of the year, and because we lack the wisdom passed from generation to generation that helps identify which roots and tubers are safe to eat and which are not, we rely on modern equivalents of primitive sources. Thus, green, unripe bananas, raw potatoes and other such fiber sources in the Cureality lifestyle.

There is therefore no need to purchase prebiotic fibers outside of your daily effort at including an unripe green banana, say, or inulin and fructooligosaccharides (FOS), or small servings of legumes as a means of cultivating healthy bowel flora. These are powerful strategies that change the number and species of bowel flora over time, thereby leading to beneficial health effects that include reduced blood sugar and blood pressure, reduction in triglycerides, reduced anxiety and improved sleep, and reduced colon cancer risk.

HOWEVER, convenience can be a struggle. Traveling by plane, for example, makes lugging around green bananas or raw potatoes inconvenient. Inulin and FOS already come as powders or capsules and they are among the options for a convenient, portable prebiotic fiber strategy. But there are others that can be purchased. This is a more costly way to get your prebiotic fibers and you do not need to purchase these products in order to succeed in your bowel flora management program. These products are therefore listed strictly as a strategy for convenience.

Most perspectives on the quality of human bowel flora composition suggest that diversity is an important feature, i.e., the greater the number of species, the better the health of the host. There may therefore be advantage in varying your prebiotic routine, e.g., green banana on Monday, inulin on Tuesday, PGX (below) on Wednesday, etc. Beyond providing convenience, these products may introduce an added level of diversity, as well.

Among the preparations available to us that can be used as prebiotic fibers:

PGX

While it is billed as a weight management and blood sugar-reducing product, the naturally occurring fiber--α-D-glucurono-α-D-manno-β-D-manno- β-D-gluco, α-L-gulurono-β-D mannurono, β-D-gluco-β- D-mannan--in PGX also exerts prebiotic effects (evidenced by increased fecal butyrate, the beneficial end-product of bacterial metabolism). PGX is available as capsules or granules. It also seems to exert prebiotic effects at lower doses than other prebiotic fibers. While I usually advise reaching 20 grams per day of fiber, PGX appears to exert substantial effects at a daily dose of half that quantity. As with all prebiotic fibers, it is best to build up slowly over weeks, e.g., start at 1.5 grams twice per day. It is also best taken in two or three divided doses. (Avoid the PGX bars, as they are too carb-rich for those of us trying to achieve ideal metaobolic health.)

Prebiotin

A combination of inulin and FOS available as powders and in portable Stick Pacs (2 gram and 4 gram packs). This preparation is quite costly, however, given the generally low cost of purchasing chicory inulin and FOS separately.

Acacia

Acacia fiber is another form of prebiotic fiber.  RenewLife and NOW are two reputable brands.

Isomalto-oligosaccharides

This fiber is used in Quest bars and in Paleo Protein Bars. With Quest bars, choose the flavors without sucralose, since it has been associated with undesirable changes in bowel flora.

There you go. It means that there are fewer and fewer reasons to not purposefully cultivate healthy bowel flora and obtain all the wonderful health benefits of doing so, from reduced blood pressure, to reduced triglycerides, to deeper sleep.

Disclaimer: I am not compensated in any way by discussing these products.

How Not To Have An Autoimmune Condition


Autoimmune conditions are becoming increasingly common. Estimates vary, but it appears that at least 8-9% of the population in North America and Western Europe have one of these conditions, with The American Autoimmune Related Diseases Association estimating that it’s even higher at 14% of the population.

The 200 or so autoimmune diseases that afflict modern people are conditions that involve an abnormal immune response directed against one or more organs of the body. If the misguided attack is against the thyroid gland, it can result in Hashimoto’s thyroiditis. If it is directed against pancreatic beta cells that produce insulin, it can result in type 1 diabetes or latent autoimmune diabetes of adults (LADA). If it involves tissue encasing joints (synovium) like the fingers or wrists, it can result in rheumatoid arthritis. It if involves the liver, it can result in autoimmune hepatitis, and so on. Nearly every organ of the body can be the target of such a misguided immune response.

While it requires a genetic predisposition towards autoimmunity that we have no control over (e.g., the HLA-B27 gene for ankylosing spondylitis), there are numerous environmental triggers of these diseases that we can do something about. Identifying and correcting these factors stacks the odds in your favor of reducing autoimmune inflammation, swelling, pain, organ dysfunction, and can even reverse an autoimmune condition altogether.

Among the most important factors to correct in order to minimize or reverse autoimmunity are:


Wheat and grain elimination

If you are reading this, you likely already know that the gliadin protein of wheat and related proteins in other grains (especially the secalin of rye, the hordein of barley, zein of corn, perhaps the avenin of oats) initiate the intestinal “leakiness” that begins the autoimmune process, an effect that occurs in over 90% of people who consume wheat and grains. The flood of foreign peptides/proteins, bacterial lipopolysaccharide, and grain proteins themselves cause immune responses to be launched against these foreign factors. If, for instance, an autoimmune response is triggered against wheat gliadin, the same antibodies can be aimed at the synapsin protein of the central nervous system/brain, resulting in dementia or cerebellar ataxia (destruction of the cerebellum resulting in incoordination and loss of bladder and bowel control). Wheat and grain elimination is by far the most important item on this list to reverse autoimmunity.

Correct vitamin D deficiency

It is clear that, across a spectrum of autoimmune diseases, vitamin D deficiency serves a permissive, not necessarily causative, role in allowing an autoimmune process to proceed. It is clear, for instance, that autoimmune conditions such as type 1 diabetes in children, rheumatoid arthritis, and Hashimoto’s thyroiditis are more common in those with low vitamin D status, much less common in those with higher vitamin D levels. For this and other reasons, I aim to achieve a blood level of 25-hydroxy vitamin D level of 60-70 ng/ml, a level that usually requires around 4000-8000 units per day of D3 (cholecalciferol) in gelcap or liquid form (never tablet due to poor or erratic absorption). In view of the serious nature of autoimmune diseases, it is well worth tracking occasional blood levels.

Supplement omega-3 fatty acids

While omega-3 fatty acids, EPA and DHA, from fish oil have proven only modestly helpful by themselves, when cast onto the background of wheat/grain elimination and vitamin D, omega-3 fatty acids compound anti-inflammatory benefits, such as those exerted via cyclooxygenase-2. This requires a daily EPA + DHA dose of around 3600 mg per day, divided in two. Don’t confuse EPA and DHA omega-3s with linolenic acid, another form of omega-3 obtained from meats, flaxseed, chia, and walnuts that does not not yield the same benefits. Nor can you use krill oil with its relatively trivial content of omega-3s.

Eliminate dairy

This is true in North America and most of Western Europe, less true in New Zealand and Australia. Autoimmunity can be triggered by the casein beta A1 form of casein widely expressed in dairy products, but not by casein beta A2 and other forms. Because it is so prevalent in North America and Western Europe, the most confident way to avoid this immunogenic form of casein is to avoid dairy altogether. You might be able to consume cheese, given the fermentation process that alters proteins and sugar, but that has not been fully explored.

Cultivate healthy bowel flora

People with autoimmune conditions have massively screwed up bowel flora with reduced species diversity and dominance of unhealthy species. We restore a healthier anti-inflammatory panel of bacterial species by “seeding” the colon with high-potency probiotics, then nourishing them with prebiotic fibers/resistant starches, a collection of strategies summarized in the Cureality Digestive Health discussions. People sometimes view bowel flora management as optional, just “fluff”–it is anything but. Properly managing bowel flora can be a make-it-or-break-it advantage; don’t neglect it.

There you go: a basic list to get started on if your interest is to begin a process of unraveling the processes of autoimmunity. In some conditions, such as rheumatoid arthritis and polymyalgia rheumatica, full recovery is possible. In other conditions, such as Hashimoto’s thyroiditis and the pancreatic beta cell destruction leading to type 1 diabetes, reversing the autoimmune inflammation does not restore organ function: hypothyroidism results after thyroiditis quiets down and type 1 diabetes and need for insulin persists after pancreatic beta cell damage. But note that the most powerful risk factor for an autoimmune disease is another autoimmune disease–this is why so many people have more than one autoimmune condition. People with Hashimoto’s, for instance, can develop rheumatoid arthritis or psoriasis. So the above menu is still worth following even if you cannot hope for full organ recovery

Five Powerful Ways to Reduce Blood Sugar

Left to conventional advice on diet and you will, more than likely, succumb to type 2 diabetes sooner or later. Follow your doctor’s advice to cut fat and eat more “healthy whole grains” and oral diabetes medication and insulin are almost certainly in your future. Despite this, had this scenario played out, you would be accused of laziness and gluttony, a weak specimen of human being who just gave into excess.

If you turn elsewhere for advice, however, and ignore the awful advice from “official” sources with cozy relationships with Big Pharma, you can reduce blood sugars sufficient to never become diabetic or to reverse an established diagnosis, and you can create a powerful collection of strategies that handily trump the worthless advice being passed off by the USDA, American Diabetes Association, the American Heart Association, or the Academy of Nutrition and Dietetics.

Among the most powerful and effective strategies to reduce blood sugar:

1) Eat no wheat nor grains

Recall that amylopectin A, the complex carbohydrate of grains, is highly digestible, unlike most of the other components of the seeds of grasses AKA “grains,” subject to digestion by the enzyme, amylase, in saliva and stomach. This explains why, ounce for ounce, grains raise blood sugar higher than table sugar. Eat no grains = remove the exceptional glycemic potential of amylopectin A.

2) Add no sugars, avoid high-fructose corn syrup

This should be pretty obvious, but note that the majority of processed foods contain sweeteners such as sucrose or high-fructose corn syrup, tailored to please the increased desire for sweetness among grain-consuming people. While fructose does not raise blood sugar acutely, it does so in delayed fashion, along with triggering other metabolic distortions such as increased triglycerides and fatty liver.

3) Vitamin D

Because vitamin D restores the body’s normal responsiveness to insulin, getting vitamin D right helps reduce blood sugar naturally while providing a range of other health benefits.

4) Restore bowel flora

As cultivation of several Lactobacillus and Bifidobacteria species in bowel flora yields fatty acids that restore insulin responsiveness, this leads to reductions in blood sugar over time. Minus the bowel flora-disrupting effects of grains and sugars, a purposeful program of bowel flora restoration is required (discussed at length in the Cureality Digestive Health section.)

5) Exercise

Blood sugar is reduced during and immediately following exercise, with the effect continuing for many hours afterwards, even into the next day.

Note that, aside from exercise, none of these powerful strategies are advocated by the American Diabetes Association or any other “official” agency purporting to provide dietary advice. As is happening more and more often as the tide of health information rises and is accessible to all, the best advice on health does not come from such agencies nor from your doctor but from your efforts to better understand the truths in health. This is our core mission in Cureality. A nice side benefit: information from Cureality is not accompanied by advertisements from Merck, Pfizer, Kelloggs, Kraft, or Cadbury Schweppes.

Cureality App Review: Breathe Sync



Biofeedback is a wonderful, natural way to gain control over multiple physiological phenomena, a means of tapping into your body’s internal resources. You can, for instance, use biofeedback to reduce anxiety, heart rate, and blood pressure, and achieve a sense of well-being that does not involve drugs, side-effects, or even much cost.

Biofeedback simply means that you are tracking some observable physiologic phenomenon—heart rate, skin temperature, blood pressure—and trying to consciously access control over it. One very successful method is that of bringing the beat-to-beat variation in heart rate into synchrony with the respiratory cycle. In day-to-day life, the heart beat is usually completely out of sync with respiration. Bring it into synchrony and interesting things happen: you experience a feeling of peace and calm, while many healthy phenomena develop.

A company called HeartMath has applied this principle through their personal computer-driven device that plugs into the USB port of your computer and monitors your heart rate with a device clipped on your earlobe. You then regulate breathing and follow the instructions provided and feedback is obtained on whether you are achieving synchrony, or what they call “coherence.” As the user becomes more effective in achieving coherence over time, positive physiological and emotional effects develop. HeartMath has been shown, for instance, to reduce systolic and diastolic blood pressure, morning cortisol levels (a stress hormone), and helps people deal with chronic pain. Downside of the HeartMath process: a $249 price tag for the earlobe-USB device.

But this is the age of emerging smartphone apps, including those applied to health. Smartphone apps are perfect for health monitoring. They are especially changing how we engage in biofeedback. An app called Breathe Sync is available that tracks heart rate using the camera’s flash on the phone. By tracking heart rate and providing visual instruction on breathing pattern, the program generates a Wellness Quotient, WQ, similar to HeartMath’s coherence scoring system. Difference: Breathe Sync is portable and a heck of a lot less costly. I paid $9.99, more than I’ve paid for any other mainstream smartphone application, but a bargain compared to the HeartMath device cost.

One glitch is that you need to not be running any other programs in the background, such as your GPS, else you will have pauses in the Breathe Sync program, negating the value of your WQ. Beyond this, the app functions reliably and can help you achieve the health goals of biofeedback with so much less hassle and greater effectiveness than the older methods.

If you are looking for a biofeedback system that provides advantage in gaining control over metabolic health, while also providing a wonderful method of relaxation, Breathe Sync, I believe, is the go-to app right now.

Amber’s Top 35 Health and Fitness Tips

This year I joined the 35 club!  And in honor of being fabulous and 35, I want to share 35 health and fitness tips with you! 

1.  Foam rolling is for everyone and should be done daily. 
2.  Cold showers are the best way to wake up and burn more body fat. 
3.  Stop locking your knees.  This will lead to lower back pain. 
4.  Avoid eating gluten at all costs. 
5.  Breath deep so that you can feel the sides or your lower back expand. 
6.  Swing a kettlebell for a stronger and great looking backside. 
7.  Fat is where it’s at!  Enjoy butter, ghee, coconut oil, palm oil, duck fat and many other fabulous saturated fats. 
8.  Don’t let your grip strength fade with age.  Farmer carries, kettlebells and hanging from a bar will help with that. 
9.  Runners, keep your long runs slow and easy and keep your interval runs hard.  Don’t fall in the chronic cardio range. 
10.  Drink high quality spring or reverse osmosis water. 
11.  Use high quality sea salt season food and as a mineral supplement. 
12.  Work your squat so that your butt can get down to the ground.  Can you sit in this position? How long?
13.  Lift heavy weights!  We were made for manual work,.   Simulate heavy labor in the weight room. 
14.  Meditate daily.  If you don’t go within, you will go with out.  We need quiet restorative time to balance the stress in our life. 
15.  Stand up and move for 10 minutes for every hour your sit at your computer. 
16. Eat a variety of whole, real foods. 
17.  Sleep 7 to 9 hours every night. 
18.  Pull ups are my favorite exercise.  Get a home pull up bar to practice. 
19.  Get out and spend a few minutes in nature.  Appreciate the world around you while taking in fresh air and natural beauty. 
20.  We all need to pull more in our workouts.  Add more pulling movements horizontally and vertically. 
21. Surround yourself with health minded people. 
22. Keep your room dark for deep sound sleep.  A sleep mask is great for that! 
23. Use chemical free cosmetics.  Your skin is the largest organ of your body and all chemicals will absorb into your blood stream. 
24. Unilateral movements will help improve symmetrical strength. 
25. Become more playful.  We take life too seriously, becoming stress and overwhelmed.  How can you play, smile and laugh more often?
26.  Choose foods that have one ingredient.  Keep your diet simple and clean. 
27.  Keep your joints mobile as you age.  Do exercises that take joints through a full range of motion. 
28. Go to sleep no later than 10:30pm.  This allows your body and brain to repair through the night. 
29. Take care of your health and needs before others.  This allows you to be the best spouse, parent, coworker, and person on the planet. 
30.  Always start your daily with a high fat, high protein meal.  This will encourage less sugar cravings later in the day. 
31. Approach the day with positive thinking!  Stinkin’ thinkin’ only leads to more stress and frustration. 
32. You are never “too old” to do something.  Stay young at heart and keep fitness a priority as the years go by. 
33. Dream big and go for it. 
34.  Lift weights 2 to 4 times every week.  Strong is the new sexy. 
35.  Love.  Love yourself unconditionally.  Love your life and live it to the fullest.  Love others compassionately. 

Amber B.
Cureality Exercise and Fitness Coach

To Change, You Need to Get Uncomfortable

Sitting on the couch is comfortable.  Going through the drive thru to pick up dinner is comfortable.  But when you notice that you’re out-of-shape, tired, sick and your clothes no longer fit, you realize that what makes you comfortable is not in align with what would make you happy.   

You want to see something different when you look in the mirror.  You want to fit into a certain size of jeans or just experience your day with more energy and excitement.  The current condition of your life causes you pain, be it physical, mental or emotional.  To escape the pain you are feeling, you know that you need to make changes to your habits that keep you stuck in your current state.  But why is it so hard to make the changes you know that will help you achieve what you want?  

I want to lose weight but….

I want a six pack but…

I want more energy but….

The statement that follows the “but” is often a situation or habit you are comfortable with.  You want to lose weight but don’t have time to cook healthy meals.  So it’s much more comfortable to go through the drive thru instead of trying some new recipes.   New habits often require a learning curve and a bit of extra time in the beginning.  It also takes courage and energy to establish new routines or seek out help.  

Setting out to achieve your goals requires change.  Making changes to establish new habits that support your goals and dreams can be uncomfortable.  Life, as you know it, will be different.  Knowing that fact can be scary, but so can staying in your current condition.  So I’m asking you to take a risk and get uncomfortable so that you can achieve your goals.  

Realize that it takes 21 days to develop a new habit.  I believe it takes triple that amount of time to really make a new habit stick for the long haul.  So for 21 days, you’ll experience some discomfort while you make changes to your old routine and habits.  Depending on what you are changing, discomfort could mean feeling tired, moody, or even withdrawal symptoms.  However, the longer you stick to your new habits the less uncomfortable you start to feel.  The first week is always the worst, but then it gets easier.

Making it through the uncomfortable times requires staying focused on your goals and not caving to your immediate feelings or desires.  I encourage clients to focus on why their goals important to them.  This reason or burning desire to change will help when old habits, cravings, or situations call you back to your old ways.
Use a tracking and a reward system to stay on track.  Grab a calendar, journal or index card to check off or note your daily successes.  Shoot for consistency and not perfection when trying to make changes.  I encourage my clients to use the 90/10 principle of change and apply that to their goal tracking system.  New clothes, a massage, or a day me-retreat are just a few examples of rewards you can use to sticking to your tracking system.  Pick something that really gets you excited.  

Getting support system in place can help you feel more comfortable with being uncomfortable.  Hiring a coach, joining an online support group, or recruiting family and friends can be very helpful when making big changes.  With a support system in place you are not alone in your discomfort.  You’re network is there for you to reach out for help, knowledge, accountability or camaraderie when you feel frustrated and isolated.  

I’ve helped hundreds of people change their bodies, health and lives of the eleven years I’ve worked as a trainer and coach.  I know it’s hard, but I also know that if they can do it, so can you.  You just need to step outside of your comfort zone and take a risk. Don’t let fear create uncomfortable feelings that keep you stuck in your old ways.  Take that first step and enjoy the journey of reaching your goals and dreams.  

Amber Budahn, B.S., CSCS, ACE PT, USATF 1, CHEK HLC 1, REIKI 1
Cureality Exercise Specialist

The 3 Best Grain Free Food Swaps to Boost Fat Burning

You can join others enjoying substantial improvements in their health, energy and pant size by making a few key, delicious substitutions to your eating habits.  This is possible with the Cureality nutrition approach, which rejects the idea that grains should form the cornerstone of the human diet.  

Grain products, which are seeds of grasses, are incompatible with human digestion.  Contrary to what we have been told for years, eating healthy whole grain is not the answer to whittle away our waists.  Consumption of all grain-based carbohydrates results in increased production of the fat storage hormone insulin.  Increased insulin levels create the perfect recipe for weight gain. By swapping out high carbohydrate grain foods that cause spikes in insulin with much lower carbohydrate foods, insulin release is subdued and allows the body to release fat.

1. Swap wheat-based flour with almond flour/meal

  • One of the most dubious grain offenders is modern wheat. Replace wheat flour with naturally wheat-free, lower carbohydrate almond flour.  
  • Almond flour contains a mere 12 net carbs per cup (carbohydrate minus the fiber) with 50% more filling protein than all-purpose flour.
  • Almond flour and almond meal also offer vitamin E, an important antioxidant to support immune function.

2. Swap potatoes and rice for cauliflower

  • Replace high carb potatoes and pasta with vitamin C packed cauliflower, which has an inconsequential 3 carbs per cup.  
  • Try this food swap: blend raw cauliflower in food processor to make “rice”. (A hand held grater can also be used).  Sautee the “riced” cauliflower in olive or coconut oil for 5 minutes with seasoning to taste.
  • Another food swap: enjoy mashed cauliflower in place of potatoes.  Cook cauliflower. Place in food processor with ½ a stick organic, grass-fed butter, ½ a package full-fat cream cheese and blend until smooth. Add optional minced garlic, chives or other herbs such as rosemary.
3. Swap pasta for shirataki noodles and zucchini

  • Swap out carb-rich white pasta containing 43 carbs per cup with Shirataki noodles that contain a few carbs per package. Shirataki noodles are made from konjac or yam root and are found in refrigerated section of supermarkets.
  • Another swap: zucchini contains about 4 carbs per cup. Make your own grain free, low-carb noodles from zucchini using a julienne peeler, mandolin or one of the various noodle tools on the market.  

Lisa Grudzielanek, MS,RDN,CD,CDE
Cureality Nutrition Specialist

Not so fast. Don’t make this mistake when going gluten free!

Beginning last month, the Food and Drug Administration began implementing its definition of “gluten-free” on packaged food labels.  The FDA determined that packaged food labeled gluten free (or similar claims such as "free of gluten") cannot contain more than 20 parts per million of gluten.

It has been years in the making for the FDA to define what “gluten free” means and hold food manufactures accountable, with respect to food labeling.  However, the story does not end there.

Yes, finding gluten-free food, that is now properly labeled, has become easier. So much so the market for gluten-free foods tops $6 billion last year.   However, finding truly healthy, commercially prepared, grain-free foods is still challenging.

A very common mistake made when jumping into the gluten-free lifestyle is piling everything labeled gluten-free in the shopping cart.  We don’t want to replace a problem: wheat, with another problem: gluten free products.

Typically gluten free products are made with rice flour (and brown rice flour), tapioca starch, cornstarch, and potato flour.  Of the few foods that raise blood sugar higher than wheat, these dried, powdered starches top the list.

 They provide a large surface area for digestion, thereby leading to sky-high blood sugar and all the consequences such as diabetes, hypertension, cataracts, arthritis, and heart disease. These products should be consumed very rarely consumed, if at all.  As Dr. Davis has stated, “100% gluten-free usually means 100% awful!”

There is an ugly side to the gluten-free boom taking place.  The Cureality approach to wellness recommends selecting gluten-free products wisely.  Do not making this misguided mistake and instead aim for elimination of ALL grains, as all seeds of grasses are related to wheat and therefore overlap in many effects.

Lisa Grudzielanek MS, RDN, CD, CDE
Cureality Health & Nutrition Coach

3 Foods to Add to Your Next Grocery List

Looking for some new foods to add to your diet? Look no further. Reach for these three mealtime superstars to encourage a leaner, healthier body.

Microgreens

Microgreens are simply the shoots of salad greens and herbs that are harvested just after the first leaves have developed, or in about 2 weeks.  Microgreen are not sprouts. Sprouts are germinated, in other words, sprouted seeds produced entirely in water. Microgreens are grown in soil, thereby absorbing the nutrients from the soil.

The nutritional profile of each microgreen depends greatly on the type of microgreen you are eating. Researchers found red cabbage microgreens had 40 times more vitamin E and six times more vitamin C than mature red cabbage. Cilantro microgreens had three times more beta-carotene than mature cilantro.

A few popular varieties of microgreens are arugula, kale, radish, pea, and watercress. Flavor can vary from mild to a more intense or spicy mix depending on the microgreens.  They can be added to salads, soup, omelets, stir fry and in place of lettuce.  

Cacao Powder

Cocoa and cacao are close enough in flavor not to make any difference. However, raw cacao powder has 3.6 times the antioxidant activity of roasted cocoa powder.  In short, raw cacao powder is definitely the healthiest, most beneficial of the powders, followed by 100% unsweetened cocoa.

Cacao has more antioxidant flavonoids than blueberries, red wine and black and green teas.  Cacao is one of the highest sources of magnesium, a great source of iron and vitamin C, as well as a good source of fiber for healthy bowel function.
Add cacao powder to milk for chocolate milk or real hot chocolate.  Consider adding to coffee for a little mocha magic or sprinkle on berries and yogurt.




Shallots


Shallots have a better nutrition profile than onions. On a weight per weight basis, they have more anti-oxidants, minerals, and vitamins than onions. Shallots have a milder, less pungent taste than onions, so people who do not care for onions may enjoy shallots.

Like onions, sulfur compounds in shallot are necessary for liver detoxification pathways.  The sulfur compound, allicin has been shown to be beneficial in reducing cholesterol.  Allicin is also noted to have anti-bacterial, anti-viral, and anti-fungal activities.

Diced then up and add to salads, on top of a bun less hamburger, soups, stews, or sauces.  Toss in an omelet or sauté to enhance a piece of chicken or steak, really the possibilities are endless.  

Lisa Grudzielanek,MS,RDN,CD,CDE
Cureality Nutrition & Health Coach

3 Band Exercises for Great Glutes

Bands and buns are a great combination.  (When I talk about glutes or a butt, I use the word buns)  When it comes to sculpting better buns, grab a band.   Bands are great for home workouts, at gym or when you travel.  Check out these 3 amazing exercises that will have your buns burning. 

Band Step Out

Grab a band and place it under the arch of each foot.  Then cross the band and rest your hands in your hip sockets.  The exercise starts with your feet hip width apart and weight in the heels.  Slightly bend the knees and step your right foot out to the side.  Step back in so that your foot is back in the starting position.  With each step, make sure your toes point straight ahead.  The tighter you pull the band, the more resistance you will have.    You will feel this exercise on the outside of your hips. 

Start with one set of 15 repetitions with each foot.  Work on increasing to 25 repetitions on each side and doing two to three sets.



Band Kick Back

This exercise is performed in the quadruped position with your knees under hips and hands under your shoulders.    Take the loop end of the band and put it around your right foot and place the two handles or ends of the band under your hands.  Without moving your body, kick your right leg straight back.  Return to the starting quadruped position.  Adjust the tension of the band to increase or decrease the difficulty of this exercise. 

Start with one set of 10 repetitions with each foot.  Work on increasing to 20 repetitions on each side and doing two to three sets. 



Band Resisted Hip Bridge

Start lying on your back with feet hip distance apart and knees bent at about a 45-degree angle.  Adjust your hips to a neutral position to alleviate any arching in your lower back.  Place the band across your hipbones.  Hold the band down with hands along the sides of your body.  Contract your abs and squeeze your glutes to lift your hips up off the ground.  Stop when your thighs, hips and stomach are in a straight line.  Lower you hips back down to the ground. 

Start with one set of 15 repetitions.  Work on increasing to 25 repetitions and doing two to three.  Another variation of this exercise is to hold the hip bridge position.  Start with a 30 second hold and work up to holding for 60 seconds.

Niacin: What forms are safe?

Niacin: What forms are safe?

Niacin, or vitamin B3, remains a confusing issue for many people. It shouldn't be.

It doesn't help that most physicians and many pharmacists also do not understand the basic issues surrounding niacin. The only reason why there is any level of prevailing knowledge about niacin is that Kos Pharmaceuticals managed to "pharmaceuticalize" a niacin preparation, prescription Niaspan, that provided the revenue to fund professional "education."

Niacin can be helpful to increase HDL, reduce small LDL particles and shift them towards the more benign large particles, reduce triglycerides, and reduce lipoprotein(a).

So here's a brief description of the various forms that you will find niacin:

Immediate-release niacin--Also called crystalline niacin or just niacin. This is the original niacin that releases within minutes of ingestion. Because it releases rapidly, it triggers the most intense "hot flush." While this form of niacin works wonderfully well, is the safest, and is dirt cheap, the majority of people are simply unable to tolerate the intense flush. It also works best taken twice a day, generating two intolerable flushes per day.

Slow-release niacin--These preparations were popular in the 1980s, since the slow 12 to 24 hour pattern of release minimized the annoying hot flush. But, with prolonged use, it also became apparent that an unnaceptable frequency of liver toxicity developed. Unfortunately, this means that any niacin preparation that trickles niacin out over an extended period, including many of the slow-release preparations now sold in health food stores and pharmacies, have potential for liver toxicity. These preparations should be avoided.

6-hour release niacin--Releasing niacin more slowly than immediate-release niacin but more rapidly than slow-release niacin, 6-hour release (or what the Niaspan people call "extended-release" niacin) is nearly as effective as immediate-release niacin with approximately the same low potential for liver toxicity. It is far less liver toxic than slow-release niacin. 6-hour release niacin therefore offers the best balance between effectiveness and safety. Preparations that show this pattern of release include Niaspan ($180 per month), the poorly-named Sloniacin (about $8 per month), and Enduracin (about $7 per month) for 1000 mg per day. (Some Track Your Plaque Members have also determined that several other over-the-counter preparations have been demonstrated to share a similar pattern of release.)

Then there are the scam products that have no useful effect at all:

Flush-free or no-flush niacin--Inositol hexaniacinate, or 6 niacin molecules bound to the sugar, inositol, has no effect in humans, at least not with the dozen or so preparations that I've seen used. Nor are there any data to document the effectiveness of flush-free niacin. It's also more expensive.

Nicotinamide--This niacin derivative likewise has no effect on the usual targets for niacin treatment.

While I used to prescribe Niaspan, the ridiculous pricing and aggressive marketing really turned me off. I now advise my patients and our online followers to use only Sloniacin or Enduracin, unless you can tolerate immediate-release niacin.

Comments (52) -

  • Mikie

    4/19/2011 7:08:18 PM |

    How about this interesting source of Niacin ... drum roll please ....

    Food.

    Why the pills?  I guess to a hammer the whole world is a nail.

  • Anonymous

    4/19/2011 7:14:26 PM |

    Humans need about 20mg daily of Niacin, which can be met thru diet.
    Lipid modifying effects start to occur at levels above 1000 mg daily (sometimes not until 2000 mg).  It is essentially a type of over dose reaction.

    Tried niacin myself at only a few hundred mg daily.  Was able to tolerate the flushing, but then had the pleasure of passing 2 kidney stones.  Niacin has been given the boot ever since.

  • Anonymous

    4/19/2011 7:47:12 PM |

    Is there a relationship between niacin and kidney stones? I've had a kidney stone before and it isn't much fun.

    I tried Niacin several times, IR, Niaspan, and Enduracin. But I ended up getting heart palpitations on each. I also kinda felt weird, tired and generally lousy. And strangely enough, even though I toughed it out for several months, my HDL went down a point (at 500mg/daily -- Niaspan & Enduracin)

    Just wondering what can be done for those who are Niacin intolerant.

    And I tried the aspirin beforehand, taking with food, etc. Didn't matter in my case.

  • Anonymous

    4/19/2011 8:07:24 PM |

    Well, great...just great.  I've been taking NOW Foods Double Strength Flush-Free Niacin (500 mg) for a few months and now I'm told its for naught at best, and possibly damaging my liver.  There is a slight difference in the chemical name - Inositol Hexanicotinate.  I don't suppose that is significant?

    Anyway, I guess its back to the Sloniacin I took before.  At least that's considered safe.

    Regardless, I'm ever so grateful for this blog.  I learn something from most every post - even when it means I've been doing something wrong.

  • Daniel A. Clinton, RN, BSN

    4/19/2011 10:04:59 PM |

    I know Niacin has the power to make some numbers change, but is there any sort of credible evidence directly studying Niacin's effect on outcomes like heart attack and death? I am not comfortable inferring a benefit from alledged "cholesterol lowering."

  • Tara

    4/19/2011 10:12:41 PM |

    Good reminder post, Doc!  

    Mikie-
    I'm normally a proponent of getting your micronutrients from food, but in the case of therapeutic doses of niacin it's just not feasible.  1000mg of niacin= 19 pounds of yellowfin tuna, 17 lbs of chicken, or 500 cups of asparagus

  • Anonymous

    4/19/2011 10:45:33 PM |

    quote:
    .. but is there any sort of credible evidence directly studying Niacin's effect on outcomes like heart attack and death? I am not comfortable inferring a benefit from alleged "cholesterol lowering."

    It's interesting with niacin, even after discontinuation it seems to have an effect on mortality:

    http://www.ncbi.nlm.nih.gov/pubmed/3782631

  • Anonymous

    4/19/2011 11:09:27 PM |

    Daniel,

    It is my understanding that therapeutic doses of Niacin is VERY cardio-protective (assuming the person in question can tolerate it). Lookup the HATS, FATS & CLAS trials. Check out Dr. B G's blog for more info on this:

    http://drbganimalpharm.blogspot.com/2009/09/cardio-controversies-dr-superko-md.html

    John M.

  • Anonymous

    4/19/2011 11:16:17 PM |

    I've been taking SloNiacin at 1500 mg/day for quite some time. Recently my HDL went up to 60 mg/dl from 50. No problems with flushing or liver fuction or kidney stones. I've become interested in the use of Niacin plus bile acid binding resin (colestipol) to reduce plaque in arteries (PAD). The studies are old, 1980's and 1990's, and of limited number of patients. However on the Niaspan website they claim that Niaspan along with diet and a bile acid binding resin is FDA approved not only to slow down plaque buildup, but also to help reduce plaque that already exists. niaspan.com/heart-healthy/plaque-build-up.aspx  ...  They cite the old studies on the web page.

    I wonder if the claim is substantially true about plaque reduction and FDA approval.

  • steve

    4/19/2011 11:51:44 PM |

    interesting post.  My doctor said that Slo Niacin is less tolerated than Niaspan.  He does not care which you use.

    Separate question: what impact does Niacin have on blood sugars and homocysteine?

  • michael goroncy

    4/20/2011 12:21:50 AM |

    I have reason to treat aggressively this 'spooky' disease of the heart. The science and anecdotal experience of cardiologists (who stay on the 'cutting edge') like Dr Davis and a few others will attest to the overwhelming positive effects of NIACIN.
    I have titrated my Nicotinic Acid (OTC ..100 tabs..cost $11) up to a daily dose of 1.5gm.
    The intolerable flush I concluded is in the main...PSYCHOSOMATIC.
    At first I thought the uncomfortable feeling was unnatural and  possibly harmful but, the science convinced me that it was harmless. The tact I adopted was to enjoy the flush and look on it as a
    wonderful healing zooming through the body. The actual flush cannot harm...the liver is another story.
    Sheesh! The things you have to do to play mind games.
    The use and other add on supplements  have created excellent lipids (Iam thinking of entering them in the State Championships)
    Learn to love the flush..small discomfort-huge benefits.

  • Bobby

    4/20/2011 12:51:34 AM |

    I have been taking good old regular niacin and actually like the flush--it makes me feel like it is doing something. However, my blood glucose is somewhat elevated (104) over what I believe it should be. My doctor isn't concerned , but I'm not sure. Any feed back?

  • Dr. William Davis

    4/20/2011 2:22:21 AM |

    That's great, Tara!

    It would be a great episode of Man vs. Food.

  • Dr. William Davis

    4/20/2011 2:23:55 AM |

    A discussion of the downsides of niacin, even when done properly, sounds like it might be of help to many people.

    I'l put it on the "to-do" list.

  • Dymphna

    4/20/2011 2:29:15 AM |

    Did anyone have nausea with higher levels of niacin? I've tried it but it makes me somewhat sick-feeling.

    Any ideas?

  • Anonymous

    4/20/2011 12:09:20 PM |

    I'd second the notion to avoid real-slow release niacin...I looked in the mirror to see someone with yellow skin when taking some.

    So what are the available 6 hour release brands?

    And what about pomegranate extracts to help clear plaque buildup?

  • Renfrew

    4/20/2011 12:37:06 PM |

    Good thread.
    I am taking a form of niacin that has 1000 mg of Niacin plus 20 mg of Laropiprant. The Laropiprant is a prostaglandin inhibitor and prevents flushes.
    The brand name is "Tredaptive".

    My LDL Cholesterol went from 160 to 120 within 1 month. Trigs from 75 to 55.

    I combine the tablet with 500 mg of milk-thistle (for liver protection) and have not had any increase in liver enzymes.

    That is really a workable compromise and easy to take as one tablet a day.

    Not sure if this is available in the US though, I am living in Germany.

  • Anonymous

    4/20/2011 1:06:25 PM |

    I'd be interested in knowing more about the twice-a-day recommendation. I've been taking my immediate-release 2gm/day dose once a day for a couple of years now. (Yes, I get the flush--and my liver numbers are good.)  Dr Davis seems to be saying to take (in my case) 1gm every 12 hours?  Is this easier on the liver?

  • Anonymous

    4/20/2011 1:22:59 PM |

    Too many adverse effects from taking Niacin.  It's not worth the risk.

  • Anonymous

    4/20/2011 2:52:24 PM |

    I would like to hear the author's opinions on the best forms of excersise for heart health.

  • Dr. William Davis

    4/20/2011 3:17:43 PM |

    Hi, Renfrew-

    I believe you have earlier access to this preparation than we do.

    This may an interesting, though prescription, possibility for those who have intolerable flushes.

  • Dr. William Davis

    4/20/2011 3:19:36 PM |

    Re: comments about the potential dangers of niacin.

    We always have to weight the risks vs. benefits. If I have, for instance, a 45-year survivor of sudden cardiac death with 3 stents who I meet with BMI 23.0 and a lipoprotein(a) of 450 nmol/L, then niacin is a small price to pay.

    Every situation is unique.

  • Anonymous

    4/20/2011 4:45:00 PM |

    In regards to the risks - can you direct me to research on that. A personal friend of mine had been on a research program in the past for a major pharma in northern Illinois. What they were trying to do was find exactly how niacin works so the process could be synthesized and patented. The project was not successful. In laying the groundwork for the project he had to look at past use of it in the treatment for heart disease. Older docs he interviewed had used up to 3 grams a day with no adverse effects to their patients. Used as a drug, my friend feels it is the safest non diet way to control Tri's and raise HDL. Personally I have take 2 grams a day for well over a year. No harmful effects, blood work normal.
    Without statins, tri - 151, HDL - 32
    With Crestor 10mg tri 80 to 100, HDL 45.
    With 2 gram niacin - Tri 52, HDL 80.
    I take regular niacin. After a while, you will experience almost no flushing. Your body will acclimate.
    I tout the use of it because it seems a lot of docs have forgotten it's usefulness. Keep up the info when you can.

  • Anonymous

    4/20/2011 4:59:05 PM |

    I've taken immediate-release niacin since 2003 and the only time I developed elevated liver enzymes was when I split a 4 gram daily dose into three divided doses.  I can take 1 gram three times a day with no problems, or up to 2.5 grams twice a day with no problems.  However, HDL elevation seems to plateau at 3 grams a day.

    Once in the last 3 years my doctor took me off niacin for 3 weeks to perform an NMR lipoprotein test.  With carbohydrate consumption under 70 grams a day and fat intake of 67%, my LDL particle count was over 2,000 and over 75% of them were small and dense.

    Niacin is the only way for me to reduce my small, dense LDL to a safer level.  Diet and exercise is not enough.  I suppose this explains why every male (except for me) has a major heart attack or stroke by the age of 50.

  • Anonymous

    4/20/2011 5:04:31 PM |

    One reason aspirin blocks only part of the flush is that the flush is produced by two separate mechanisms.  The most well known is the release of PGD2 from mast cells.  The other, which is rarely mentioned, is the release of serotonin from platelets.  Serotonin antagonists completely block the flushing due that mechanism (see "Niacin-induced “flush” Involves Release of PGD2 from Mast Cells and Serotonin from Platelets: Evidence from Human Cells In Vitro and an Animal Model", Dean Papaliodis,2008, American Society for Pharmacology and Experimental Therapeutics"

  • Sara

    4/20/2011 7:42:08 PM |

    I think niacin and metformin are 2 of the most powerful and safest drugs for metabolic syndrome.

  • pjnoir

    4/20/2011 9:39:57 PM |

    High doses of Niacin will increase blood sugars - I'll take my chances with Chloresterol (mind is low enough) then mess with my sugars.

  • pjnoir

    4/20/2011 10:07:25 PM |

    *mine    not mind  
    Sara- since blood sugars go up- how can it be a good choice to improve metabolism?

  • Might-o'chondri-AL

    4/20/2011 11:00:14 PM |

    ? Anyone with input on the supposed benefit of taking Niacin every other day, instead of daily ?
    Someone brought it up once in an old niacin post of this blog, but nobody else seemed to know about that dosing.

  • Christi

    4/21/2011 12:16:02 AM |

    You could also add Protandim to your daily regimen. Pubmed.gov studies have shown Protandim to be extremely helpful in heart disease. It reduces Oxidative Stress and inflammation in the cells. www.dailylifesource.com

  • christi

    4/21/2011 12:18:13 AM |

    You should also add Protandim to your daily regimen. I first was exposed to this product on the ABC Primetime news investigative report. Pubmed.gov has published peer reviewed studies that show Protandim is very effective with heart disease. Check out the ABC news program here: www.dailylifesource.com

  • Anonymous

    4/21/2011 3:18:08 AM |

    Christi:

    I looked up on Wikipedia the supplement Protandim you mentioned. I am familiar with 4 of the 5 ingredients it contains and while the 4 have a good reputation, I am not impressed with the overall product. Most of the studies were conducted in an animal model. If I was looking to raise my endogenous antioxidant levels (SOD, catalase & glutathione) like Protandim claims, I would take GliSODin instead...probably in the form of Life Extension brand Endothelial Defense. I am sure Endothelial Defense is more cost effective and a has meaningful doses of better researched ingredients.

    Pjnoir:

    While it is true that Niacin can raise fasting glucose a few points, this can be more than made up for with a better diet and exercise. In fact, niacin might actually increase insulin sensitivity. Niacin is also extremely cardio protective. The HATS trial showed that Simvastatin+niacin reduced CHD events 89% less than the placebo group.

    John M.

  • Anonymous

    4/21/2011 6:42:52 AM |

    Kenneth....
    After a long period of utterly fruitless treatment with flush-free niacin as high as 4 grams a day, I started good old fashioned immediate release niacin.

    The flushing is manageable. The key is in slowly titrating up to your target dose. I think I went up maybe 50 mg a day every two weeks. I've been at 500 mg twice a day for months. I only get bad flushing when I let myself get dehydrated or indulge in sugar or other pro-inflammatory foods ie fast food or chips, things you shouldn't be eating anyway.

    There is some evidence that flavanoids can mitigate the flush, and I've had good luck with 600 mg or so of quercetin taken with my fish oil half an hour or so before the niacin. Baby aspirin helps, as does celebrex when I happen to take it for aches. I haven't been able to escalate the dose as I started getting muscle pains and fatigue even though my liver panels didn't indicate any problem. Everyone has different reactions, but don't write off niacin until you've given it a fair shot.  

    I will also tell you that Niaspan is NOT in fact flush-free either. I tried it for a short while and found that it simply delayed the flushing. The product literature says as much. The strategy is simply to put off the flushing until you're already asleep, and you pay hundreds of dollars more for that dubious benefit.

  • Hans Keer

    4/21/2011 10:07:15 AM |

    Why pills? Meat, vegetables and fruit deliver all the B3 you need.

  • Anonymous

    4/21/2011 12:36:50 PM |

    Even though I'm pre-diabetic, I've never experienced blood sugar elevation with niacin.

    The tolerance to the flushing develops with continuous use.  Although I've never tried it, every other day dosing may result in a more pronounced flushing effect.

    I've also used quercetin concurrently with niacin and have noticed a decrease in flushing.  I'm very fair-skinned and still experience flushing after all these years.

  • Anonymous

    4/21/2011 12:50:54 PM |

    What would be interesting if people who are using Niacin here tell us, what effect it had on their respective Cholesterol levels (HDL, LDL, Trigs).
    And if they had any issues with increasing liver enzymes or higher bloodsuger.

  • Kent

    4/21/2011 3:16:42 PM |

    Just an observation on the (Niaspan or intermediate release verses the imediate release.  I found Niaspan along with other LP(a) supplements (fish oil, Coq10, Pauling Protocol, low wheat) to work much better than the Intermediate release niacin. My LP(a) started at 198 and dropped to 45 with Naiaspan included in the regimen. I switched to imediate release and it went up to 150. I switched back to Niaspan and the LP(a) dropped back down. Has anyone else experienced this phenomena?

  • Leshme

    4/22/2011 2:30:31 AM |

    Since I began taking 1,000mg of regular niacin/day, my blood platelet count has hovered around 120,000. I have read online that niacin may cause a reduction in blood platelets. Can anyone comment?

  • Anonymous

    4/22/2011 6:52:39 AM |

    I use immediate release Niacin 2 grams a day.  Have used as much as 4 grams a day.

    I find that if I take any other supplements with plenty of fluid/food - usually a glass of tomato juice and a glass of water - and then wait for about 15 minutes before taking the niacin, I don't get a flush except maybe once a month and only slightly.  I use capsules and pull them slightly apart so that I can seperate them before swallowing, otherwise I might get a flush at some random time in the future when the capsules finally break open.  When I used to use tablets, I would chew them up so I wouldn't get a random flush at some future point.

  • Anonymous

    4/22/2011 3:26:02 PM |

    I took Niaspan for almost six months.  My physician started me off at 700mg and I ended up at 1000mg by the time I was taken off of it.  My blood work was somewhat better but nothing spectacular and it sure wasn't good enough for me to endure the extreme flushing I experienced three or four times a week. My whole body turned a dark apple red and I experienced extreme itching over every square inch of my body at once for thrity to forty-five minutes, as if I had millions of ants crawling on me.  I've read comments about how people enjoy this experience and I cannot begin to comprehend that as it was like being tortured to me.  I would scratch myself so much that I tore my skin.  Flushing took place even after taking aspirin and eating yogurt thirty minutes to an hour prior to taking it. You can have your niacin.  I'll stick to my Crestor.

  • Anonymous

    4/22/2011 5:08:25 PM |

    Dr. William Davis said...

        A discussion of the downsides of niacin, even when done properly, sounds like it might be of help to many people.

        I'l put it on the "to-do" list.
    .................

    I scheduled a general checkup in a few weeks, which I'm going to request a purines test, since I've read Niacin might affect gout sufferers.

    I've not been diagnosed with gout, but as it runs in my family, and I've also read that even though females get it less - that changes after (menopause, which I've started).

    Paternal grandfather suffered from diagnosed gout for years - he had many stomach bleeds from gout meds, so was taken off them. His last gout attack landed him in the hospital: Normal diet, IVF @ 125cc/hr, Foley output at end of day: ZERO.

    Younger brother's first gout attack  in late 30's (has one kidney, which probably hastened things). Mother also thinks she had one gout attack after over-indulging on a roast too many days in a row - she recognized her toe as looking like granddaddy's (not her father).

    So I'll play it safe and wait to see that my hormone situation didn't trigger high purine levels before starting slowly on SloNiacin.

    Please consider including Gout/Niacin info in your article Dr. Davis, and correct any mis-info I might have misinterpreted. I'll ask my GP if he orders liver functions with checkups at my age.

    Shreela

  • Jim (formerly anonymous)

    4/22/2011 11:53:16 PM |

    A Different Anonymous said...

        What would be interesting if people who are using Niacin here tell us, what effect it had on their respective Cholesterol levels (HDL, LDL, Trigs).
        And if they had any issues with increasing liver enzymes or higher bloodsuger.

        April 21, 2011

    I gave my results much earlier.

    I think that people here fail to understand that the very first successful Cholesterol lowering "drug" was niacin, plain old drugstore type.

    Evidently, the first American drug trial of Niacin was run by William Parsons Jr. MD in 1955 who was then a Resident at Mayo clinic. The actual use of Niacin was pioneered by the Canadians, and Parsons heard about it from a visiting Canadian Physician.

    There is therefore well over a half a century of use of Niacin for cholesterol control.

    Many MD's did't like it, because it is an unregulated non-prescription substance. Now there is a prescription form which is very expensive and well promoted with big bucks and drug representatives to push it.

    Dr. Parsons became less of a researcher and more of a clinician in later years. He has published a book "Cholesterol Control Without Diet : The Niacin Solution" which I suggest that you look at (library) or buy, if you are interested in the use of Niacin for cholesterol control.ISBN 0966256875 $14.95. 276 pages.

    With the expensive prescription Niaspan, now made and sold and marketed by Abbott Laboratories,the classical resistance of MD's to use this treatment is falling. No vitamin supplement firm could do this level of marketing for a cheap generic pill.

    From page 196:
    "Since the 1996 edition, there have been no more significant reports of liver problems with niacin. ...... and yet there are still no more than the 18 cases we listed here, 5 of them questionable."

    He also discusses the studies designed to make Niacin look bad, and Statins look good.

    It can be said that there is considerable confusion as to how Statins actually work. The first theory was cholesterol lowering. As evidence for inflammation to be a more dominant mechanism for CHD, there are now more reports that Statins have anti-inflammatory properties. But after all of the millions and millions of dollars spent on Statin R&D, the exact behavior of Statins is still not understood in detail.

    In fact, there were no real good theories for the painkilling behavior of Aspirin until sometime in about the 1960's or later.

    There are tons of information about Niacin out there, you have to go look for them, or buy the books. Well, you can just ask somebody to feed the information to you. That still works as a labor saving device.

  • Anonymous

    4/23/2011 2:23:35 PM |

    Thank you for the reminder to check into my "Now" brand Niacin.  

    Now claims sustained release formula on the bottle but there is nothing in the ingredients to suggest any coating or binding.  Regardless, I have been taking 2grms for a long time last thing at night along with my 2.7grms omega3 and 20mg crestor. Trigs and LDL were well controlled with this combo but my HDL was still only 45.  Then I switched back to eating meat(saturated fat), lowered my grain intake and last blood test HDL was 67.  the down side was my LDL went up 10%

    Regarding the Flush. If I awake after a few hrs into my sleep, often I will feel the flush/itchy skin.  Small price to pay for 90% reduction in a heart attack.

    Trev

  • Anonymous

    4/23/2011 2:45:06 PM |

    http://www.scribd.com/doc/50437/Niacin#fullscreen:off

    excellent summary of Niacin types and explanation  for liver toxicity.
    Trev

  • jbuch

    4/26/2011 2:51:35 PM |

    Excellent article on the Pharmacists knowledge of the different forms of niacin.

    Inspired me to do some more digging and I found this excellent webpage which is a baseline discussion of the ARBITER 6 Trial, with excellent comments on Niacin myths and factoids.

    http://www.theheart.org/article/1022265.do

    In particular, look at the readers comments, evidently almost exclusively MD, numbers 34 to about 57. It is here that some of the common myths and factoids are noted, mostly with literature citations rather than unsubstantiated claims.

    Below is one example.
    ---------------------------

    Niacin Dissolution Rates
    I recently came across an interesting paper on the dissolution rates of various niacin formulations. Niaspan was best in terms of slow dissolution, followed by Enduracin and Slo-niacin. For those interested:

    Poon, Ivy O., Chow, Diana S.-L., Liang, Dong
    Dissolution profiles of nonprescription extended-release niacin and inositol niacinate products
    Am J Health Syst Pharm 2006 63: 2128-2134
    ------------------------

  • Susan

    5/8/2011 7:20:26 AM |

    You might want to take a closer look at Protandim, it's not a simple product and takes a bit of time to take in what it really does in the body. There is proof that it  raises SOD in a human peer-reviewed study. Protandim is proven to increase catalase, glutathione, and a number of other endogenous antioxidants in addition to increasing SOD. The science is there, but how I really know it works is through what it has done for me and quite a number of people I know who have had notable improvements in their health. There is nothing wrong with glisodin, but it isn't in the same class as Protandim.  Protandim is proven to work through the activation of the Nrf2 transcription factor, up-regulating the antioxidant response gene sequence that causes the body to produce it's own native antioxidant products in every cell of the body. This site explains more about it and has links to supportive science:  www.radicalresults.net

  • yves

    5/11/2011 12:37:31 AM |

    Any insight as to whether Nicotinamide may be effective for those with fungal infections?
    http://www.wellnessresources.com/studies/niacinamide_helps_combat_candida_albicans/

  • georgepds

    5/20/2011 4:40:12 PM |

    "Why pills? Meat, vegetables and fruit deliver all the B3 you need."

    Because you would have to eat too much to get a clinical benefit

    You need 1000 to 2000 mg, 4 oz of chicken gets only 14 mg.. so, for the clinical benefit, you'd have to eat ~400 oz of chicken, or about 25 pounds of chicken a day.. just a  tad too much chiken for me


    http://www.whfoods.com/genpage.php?tname=nutrient&dbid=83

  • Ken Levin

    6/5/2011 11:00:23 PM |

    Hi Dr Davis, I'm a new Track Your Plaque member and noticed two new studies claiming niacin was not helpful in reducing the incidence of heart attack. One study compared Zocor with and without  niaspan (summarized in New York Times about a week ago)  and one studied niacin (not sure which form, heard about the study through a physician)  alone.   Do these studies change your recommendations about niacin for Track Your Plaque members?  Thanks in advance and thank you for your Track your Plaque program.

  • Jonathan

    6/6/2011 5:03:29 PM |

    All I could find around here locally was slow release niacin (capsule shaped tablet).  I pop two 500mg and chew them.  I get a real nice flush.

  • Jesse

    6/24/2011 4:42:46 PM |

    Dr Davis, can you comment on the studies mentioned by Ken Levin above? I would be interested to know the specifics about them, and if they hold nay water.

    Thanks

  • M2

    7/2/2011 6:17:01 PM |

    Dr. Davis, very interested in a response to the niacin studies referenced by Ken and Jesse above.

    Thanks!

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