However, you can easily and now cheaply check your blood sugar. Because blood sugar parallels small LDL, checking blood sugar can provide insight into how you respond to various foods and know whether glucose/small LDL have been triggered.

Can you get the page 2 result directly from Liposcience?

We've tried and encountered resistance.

The Liposcience people have deferred to LabCorp when the results were delivered via LabCorp. I believe that  Liposcience is honoring the terms of a contract. LabCorp is serving its own misguided purposes.

Dr. Davis,

When you get VAP results from  Quest all the info is included,to include the ApoB100.

LabCorp reports almost all the info except the ApoB100 number. So, they don't include one line not a whole page.  I realize this may not help LabCorp much and may just be more fuel to the fire, but I thought you should know.

The nice thing about VAP is that you get Lp(a) without having to pay for an additional test like you do if you want NMR and Lp(a).

Thanks and keep up the good work!

As a former employee of LabCorp, I would like to offer another possibility, they just screwed up.  The aim of top management has been to run up the stock price (and the value of their stock options)at the expense of their clients and employees.  The IT department in particular has been hard hit by corporate corner-cutting that has turned the flow of information from client to lab and back again into a nightmare. Losing a page of data from patient results is a very real possibility. MacMahon et. al. have been made aware of these problems in the past and yet continued their destructive policies.  I seriously doubt they will pay any attention to your complaints now.  Protect yourself and just go elsewhere.

As another former employee, I tried sharing similiar concerns about issues like this, and they ended up firing me. Take your business elsewhere!

LabCorp Sucks! I have had so many problems with them that I finally got fed up and created a website just to document all the complaints that people have against this sorry excuse for a clinical lab company, www.labcorpsucks.com. We will be taking all the complaints and providing them to investigative agencies in government. While they have some very nice people working for them, the majority of their mid-level managers are incompetent. Maybe after they are all unemployed they will "get it". Al - www.labcorpsucks.com

Hi Dr. Davis, we've got the same problem, except it's with a hemochromatosis test that was just run. When we get my husband's blood iron count levels tested at the Red Cross, the nurses always raise their eyebrows, and say, my goodness! You have a LOT of iron in your blood!
My husband was adopted in NC, which is THE hotspot for JH (juvenile hemochromatosis) in the United States. He has all the symptoms, has suffered them since he was very little, and they've become increasingly worse over the years. Doctors have looked him over and have never been able to figure out what is wrong. Some even told him he was simply lazy! We finally stumbled across this website for JH one day... and said, Eureka! That's EXACTLY it! He feels a million times better after he's bled... which gradually worsens over the next day or two, but for that little while, he's free of pain and loves life.
So we went to get him tested, and guess what... the results came back "negative." What the heck does "negative" mean? There are numbers for each test, right? We are looking for an independent blood lab with a commitment to quality... do you have any suggestions? We fear that the damage to his organs is so great that he needs help NOW, if you have any suggestions, we'd love to know! The tests are total iron binding count, serum iron and serum ferritin.

I must confess that I have worked at the Burlington location of LabCorp and have witnessed lab techs goofing off instead of watching the tests done, some of them timed precisely to give the accurate reading. Many of the people there are hired because of nepotism or cronyism and do not have the skills necessary or the lab degrees that they should, but have been "grandfathered" in. I know others who have worked there who ran microbiological testing and would screw up entire batches of gram pos/neg tests because they couldn't run the machine right... HUNDREDS of tests to be run again. If they sit too long, you get false positives and negatives... way to go... you could be dying, and you won't know! Way to go!

We're thinking about suing them if we get independent lab tests done and they come back positive (which they should... it's just a classic case). It's a fatal disease and he needs immediate help.

You need to have an unsaturated iron binding capacity done, all of the other test could be negative but very few labs calculate this test.  It is the most important when testing for hereditary hemachromatosis.  I broght  it up to our lab manager about a month ago and we started running it with all of our iron profiles.  We are starting to see more positives of this test along with the negatives on the total iron, tibc and iron saturation.  This test really makes a difference.  Feel free to email me, I would be happy to give you some advice.  cjpirkle@hotmail.com

I have even a more serious complaint with this lab. I am a patient of a doctor for chronic pain and nasty panic attacks.

It cost me $240 cash to have a drug test to prove to my doctor I AM taking both my pain and nerve meds. It's true, the UNINSURED people are the ones paying the price, we get charged the FULL RATE, medical insurance will negotiate a much lower price (I tried and they laughed at me!!) Well people, I hate too tell you this, but my results were NOT accurate and it may very well cost me my sanity and even my job if I have no meds during a work related panic attack I will be unable to work and likely will end up in the hospital, still with no medical insurance. I did everything I was supposed to to as told and directed.

The medication not detected was Klonopin (Clonazepam)- I have needed and taken this medication along with my pain killers for years, and now my life is much better and I can once again work for a living. Because of this screwed up test result my life now is in the hands of LabCorp and my doctor. - Most likely I will end up in a hospital if my doctor cuts me off. I’m in shock over this. I’m innocent. I can not understand what the problem is with the lab not detecting this particular nerve/panic med, but I have read that it’s happening to others too.

I have found much evidence that shows how the most expensive drug testing labs can go by NOT detecting Klonopin (Clonazepam)in patients that take it- and you can bet I have submitted all of such information to my doctor. This is my life as I know whats at stake here, (A LOT!!) and for $240 one would think a lab could find a med I was taking every single day for years, and even on the day of the drug test.

I had to pay CASH $$ for my drug test, so I hate their rates AND their screwed up lab work. My life as I know it is in the hands of a bunch of people that can screw up my life for a very long time. I suggest NOBODY uses this drug testing company.

Now I have to worry about real life nightmares hitting me while I drive, all because of a drug test that was wrong and a doctor that places too much faith in such tests. I’m not very happy, and I’m broke. I did nothing wrong and I fear there must be many others just like me in the same boat. Doctors should not place so much faith in these drug tests- they can be WRONG!

      ME

To me, this LabCorp policy is criminal. In fact, I wonder if this has the substance to justify a class action lawsuit against LabCorp. I believe that we can easily make a case that crucial health information is being systematically denied to people.

As a fromer employee and department manager for Labcorp I do now that from a Legal standpoint we are a third party that is contracted with your primary care physician to do you lab work.  If you ahve not received all of the information on a lab report then you need to bring thast up with your primary care physician.  We are only aloowed to release information directly to them in most cases, becasue we are a third party.  More often than not the final page of a report does not have anything on it but Labcorp information and nothing related to your test results.  As I said before the best option would be to go to your primary care physician and find out if they have the second page you are looking for and if not get them to request the page you are looking for or get a form of permission from your Dr to release this information to you.  The second part of this could take a little while becasue of our legal responsibilities in our contracts with the Dr's.  The lab that Iworked in was very thorough and caring about their patients and would have taken the time to explain why we could not release these results directly to you.  It is unfortunate that the lab you worked with did not take then time to help you further in your quest.  As with most compnaies some locations are not run as well as others.

okay its 4/2011    has anything changed?   I need to get this test done. what are my options?  I do get the numbers I need, right?

Feb 2013
LabCorp in Palo Alto on Middlefield Rd.  was shocking.  I thought I was in the third world.
Understaffed, specimens sat overnight, specimen box on floor outside on sidewalk, rude and very
stressed staff person working alone and doing the job of 3 people taking it out on the customers.
Our medical system is the worst of all the developing countries and the most expensive.    Blood
analysis is the heart of that system and if its completely deteriorated and no monitoring agency is
able to enforce standards, then what hope is there?  something is terribly wrong.

Just found your blog from Regina at Weight of the Evidence. Boy, am I glad to read your stuff. You are fair, balanced, and quite in tune with what's going on with the hearts of humanity. I take Coenzyme Q10, 100mgs. twice a day--I was taking it all along so I wasn't that upset when my doctor added Lipitor to my regimen because of a bad family history. And I don't care what the media plasters all over the airwaves down the road (as you indicated in your post as a possibility) I'm sticking with this stuff for peace of mind alone.
Nice to meet you.
Adam Wilk

The biggest thing I found about Ubiquinol is that yes it is up to 8 x more absorbable however, the claim is that the body is skipping a step.  "Regular" ubiquinone is broken down in the body into Ubiquinol which is what the body absorbs.  So if you take Ubiquinol, then your body doesn't need to break anything down to absorb it.  People over the age of 40 have a harder time breaking down and absorbing ubiquinone so Ubiquinol might be better for them.  You are right, most of my information has come from retailers or manufacturer's but they aren't trying to sway people from buying regular CoQ10 because they all still sell it, they are just offering another option for people who don't see any benefits from CoQ10.  Good info on the blog!

Why has QH not been launched in Japan, the home country of the manufacturer?

You cannot assume that any of the CoQ10 research applies to ubiquinol.

Enhanced bioavailability does not necessarily mean enhanced bioactivity. They have to show what their supplement does in a clinical setting.

What is the shelf life stability data for when the ubiquinol oxidizes to ubiquinone.

Marketing shows 8x (Swanson), 62% (Integrative Therapy), 400% (Jarrow), 8x (Life Extension)  What is the truth?

There has been a lot of clinical research on CoQ10. I think most if not all of it has been on ubiquinone. You cannot assume that any of those results are the same for ubiquinol supplements. People use products because they work, or they don't. What does the evidence support?

The clinical study was performed by the manufacturer not a third party.  The results has not been published in a peer-reviewed journal, escaping criticism

Just FYI regarding Sander's comment about which of the many stats to believe...

Keep in mind that a claim of 100% increase is the same as a factor of 2X. That given, 8X is the same as 400%. So, 3 out of the 4 examples of 8X, 62%, 400% and 8X are are equivalent to one another.

I haven't found any information about "Integrative Therapy", though I'd tend to err on the conservative side with regards to most any claim, as it seems they have done.

Todd, here is a link to the claims from Integrative Theraputics http://www.naturalgreens.com/ProdDetail.asp/ProdID/244

Coenzyme Q10 Facts or Fabrications
William V. Judy, Ph.D., Willis W. Stogsdill, M.D., Daniel S. Judy, M.D. and Janet S. Judy, R.N. CRC

CoEnzymeQl0 has been researched for years by scientists around the world, and its importance to the human body and its reported health benefits are widely known. For more than 30 years, people have been taking CoQ10 supplements in its oxidized form, ubquinone. When ubiquinol — the reduced form of CoQ10 — entered the US commercial market, manufacturers claimed that they had discovered a way to make the product stable so it could be used as a food or nutritional supplement in various delivery forms including softgels and free CoQ10 molecules in water and/or lipid based solutions such as liposomes, micelles, or nanoparticles. Several marketers also claimed that ubiquinol was the most bioactive and preferred form of CoQ10 in that 90-95% of the total body CoQ10 was in the form of ubiquinol. The absorption and bioavailability was claimed to be 300% better than of the oxidized (ubiquinone) forms of CoQ10. The information provided to the consumers led to a general feeling or understanding that the oxidized form that had been in the market for three decades was an inferior compound and not the product form the body preferred — and thus consumers should consider switching to the new reduced and "bioactive" product form.
Obviously, this marketing approach, and the claims made, created controversies among and between CoQ10 scientists around the world and the marketing groups. These controversies led to editorials written by a scientist to explain the differences between Ubiquinone and Ubiquinol, and resulted in rebuttals from marketing groups regarding their opinions in the accuracy of the editorials. The opinions in the editorials were from the scientist who discovered CoQ10 in 1957 and from the President of the International Coenzyme Q10 Association. Those opinions in the rebuttal referenced one study on the absorption of Ubiquinone and several papers on the antioxidant capacity of Ubiquinol along with the conversion of one form to the other in response to oxidative or metabolic stress. In evaluating the claims made relative to Ubiquinol, we have judged many to be factual yet not functional. Other claims appear to be mere fabrications to meet marketing needs and confusing many consumers.
The following is a list of claims made by various CoQ10 marketing groups relative to CoQ10, in the oxidized Ubiquinone and the reduced Ubiquinol forms. We have evaluated many of these claims based on scientific FACT or marketing group FABRICATIONS. The areas to be discussed are:
1. The CoQ10 molecule
2. CoQ10 absorption
3. CoQ10 transport
4. Conversion of Ubiquinone to Ubiquinol and vice versa
5. CoQ10 bioavailability
6. Functions of Ubiquinone and Ubiquinol
1. The CoQ1O Molecule
The characteristics of the CoQ10 molecule in many ways control its absorption and thus its bioavailability to the body cells. Ubiquinone (oxidized form) has a molecular weight of 864 Dalton's whereas Ubiquinol (reduced form) has two more hydrogen molecules and forms with the oxygen, a hydroxyl unit on the head of the molecule, thus having an 866 molecular weight. Both forms are highly lipid soluble due to the predominance of the 10 unit isoprene tail. Ubiquinone is bright yellow in color and Ubiquinol is milky white in color. Ubiquinone and Ubiquinol form a redox (Oxidation - Reduction) pair and can be readily converted from one form to the other in the cells, lymph or blood when their respective functions are in demand.
In the cell, CoQ10 is predominantly found in the outside of the mitochondria inner membrane in the Ubiquinol form (90-95%). CoQ10 in man and large animals has 10 isoprene units in its tail (CoQ10), while smaller vertebrates have 9 isoprene units (CoQ9). The body synthesizes Ubiquinone in all living cells. Commercial CoQ10 is manufactured by two different processes: 1) partial synthesis of CoQ9 to CoQ10 and 2) a yeast fermentation extraction process from which CoQ10 is made by a friendly bacterium. CoQ10 has two isomers (Trans and Cis). The trans isomer makes up 99.95 to 100 percent of the CoQ10 in both commercial product types.
                                              The following is a list of claims made about the CoQ10 molecules or crystals.
• CoQ10 is a vitamin like substance produced in all living human body cells. FACT
• CoQ10 is commercially made from sugar beets. FABRICATION CoQ10 is made by a partial synthesis from CoQ9 or by a yeast fermentation extraction process. The microorganisms which make the CoQ10 in the fermentation process could be fed sugar beets.
• Dr Karl Folkers discovered CoQ10 in beef heart Mitochondria in 1957. FABRICATION
Dr. Fred Crane discovered CoQ10 and Dr. Folkers determined its chemical structure.
• CoQ10 is a lipid-soluble molecule. FACT
• Converting or placing lipid-soluble CoQ10 molecules into liposomes, micelles or nanoparticles make CoQ10 molecules soluble in water. FABRICATION
The particles formed are dispersible in water due to the hydrophilic heads of the CoQ10 molecules forming the outer shell of the particles, and usually with the help of some surfactants. The CoQ10 molecule is still lipid-soluble and is absorbed in the body as such.
• Reducing the size of the CoQ10 molecule makes it more water soluble. FACT
Reducing CoQ10 to CoQ 9, 8, 7 by cutting off its lipophilic tail will make it more water-soluble, however it then is no longer CoQ10.
• Making the CoQ10 molecule smaller and thus more water-soluble will allow it to be rapidly absorbed through water filled pores in the absorption cell membrane. FABRICATION
Small lipid soluble molecules with 5-12 carbon atoms can be absorbed passively through water filled pores; however CoQ10 with 54 carbon atoms can not be absorbed through these hydrophilic pores.
• Ubiquinol, the reduced form of CoQ10, is synthesized in the body cells. FABRICATION
The oxidized Ubiquinone form of CoQ10 is synthesized in the body's cells.
• Ubiquinone is yellow in color while Ubiquinol is a milky white color. FACT
• The term hydrophilic means readily dissolved in water, water-soluble, or absorbable. FABRICATION
In fact, water-soluble molecules can be rapidly dissolved in water, however, if they are very large in size, their absorption may be poor. Water-soluble does not always equate or mean high absorption. Some molecules are simply too large to be absorbed well. CoQ10 cannot be converted into a water-soluble molecule.
• All CoQ10 product types must be placed in colored capsules or dark containers because CoQ10 is sensitive to light. FABRICATION Independent laboratory testing has dearly shown that crystal free CoQ10 in clear gelatin softgel capsules or crystalline CoQ10 have less than 1% by weight loss and no significant sensitivity to light. The primary reason for colored softgel capsules is to prevent the consumer from seeing crystals being formed inside the product.
2. CoQ1O Absorption
CoQ10, being a rather large molecule, is absorbed through the absorption cells in the small intestines by a "simple passive facilitated diffusion" process. Passive means that the process does not require energy. Facilitated means that the process requires a lipid molecule to act as a carrier for the CoQ10 molecules. Passive diffusion is down-hill transport and requires a greater CoQ10 concentration in the water phase adjacent to the side of the absorption cell


membrane compared to that inside the cell membrane. To a point, the greater this gradient is, the faster and greater the absorption.
CoQ10 crystals cannot be absorbed. Thus, crystalline compounds must be dissolved to single molecules before absorption. Intestinal absorption occurs on a molecular level; meaning only single molecules can be absorbed. CoQ10 in its crystallized form has poor dissolution within the chyme of the intestines, because its melting point is 10 degrees centigrade above body temperature. Without the addition of a lipid carrier molecule to facillate the absorption of CoQ10, even single molecules are poorly absorbed. This is evidenced by the poor absorption of CoQ10 plain powder: less than 1%.
The following is a list of claims about CoQ10 absorption:
• For crystals of CoQ10 to be absorbed, they have to be dissolved to single molecules. FACT
The body's intestinal absorption cells can not absorb crystals of any type.
• CoQ10 is absorbed through an active transport mechanism like that of sugar. FABRICATION
CoQ10 being a large lipid-soluble molecule, is absorbed by a process called "simple passive facilitated diffusion" through the phospholipid cell membranes, not the active transport process.
• Combining CoQ10 with a sugar will allow the CoQ10 to be absorbed with sugar directly into the blood. FABRICATION
Membrane proteins are involved in the absorption of sugar and sodium via an active transport mechanism. If CoQ10 was absorbed while being bound to sugar, its Cmax (maximum concentration in blood) would peak with sugar in about two hours instead of 5-8 hours as for most lipids.
• CoQ10 is absorbed across the intestinal cells directly into the venous blood. FABRICATION
CoQ10 is absorbed across the intestinal cell membranes into the lymph vessels in the intestinal microvillus, not into the bloodstream.
• The poor dissolution of powder based CoQ10 tablets and lipid filled softgels in simulated gastric juice is a good indicator of poor absorption. FACT
However, since CoQ10 is not soluble in water but is soluble in a lipid, shouldn't the solubility test for lipid soluble molecules be done in a lipid solution?
• Ubiquinol has far greater water solubility and much better absorption into the blood stream than does Ubiquinone. FABRICATION
The addition of two hydrogen ions on the polar head of the Ubuquinol molecule will not make the molecule highly water-soluble or absorbed as a water-soluble molecule.
• Ubiquinol is more water-soluble than Ubiquinone. FACT
When two hydrogen's atoms are added to the polar (water-soluble) head of the CoQ10 molecule, the increased mass will make Ubiquinol slightly more water-soluble than Ubiquinone. However, due to the larger total mass of the nonpolar tail of the molecule, it is still more lipid-soluble than water-soluble.
• Liposomes, micelles and nanoparticle CoQ10 products are absorbed, transported in lymph, blood and to the target body cells as liposomes, micelles or nanoparticles. FABRICATION
The microspheres can not be absorbed. They are simply transport vehicles for ingested CoQ10, to be delivered to the intestinal absorption cells.
• Reduced CoQ10, an antioxidant, remains in the reduced form when ingested and absorbed. FABRICATION
Reduced CoQ10 is highly unstable in the contents of the stomach and is converted to oxidized CoQ10 before absorption.
• The rapid dissolution of a liposome, micelle or nanoparticle CoQ10 products in water is a good indicator of high CoQ10 absorption. FABRICATION
The rapid dissolution of these CoQ10 products types tells that these polar particles (water-soluble microspheres) will disperse rapidly in water. This does not mean that they are better absorbed. Only the CoQ10 molecules are absorbed, not the liposomes, micelles or nanoparticles.
3. CoQ10 Transport
Absorbed nutrients are transported from the intestines by two routes.
Small water-soluble and some small lipid-soluble nutrients, after absorption, enter the capillary blood in the intestinal microvillus and are transported by the blood to the liver. From the liver these small molecules are transported through the hepatic vein to the inferior vena cava, then to the heart and then into systemic circulation.
Large lipid-soluble nutrients such as CoQ10, after absorption, diffuse into the lymph capillary in the intestinal microvillus, and are transported in the lymph through the abdominal and thoracic lymph duct to the subclavian vein and then into the systemic circulation. In the lymph and blood, CoQ10 molecules are predominately in the reduced form and are bound to the low density lipoproteins (LIM.). The delayed peak concentration of CoQ10 in the blood is due to the very slow lymph flow compared to that of blood. The portal venous blood is a delivery system to the liver, but the lymph is not.
The following is a list of claims about CoQ10 transport:
• After CoQ10 absorption, it is transported by the lymph to the liver where it is reduced and bound to phospholipids. FABRICATION The lymph is not a delivery system to the liver.
• CoQ10 is transported from the absorption cells to the venous blood by the lymphatic system. FACT
The lymph is the delivery system for absorbed CoQ10 molecules to the systemic blood. Large animal studies show that CoQ10 peaks in the abdominal lymph duct in 2-3 hours after ingestion where as it peaks in venous blood in 6-8 hours. The reason for the delayed appearance in the venous blood is due to slow lymph flow.
• In the absorption cell, the lymph or the blood oxidized CoQ10 is converted to the reduced form of CoQ10. FACT
Circulating CoQ10 in the blood is 90-95% in the reduced (Ubiquinol) form.
• CoQ10 is rapidly absorbed in the small intestines and is slowly transported by the lymph to the venous blood. FACT
Total lymph flow is about 100 ml/minute whereas blood flow is 5,000 ml/minute.
4. Conversion of Ubiquinol to Ubiquinone and Vice-Versa
Ubiquinone and Ubiquinol, being redox pairs, are easily converted from one form to the other in the body. For example, when exogenous Ubiquinone is absorbed in the intestines it is converted to Ubiquinol in the absorption cells, the lymph, or the blood. Since CoQ10 is not used to produce energy in the lymph system or blood, it is understandable why this conversion takes place to fulfill the need for antioxidant protection in the circulation. On the other hand, in the inner membrane of the mitochondria where energy is made, the oxidized form of CoQ10 (Ubiquinone) is in great demand. Here the reduced Ubiquinol form is rapidly converted to the oxidized Ubiquinone form. In the mitochondria this conversion creates a Q-Cycle. It was once felt by the late Sir Peter Mitchell (Nobel prize, 1978) that the Q-Cycle would maintain the proportion of Ubiquione and Ubiquinol required for energy synthesis available forever. Little did he know at the time of his discovery that with age and disease the body's ability to produce Ubiquinone and to convert it to Ubiquinol would diminish and true CoQ10 deficiencies would be prevalent in an aging society.
The following is a list of claims about CoQ10 conversion:
• CQ10 can be converted from the reduced to oxidized form and vise versa in the body as needed. FACT
This is a unique characteristic of redox pairs.
• CoQ10 in the foods we eat is in the reduced form. FACT & FABRICATION The CoQ10 in fresh uncooked animal protein in is the reduced form. However, when cooked, it is converted to the oxidized form. Even when ingested uncooked (such as sushi or steak tartar), CoQ10 will be converted in the stomach to the oxidized form.
• CoQ10's ability to cycle back and forth between Ubiquinone and Ubiquinol accounts for many of its unique properties. FACT


5. CoQ10 Bioavailability
After absorption, CoQ10 accumulates in the blood and becomes bioavailable to all body cells. Bioavailability reflects absorption but it is not the actual absorption and should not be used as an accurate measure of such, It does, however, give a good estimate of the amount of CoQ10 available as an antioxidant in the blood and that available to the body cells. CoQ10 is accumulated and is stored in the cell membranes and in the membranes of the organelles in the cell.
It has been known for two decades that the bioavailability of the pure crystalline CoQ10 is less than that of liposome, micelle, and dissolved CoQ10 products. The current commercial and scientific issue is the bioavailability of the Ubiquinol form compared to that of the Ubiquinone form of CoQ10.
The following is a list of claims about CoQ10 bioavailability:
• Ubiquinol has a much higher bioavailability then the Ubiquinone used in other commercial CoQ10 supplements. FABRICATION
In fact, the data on ubiquinol state that its bioavailability is 300 percent more than that of the oxidized dry powder products. Most dissolved, liposome, micelle and nanoparticle CoQ10 products claim to have a 260 to 350 percent greater bioavailability than oxidized dry powder CoQ10.
• The two hydroxyl groups on the Ubiquinol compound results in its stronger bonding with water and helps explain why it is so much more bioavailable than Ubiquinone. FACT
This bonding does make Ubiquinol slightly more water soluble than Ubiquinone. However, the molecule is still lipophilic and is absorbed as a lipid.
6. Functions of Ubiquinone and Ubiquinol
Currently CoQ10 has two main functions in the body: it is used for energy production and functions as an antioxidant in the body.
Ubiquinone is a cofactor in the inner membrane of the mitochondria for the synthesis of energy (ATP). Since the body does not store energy (ATP), it must be rapidly produced through an oxidative phosphorlation process. CoQ10 is positioned between NADH and Cyto-Chrome C in the inner membrane and acts as cofactor stimulation to all three mediators to give up electrons to run the electron transport through complexes I-IV in this system. This function is specific to Ubiquinone in that no other molecule can replace Ubiquinone in this process. However, Ubiquinone and Ubiquinol as a redox pair form the Q Cycle in which they act to conserve each other in this process.
Ubiquinol is an antioxidant throughout the body. This is especially true in the cell membranes and those of the cell organelles. In these membranes CoQ10 may well be the primary lipophilic molecule essential for the prevention of lipid peroxidation resulting in cell damage and eventually cell death. Outside the cell and organelle membrane and in the presence of other lipophilic and hydrophilic antioxidants, Ubiquinol may recycle other antioxidants such as vitamin E and C.
The following is a list of claims about the functions of CoQ10
• Ubiquinol protects the body against toxic oxidative reactions. FACT
Yes, but equally beneficial it also recycles Ubiquinone in the synthesis of energy.
• The functions of Ubiquinol in the body are more diverse than those of Ubiquinone. FABRICATION
Ubiquinol functions in the body as an antioxidant and in the recycling of Ubiquinone, Vitamin E and Vitamin C. Ubiquinone, through its synthesis of energy, is involved in all body processes requiring energy: energy synthesis, active transport, membrane and nucleotide stability, synthesis of enzymes, coenzymes, hormones, neuro-transmitter synthesis and reuptake, cillary activity in the upper respiratory systems, all muscle contractile functions, sperm production and motility, deactivation of muscle contraction, pumping action of sweat and other cutaneous glands, etc. In fact, Ubiquinone is possibly the hub around which life processes revolve in the human body.
• Clinical studies with Ubiquinol show it is superior to Ubiquinone. FABRICATION
In fact, Ubiquinol became available in 2006 and to date, no clinical studies in human beings using Ubiquinol have been published in the

peer-reviewed scientific literature. An anti-aging study in genetic mutated mice has been described, but the role of the genetic mutations in these mice as they pertain to CoQ10 conversion are not understood. This is a concern since mice use CoQ9 as an energizer and antioxidant whereas human beings use CoQ10.
• Ubiquinol supplements make Ubiquinone supplements
obsolete. FABRICATION
In fact, hundreds of clinical studies show that Ubiquinone is effective and is still the choice of practicing cardiologists. Ubiquinone and Ubiquinol are rapidly inter-converted back and forth as needed, regardless of which form is ingested.
The existence of CoQ10 in two forms and structures, having two separate but essential functions, and its ability to act as a redox pair to recycle each other as needed is the beauty of this molecule. Although Ubiquinone was discovered first and found to be essential for life, the discovery of Ubiquinol broadened the overall scope of this molecule relative to the health characteristics and benefits to man. Without Ubiquinone life is not possible in that the body can not survive without energy. On the other hand, the life sustaining feature of energy has to be maintained and protected. Since Ubiquinol recycles Ubiquinone, the life cycle is maintained for about 8 decades in man. This would not be possible if it was not for Ubiquinol and other antioxidants. The antioxidants act as part of the host defense system and thus, prevent the toxic by-products (free radicals and super oxides) from the synthesis of energy and all substances produced by the body from rapidly aging all cells and shortening and reducing the quality of life.
CoQ10 as a scientific entity is 50 years old. As a commercial food supplement it has been around for about 37 years. The basic and clinical science is still growing. It is now presented in basic and graduate level text books of the biomedical sciences. Its entry into clinical text and its acceptance in the clinical societies will eventually occur with more well controlled clinical trials. These clinical trials are currently a world wide effort. CoQ10 as a supplemental nutrient to standard clinical therapy is here now. Its use as a stand alone nutrient to insure and maintain normal health characteristics of man is rapidly growing throughout the world. This will continue to grow with continued and more advanced research.
In summary, many aggressive marketing campaigns introducing Ubiquinol have created false and misleading claims that have only generated more confusion about CoQ10.
The apparent lack of superior absorption, instability in the stomach, no clinical efficacy studies and the high cost of Ubiquinol have to be considered when making a decision as to which CoQ10 form should be sourced. Millions of consumers experience its many benefits each day. Ubiquinone and Ubiquinol are redox pairs in that one can be rapidly converted to the other and vice versa in areas where their specific functions are required. Thus, does it really matter which form is taken as a supplement? Yes, it does matter.
First, there is a cost comparison in that consumers still look for the lowest cost and effective products. Since the forms of CoQ10 can be easily converted from one form to another, it makes sense to choose a form that is more affordable. It was previously mentioned that Ubiquinol molecule becomes oxidized in the stomach. Consequently, taking Ubiquinol as a nutrient is essentially the same as taking the more stable and less expensive oxidized form.
Second, regardless of the product type, the most critical aspect of CoQ10 supplementation is absorption. Due to the high cost of CoQ10, an understanding of the best delivery system to maximumize absorption becomes the critical component in an effective and successful CoQ10 supplement. Based on the current CoQ10 research, the consumer's best bet is a CoQ10 product with superior absorption properties because dosage levels can be reduced to attain the same effective blood levels and health benefits.
References available upon request.
About the Author:
Dr. William Judy is a retired Professor of Physiology and Biophysics at the Indiana University School of Medicine and the Founder and President SIBR Research, Inc. SIBR Research, Inc. is a contract research center that conducts clinical trials on natural products for the international community. Dr. Judy has researched Ubiquinone (CoQ10) and used it with patients for over 35 years. His initial work was in collaboration with Dr. Karl Folkers, University of Texas. He was one of the first researchers to run long-term clinical trials, spanning 10 years or longer, on hundreds of cardiac patients, many of whom had been "left to die' by the medical establishment. Dr. Judy's articles, reports and reviews have appeared in multiple publications, and he has traveled the world, lecturing to physicians, health care professionals and scientists about the benefits o f CoQ10 in health maintenance and disease prevention. Dr. Judy can be reached at sibrinc@cs.com.

This works for me, period, really life, honest to goodness works.  I was having muscle cramps quite a bit, and tried 30mg first, not enough, then 100mg, and bingo, maybe one mild cramp in the last year.  Powder or gel, don't know, I used both, and they worked for me.

In our experience, CoQ10 does work. It doesn't work all of the time, perhaps just 80-90% of the time. It does generally require higher doses (100 mg per day, occasionally more). It very clearly must be an oil-based gelcap (just like vitamin D) to work; capsules containing powder do not work.