We got the drug industry we deserve

A biting commentary on just who is writing treatment guidelines for diabetes and cardiovascular disease was published in the British Medical Journal, summarized in theHeart.org's HeartWire here.

"About half the experts serving on the committees that wrote national clinical guidelines for diabetes and hyperlipidemia over the past decade had potential financial conflicts of interest (COI), and about 4% had conflicts that were not disclosed.

"Five of the guidelines did not include a declaration of the panel members' conflicts of interest, but 138 of the 288 panel members (48%) reported conflicts of interest at the time of the publication of the guideline. Eight reported more than one conflict. Of those who declared conflicts, 93% reported receiving honoraria, speaker's fees, and/or other kinds of payments or stock ownership from drug manufacturers with an interest in diabetes or hyperlipidemia, and 7% reported receiving only research funding. Six panelists who declared conflicts were chairs of their committee.

"Of the 73 panelists who had a chance to declare a conflict of interest but declared none, eight had undeclared COI that the researchers identified by searching other sources. Among the 77 panel members who did not have an opportunity to publicly declare COI in the guidelines documents, four were found to have COI.
"

The closing quote by Dr. Edwin Gale of the UK is priceless:
"Legislation will not change the situation, for the smart money is always one step ahead. What is needed is a change of culture in which serving two masters becomes as socially unacceptable as smoking a cigarette. Until then, the drug industry will continue to model its behavior on that of its consumers, and we will continue to get the drug industry we deserve."

It's like having Kellogg's tell us what to each for breakfast, or Toyota telling us what car to drive. The sway of the drug industry is huge. Even to this day, I observe colleagues kowtow to the sexy sales rep hawking her wares. But that's the least of it. Far worse, even the "experts" who we had trusted to have objectively reviewed the evidence to help the practitioner on Main Street appears to be little more than a hired lackey for Big Pharma, hoping for that extra few hundred thousand dollars.

Comments (6) -

  • Jim Purdy

    10/14/2011 1:36:03 AM |

    I am not a fan of any drugs, and as a result, I change primary care physician regularly, usually after two visits.
    ON THE FIRST VISIT, I explain to the new doctor that I do not, and will not, take prescription medications. I explain that the only reason I am in their office is to get orders for lab work, so that I can review the results and make my own decisions about lifestyle changes, especially diet. The doctor then calls me" non-compliant" and prints numerous computer-generated prescriptions anyway. Obviously, it is the doctor who is non-compliant, since I have already said I do not want drugs.
    ON THE SECOND VISIT, the doctor asks, "Have you been taking your medications as ordered?" When I tell the doctor again, as I did at the first visit, that I do not take medications, the doctor says, "You're crazy and suicidal." I then find the next doctor, and the cycle starts over.
    As I see things, I have two choices when I feel ill:
    1. I could attack my body with some bizarre BigPharma chemicals that our ancestors' bodies have never dealt with in millions of years of evolution (Oxycodone, hydrocodone? Really? Are doctors nuts?).
    2. Or I could get out of the way and let my body heal itself as has been done over many millions of years of evolution. All I want to do is support that process by making sure to give my body the proper nutrition in the form of the appropriate whole foods.

  • Dr. William Davis

    10/14/2011 3:40:23 AM |

    Wow, Jim. Creepy.

    Don't despair: I'm confident that you will eventually find a healthcare practitioner who will act as your advocate, not a provider of drugs. It may take, unfortunately, going through quite a few practitioners before you come on such a person.

  • Suze

    10/19/2011 1:44:46 AM |

    Great post. I am starting to think there are two kinds of people - those who seek drugs and those who run from them. LOL.
    Among other occupations, I am an OR nurse. I have been wined and dined by the best reps ever, to buy their wares for surgery. It's all about the money.The drug companies have a lot to lose if we all quit taking their meds. Which is exactly what I want to do. I do not want to be a slave to a diagnosis and accompanying pill bottle. I want to be freeeeee.
    This is not to say there is a time and place for medicine. There IS. But not for every sniffle.

  • Jeanne

    10/20/2011 11:44:20 AM |

    Boy Suze, I can relate!  I'm a nurse as well and spent lots of years in NICU, but a change to chemical dependancy/psych was eye opening and downright disgusting in the amount of meds handed out.

    I used to ask patients if they were hungry when dispensing a 6oz. Cup FULL of various pills before breakfast!
    Couldn't take it and quit. Couldn't be a party to pharm management over real therapy.  I also take as few pills as possible, especially antibiotics.

  • N

    11/30/2011 6:36:01 PM |

    Hi Doc,

    I just visited my parents, and my mom shared her recent blood work with me.
    Her cholesterol was a mere 210, and her doc (general practitioner), put her on a statin !!!
    I told her about your blog a bit and particle size, but of course she's hesitant since her doctor obviously has more credibility than me.

    Outside of eating better, what next steps should I advise her to take?  She agreed to request a cholesterol particle size test (is there an official name for this?).

  • Dr. William Davis

    12/1/2011 4:22:01 AM |

    Yes, N: Lipoprotein testing, such as NMR Lipoprofile or Atherotech VAP.

    It really shouldn't be that tough, but we are battling the incredible ignorance in the primary care community who is spread too thin to master any one area.

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My bread contains 900 mg omega-3

My bread contains 900 mg omega-3

Phyllis is the survivor of a large heart attack (an "anterior" myocardial infarction involving the crucial front of the heart) several years ago. Excessive fatigue prompted a stress test, which showed poor blood flow in areas outside the heart attack zone. This prompted a heart catheterization, then a bypass operation one year ago.

FINALLY, Phyllis began to understand that her unhealthy lifestyle played a role in causing her heart disease. But lifestyle alone wasn't to blame. Along with being 70 lbs overweight and overindulging in unhealthy sweets every day, she also had lipoprotein(a), small LDL particles, and high triglycerides. The high triglycerides were also associated with its evil "friends," VLDL and IDL (post-prandial, or after-eating, particles).

When I met her, Phyllis' triglycerides typically ranged from 200-300 mg/dl . Fish oil was the first solution, since it is marvelously effective for reducing triglycerides, as well as VLDL and IDL. Her dose: 6000 mg of a standard 1000 mg capsule (6 capsules) to provide 1800 mg EPA + DHA, the effective omega-3 fatty acids.

But Phyllis is not terribly good at following advice. She likes to wander off and follow her own path. She noticed that the healthy bread sold at the grocery store and containing flaxseed boasted "900 mg of omega-3s per slice!". So she ate two slices of the flaxseed-containing bread per day and dropped the fish oil.

Guess what? Triglycerides promptly rebounded to 290 mg/dl, along with oodles of VLDL and IDL.

A more obvious example occurs in people with a disorder called "familial hypertriglyceridemia," or the inherited inability to clear triglycerides from the blood. These people have triglycerides of 800 mg/dl, 2000 mg/dl, or higher. Fish oil yields dramatic drops of hundreds, or even thousands of mg. Fish oil likely achieves this effect by activating the enzyme, lipoprotein lipase, that is responsible for clearing blood triglycerides. Flaxseed oil and other linolenic acid sources yield . . .nothing.

Don't get me wrong. Flaxseed is a great food. As the ground seed, it reduces LDL cholesterol, reduces blood sugar, provides fiber for colon health, and may even yield anti-cancer benefits. Flaxseed oil is a wonderful oil, rich in monounsaturates, low in saturates, and rich in linolenic acid, an oil fraction that may provides heart benefits a la Mediterranean diet.

But linolenic acid from flaxseed is not the same as EPA + DHA from fish oil. This is most graphically proven by the lack of any triglyceride-reducing effects of flaxseed preparations.

Enjoy your flaxseed oil and ground flaxseed--but don't stop your fish oil because of it. Heart disease and coronary plaque are serious business. You need serious tools to combat and control them. Fish oil is serious business for triglycerides. Flaxseed is not.

Comments (8) -

  • John Townsend

    2/15/2007 6:59:00 PM |

    re: " Her dose: 6000 mg of a standard 1000 mg capsule (6 capsules) to provide 1800 mg EPA + DHA, the effective omega-3 fatty acids."

    Excellent blog entry! On fish oil, this dose seems to be very high. Do you recommend this as a typical regimen?

    On another related topic, your views on common statins (eg lipitor, crestor, zocor, etc) would be appreciated. I'm getting strong warnings from knowledgable friends that statins are dangerous for liver function and can cause irreversiable damage. On the other hand I personally have found them to be very effective in bringing my cholesteral numbers in line, more than anything else I've tried. TIA

  • Dr. Davis

    2/16/2007 2:19:00 AM |

    John--
    No. This dose is for treatment of high triglycerides or postprandial disorders. Our usual starting dose is 4000 mg (1200 mg EPA+DHA).

    Regarding the statin issue. I'd refer you to an article I wrote for Life Extension magazine  archived on their website, www.lef.com. The article, entitled Cholesterol and Statin Drugs: Separating Hype from Reality, can be accessed at http://search.lef.org/cgi-src-bin/MsmGo.exe?grab_id=0&page_id=1044&query=davis%20statin&hiword=DAVI%20DAVID%20DAVIE%20DAVIES%20DAVIN%20DAVIO%20DAVISON%20DAVISS%20DAVIT%20STATI%20STATING%20STATINS%20STATIS%20davis%20statin%20

  • Cindy

    2/16/2007 3:24:00 AM |

    I just read your article that you referred to in your previous comment answer.

    I was on statins several years ago. Not only did I experience muscle and joint pains, I also had serious memory problems, depression and sleep problems. I also found that my long-standing "restless legs syndrome" became much much worse. I've also talked to many people who have experienced serious PND (peripheral nerve disorders).

    What I also experinced was a rather significant drop in HDL cholesterol.

    Thoughts?

  • Mike

    2/16/2007 3:37:00 PM |

    "But Phyllis is not terribly good at following advice. She likes to wander off and follow her own path. She noticed that the healthy bread sold at the grocery store and containing flaxseed boasted "900 mg of omega-3s per slice!". So she ate two slices of the flaxseed-containing bread per day and dropped the fish oil."

    Allow me to defend Phyllis. If all she had been told was to take a given amount of omega-3s, then she was following the prescribed path. She should have been educated as to what the various omega-3s are and which type she needed to consume.

  • John Townsend

    2/16/2007 9:31:00 PM |

    Thank you for passing on your article 'Statin Drugs: Separating Hype from Reality'... very informative I must say! Just a quick heads up on your comment about folic acid (ie “always take folic acid and vitamin B12 with niacin to protect against disruption of healthy methylation patterns”), although studies are not conclusive, apparently folate therapy (taking a combination of folic acid, vitamin B6, and vitamin B12) may be harmful after stent placement and probably should be avoided. For those who have this condition it’s advised instead, to try to get enough vitamin B by eating a balanced diet. [ref: Lange H, et al. (2004). Folate therapy and in-stent restenosis after coronary stenting. New England Journal of Medicine, 350(26): 2673–2681]

  • madcook

    2/17/2007 5:32:00 PM |

    I have to chime in here regarding Cindy's comment on statins:

    I dutifully tried for nearly two years to tolerate the various statins prescribed by my doctor.  The deep muscle aches and spasms were nearly unbearable... getting far worse when my "numbers" still weren't right and he decided to DOUBLE my dosage of Vytorin (Zocor + Zetia) from 10/20 to 10/40.  What resulted was a true nightmare for me.  I terminated this med when I had such severe muscle aching, spasms and dis-coordination that navigating up a flight of stairs was nearly impossible.  Not only that, but my memory was (fortunately temporarily) impaired, and I can remember little from a three month period of time.  Interestingly my CK was never elevated and this all happened while taking 200mgs. daily of a very reputable Co -Q10 formulation.  Cessation of the Vytorin saw the aches subside within 2 or 3 days and full mental clarity resumed within a week.  I was lucky.

    My doctor stated that there were three other statins we hadn't yet tried... fat chance doc!

    What chaps me is that the pharmaceutical companies continue to state that there is only a small percentage of patients who have side effects.  In practice, LOTS of people have problems tolerating statins, BUT these things never are reported, certainly mine wasn't by my doctor.

    Side effects can be reported to the UCSD Statin Study, and to the FDA.  The FDA form is unduly cumbersone and frankly, unless you nearly died, it probably isn't worth the time.  The UCSD Statin Study questionnaire is very thorough... and as soon as I get some time I'm planning to report my experiences with statins to them.

    I am not optimistic that doing either of the above will change the statistical misinformation out there on statin side effects.  The pharmaceutical giants have too many billions at stake to ever allow this information to attain credibility.  Their advertising billions shout otherwise...

    Great meds, IF they work for you without problems.  For me they appear to be deadly, so I think I'll just stick with the other strategies, including niacin, fish oil, etc., etc. that I've learned through TYP.

    madcook

  • madcook

    2/17/2007 5:33:00 PM |

    I have to chime in here regarding Cindy's comment on statins:

    I dutifully tried for nearly two years to tolerate the various statins prescribed by my doctor.  The deep muscle aches and spasms were nearly unbearable... getting far worse when my "numbers" still weren't right and he decided to DOUBLE my dosage of Vytorin (Zocor + Zetia) from 10/20 to 10/40.  What resulted was a true nightmare for me.  I terminated this med when I had such severe muscle aching, spasms and dis-coordination that navigating up a flight of stairs was nearly impossible.  Not only that, but my memory was (fortunately temporarily) impaired, and I can remember little from a three month period of time.  Interestingly my CK was never elevated and this all happened while taking 200mgs. daily of a very reputable Co -Q10 formulation.  Cessation of the Vytorin saw the aches subside within 2 or 3 days and full mental clarity resumed within a week.  I was lucky.

    My doctor stated that there were three other statins we hadn't yet tried... fat chance doc!

    What chaps me is that the pharmaceutical companies continue to state that there is only a small percentage of patients who have side effects.  In practice, LOTS of people have problems tolerating statins, BUT these things never are reported, certainly mine wasn't by my doctor.

    Side effects can be reported to the UCSD Statin Study, and to the FDA.  The FDA form is unduly cumbersone and frankly, unless you nearly died, it probably isn't worth the time.  The UCSD Statin Study questionnaire is very thorough... and as soon as I get some time I'm planning to report my experiences with statins to them.

    I am not optimistic that doing either of the above will change the statistical misinformation out there on statin side effects.  The pharmaceutical giants have too many billions at stake to ever allow this information to attain credibility.  Their advertising billions shout otherwise...

    Great meds, IF they work for you without problems.  For me they appear to be deadly, so I think I'll just stick with the other strategies, including niacin, fish oil, etc., etc. that I've learned through TYP.

    madcook

  • John Townsend

    2/17/2007 8:05:00 PM |

    RE: Madcook's comment "Side effects can be reported to the UCSD Statin Study, and to the FDA. "

    I'm wondering if the 'UCSD Statin Study' provide summary reports on submission findings?

    BTW, his note is a very interesting personal account which echos mine to a certain extent, albeit I'm seemingly in the early stages. I'm starting to have pretty severe shoulder pain coming out of nowhere after six mths on Zocor. I've started taking Q-10 (re: your rec) to see if it helps. Previously my reaction to Lipidor was almost immediate with severe skin rash symptoms.

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