Stents, defibrillators, and other profit-making opportunities

As a practicing cardiologst, every day I receive a dozen or more magazines or newspapers targeting practicing physicians, not to mention the hundreds of letters, postcards, invitations to "talks", etc. that I receive. All of these materials share one common goal: To get the practicing cardiologist/physician to insert more of a manufacturer's stents, defibrillators, prescribe more of their drugs, etc.

This is a highly effective and profitable area. Pfizer's Lipitor, for instance, generated $12.2 billion just last year alone. This kind of money will fund an extraordinary amount of marketing.

I'm on the www.heart.org mailing list, a website for cardiologists. I'd estimate that 90% or more of their content is device-related: discussions of situations in which to insert stents, the expanding world of implantable devices, the ups and downs of various drugs. Rarely are discussions of healthy lifestyles, exercise, nutritional supplements, part of the dialogue.

How can you protect yourself from the brainwashed physician, flooded with visions of all the devices he can put in you, all the drugs that can "cure" your disease? Simple: information. Be better informed. Ask pointed questions. The idiotic lay press tells you to ask a doctor about his education. That's not generally the problem. Some of the best educated doc's I know are also the most flagrantly guilty of profiteering medicine.

Ask your doctor about his/her philosphy about the use of medications, devices, etc. If their word is God, take it or leave it, run the other way.

Will radiation kill you?

Several people have asked me lately if radiation is truly dangerous. These conversations were sparked by an editorial comment made on a column I wrote for Life Extension Magazine's April, 2006 issue on "Three ways to detect hidden heart disease".

Among the methods that were discussed in this piece was, of course, CT heart scanning. Anyone who is involved with CT heart scans Quickly recognizes the spectacular power of this test to uncover hidden, unsuspected heart disease, literally within seconds. In 2006, there's really nothing like it for the every day person to have hidden heart disease detected and precisely quantified.

Yet, the "rebuttal" to my article claimed that the broad use of heart scans was only my personal view and that, in truth, radiation kills people.

NONSENSE! If an ovarian cancer is discovered by a CT scan of the abdomen, is that unwise use of radiation? If pneumonia or lung cancer is discovered on a chest x-ray with minimal radiation exposure, have we performed a disservice. Of course not. In fact, these are often lifesaving applications of radiation.

Can radiation be used unwisely with excessive exposure? Of course. The 64 slice CT angiograms are just an example of this. Dr. Mehmet Oz announced on Oprah recently that this was a test to be used for broad screening of women for heart disease. This is wrong. The radiation required for a full 64 slice CT angiogram test is truly excessive for a screening application. You wouln't want to get breast cancer from your mammogram, would you? The radiation from a 64-slice CT angiogram is similar to that of a heart catheterization in the hospital--too much for screening. This is not to be confused with a CT heart scan for a calcium score performed on a 64 slice device. I think this can be performed with acceptable radiation exposure.

Think about what would happen, for instance, if you had your heart disease undetected, had a heart attack, and went to the hospital? During your hospitalization, you'd likely get five chest x-rays, a heart catheterization, perhaps one or more nuclear imaging tests, maybe even a full CT scan (with far more radiation than a screening heart scan). The amount of radiation of a heart scan is trivial compared to what you obtain in a hospital.

So take it all in perspective. The low level of radiation required for a simple heart scan (not an angiogram) does not by itself substantially add to your lifetime risk of radiation exposure. It may, in fact, save your life or reduce your life long exposure to radiation.

Are you using bogus supplements?

I consider nutritional supplements an important, many times a critical,part of a coronary plaque control program.

But use the wrong brand or use it in the wrong way, and you can obtain no benefit. Occasionally, you can even suffer adverse effects.

Take coenzyme Q10, for instance. (Track Your Plaque Members: A full, in-depth Special Report on coenzyme Q10 will be on the website in the next couple of weeks.) Take the wrong brand to minimize the likelihood of statin-related muscle aches, and you may find taking Lipitor, Zocor, Crestor, etc. intolerable or impossible. However, take a 100 mg preparation from a trusted manufacturer in an oil-based capsule, and you are far more likely to avoid the inevitable muscle aches. (Though, of course, consult with your doctor, for all it's worth, if you develop muscle aches on any of these prescription agents.)

Unfortunately, you and I often don't truly know for a fact if a bottle from the shelf of a health food store or drugstore is accurately labeled, pure, free of contaminants, and efficacious.

One really great service for people serious about supplements is the www.consumerlab.com website. They are a membership website (with dues very reasonable) started by a physician interested in ensuring supplement quality. Consumer Lab tests nutritional supplements to determine whether it 1) contains what the label claims, and 2) is free of contamination. (I have no reason to pitch this or any other site; it's just a great service.) They recently found a supplement with Dr. Andrew Weil's name on it to have excess quantities of lead!

What Consumer Lab does not do is determine efficacy. In other words, they do a responsible job of reporting on what clinical studies have been performed to support the use of a specific supplement. However, true claims of efficacy of supplement X to treat symptom or disease Y can only come with FDA approval. Supplements rarely will be put through the financial rigors of this process.

If you're not a serious supplement user, but just need a reliable source, we've had good experiences with:

--GNC--the national chain
--Vitamin Shoppe--also a national chain
--www.lifeextension.com or www.lef.org--A great and low-priced source, but they do charge a $75 annual membership that comes with a subscription to their magazine, Life Extension (which I frequently write for) and several free supplements that you may or may not need. Again, I'm not pitching them; they are simply a good source.
--Solgar--a major manufacturer
--Vitamin World
--Nature's Bounty
--Sundown

There are many others, as well. Unfortunately, it's only the occasional manufacturer or distributor that permits unnacceptable contamination with lead or other poisons, or inaccurately labels their supplement (e.g., contains 1000 mg of glucosamine when it really contains 200 mg). I have not come across any manufacturer/distributor who has systemtically marketed uniformly bad products.

It really helps to have someone to lean on

Among my patients are several husband and wife teams, both of whom have heart disease by some measure. Several couples, for instance, consist of a huband who's received a stent, survived a heart attack, or has some other scar of the conventional approach. The wives generally have a substantial heart scan score in the several hundred range.

There are a few couples for which the roles are reversed: wife with bypass, heart attack, etc. and husband with a substantial quantity of coronary plaque by CT heart scan.

From them all, however, I've learned the power of teamwork. When both wife and husband (or even "significant other") are committed to the effort of controlling or reversing heart disease risk, the likelihood of success is magnified many-fold. Everything is easier: shopping for and choosing foods, incorporating supplements in the budget, taking vacations with a healthy focus, following through and sticking with your program.

Several of the couples have succeeded in obtaining regression of plaque for both man and woman. Both have reduced their heart scan scores and, as a result, dramatically reduced the potential for future heart attack and procedures.

Unfortunately, I will also see the opposite situation: One spouse committed to the program but the other indifferent. They may say such things as "You can't control what happens in the future." Or, "There's no way you can get rid of risk for heart disease. My doctor says it's hereditary." Or, "I've eaten this way since I was a kid. I'm not changing now for you or for anybody else."

Such negative commentary can't help but erode your commitment to health. Most of us recognize these sorts of comments as self-fulfulling and self-defeating.

What should you do if you have an unsupportive partner? Not easy. But it really can help to seek out a supportive partner, whether it's a friend, relative, or other significant person in your life. Of course, not everybody can find such a person. Perhaps that's another way our program can help.

I'd like to hear from anyone who does obtain substantial support of someone close, or if you are struggling to do so.

Five foods that can booby trap your heart disease prevention program

There are several foods that commonly come up on people's lists of habitual foods that are truly undesirable for a heart disease prevention program. Curiously, people choose these foods because of the mis-perception that they are healthy. My patients are often shocked when I tell them that they are not healthy and are, in fact, detrimental to their program.

I'm not talking about foods that are obviously unhealthy. You know these: fried foods, greasy cheeseburgers, French fries, bacon, sausage, etc. Nearly everyone knows that the high saturated fat content, low fiber, and low nutritional value of these foods are behind heart disease, hypertension, and a variety of cancers.

I'm talking about foods that people say they eat because they view them as healthy--but they're not.

Here's the list:

1) Low-fat or non-fat salad dressings--Virtually all brands we've examined have high-fructose corn syrup as one the main ingredients. What does high fructose corn syrup do? Triggers sugar cravings, makes your triglycerides skyrocket (causing formation of abnormal lipoproteins like small LDL), and causes diabetes. The average American now ingests nearly 80 lbs of this evil sweetener per year. You're far better off with olive, canol, grapeseed, or flaxseed based salad dressings.

2) Breakfast cereals--If you've been following these discussions, you know that the majority of breakfast cereals are sugar. They may not actually contain sugar, but they contain ingredients that are converted to sugar in your body. They may be cleverly disguised as healthy--Raisin Bran, Shredded Wheat, etc.

3) Pretzels--"A low-fat snack". That's right. A low-fat snack that raises blood sugar like eating table sugar from the bowl.

4) Margarine--Forget this silly argument about which is worse, butter or margarine. Which is worse, strychnine or lead? Both are poisons to the human body. Who cares which is worse? Fortunately, there are now healthy "margarines" like Smart Balance and Benecol that lack the saturated fat or hydrogenated fat of either.

4) Bananas--Bananas are not all that intrinsically unhealthy. The problem is that people will say to me, "Oh sure, I eat fruit. Two bananas a day." What I hear is "I don't really eat fruit with high nutrient value, fiber, and reduced sugar release. I reach for only bananas which yield extreme sugar rises in my blood and are low fiber." Aren't they high in potassium? Yes, but there are better sources. Cut back if you are a banana freak.


Why the mis-perceptions? A holdover from the low-fat diet days and marketing from food manufacturers are the principal reasons. Of course, foods are meant to be enjoyed, but be informed about it. Choose foods for the right reasons, not because of some cleverly-crafted marketing campaign.

Breakfast of champions?

I spend time every day educating or reminding patients that breakfast cereals are not health foods.

I see jaws drop in shock when I tell them that, in my opinion and despite the marketing claims, Cheerios, Raisin Bran, Shredded Wheat, and the like do not yield health benefits. In fact, they do the the opposite: dramatically raise blood sugar and trigger an adverse cascade of events that eventually leads to diabetes and heart disease.

Why the health claims in advertising? Because these products contain insoluble fiber, the sort that makes your bowels regular. Yes, your bowels are important to health, too. But the benefits end there.

Breakfast cereals are a highly refined, processed food that are not good for your plaque control program. What they are is a highly profitable, multi-billion dollar business, deeply entrenched in American culture ("They'rrrre grrrrrreat!"--Tony the Tiger; "There's a whole scoop of raisins in every box of Post Raisin Bran!" Bet you remember them all.)

I find it particularly upsetting when I see the stamp of approval from the American Heart Association on some products. Gee, if the Heart Association says it's good for you, it must be true! Don't you believe it. The American Heart Association relies on corporate donations, just like any other charity.

If you must eat breakfast cereals, refer to www.glycemicindex.com for a full database of glycemic indexes. You can look up a specific product and it will list its glycemic index, or sugar-releasing properties. You should try to keep glycemic index of the foods you choose below 50.

For a revealing discussion of the influence of food marketers on our perceptions of food, see Track Your Plaque nutrition expert, Gay Riley's discussion The Marketing of Food and Diets in America at her website, www.netnutritionist.com.

In heart disease prevention, shoot for perfection

It really struck me today that it's the people who've chosen to compromise their prevention program who end up with trouble--heart procedures, heart attack, even heart failure.

Take Bob, for example. Bob is 73 years old and had a bypass operation in 2000. The procedure went well and Bob enjoyed 6 years of seemingly trouble-free life. Bob had a seriously low HDL cholesterol for which he as taken a modest dose of niacin, but was unwilling to do much more. His HDL cholesterol was thererefore "stalled" at around 40 mg. (We aim for 60 mg or greater.) We talked repeatedly about the options for increasing HDL but Bob was content with his results. After all, since his bypass operation, he'd felt well and could do all he wanted without physical limitation.

But Bob underwent a stress test for surveillance purposes (which we routinely do 5 or more years after bypass surgery). The test was markedly abnormal with two major areas of poor blood flow to his heart (signalling potential heart attack in future). Bob ended up getting 5 stents to salvage two bypass grafts, both of which showed signs of substantial degeneration.

I've seen this scenario repeatedly: A person is unwilling to go the extra mile to obtain perfection in lipid/lipoprotein patterns, lifestyle changes, and taking the basic, required supplements. Compromises eventually catch up to you in the form of another heart attack, more procedures, heart failure, physical disability, even death.

The message: Don't draw compromises in heart disease prevention. Coronary plaque is a chronic process. It will take advantage of you if you ever let your guard down.

The epidemic of small LDL

Of the patients I saw in my office yesterday, virtually EVERYONE had small LDL.

Small LDL is emerging as an extraordinarily prevalent lipoprotein pattern that drives coronary plaque growth. Previous estimates have put small LDL as affecting only 20-30% of people with coronary disease. However, in my experience in the last few years, I would estimate that greater than 80% of people with measurable coronary plaque have small LDL.

If you have a heart scan score >zero, chances are you have it, too.

I call small LDL a "modern" disease because it has skyrocketed in prevalence recently because of the great surge in inactivity in Americans.

When's the last time you walked to the grocery store and back, lugging two bags of groceries? How many years has it been since you've push-mowed your lawn? All the small conveniences of life have permeated further and further into our activities. Most of us spend the great majority of our day right where you are now--on your duff.

On the bright side, small LDL in most people is reducable by simply getting up and going. But the old teaching of 30 minutes of activity per day is now outdated. This was true when the other hours of your life included physical activities, like housework or a moderately active job. However, if the other 23 1/2 hours of your day are sedentary, then 30 minutes a day won't do it. An hour or more of activity, whether exercise or physical labor of some variety will get you better small LDL-suppressing results.

For most people with small LDL, fish oil and niacin are also necessary to fully suppress small LDL to the Track Your Plaque goal of <10 mg/dl.

A great discussion on vitamin D

If you need better convincing that vitamin D is among the most underappreciated but crucial vitamins for health, see Russell Martin's review of vitamin D and its role in cancer prevention. You'll find it in March, 2006 Life Extension Magazine or their www.LEF.org website at:

http://search.lef.org/cgi-src-bin/MsmGo.exe?grab_id=0&page_id=1308&query=vitamin%20d&hiword=VITAM%20VITAMER%20VITAMERS%20VITAMI%20VITAMINA%20VITAMINAS%20VITAMINC%20VITAMIND%20VITAMINE%20VITAMINEN%20VITAMINES%20VITAMINIC%20VITAMINK%20VITAMINS%20d%20vitamin%20

Our preliminary experience over the past year suggests that vitamin D may be the crucial missing link in many people's plaque control program. We've had a handful of people who, despite an otherwise perfect program (LDL<60, HDL>60, etc.; vigorous exercise, healthy food selection, etc.--I mean perfect)continued to show plaque growth. The rate of growth was slower than the natural expected rate of 30% per year, but still frightening rates of 14-18% per year--until we added vitamin D. All of a sudden, we saw dramatic regression of 7-25% in 6 months to a year.

This does not mean that vitamin D all by itself regresses plaque. I believe it means that vitamin D exerts a "permissive" effect, allowing all the other treatments (fish oil, LDL reduction, HDL raising, correction of small LDL, etc.) to exert their full benefit. So please don't stop everything and just take D. This will not work. However, adding vitamin D to your program on top of the basic Track Your Plaque approach--that's the best way I know of.

MSNBC Report: We need more heart procedures!

A recent headline from MSNBC by Robert Bazell reads:

NEW YORK - Angioplasty, bypass surgery and cholesterol-lowering medications are among the many interventions that have brought a sharp decrease in heart disease deaths in recent years. But, as Dr. Sharon Hayes of the Mayo Clinic points out, there is one big problem.

“The death rates in women have not declined as much as they have in men,” she says.

The piece goes on to suggest that women are getting short-ended in the diagnosis of heart symptoms and heart attack. The solution: More testing to assess the need for procedures like bypass.

This is typical of the device and medication-dominated media consciousness: More procedures, more medication, more devices. Who's paying for advertising, after all? The money at stake is huge. But is this what you want?

Don't be swayed by media reporters with limited understanding of the real issues (at best), consciousness of who's paying for advertising (at worst). Yes, heart disese is often underestimated or misdiagnosed in women. The answer is better detection earlier in life followed by efforts to halt the process--effective, safe treatments for people's benefit, not just profit.
No-flush niacin kills

No-flush niacin kills

Gwen was miserable and defeated.

No wonder. After a bypass operation failed just 12 months earlier with closure of 3 out of 4 bypass grafts, she has since undergone 9 heart catheterization procedures and received umpteen stents. She presented to me for an opinion on why she had such aggressive coronary disease (despite Lipitor).

No surprise, several new causes of heart disease were identified, including a very severe small LDL pattern: 100% of LDL particles were small.

Given her stormy procedural history, I urged Gwen to immediately drop all processed carbohydrates from her diet, including any food made from wheat or corn starch. (She and her husband were shocked by this, by the way, since she'd been urged repeatedly to increase her whole grains by the hospital dietitians.) I also urged her to begin to lose the 30 lbs of weight that she'd gained following the hospital dietitians' advice. She also added fish oil at a higher-than-usual dose.

I asked her to add niacin, among our most effective agents for reduction of small LDL particles, not to mention reduction of the likelihood of future cardiovascular events.

Although I instructed Gwen on where and how to obtain niacin, she went to a health food store and bought "no-flush niacin," or inositol hexaniacinate. She was curious why she experienced none of the hot flush I told her about.

When she came back to the office some weeks later to review her treatment program, she told me that chest pains had returned. On questioning her about what she had changed specifically, the problem became clear: She'd been taking no-flush niacin, rather than the Slo-Niacin I had recommended.

What is no-flush niacin? It is inositol hexaniacinate, a molecule that indeed carries six niacin molecules attached to an inositol backbone. Unfortunately, it exerts virtually no effect in humans. It is a scam. Though I love nutritional supplements in general, it pains me to know that supplement distributors and health food stores persist in selling this outright scam product that not only fails to exert any of the benefits of real niacin, it also puts people like Gwen in real danger because of its failure to provide the effects she needed.

So, if niacin saves lives, no-flush niacin in effect could kill you. Avoid this scam like the plague.

No-flush niacin does not work. Period.


Disclosure: I have no financial or other relationship with Upsher Smith, the manufacturer of Slo-Niacin.


Copyright 2008 William Davis, MD

Comments (18) -

  • Liss

    3/20/2008 2:03:00 AM |

    Dr Davis is there a way to minimize the niacin-induced flush for people with rosacea who have been advised to avoid flushing?  Thank you for making this post.  I've been taking the no-flush niacin not realizing it wasn't effective.

  • Anonymous

    3/20/2008 2:16:00 AM |

    How stressful is it on the liver?  I've taken Niacin for over a year at either 500 mg or 1 gr doses.  As soon as I started with a timed-release formula (another brand), my liver started to show signs of stress.  I went back to regular Niacin and the results were back to normal in two months.  I've been leery of time-release versions since then.

  • Anonymous

    3/20/2008 3:44:00 AM |

    Why is Slo-niacin recommended over Niaspan or Enduracin? Isn't Slo-niacin extended release, which means it takes a long time to clear out of the liver?

    Wouldn't a sustained release (6-7 hr) version, like Enduracin (if going OTC) or Niaspan be better for the liver?

  • Anonymous

    3/20/2008 1:37:00 PM |

    Slo-Niacin is a sustained release version of Niacin very much akin to Enduracin or Niaspan.  Slo-Niacin has a very good track record and a history of medical trial success without causing liver damage.

  • Ross

    3/21/2008 2:19:00 AM |

    You can minimize niacin flushing by being well hydrated, by taking a normal or enteric aspirin 30 minutes before the niacin, by gradually increasing your dose, by spreading your daily dose into three or four daily doses, and simply by having your body get used to the niacin.

    What's nice is that you can combine these strategies, taking aspirin before the niacin for a few weeks and then dropping the aspirin since your body will be more used to it.  

    But really make sure you're well hydrated as that has made the biggest difference for me.

    Oh, and don't panic.  The first time you feel the flush it will be a bit suprising.  But if you respond to it with a kick of adrenalin, it will get worse.  If you instead say, "Ah, there's the niacin." and have another glass of water, it will pass fairly quickly.

  • Dr. William Davis

    3/21/2008 12:21:00 PM |

    Ross--

    Thanks for the comments.

    However, please be aware that spacing your doses of niacin out DRAMATICALLY increases liver toxicity. Once per day, twice per day at most, is what I tell my patients to minimize liver toxicity.

  • Michael

    3/21/2008 6:44:00 PM |

    Thanks for the information regarding slo-niacin. I could have sworn I read somewhere that it was an extended release form (12 hrs or more), but perhaps that site was wrong.

    Is there any advice for people who get side effects from niacin not related to flush? I sometimes notice my heart beating slightly more forcefully after I take niacin. It also seems to make me a little tired after taking it.

    The flush may be minimal to non-existent,  but this side effect still sometimes occurs. I've worn a holter monitor, so it's not producing any dangerous heart beats nor tachycardia, but it's still somewhat annoying.

    Any advice?

  • Anonymous

    3/21/2008 9:58:00 PM |

    Quercetin has been shown to reduce the flushing-effect.

    "Key results:

    Niacin (7.5 mg per rat, equivalent to a human dose of 1750 mg per 80 kg) maximally increased ear temperature to 1.9plusminus0.2 oC at 45 min.

    Quercetin and luteolin (4.3 mg per rat; 1000 mg per human), administered i.p. 45 min prior to niacin, inhibited the niacin effect by 96 and 88%, respectively.

    Aspirin (1.22 mg per rat; 325 mg per human) inhibited the niacin effect by only 30%. Niacin almost doubled plasma PGD2 and 5-HT, but aspirin reduced only PGD2 by 86%.

    In contrast, luteolin inhibited both plasma PGD2 and 5-HT levels by 100 and 67%, respectively."

    http://www.nature.com/bjp/journal/
    vaop/ncurrent/abs/0707668a.html;
    jsessionid=E91B46D4E63909EB
    593744E596A55668

  • mit

    4/29/2008 7:59:00 PM |

    Big Pharma is now trying to capitalize on niacin.

    Apparently, niacin, which is available without prescription for pennies, is more effective than anything else for controlling & improving lipid/blood ratios (and more).

    Statin drugs, even though less effective and more dangerous than niacin, have been the most profitable drugs in history. Big Pharma’s “education” of physicians has, until recently, discouraged the use of niacin for obvious, bottom-line reasons.

    The fact is that niacin’s side-effects are not at all as bad as suggested by Big Pharma. Ask anyone who’s been using niacin to control cholesterol for a few months.

    See www.cholesterolscore.com for many articles and studies on this subject.

  • Ben

    6/23/2008 3:02:00 PM |

    Dr. Davis,

    First, Let me state how happy I am to have found your blog. Niacin has really worked for me.

    Following your posts, I ordered some Slo-Niacin (500 mg). However, I'm concerned that one of the inactive ingredients is hydrogenated vegetable oil. Are you sure it's a good idea to prescribe trans-fat to heart patients?

    Thanks for your feedback.

  • Anonymous

    8/14/2008 2:49:00 AM |

    Inositol Hexanicotinate (no-flush Niacin) has been shown to lower LDL cholesterol and raise HDL by up to 30% in numerous test. Also it's shown to be less liver toxic than regular 'nicotinic acid' Niacin. Standard Niacin has been tied to numerous deaths via liver disease. So this 'article' is quite shocking when 1,000 of other physicians say the opposite. Unless you sell nicotinic acid  Smile

  • Denise

    12/17/2008 4:51:00 AM |

    I just wanted to say that I've been taking Slo-Niacin for almost 9 months now, doctor increased the dosage about 3 months ago, and until today, literally, I had never experienced any noticable side effects, and it's working.  My cholesterol has dropped almost 100 points in the past six months.  

    Today I experienced the flushing, itching, burning, fire-ants-under the skin feeling for the first time, and it was MISERABLE!!!  I have to say, working or not, if I have to go through THAT every night, I won't continue the program.  I already take Motrin and Aspirin at the same time as the Slo-Niacin,  I already drink a full glass of water with it, and I always eat something small as the combination of medications I take makes me nauseous anyway.  I took a Benadryl, which I don't normally take as I get weird side effects from that, too, but I was desperate!!

    Anyone have any idea why I would experience this particular side effect after 9 months of treatment and not earlier in the program???

    Thanks!

  • Anonymous

    3/28/2009 3:03:00 AM |

    I wanted to clarify a few things I've read in various posts.

    First off, Slo-Release Niacin is not akin to Niaspan. Niaspan is actually Extended Release which means that it releases quicker than Slo-Release but slower than Immediate Release Niacin. The point of the ER Niacin is that it releases slowly enough to minimize the flushing (unlike IR) but quickly enough that you don't have to be as concerned with elevated liver toxicity (as with the SR).

    Also a major concern with OTC versions of Niacin is that they're not regulated by the FDA, therefore you could be getting different variations of Niacin with each new pill/bottle.  

    With Niaspan, which I have taken for about a year now, it's the only form of Niacin ER and is actually indication (by the FDA) to promote regression of plaque buildup in the arteries as well as significantly raise your HDL (good cholesterol, or as my doctor refers to it: "happy" cholesterol). Being a patient with a bad family history of stroke and heart attack, I would much rather be on something approved by the FDA and have a little (or even a lot when I first started) flushing. Think of the flushing as your arteries expanding aka you know it's working. I much prefer this over risking a heart attack or some other serious condition - physically, emotionally and financially.

    The way I take it really helped manage the flushing - I always take an aspirin 30 minutes prior and as soon as I hop in bed, I take the Niaspan. That way, if I do experience any flushing I can hopefully just sleep through it. It's also important to remember that the flushing is not a permanent side-effect, it does go away (mine took about a month).

    Happy Flushing!!

  • Anonymous

    11/1/2009 1:03:12 AM |

    In additon to taking the asprin and being well hydrated I reccomend eating some soluable fiber 30 min. before you dose and do not eat foods high in fat.  Niaspan is fat soluable and will disperse more rapidly if you have consumed a high fat content meal.  I am curious as to what dosages people are taking.  I have titrated up to 3 grams per day over six months.

  • Jennifer Lynn

    11/18/2009 11:00:18 PM |

    There are studies on No-Flush niacin.

  • buy jeans

    11/3/2010 2:55:38 PM |

    When she came back to the office some weeks later to review her treatment program, she told me that chest pains had returned. On questioning her about what she had changed specifically, the problem became clear: She'd been taking no-flush niacin, rather than the Slo-Niacin I had recommended.

  • Anonymous

    4/25/2011 4:01:26 AM |

    Doctor Ross:  I & I'm sure there are others too who are dismayed @ the disparity of opinions on 'no-flush' niacin -  This has been used for over thirty-five years in Europe, is there no record of results available there?
    & if no-flush kills, then why is it not banned? Confused as all get out!

  • Patricia Donovan

    10/26/2011 10:19:57 PM |

    Great article.

    I strongly agree with your stance that no-flush niacin is a big scam.
    It is also very logical why 'normal' niacin is that much better than the flush free version:
    When you take in 'normal' niacin, your veins will widen a little,
    enabling all the benefits associated with niacin flushing.
    However, none of this is possible with flush-free niacin.

    My source of this information is http://www.niacinflushsolutions.com

    I also really recommend this website to all people curious about the other benefits
    of niacin flushing.

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