Who cares if you're pre-diabetic?

Marta is a smart lady. She's worked in hospital laboratories for the last 23 years and knows many of the ins and outs of lab tests and their implications.

After years of being told that her cholesterol was acceptable, she needed to undergo urgent bypass surgery after experiencing severe breathlessness that proved to be a small warning heart attack at age 57. But this made Marta skeptical of relying on cholesterol to identify heart disease risk.

I met Marta two years after her bypass surgery when she was seeking better answers. And, indeed, she proved to have several concealed sources of heart disease: small LDL particles, Lipoprotein(a), intermediate-density lipoprotein (IDL--a very important abnormality that means she is unable to clear dietary fats from her blood), among others. But she was also mildly diabetic with a blood sugar of 131 mg (normal < or = 100 mg). This had not been previously recognized.

As I'm a cardiologist and our program focuses on reversal and control of coronary plaque, I asked Marta to return to her primary care doctor to continue the conversation about diabetes. She was a bit frightened but followed through.

"Well, you're not urinating excessively. And your long-term measure of blood sugar, hemoglobin A1C, is still normal. I wouldn't worry about it. We'll just watch it."

I guess I should know better. What the poor primary care doctor doesn't know is that pre-diabetes and mild diabetes are potent risks for heart disease. In fact, some of the most explosive rates of plaque growth occur when these patterns are present. It's well established that risk for heart attack in a diabetic is the same as that of someone who's already suffered a prior heart attack--very high risk, in other words.

Marta's primary care doctor's advice would be like inquiring about cancer and the doctor says "Let's just wait until it's metastatic--then we'll start to worry." Of course, this is insane.

Pre-diabetes and mild diabetes should not be ignored or just "watched". Even though the blood sugar itself may not be high enough to endanger you, the hidden patterns underlying your body's unresponsiveness to insulin creates a torrent of hidden coronary risk.

For better answers, Track Your Plaque members can read "Shutting Off Metabolic Syndrome" at http://www.cureality.com/library/fl_dp001metabolic.asp on the www.cureality.com website. ("Metabolic syndrome" is the name commonly given to the constellation of abnormalities associated with pre-diabetes and diabetes.)
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Is direct-to-consumer drug marketing a failure?

Is direct-to-consumer drug marketing a failure?

According to the poll just completed by 80 participants on The Heart Scan Blog, 50% of respondents said they were less likely to take a drug after viewing an advertisement for it. A whopping 3 (4%) said that they would be more likely to take the drug after viewing an advertisement.

I find that interesting. If half the people responding are less likely to become customers of a drug company, then how does the drug industry justify running around-the-clock, every-few-minute ads? Spending by the drug industry for direct-to-consumer (DTC) advertising has ballooned over the past few years, and is now well over $30 billion dollars per year.

Unfortunately, despite the views of the highly-educated, curious, think-for-yourself, health information-seeking sorts of people who read this blog, drug companies still come out on top by DTC advertising. Estimates vary, with a 2006 U.S. Government Accountability Office study reporting that, for every $1 DTC advertising, sales are increased by $2.20. A 2000 Harvard study showed a higher return of $4.40 for every advertising dollar spent.

I'm sure the drug companies themselves have a very tight accounting handle on their own set of figures. We may not be terribly fond of these people and their often suspect tactics, but they're not stupid. They are certainly not stupid when it comes to making money.

Interestingly, 80% of the funds spent on DTC advertising focus on the 20 or so most popular drugs, all of which are used for treatment of chronic conditions like high cholesterol and high blood pressure, markets that are large and long-term. It pays very little to advertise drugs that may serve small markets for a short period. The implicit message is that this is not at all about informing the public. It is about advertising to grow revenues and profits--pure and simple.

It makes me wonder what the results of our poll would have been had we conducted it in 2000 before many people hadn't yet been brought to the brink of vomiting from the endless onslaught of commercial after commercial, complete with smarmy spokespeople (a la Lipitor's Dr. Robert Jarvik). What will it show in two years? Will the broader public join the more informed people who read this blog and become increasingly inured to the hard sell tactics?

For further discussion of this topic, click here for a reprint of an August, 2007 New England Journal of Medicine study, A Decade of Direct-to-Consumer Advertising of Prescription Drugs provides background, along with commentary on the impact of DTC drug marketing since the FDA allowed it 10 years ago. (Because it is a study and not an editorial, the editors fall short of making any recommendations for improvement or calling for a moratorium.)


Copyright 2008 William Davis, MD

Comments (4) -

  • shreela

    4/23/2008 9:22:00 PM |

    I usually try to avoid taking a drug that hasn't been on the market for 5 years. One exception was when my knee doctor HIGHLY recommended Celebrex. It worked great at first, but the effectiveness wore off after a while, so I stopped taking it, and just took iced my knee when it swelled, and took ibuprofen if the ice wasn't enough. I also discovered later that biking brought down the swelling.

    Looking back on that, although I'm glad he gave me Celebrex instead of Vioxx (shudders), I'm glad I only took the Celebrex for a little while. Even though their commercial brag that they're the only prescription anti-inflammatory that hasn't been taken off the market, I recall reading about some severe side-effects I'd rather not have.

    If there's a natural way to decrease any ailment, I'd much rather try that, instead of taking a new drug, as long as there's studies that back up the natural treatment/diet. That's why I'm so grateful for your blog, and others like it from licensed health professionals; you and the others provide balance between the old school AMA way, and the 'alternative' methods that sometimes are a bit out there.

  • Anonymous

    4/24/2008 10:31:00 AM |

    It's all about supply and demand really. Make people believe they need it and they will want it. Marketing trumps truth a lot fortunately.

    But then there's those of us who realise that if a company's trying too hard to push something, they're trying to sell us off yogurt with a fragrance in it.

  • ethyl d

    4/24/2008 4:48:00 PM |

    Most Americans are not "highly-educated, curious, think-for-yourself, health information-seeking sorts of people," and many of them prefer taking a pill to control a health condition rather than changing what they eat and how they live, so the drug ads probably are influential. I also suspect that the bombardment of all those ads makes people more likely to worry about having or someday getting the diseases the drugs supposedly help with, and instilling the belief that prescription drugs are the best or even the only way to alleviate or cure the condition. "Don't worry, American public, if you get sick, we've got a pill to make you all better."

  • Anne

    4/26/2008 1:17:00 PM |

    I probably would have answered "more likely" 6 years ago before I got on the internet and met some very smart people. It was with their help I discovered that lifestyle changes, not more prescription medication, would do more to optimize my health. This is an ongoing journey. I am still learning.

    Sadly, I have found most people I meet are more interested in the newest drug for their symptoms than in changing lifestyle.

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