Why haven't you heard about lipoprotein(a)?

1. July 2010 William Davis (26)
Lipoprotein(a), or Lp(a), is the combined product of a low-density lipoprotein (LDL) particle joined with the liver-produced protein, apoprotein(a).

Apoprotein(a)'s characteristics are genetically-determined: If your Mom gave the gene to you, you will have the same type of apoprotein(a) as she did. You will also share her risk for heart disease and stroke.

When apoprotein(a) joins with LDL, the combined Lp(a) particle is among the most aggressive known causes for coronary and carotid plaque. If apoprotein(a) joins with a small LDL, the Lp(a) particle that results is especially aggressive. This is the pattern I see, for instance, in people who have heart attacks or have high heart scan scores in their 40s or 50s.

Lp(a) is not rare. Estimates of incidence vary from population to population. In the population I see, who often come to me because they have positive heart scan scores or existing coronary disease (in other words, a "skewed" or "selected" population), approximately 30% express substantial blood levels of Lp(a).

Then why haven't you heard about Lp(a)? If it is an aggressive, perhaps the MOST aggressive known cause for heart disease and stroke, why isn't Lp(a)featured in news reports, Oprah, or The Health Channel?

Easy: Because the treatments are nutritional and inexpensive.

The expression of Lp(a), despite being a genetically-programmed characteristic, can be modified; it can be reduced. In fact, of the five people who have reduced their coronary calcium (heart scan) score the most in the Track Your Plaque program, four have Lp(a). While sometimes difficult to gain control over, people with Lp(a) represent some of the biggest success stories in the Track Your Plaque program.

Treatments for Lp(a) include (in order of my current preference):

1) High-dose fish oil--We currently use 6000 mg EPA + DHA per day
2) Niacin
3) DHEA
4) Thyroid normalization--especially T3

Hormonal strategies beyond DHEA can exert a small Lp(a)-reducing effect: testosterone for men, estrogens (human, no horse!) for women.

In other words, there is no high-ticket pharmaceutical treatment for Lp(a). All the treatments are either nutritional, like high-dose fish oil, or low-cost generic drugs, like liothyronine (T3) or Armour thyroid.

That is the sad state of affairs in healthcare today: If there is no money to be made by the pharmaceutical industry, then there are no sexy sales representatives to promote a new drug to the gullible practicing physician. Because most education for physicians is provided by the drug industry today, no drug marketing means no awareness of this aggressive cause for heart disease and stroke called Lp(a). (When a drug manufacturer finally releases a prescription agent effective for reducing Lp(a), such as eprotirome, then you'll see TV ads, magazine stories, and TV talk show discussions about the importance of Lp(a). That's how the world works.)

Now you know better.

How to have a heart attack in 10 easy steps

29. June 2010 William Davis (48)
If you would like to plan a heart attack in your future, here are some easy-to-follow steps to get you there in just a few short months or years:


1) Follow a low-fat diet.

2) Replace fat calories with "healthy whole grains" like whole wheat bread.

3) Eat "heart healthy" foods like heart healthy yogurt and breakfast cereals from the grocery store.

4) Use cholesterol-reducing plant sterols.

5) Take a multivitamin to obtain all the "necessary" nutrients.

6) Take the advice of your doctor who declares your heart "in great shape" based on your cholesterol values.

7) Take the advice of your cardiologist who declares your heart "like that of a 30-year old" based on a stress test.

8) Take a statin drug to reduce LDL and c-reactive protein while maintaining your low-fat diet.

9) Neglect sun exposure and vitamin D restoration.

10) Limit your salt intake while not supplementing iodine.



There you have it: An easy, 10-step process to do your part to help your local hospital add on its next $40 million heart care center.

If you would instead like to prevent a heart attack in your future, then you should consider not doing any of the above.

Kick inflammation in the butt

25. June 2010 William Davis (0)
C-reactive protein, or CRP, is a protein produced by the liver in response to inflammatory signals its receives. Thus, CRP has emerged as a popular measure to gauge the underlying inflammatory status of your body. Higher CRP levels (e.g., 3.0 mg/L or greater) are associated with increased risk of heart attack and other cardiovascular events.

The drug cartel have jumped on this with the assistance of Harvard cardiologist, Dr. Paul Ridker. Most physicians now regard increased CRP as a mandate to institute statin therapy, preferably at high doses based on such studies as The JUPITER Trial, in which rosuvastatin (Crestor), 20 mg per day, reduced CRP 37%.

I see this differently. Two strategies drop CRP dramatically, nearly to zero with rare exception: Vitamin D restoration and wheat elimination. Not 37%, but something close to 100%.

Yes, I know it sounds wacky. But it works almost without fail, provided the rest of your life is conducted in reasonably healthy fashion, i.e., you don't live on Coca Cola, weigh 80 lbs over ideal weight, and smoke.

How can something so easily reduced like CRP mean you "need" medication? Easy: Increased CRP means there are fundamental deficiencies and/or inflammation provoking foods in your diet. Correct neither and there is an apparent benefit to taking a statin drug.

Why not just correct the underlying causes?

Life without Lipitor

25. June 2010 William Davis (17)
One of the most common reasons people come to my office is to correct high cholesterol values without Lipitor. (Substitute "Lipitor" with Crestor, simvastatin, Vytorin, or any of the other cholesterol drugs; it's much the same.)

In the world of conventional healthcare, in which you are instructed to follow a diet that increases risk for heart disease and not advised to correct nutrient deficiencies like vitamin D and omega-3 fatty acids, then a drug like Lipitor may indeed provide benefit.

But when you are provided genuinely effective information on diet, along with correction of nutrient deficiencies, then the "need" and apparent benefits of Lipitor largely dissolve. While there are occasional genetic anomalies that can improve with use of Lipitor and other statins, many, perhaps most, people taking these drugs really would not have to if they were just provided the right information.

Anyone following the discussions on these pages knows that wheat elimination is probably one of the most powerful overall health strategies available. Wheat elimination reduces real measured LDL quite dramatically. Provided you limit other carbohydrates, such as those from fruits, as well, LDL can drop like a stone. That's not what your doctor tells you. This approach works because elimination of wheat and limiting other carbohydrates reduces small LDL. Small LDL particles are triggered by carbohydrates, especially wheat; reducing carbohydrates reduces small LDL. Conventional LDL of the sort obtained in your doctor's office will not show this, since it is a calculated value that appears to increase with reduced carbohydrates, a misleading result.

Throw vitamin D normalization and iodine + thyroid normalization into the mix (both are exceptionally common), and you have two additional potent means to reduce (measured) LDL. Not restricting fat but increasing healthy fat intake, such as the fats in lots of raw nuts, olive oil, and flaxseed oil reduce LDL.

While I still prescribe statins now and then, a growing number of people are succeeding without them.

(Note that by "measured" LDL I am referring to the "gold standard," LDL particle number by NMR provided by Liposcience. A second best is measured Apoprotein B available through most conventional labs.)

In search of wheat: Emmer

23. June 2010 William Davis (13)
While einkorn is a 14-chromosome ancient wheat (containing the so-called "A" genome), emmer is a 28-chromosome wheat (containing the "A" and "B" genomes, the "B" likely contributed by goat grass 9000 years ago).

Both einkorn and emmer originally grew wild in the Fertile Crescent, allowing Neolithic Natufians to harvest the wild grasses with stone sickles and grind the seeds into porridge.

Having tested einkorn with only a modest rise in blood sugar but without the gastrointestinal or neurological effects I experienced with conventional whole wheat bread, I next tested bread made with emmer grain.

The emmer grain was ground just like the other two grains, cardiac dietitian Margaret Pfeiffer doing all the work of grinding and baking. Margaret added nothing but water, yeast, and a little salt. The emmer rose a little more than einkorn, but not to the degree of conventional whole wheat.

I tested my blood sugar beforehand: 89 mg/dl. I then ate 4 oz of the emmer bread. It tasted very similar to conventional whole wheat, but not as nutty as einkorn. Also not as heavy as einkorn, only slightly heavier than conventional whole wheat.

One hour later, blood sugar: 147 mg/dl. I felt slightly queasy for about 2-3 hours, but that was the end of it. No abdominal cramps, no sleep disturbance or crazy dreams, no nausea, no change in ability to concentrate.

I asked four other wheat-sensitive people to try the emmer bread. Likewise, nobody reacted negatively (though nobody tested blood sugar).

So it seems to me, based on this small, unscientific experience, that ancient einkorn (A) and emmer (AB) wheat seem to act like carbohydrates, similar to, say, rice or quinoa, but lack many of the other adverse effects induced by conventional wheat.

Modern wheat , Triticum aestivum, contains variations on the "A," "B," and "D" genomes, the "D" contributed by hybridization with Triticum tauschii at about the same time that emmer wheat hybridization occurred. It is likely that proteins coded by the "D" genome are the source of most of the problems with wheat products: immune, neurologic, gastrointestinal destruction, airway inflammation (asthma), increase in appetite, etc. This is consistent with observations made in studies that attempt to pinpoint the gliadin proteins that trigger celiac, the area in which much of this research originates.

If I ever would like an indulgence of cookies or cupcakes, I think that I will order some more einkorn grain from Eli Rogosa.

In search of wheat: Another einkorn experience

23. June 2010 William Davis (6)
Lisa is a trained dietitian. Unlike many of her colleagues, she has "seen the light" and realized that the conventional advice that most dietitians are forced to dispense through hospitals, clinics, and other facilities is just plain wrong. 

I know Lisa personally and we've had some great conversations on diet and nutritional supplements. I told Lisa about my einkorn experience and how I witnessed a dramatic difference between bread made from einkorn wheat and that made from conventional whole wheat. So she decided to give it a try herself. 

Here's Lisa's experience:


This past Friday, June 18th, I conducted my "Einkorn Wheat Experiment".

7 am 
FBG [fasting blood glucose] 97 mg/dl

8 am-9 am 
1 hour high-intensity aerobic workout

10:05 am 
BG 99

10:05 am 
I embarked upon the journey of choking down, I mean enjoying, the hefty piece of Einkorn bread. Wow, was that bread dense!  It was a lot of work chewing. 

10:50 am 
(45 minutes after consumption, wanted to see what BG did a bit before the 1 hr mark)  BG 153

11:05 am 
1hr PP 120

11:35 am 
90 mins PP [postprandial] 113

12:05 pm 
2 hours PP  114 ... at this time I ate an egg & veggie omelet for lunch.

12:50 pm 
BG 100

Before dinner 5:10 pm 
BG 88

I was surprised with the BG of 153. However, it was good to see my insulin response is reactive and decreased BG 33 points in 15 minutes to end up with a BG of 120 1 hr after the bread.  

So, it appears my response is similar. A slight elevation of BG at the 1 hour mark, but not to the degree of conventional whole grain wheat bread.  

Of note, also, was the fact that I cannot remember the last time I ate a piece of wheat bread of this magnitude that did not make me bloated... not at all: No cramps, no brain fog, no headache and, did I mention not bloated?  

I believe you are on to something with tolerance of Einkorn wheat for those of us with wheat sensitivities, in addition to its apparent lower glycemic response.

Along with Lisa, I asked four other people with various acute intolerances (all gastrointestinal) to conventional wheat, i.e., people who experience undesirable effects from wheat within minutes to several hours, to eat the einkorn bread. None experienced their usual reactions.

Obviously, this does not constitute a clinical trial. Nonetheless, I find this a compelling observation: People like myself who generally experience distinct undesirable reactions to wheat did not experience these reactions with einkorn.

Note, however, that einkorn behaves like a carbohydrate. No different, say, from brown rice or quinoa. However, unlike modern whole wheat flour from Triticum aestivum,  in this little experience there were no immune reactions, no neurologic phenomena, no gastrointestinal distress--just the blood sugar consequences.

While this may not be true for all people consuming einkorn, it suggests that primordial einkorn wheat is quite different from modern conventional wheat for most people.

Increased blood calcium and vitamin D

21. June 2010 William Davis (50)
Conventional advice tells us to supplement calcium, 1200 mg per day, to preserve bone health and reduce blood pressure.

Here's a curious observation I've now witnessed a number of times: Some people who supplement this dose of calcium while also supplementing vitamin D sufficient to increase 25-hydroxy vitamin D blood levels to 60-70 ng/ml develop abnormally high levels of blood calcium, hypercalcemia.

This makes sense when you realize that intestinal absorption of calcium doubles or quadruples when vitamin D approaches desirable levels. Full restoration of vitamin D therefore causes a large quantity of calcium to be absorbed, more than you may need. In addition, two studies from New Zealand suggest that 1200-1300 mg calcium with vitamin D per day doubles heart attack risk.

We have 20 years of clinical studies demonstrating the very small benefits of supplementing calcium to stop or slow the deterioration of bone density (osteopenia, osteoporosis). These studies were performed with no vitamin D or with trivial doses, too small to make a difference. I believe those data have been made irrelevant in the modern age in which we "normalize" vitamin D.

Should hypercalcemia develop, it is not good for you. Over long periods of time, abnormal calcium deposition can occur, leading to kidney stones, atherosclerosis, and arthritis.

Until we have clarification on this issue, I have been advising patients to take no more than 600 mg calcium supplements per day. I suspect, however, that the vast majority of us require no calcium at all, provided an overall healthy diet is followed, especially one that does not leach out bone calcium. This means no foods like those made with wheat or containing powerful acids, such as those in carbonated drinks.

Heart health consultation with Dr. Joe D. Goldstrich

20. June 2010 William Davis (3)
Cardiologist, nutritionist, and lipidologist, Dr. Joe D. Goldstrich, is a frequent contributor to the Track Your Plaque Forum, where we discuss the full range of issues relevant to coronary health and coronary plaque reversal.

I have come to value Dr. Goldstrich's unique insights, especially in nutrition. Formerly National Director of Education and Community Programs for the American Heart Association and a physician at the Pritikin Center, his dietary philosophy has evolved away from low-fat and towards a low-carbohydrate focus, much as we use in Track Your Plaque. Like TYP, Dr. Goldstrich is always searching for better answers to gain control over coronary health. His unique blend of ideas and background has helped us craft new ideas and strategies. Dr. Goldstrich has proven especially adept at understanding how to incorporate new findings from clinical studies in our framework of coronary atherosclerotic plaque management strategies.

Dr. Goldstrich is offering to share his expertise with our online community. If you would like a one-on-one phone consultation with Dr. Goldstrich, you can arrange to speak with him at his HealthyHeartConsultant.com website.

Wheat aftermath

16. June 2010 William Davis (18)
Following my 4 oz whole wheat misadventure that yielded the sky-high blood sugar of 167 mg/dl, compared to einkorn wheat's 110 mg/dl, I suffered through a 36-hour period of misery.

After I obtained the blood sugar of 167 mg/dl, I biked hard for one hour. This yielded a blood sugar back down in the 80s. I felt spacey in the ensuing few hours, as well as a little queasy. However, about 12 hours later, I awoke with overwhelming nausea along with that hypersalivating thing that happens just prior to vomiting. It did not come to that, but persisted all through the following day.

The next morning, I could barely concentrate. Trying to read a study (admittedly on the complex topic of agricultural genetics), I had to read each paragraph 4 or 5 times. Abdominal cramps and a bloated feeling also developed, though I was able to eat.

The 2nd night was filled with incredibly vivid dreams and intermittent sleeplessless. I awoke about 5 times through the night, but periods of sleep were filled with detailed, colorful dreams. I dreamt that a large corporation was secretly trying to gain control over the world's water supply, and I snuck onto a complex underwater vessel that was exploring and mapping the coastline of the Great Lakes in preparation. Weird.

I recognized these odd feelings as various facets of wheat intolerance, since they were all reminiscent of feelings I used to experience before I removed wheat from my diet. They were amplified and compressed, likely because I had been wheat-free for so long.

The odd thing is that, despite the modest blood sugar effect of my einkorn experience, none of the gastrointestinal or neurologic effects of wheat developed. So far, two other people with acute gastrointestinal wheat sensitivities have consumed our einkorn bread, also without reproduction of their usual symptoms.

Einkorn contains gluten, though the structure of the many gluten proteins of einkorn differs from that of the wheat bread I consumed, an example of modern Triticum aestivum. 14-chromosome einkorn carries what biologists call the "A" genome, while Triticum aestivum has the combines genomes of 3 plants, the combination of the A, B, and D genomes. It is the D genome that contains the genes coding for the most obnoxious, immunogenic forms of gluten.

So einkorn may not be entirely benign, but it is a good deal less obnoxious than modern Triticum aestivum.

I am awaiting the reports from a few other people on their experiences.

In search of wheat: Einkorn and blood sugar

14. June 2010 William Davis (32)
There are three basic aspects of wheat's adverse health effects: immune activation (e.g., celiac disease), neurologic implications (e.g., schizophrenia and ADHD), and blood sugar effects.

Among the questions I'd like answered is whether ancient wheat, such as the einkorn grain I obtained from Eli Rogosa, triggers blood sugar like modern wheat.

So I conducted a simple experiment on myself. On an empty stomach, I ate 4 oz of einkorn bread. On another occasion I ate 4 oz of bread that dietitian, Margaret Pfeiffer, made with whole wheat flour bought at the grocery store. Both flours were finely ground and nothing was added beyond water, yeast, olive oil, and a touch of salt.

Here's what happened:

Einkorn wheat bread:

Blood sugar pre: 84 mg/dl
Blood sugar 1-hour post: 110 mg/dl

Conventional wheat bread
Blood sugar pre: 84 mg/dl
Blood sugar 1-hour post: 167 mg/dl

The difference shocked me. I expected a difference between the two, but not that much.

After the conventional wheat, I also felt weird: a little queasy, some acid in the back of my throat, a little spacey. I biked for an hour solid to reduce my blood sugar back to its starting level.

I'm awaiting the experiences of others, but I'm tantalized by the possibility that, while einkorn is still a source of carbohydrates, perhaps it is one of an entirely different variety than modern Triticum aestivum wheat. The striking difference in blood sugar effects make me wonder if einkorn eaten in small quantities can keep us below the Advanced Glycation End-Product threshold.
 
This is your brain on wheat

This is your brain on wheat

10. December 2009 William Davis (32)
Here's just a smattering of the studies performed over the past 30 years on the psychological effects of wheat consumption.

Oddly, this never makes the popular press. But wheat underlies schizophrenia, bipolar illness, behavioral outbursts in autism, Huntington's disease, and attention deficit hyperactivity disorder (ADHD).

The relationship is especially compelling with schizophrenia:

Opioid peptides derived from food proteins: The exorphins.
Zioudrou C et al 1979
"Wheat gluten has been implicated by Dohan and his colleagues in the etiology of schizophrenia and supporting evidence has been provided by others. Our experiments provide a plausible biochemical mechanism for such a role, in the demonstration of the conversion of gluten into peptides with potential central nerovus system actions."


Wheat gluten as a pathogenic factor in schizophrenia
Singh MM et al 1976
"Schizophrenics maintained on a cereal grain-free and milk-free diet and receiving optimal treatment with neuropleptics showed an interruption or reversal of their therapeutic progress during a period of "blind" wheat gluten challenge. The exacerbation of the disease process was not due to variations in neuroleptic doses. After termination of the gluten challenge, the course of improvement was reinstated. The observed effects seemed to be due to a primary schizophrenia-promoting effect of wheat gluten."


Demonstration of high opioid-like activity in isolated peptides from wheat gluten hydrolysates
Huebner FR et al 1984


Is schizophrenia rare if grain is rare?
Dohan FC et al 1984
"Epidemiologic studies demonstrated a strong, dose-dependent relationship between grain intake and the occurrence of schizophrenia."
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Comments (32) -

  • Mike

    12/9/2009 11:27:37 PM |

    Dr. Davis,

       Excellent post!  It's quite apparent the auto-immune stimulating qualities of WGA are behind a plethora of chronic diseases.

    Regarding both cardiovascular disease and obesity, though, is it a similar mechanism, strictly related to inflammation, or a combination of autoimmunity AND inflammation?  I'm often asked why wheat is "worse" than other forms of dense carbohydrates, but I'm at a loss for a simplistic explanation.

  • Charles R.

    12/10/2009 12:24:59 AM |

    You don't have to convince me.

    A number of years ago, I realized wheat was causing me problems, mostly at that time energy problems. If I ate a breakfast with toast, I would get tired almost immediately after. It was probably carbs in general, but I just stopped eating all wheat.

    About 5-6 months after that, I came home, saw a box of saltines on the counter, and devoured them. Within an half-hour, I was going through an incredible depressive episode to the point of having suicidal thoughts. It was like someone had turned on a crazy switch in my brain.

    Totally anecdotal of course, but I tried the same thing a couple of other times and really noticed immediate changes in my ideation and feelings, so got the message and stopped wheat altogether.

  • Michael

    12/10/2009 1:55:00 AM |

    I use wheat grass tablets from Pines.  Is wheat grass harmful like wheat?  I assume the answer is no because there is no gluten in wheat grass.  Am I correct?

  • Kennedy

    12/10/2009 2:31:57 PM |

    Very scary.

  • Anonymous

    12/10/2009 4:11:37 PM |

    How interesting! Thank you for sharing this.

  • Zach

    12/10/2009 4:59:49 PM |

    Dr. Davis,
    I hope you take this as a compliment!  I follow your blog regularly.  Thanks for all of the great info and wisdom that you've shared over the last year with me since I've been an avid reader of your site.

    I also follow Jimmy Moore's site, and saw your picture/name as a participant for an upcoming Low Carb/Fitness Cruise.  I was struck by how your face has really leaned out and is much more muscular/healthy looking.  The picture you currently have on your blog looks good!  I was just wondering whether since your blog picture was taken whether you've leaned out since really bearing down and following a gluten-free diet especially over the last 12+ months?

    Wish I could join you on this cruise, maybe next time.  Thanks again for being at the front of the "normal carb" revolution.

    Best Regards,
    Zach (over at The Paleo Garden)

  • Drs. Cynthia and David

    12/11/2009 12:48:52 AM |

    Here is another report for your list (from Eric Westman at Duke): "Schizophrenia, gluten, and low-carbohydrate, ketogenic diets: a case report and review of the literature" http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652467/?tool=pubmed

    They report the resolution of long standing schizophrenia using a ketogenic diet.

  • Anne

    12/11/2009 4:21:13 AM |

    My brain on wheat(gluten) was fogged and depressed. In fact, I did not know how depressed I was until I stopped eating gluten. I never knew I could feel so good.

    It is well established that gluten can cause seizures and other neurological problems. You can read articles and abstracts about the neurological effects of gluten in The Gluten File http://jccglutenfree.googlepages.com/theneurologicalmanifestationsofgluten

    What does this have to do with my heart? Well, my pitting edema and shortness of breath disappeared when I stopped eating wheat.

  • Michael

    12/11/2009 4:35:39 AM |

    I take wheat grass tablets by Pines.  Is wheat grass harmful like wheat?

  • Adam

    12/11/2009 6:44:24 AM |

    I've been on a no wheat diet for over a month now. Unfortunately, I can't say I've felt anything in the way of mental benefits. Or any benefits at all really.

    But then, I'm pretty healthy overall. I exercise at least an hour a day, and I'm relatively young.

    I must conclude that abstaining from wheat is either most beneficial to the unhealthy/elderly, or is a bunch of a hooey Smile

  • Tim

    12/11/2009 12:06:50 PM |

    Do you have more information on wheat and Huntington's Disease? Has anyone been able to prevent this disease by eliminating wheat from the diet? What evidence is there?

    Thanks

  • Dr. William Davis

    12/11/2009 12:52:47 PM |

    Wheat grass and breads like Ezekiel, to my knowledge, have no gluten. This makes them less harmful, though the bread still poses carbohydrate challenge issues.

  • Dr. William Davis

    12/11/2009 12:53:58 PM |

    Tim--

    Dr. Loren Cordain of The Paleo Diet has talked about the relationship of wheat and Huntington's recently in his latest newsletter. He sums up the literature very nicely.

  • Nigel Kinbrum BSc(Hons)Eng

    12/11/2009 6:42:49 PM |

    According to Cereal Grains:
    Humanity’s Double-Edged Sword,     gluten can cause C(o)eliac Disease, Dermatitis Herpetiformis, Sjogren's Syndrome and Cerebellar Ataxia.

    My ex-G/F used to get intensely itchy spots on her skin and she also had dry eyes. When she went gluten-free on my suggestion, the itchy spots disappeared and her eyes got a little less dry, but she still has to use artificial tears. She also commented that her belly was less bloated since going gluten-free. Result!

    A lady I know has a son with Xeroderma Pigmentosum and Cerebellar Ataxia. When she put her son on a gluten-free diet after reading the above article that I'd e-mailed her a link to, he improved dramatically and began doing things that his mum thought he would never be able to do, as he was previously deteriorating. Result!

  • Aileen

    12/11/2009 11:15:55 PM |

    I think this is a bit extremist. Whilst those effects do exist in some people, along with problems with other food groups such as Solanaceae they are not ubiquitous by any means.  There are lots of people out there who can eat anything including wheat, dairy and other food groups with gay abandon and suffer NO adverse effects. Opioid peptides are also acknowledged as occurring in other foods such as eggs and OATS and when you think about it the potential is there for them to come out of ANY protein since all proteins are broken down into peptides for digestion.

    So, whilst people do need to be aware that they can have intolerances to a wide range of foods for various reasons I think making blanket statements such as this that may compel people to exclude large numbers of food products from their diet for perhaps no good reason, is dangerous and irresponsible.

    Anyone suspecting problems with food groups should see an allergist and go through the process of a proper food elimination diet.

    I do also appreciate that food intolerances can come and go for a range of reasons.

  • Anne

    12/11/2009 11:31:23 PM |

    Food for Life makes Ezekiel bread and it is not the list of gluten free products. http://www.foodforlife.com/our-products.html

    Other breads that people often ask about are Sami's and Delands. Although they contain no gluten grains, when tested they showed high amounts of gluten.

    So if you have celiac disease or gluten sensitivity, you need to avoid these products.

    Wheat grass would be gluten free as long as there are no seeds.

  • Dr. William Davis

    12/12/2009 12:04:02 AM |

    Hi, Zach--

    Started thyroid replacement when my T3 went real low. I think that did it.

    Thanks for noticing.

  • Dr. William Davis

    12/12/2009 12:06:12 AM |

    Sorry, Aileen. All proteins do not break down into the same polypeptides, since there are numerous and varying sequences of amino acids that differ, say, between oats, wheat, beef, nuts, etc.

    So a polypeptide is not always the same polypeptide. Referring to a basic biochemistry text would show this quite clearly.

    If you think you've escaped the ill-effects of this ubiquitous, more often than not you're wrong. You just haven't realized it yet.

  • JPB

    12/12/2009 2:09:30 AM |

    Now you should write a post on the effects of wheat plus statins....

  • Aileen

    12/12/2009 6:37:26 AM |

    I do know my biochemistry thanks!  I didn't say all proteins break down into the same peptides. Also having been through a proper elimination diet in te past I can say with certainty that gluten/wheat/dairy give me no ill effects.

    As with all things in life everyone is different, different populations of receptors in the brain hence different sensitivities and responses.  You can't blanket say gluten (or anything else) is bad for you.

    And as with many other things in life - often you don't find stuff out till you look for it.  How many studies on red wine are quoted and its only now they are beginning to look at white wine and find many of the same effects!

  • Anonymous

    12/13/2009 9:05:50 PM |

    Aileen, YOU GO GIRL!  Dr D., you were a bit quick on the put down.

    I like that Dr Davis is passionate about CAD risk reduction but I frequently post here when I see generalizations based on limited or cherry picked studies. That is the sort of thing, oh I don't know, big pharma would do.

    We don't all have to live like Inuit, there are plenty of vegetarians that are healthy and have no ill effects from eating wheat gluten every day. Or does someone have a study to say all vegetarians are lethargic and overweight?

    Trevor

  • Anonymous

    12/15/2009 12:40:28 AM |

    Hi there,

    Just wondering if you are a member of THINCS (http://www.thincs.org/) run by Dr.Uffe Ravnskov,

  • Anonymous

    1/30/2010 4:27:51 PM |

    Aileen,

    Yes of course not all will get mental illnesses from gluten and a big proportion will not get immediate reaction to gluten. However, it has been shown that it can cause schizophrenia in a small part of the population. Around 30% of normal healthy people produce antibodies to gluten that can be measured in the stool. There are even reports of disappearance of schizophrenia, all sorts of unexplained fatigue and other mental illnesses. There is a strong correlation between gluten consumption and schizophrenia as well.

    Now, cannabis has been shows to cause schizophrenia and other mental problems too. Not all will get it and a lot of people can live reasonable lives with it. Would you say cannabis is bad and causes mental illnesses, when similar to gluten it causes various mental problems in a significant proportion of the population? The difference between them is that cannabis has immediate psychoactive properties in almost everyone, so people have no problem believing it's problematic. Gluten does contain exorphins, which do have opioid-like activities. Also the immunogenic factor causing gut malfunction and nutrient malabsorption. How you will handle the opioids and what effects the antibodies and immune system activation will have on your body, no one knows.

    Even if you don't get immediate reactions from wheat, I wouldn't bet my life on its harmfulness.

  • lib

    4/17/2010 10:03:30 AM |

    3 months ago i began to eliminate processed food and alchohol from my diet.It has been hard but i have lost 7 kilos and have been feeling great.
    Yesterday i was excessively bad ,gave in (the story of my life) and had 3 weetbix,foccacia bread,2 jam donuts.2 beers and 2 pieces of white flat bread.
    Well today i feel dreadful.This afternoon i yelled,slammed doors,verbally abused my husband went into depression and had suicidal thoughts.
    I have suffered from depression in the past but never as severe as this!
    I strongly believe it was due to the wheat consumption,so I went on to the web and typed in 'wheat and depression" and found your site.After reading a few of the blogs i thought i muat be right.Incredible.
    Well i will be avoiding wheat now as i have another reason too not just for weight loss.
    I'll introduce wheat say in another 2 months time and see if i get the same reaction.It may not be pleasant but will convince me.

  • Anonymous

    7/12/2010 7:39:24 PM |

    Hi, just found your site.  A year ago after going thru horrible female issues and tons of unexplained medical problems I met a nurse who told me to cut out wheat.  I was in the process of having biopsies because no Dr. could figure out what was wrong with me.  

    I have no cancerSmile I won't list all the things wrong with me at the time but it was bad, and I was doubting my sanity.  I've always struggled with depression. Cutting out the wheat has helped so much. Most of my health problems went away.  

    I may eat a little bit here and there, but not often. I find myself in tears soon after and the depression and body aches come back.

    It is a shame that so many Dr.'s know nothing of this or tell me it's all hype. Thank God for the internet, at least now we know we aren't crazy and the wheat problem is finally getting some attention.

  • buy jeans

    11/3/2010 9:10:14 PM |

    Oddly, this never makes the popular press. But wheat underlies schizophrenia, bipolar illness, behavioral outbursts in autism, Huntington's disease, and attention deficit hyperactivity disorder (ADHD).

  • Anonymous

    2/8/2011 6:51:25 PM |

    Aileen,

    If people limited all gluten grains to just 2 or 3% of their diet it would probably be fine.  BUT, the huge problem is that people think their cereal is healthy.  Then they think their whole wheat bread is healthy.  Then they think their pasta is healthy.  By now we are approaching 50 to 75% of their diet.  Then people serve breaded chicken nuggets to their kids.  It is literally killing people.

    Dr. Davis is a hero!  Many Drs. do not even take the time to care.

  • majkinetor

    3/9/2011 9:49:18 AM |

    Anonimous said: "Now, cannabis has been shows to cause schizophrenia and other mental problems too. Not all will get it and a lot of people can live reasonable lives with it".

    Cannabis DOES NOT cause schizophrenia, that is outdated and probably politicized research. The marijuana smoking is a symptom rather then cause of schizophrenia. Brain CB1 receptors are endogenously used by Anandamide neurotransmitter which is very low in schizophrenic people. THC is more potent version of Anandamide and thats the reason schizophrenic people use it more then regular people who already have normal levels of endogenous version. Cannabis is used as a medicine for most of the history.

  • JT

    7/11/2011 12:11:31 PM |

    Seriously?
    Crackers make you want to kill yourself?
    Your problems stretch far beyond wheat, sir.

  • stuart

    8/24/2011 3:55:54 PM |

    JT,

    Just because you don't understand the entirety of the problem, try not to belittle Charles.  Charles may have been exaggerating a bit.  Yes, the problems extend far beyond wheat because wheat infects almost all junk food, processed food, fast food, and "premium" prepared foods.  

    Maybe it is time you wise up JT.  Just go to a restaurant with a Gluten free menu.  Then compare all the offerings on that menu to the regular menu.  You guessed it JT,  EVERYTHING else has gluten.  Even the minestrone soup, coffee creamer, ice cream, etc.  Why?  Wheat is the quickest and cheapest way to "thicken" and to make products seem "rich".  

    Wheat is just another method of control.  Keeping the rich wealthy and the poor dumb and sick.

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