Does fish oil cause blood thinning?

Omega-3 fatty acids from fish oil have the capacity to "thin the blood." In reality, omega-3s exert a mild platelet-blocking effect (platelet activation and "clumping" are part of clot formation), while also inhibiting arachidonic acid formation and thromboxane.

But can fish oil cause excessive bleeding?

This question comes up frequently in the office, particularly when my colleagues see the doses of fish oil we use for cardiovascular protection. "Why so much fish oil? That's too much blood thinning!"

The most recent addition to the conversation comes from a Philadelphia experience reported in the American Journal of Cardiology:

Comparison of bleeding complications with omega-3 fatty acids + aspirin + clopidogrel--versus--aspirin + clopidogrel in patients with cardiovascular disease.(Watson et al; Am J Cardiol 2009 Oct 15;104(8):1052-4).

All 364 subjects in the study took aspirin and Plavix (a platelet-inhibiting drug), mostly for coronary disease. Mean dose aspirin = 161 mg/day; mean dose Plavix = 75 mg/day. 182 of the subjects were also taking fish oil, mean dose 3000 mg with unspecified omega-3 content.

During nearly 3 years of observation, there was no excess of bleeding events in the group taking fish oil. (In fact, the group not taking fish oil had more bleeding events, though the difference fell short of achieving statistical significance.) Thus, 3000 mg per day of fish oil appeared to exert no observable increase in risk for bleeding. This is consistent with several other studies, including that including Coumadin (warfarin), with no increased bleeding risk when fish oil is added.

Rather than causing blood thinning, I prefer to think that omega-3 fatty acids from fish oil restore protection from abnormal clotting. Taking omega-3 fatty acids from fish oil simply restores a normal level of omega-3 fatty acids in the blood sufficient to strike a healthy balance between blood "thinning" and healthy blood clotting.

Comments (20) -

  • Marc

    10/26/2009 9:46:32 PM |

    Long time reader, first comment.
    Thank you for so freely sharing all the information.

    Marc

  • Daniel

    10/26/2009 11:02:46 PM |

    Thank you for this!  I have had this question for a long time given the number of things I take that "thin the blood."

  • Kevin

    10/26/2009 11:44:45 PM |

    As a veterinarian I've dispensed fish oil capsules for several years.  Some owners give so many that the dogs smell 'fishy' when seen for routine care.  The owner doesn't smell it since they're with the dog a lot.  The coats are gorgeous, something that doesn't often happen in Wyoming at 7000ft altitude.

  • Dr. William Davis

    10/26/2009 11:47:45 PM |

    Hi, Kevin--

    My two Boston terriers jump for their fish oil capsules, two every day!

    I'm glad to hear from a veterinarian that the coat sheen is indeed from the fish oil.

  • Rich

    10/27/2009 1:27:09 AM |

    Due to an afib episode a couple of years ago, I was taking 20 mg of warfarin per day, plus around 5000 mg of EPA+DHA, and never had bleeding issues.  

    My INR was always a stable 2.0.

    As I've not had an afib reoccurrence, I've replaced the 20mg coumadin with 325mg aspirin daily, and still take around 5000 mg EPA+DHA.  No bleeding issues with that combo either.

  • Catherine

    10/27/2009 3:55:32 AM |

    Glad this topic came up.
    Over the last 5 years, I've had to periodically eliminate my fish oil intake as I would start to bruise badly. My internist said she has seen this occasionally with fish oil and called it "capillary fragility." I bruise easily anyway, but it would really get bad with fish oil. So there must be some quality in fish oil that influences this.

    Then about 6 months ago I started a strong supplement change to help with my low bone density--already taking magnesium and calcium but added:
    Boron, K2, silica,pomegrantate juice, and BIG increase in vitamin D.
    I also increased omegas to 3,000 a day which I was not able to tolerate before.

    It has been over 4 months since I have had ANY bruise---which is just unheard of for me. I usually have 3-4 different bruises on arms/legs. So something in these supplements  strengthened my capillaries I guess, and I can now take high fish oil doses!
    Anyone else had a bruising problem with fish oil?

  • Dr. William Davis

    10/27/2009 11:04:59 AM |

    Hi, Catherine--

    Fascinating observation!

    I'll bet it has something to do with the vitamin D, more than anything else. Vitamin D seems to strengthen structural tissues in bones, muscle, heart valves, and perhaps capillaries and other small blood vessels.

  • trix

    10/27/2009 11:59:37 AM |

    Several years ago I bruised easily for a while and attributed it to taking garlic supplements daily.  I started taking Vit C and the bruising stopped.  I don't think it had to do with fish oil (in my case); I don't think I was taking fish oil at the time.

  • Daniel

    10/27/2009 9:37:33 PM |

    I too achieve rapid blood thinning when taking 2400mg of EPA/DHA per day. That's only 4 pharmaceutical grade capsules. Even after my vitamin d levels were normalized I still got bruising.

    I now take Vitamin K2 (MK-7 natto extract) twice a week and it's allowed me to bump my EPA/DHA up to 3600mg with no ill effects or bruising.

    It was either supplement or eat a lot of aged cheese, they both seemed to do the trick in my particular case.

  • Healthy Oil Guy

    10/27/2009 9:53:51 PM |

    Thank you for sharing this study with us.  It helps clarify whether there is a risk for blood thinning from taking fish oils.  This information may help individuals who are taking blood thinning medications and considering adding fish oils to their daily diet.

  • Dave

    10/28/2009 2:22:01 AM |

    Catherine,

    Without a doubt, your cessation of bruising was due to vitamin k2. I routinely take nattokinase, large doses of fish oil, curcumin, and other blood thinning agents, and if I don't take vitamin K2, I will begin bruising. (I also take high doses of Vitamin D). When I take K2, I have absolutely no bruising.

    Vitamin K2 has many clinical trials showing that it helps endothelium  integrity and elasticity.

    Also, grapeseed extract and pine bark extract (specifically oligomeric proanthcyanins) has the same beneficial effect.

  • Catherine

    10/28/2009 4:41:41 PM |

    Daniel,

    That's really interesting! There is a lot of research on K2's effect on strengthening weak bones. Bone fractures go down considerably when high doses of K2 are used (Japan is using K2 as osteoporosis treatment) BUT studies show it needs to be in conjunction with adequate calcium and Vitamin D---they work synergistically for bone strength.  So it makes sense that K2 and D could do the same with strengthening fragile capillaries. I am also taking the M7 natto form.

  • Catherine

    10/29/2009 12:01:36 AM |

    Dave,

    Thanks for sharing your experience with this, you've really confirmed it now for me.  I can't believe I have suffered with this for most of my life with no answers (tried high dose Vit C, grape seed, etc) and now within months on K2, there's no bruising and I can tolerate fish oil. Hope my bones are responding this well!
    This blog is so helpful....

  • Mina

    10/29/2009 12:21:31 PM |

    Thanks for posting this. The question recently came up in our office. I like your assertion that omega-3s restore the blood to normal and remove abnormal clotting. And to comment on a post above, our dog has a beautifully shiny coat and takes 2 pure EPA capsules each day!

  • Term papers

    1/26/2010 3:40:08 PM |

    I have enjoyed reading That During nearly 3 years of observation, there was no excess of bleeding events in the group taking fish oil. (In fact, the group not taking fish oil had more bleeding events, though the difference fell short of achieving statistical significance.

  • Viagra Online

    8/23/2010 6:41:39 PM |

    I've been drinking fish oil for many year and I don't have any chance in my body people use to said me that but I think it is just a rumor.

  • buy jeans

    11/3/2010 10:19:55 PM |

    I'm also especially gratified that a woman now holds our record. I'm uncertain why, but the ladies have been shy and the men remain the dominant and vocal participants in our program. Speak up, ladies!

  • moseley2010

    12/7/2010 2:37:16 AM |

    I haven't heard of this problem
    fish oil supplements. But now we know what to tell them when this sort of concern comes up. Fish oil or Omega-3 is really beneficial to health. It's just important that it comes from clean waters.

  • Jack

    3/12/2013 7:03:38 PM |

    What is an appropriate dose of fish oil for someone taking coumadin?

  • dorange

    6/15/2014 3:53:03 PM |

    Dr. Davis, when  person is taking Tamoxifen...
    (1) is it safe to take vitamin k2 or K1?
    (2) will fish oil have a role in preventing blood clots?

Loading
Mustard: Super health food?

Mustard: Super health food?

Could mustard--yes, the yellow condiment you smear on hot dogs--be a super heart healthy food in disguise?

Consider that mustard contains:

Vinegar

Turmeric

No appreciable sugar


The vinegar slows gastric emptying, resulting in slower absorption of any carbohydrates and a reduced glucose area-under-the-curve. Of the little fats contained (about 3 grams per 1/4 cup), most are desirable monounsaturates. Mustards are relatively rich in selenium, with 20 mcg per 1/4 cup, helpful for protection against cancer and thyroid disease, and magnesium, 31 mg per 1/4 cup.

Turmeric is added to most mustards. One of the constituents of turmeric, curcumin, the substance that confers the bright yellow color, has been a focus of interest for its anti-inflammatory effects. Curcumin has been documented to reduce activity of the inflammatory enzymes cyclooxygenase-2 (COX-2), lipoxygenase, and reduce activity of inflammatory signal molecules, tumor necrosis factor-alpha (TNF-a), interleukin (IL)-1,2,6,8, and 12, and monocyte chemoattractant protein (MCP). Curcumin also has been shown to reduce LDL oxidation, a potentially important step in atherosclerotic plaque formation. Turmeric is used as a tea by Okinawans. (Hmmmm . . . )

Turmeric content of mustard can vary, of course. Likewise, sugar content. Look for mustards that are not sweetened, so avoid honey mustard in particular. Look for hot, brown, horseradish, Dijon, etc. If there is a downside to mustard, it's sodium content, though the 709 mg per 1/4 cup should only be a problem for those who are sodium-sensitive (African Americans, in particular).

So perhaps mustard isn't exactly a super health food. But it may have some bona fide health effects and should be used generously especially if you are concerned about blood sugar and inflammatory phenomena.

Comments (32) -

  • Anonymous

    3/6/2010 4:21:13 PM |

    Hmmm.... I might have to pick up some mustard next time at the health shop.  Turmeric is the only herbal extract I take.  Basically it makes me feel well.

  • Anonymous

    3/6/2010 4:23:34 PM |

    Keep in mind that almost all brands of mustard have gluten in them.  For some reason they tend to use non-distilled malt vinegar to make mustard.  All distilled vinegars are gluten free, and there are a few brands of good gluten free mustard.

  • Dexter

    3/6/2010 9:09:21 PM |

    Since reading about the benefits of cucurmin at Nephropal and the benefits of cinnamon on BG, I have started the practice every morning of melting one tbsp of coconut oil and one tbsp of butter together and then mixing in a teaspoon of
    cinnamon and a teaspoon of tumeric.

  • dave

    3/7/2010 1:22:50 AM |

    i just take 500 mg. of curcumin. I find it to raise my HDL also

  • Michaela

    3/7/2010 4:31:51 AM |

    I'm pleased to read that, I've been giving a Turmeric Curcumin supplement to my CHF sufferer for many months now.

  • Peter

    3/7/2010 10:42:06 AM |

    I've been trying to figure out why southern India (with it's rice diet) has much higher heart disease rates than northern India with it's wheat diet, and one theory that I read said that in the north they use a lot of mustard seed oil for cooking.

  • chris

    3/7/2010 12:39:49 PM |

    Most other brassica cultivars seems well loaded with good things, though i've not read much on rapeseed.

  • Anonymous

    3/7/2010 7:16:40 PM |

    As far as slowing gastric emptying, does it matter when vinegar or cinnamon is ingested?

  • Lori Miller

    3/7/2010 9:11:18 PM |

    Using mustard is a good way to keep a lean burger moist. I make a thin patty, squeeze a lot of mustard on top, put on a few spoonfuls of minced garlic and spread it evenly. I sprinkle dried rosemary on top and broil the burger for 10 minutes. Cooking mellows the flavors. (Recipe inspired by chef Nick Stellino.)

  • Wild Mountain Gourmet

    3/8/2010 5:07:56 PM |

    Very interesting perspective on mustard. We are familiar with some of the benefits, but weren't aware of the anti-inflamatory piece. Thanks for sharing,  Wild Mountain Gourmet!

  • Anand Srivastava

    3/8/2010 9:08:22 PM |

    For Indians mustard means mustard. It does not mean Turmeric or Vinegar.

    We generally use mustard as itself in preparing curry. Its required for most fish dishes.

    Mustard oil was the second most popular oil, after ghee. Now it has a higher usage than ghee, because vegetable oil has replaced ghee.

    Virgin Mustard oil contains a balance of O3 and O6 (1:1.4), which is better than canola.

  • Anonymous

    3/10/2010 1:13:55 AM |

    what brands of mustard are GF?

  • Ateronon

    3/10/2010 7:15:16 PM |

    Don't forget to take pepper with your turmeric. Makes a 20 fold difference in its bioavailabilty.

  • Tom

    3/10/2010 8:00:19 PM |

    Only yellow mustard generally contains turmeric. Most brown mustards (Dijon, Dusseldorf, etc.) do not, although they're still very healthy and delicious.

    Curry powder contains turmeric, so any curry dish has that benefit as well.

  • jacque k

    3/11/2010 8:34:28 PM |

    You can also add turmeric to a vinegar and olive oil salad dressing--no gluten or sodium. And remember to sprinkle pepper on the salad, too.

  • P

    3/13/2010 12:27:18 AM |

    I have to second Ananad. This is way Indians eat regularly. We eat mustard everyday! We eat turmeric everyday! If I have sore throat or feel a cold coming, I take a tsp of turmeric powder with hot milk. Feel just fine next day. People in India also use turmeric powder directly over wounds too!

  • Cure Acne

    6/12/2010 5:45:39 AM |

    I make a thin patty, squeeze a lot of mustard on top, put on a few spoonfuls of minced garlic and spread it evenly.

  • Teeth Whitening

    6/12/2010 8:39:16 AM |

    Very interesting post. Thanks for you information. Mustard is not a super healthy food.

  • E Xtenze

    6/13/2010 4:26:11 AM |

    Yes, you are right man, mustard a secret of super health, but if you take it in very low quantity.

  • website promotion company

    7/24/2010 4:26:38 AM |

    I read your post, i really appreciate your experience and i will get good knowledge from their as well.

  • geongia

    9/15/2010 9:03:26 AM |

    I haven’t any word to appreciate this post….the person who create this post it was a great human..thanks for shared this with us.i found this informative and interesting blog so i think so its very useful and knowledgeable.


    health

  • buy jeans

    11/3/2010 2:19:21 PM |

    Turmeric content of mustard can vary, of course. Likewise, sugar content. Look for mustards that are not sweetened, so avoid honey mustard in particular. Look for hot, brown, horseradish, Dijon, etc. If there is a downside to mustard, it's sodium content, though the 709 mg per 1/4 cup should only be a problem for those who are sodium-sensitive (African Americans, in particular).

  • Atlanta cosmetic surgery

    12/5/2010 5:00:06 AM |

    There are spices that are very good for health and should be consumed regularly.Turmeric is also very good for keeping worms at bay.

  • SEO Company Delhi

    1/6/2011 3:39:11 PM |

    The information in this blog is really a appreciable. I would really like to say that the knowledge you have about this is quit impressing. But the main thing here is the way to present the information, and you have done it very nicely. Great work and love to visit on your blog again and again. Keep posting nice information.

  • SEO Services Delhi

    1/6/2011 3:39:42 PM |

    Im impressed. I dont think Ive met anyone who knows as much about this subject as you do. Youre truly well informed and very intelligent. You wrote something that people could understand and made the subject intriguing for everyone. Really, great blog youve got here.

  • seo specialist india

    1/6/2011 3:40:11 PM |

    Can I just say, this blog is what got me through the day today.  Every time I read it, I just get more and more excited about whats next.  Very refreshing blog and very refreshing ideas.  Im glad that I came across this when I did.  I love what youve got to say and the way you say it.

  • delhi independent escort

    1/6/2011 3:40:38 PM |

    This blog is fantastic. Thats not really a really huge statement, but its all I could come up with after reading this. You know so much about this subject. So much so that you made me want to learn more about it. Your blog is my stepping stone, my friend. Thanks for the heads up on this subject.

  • revision rhinoplasty beverly hills

    1/27/2011 6:36:22 PM |

    Turmeric has antiseptic qualities and is much used in the Asian countries.Vinegar is used more in the west...so some fusion food with all these ingredients could make some very good health diet eh?

  • rose

    5/28/2011 7:11:45 PM |

    Dr, William Davis for some reason looks more like a business man to me; not that there is anything wrong with a business man.

  • Matt

    2/7/2012 9:28:10 PM |

    Nice writeup. So true, there are benefits to eating mustard!! Check out our varieties...  Wild Mountain Gourmet

Loading