For the sake of convenience: Commercial sources of prebiotic fibers

Our efforts to obtain prebiotic fibers/resistant starches, as discussed in the Cureality Digestive Health Track, to cultivate healthy bowel flora means recreating the eating behavior of primitive humans who dug in the dirt with sticks and bone fragments for underground roots and tubers, behaviors you can still observe in extant hunter-gatherer groups, such as the Hadza and Yanomamo. But, because this practice is inconvenient for us modern folk accustomed to sleek grocery stores, because many of us live in climates where the ground is frozen much of the year, and because we lack the wisdom passed from generation to generation that helps identify which roots and tubers are safe to eat and which are not, we rely on modern equivalents of primitive sources. Thus, green, unripe bananas, raw potatoes and other such fiber sources in the Cureality lifestyle.

There is therefore no need to purchase prebiotic fibers outside of your daily effort at including an unripe green banana, say, or inulin and fructooligosaccharides (FOS), or small servings of legumes as a means of cultivating healthy bowel flora. These are powerful strategies that change the number and species of bowel flora over time, thereby leading to beneficial health effects that include reduced blood sugar and blood pressure, reduction in triglycerides, reduced anxiety and improved sleep, and reduced colon cancer risk.

HOWEVER, convenience can be a struggle. Traveling by plane, for example, makes lugging around green bananas or raw potatoes inconvenient. Inulin and FOS already come as powders or capsules and they are among the options for a convenient, portable prebiotic fiber strategy. But there are others that can be purchased. This is a more costly way to get your prebiotic fibers and you do not need to purchase these products in order to succeed in your bowel flora management program. These products are therefore listed strictly as a strategy for convenience.

Most perspectives on the quality of human bowel flora composition suggest that diversity is an important feature, i.e., the greater the number of species, the better the health of the host. There may therefore be advantage in varying your prebiotic routine, e.g., green banana on Monday, inulin on Tuesday, PGX (below) on Wednesday, etc. Beyond providing convenience, these products may introduce an added level of diversity, as well.

Among the preparations available to us that can be used as prebiotic fibers:

PGX

While it is billed as a weight management and blood sugar-reducing product, the naturally occurring fiber--α-D-glucurono-α-D-manno-β-D-manno- β-D-gluco, α-L-gulurono-β-D mannurono, β-D-gluco-β- D-mannan--in PGX also exerts prebiotic effects (evidenced by increased fecal butyrate, the beneficial end-product of bacterial metabolism). PGX is available as capsules or granules. It also seems to exert prebiotic effects at lower doses than other prebiotic fibers. While I usually advise reaching 20 grams per day of fiber, PGX appears to exert substantial effects at a daily dose of half that quantity. As with all prebiotic fibers, it is best to build up slowly over weeks, e.g., start at 1.5 grams twice per day. It is also best taken in two or three divided doses. (Avoid the PGX bars, as they are too carb-rich for those of us trying to achieve ideal metaobolic health.)

Prebiotin

A combination of inulin and FOS available as powders and in portable Stick Pacs (2 gram and 4 gram packs). This preparation is quite costly, however, given the generally low cost of purchasing chicory inulin and FOS separately.

Acacia

Acacia fiber is another form of prebiotic fiber.  RenewLife and NOW are two reputable brands.

Isomalto-oligosaccharides

This fiber is used in Quest bars and in Paleo Protein Bars. With Quest bars, choose the flavors without sucralose, since it has been associated with undesirable changes in bowel flora.

There you go. It means that there are fewer and fewer reasons to not purposefully cultivate healthy bowel flora and obtain all the wonderful health benefits of doing so, from reduced blood pressure, to reduced triglycerides, to deeper sleep.

Disclaimer: I am not compensated in any way by discussing these products.

How Not To Have An Autoimmune Condition


Autoimmune conditions are becoming increasingly common. Estimates vary, but it appears that at least 8-9% of the population in North America and Western Europe have one of these conditions, with The American Autoimmune Related Diseases Association estimating that it’s even higher at 14% of the population.

The 200 or so autoimmune diseases that afflict modern people are conditions that involve an abnormal immune response directed against one or more organs of the body. If the misguided attack is against the thyroid gland, it can result in Hashimoto’s thyroiditis. If it is directed against pancreatic beta cells that produce insulin, it can result in type 1 diabetes or latent autoimmune diabetes of adults (LADA). If it involves tissue encasing joints (synovium) like the fingers or wrists, it can result in rheumatoid arthritis. It if involves the liver, it can result in autoimmune hepatitis, and so on. Nearly every organ of the body can be the target of such a misguided immune response.

While it requires a genetic predisposition towards autoimmunity that we have no control over (e.g., the HLA-B27 gene for ankylosing spondylitis), there are numerous environmental triggers of these diseases that we can do something about. Identifying and correcting these factors stacks the odds in your favor of reducing autoimmune inflammation, swelling, pain, organ dysfunction, and can even reverse an autoimmune condition altogether.

Among the most important factors to correct in order to minimize or reverse autoimmunity are:


Wheat and grain elimination

If you are reading this, you likely already know that the gliadin protein of wheat and related proteins in other grains (especially the secalin of rye, the hordein of barley, zein of corn, perhaps the avenin of oats) initiate the intestinal “leakiness” that begins the autoimmune process, an effect that occurs in over 90% of people who consume wheat and grains. The flood of foreign peptides/proteins, bacterial lipopolysaccharide, and grain proteins themselves cause immune responses to be launched against these foreign factors. If, for instance, an autoimmune response is triggered against wheat gliadin, the same antibodies can be aimed at the synapsin protein of the central nervous system/brain, resulting in dementia or cerebellar ataxia (destruction of the cerebellum resulting in incoordination and loss of bladder and bowel control). Wheat and grain elimination is by far the most important item on this list to reverse autoimmunity.

Correct vitamin D deficiency

It is clear that, across a spectrum of autoimmune diseases, vitamin D deficiency serves a permissive, not necessarily causative, role in allowing an autoimmune process to proceed. It is clear, for instance, that autoimmune conditions such as type 1 diabetes in children, rheumatoid arthritis, and Hashimoto’s thyroiditis are more common in those with low vitamin D status, much less common in those with higher vitamin D levels. For this and other reasons, I aim to achieve a blood level of 25-hydroxy vitamin D level of 60-70 ng/ml, a level that usually requires around 4000-8000 units per day of D3 (cholecalciferol) in gelcap or liquid form (never tablet due to poor or erratic absorption). In view of the serious nature of autoimmune diseases, it is well worth tracking occasional blood levels.

Supplement omega-3 fatty acids

While omega-3 fatty acids, EPA and DHA, from fish oil have proven only modestly helpful by themselves, when cast onto the background of wheat/grain elimination and vitamin D, omega-3 fatty acids compound anti-inflammatory benefits, such as those exerted via cyclooxygenase-2. This requires a daily EPA + DHA dose of around 3600 mg per day, divided in two. Don’t confuse EPA and DHA omega-3s with linolenic acid, another form of omega-3 obtained from meats, flaxseed, chia, and walnuts that does not not yield the same benefits. Nor can you use krill oil with its relatively trivial content of omega-3s.

Eliminate dairy

This is true in North America and most of Western Europe, less true in New Zealand and Australia. Autoimmunity can be triggered by the casein beta A1 form of casein widely expressed in dairy products, but not by casein beta A2 and other forms. Because it is so prevalent in North America and Western Europe, the most confident way to avoid this immunogenic form of casein is to avoid dairy altogether. You might be able to consume cheese, given the fermentation process that alters proteins and sugar, but that has not been fully explored.

Cultivate healthy bowel flora

People with autoimmune conditions have massively screwed up bowel flora with reduced species diversity and dominance of unhealthy species. We restore a healthier anti-inflammatory panel of bacterial species by “seeding” the colon with high-potency probiotics, then nourishing them with prebiotic fibers/resistant starches, a collection of strategies summarized in the Cureality Digestive Health discussions. People sometimes view bowel flora management as optional, just “fluff”–it is anything but. Properly managing bowel flora can be a make-it-or-break-it advantage; don’t neglect it.

There you go: a basic list to get started on if your interest is to begin a process of unraveling the processes of autoimmunity. In some conditions, such as rheumatoid arthritis and polymyalgia rheumatica, full recovery is possible. In other conditions, such as Hashimoto’s thyroiditis and the pancreatic beta cell destruction leading to type 1 diabetes, reversing the autoimmune inflammation does not restore organ function: hypothyroidism results after thyroiditis quiets down and type 1 diabetes and need for insulin persists after pancreatic beta cell damage. But note that the most powerful risk factor for an autoimmune disease is another autoimmune disease–this is why so many people have more than one autoimmune condition. People with Hashimoto’s, for instance, can develop rheumatoid arthritis or psoriasis. So the above menu is still worth following even if you cannot hope for full organ recovery

Five Powerful Ways to Reduce Blood Sugar

Left to conventional advice on diet and you will, more than likely, succumb to type 2 diabetes sooner or later. Follow your doctor’s advice to cut fat and eat more “healthy whole grains” and oral diabetes medication and insulin are almost certainly in your future. Despite this, had this scenario played out, you would be accused of laziness and gluttony, a weak specimen of human being who just gave into excess.

If you turn elsewhere for advice, however, and ignore the awful advice from “official” sources with cozy relationships with Big Pharma, you can reduce blood sugars sufficient to never become diabetic or to reverse an established diagnosis, and you can create a powerful collection of strategies that handily trump the worthless advice being passed off by the USDA, American Diabetes Association, the American Heart Association, or the Academy of Nutrition and Dietetics.

Among the most powerful and effective strategies to reduce blood sugar:

1) Eat no wheat nor grains

Recall that amylopectin A, the complex carbohydrate of grains, is highly digestible, unlike most of the other components of the seeds of grasses AKA “grains,” subject to digestion by the enzyme, amylase, in saliva and stomach. This explains why, ounce for ounce, grains raise blood sugar higher than table sugar. Eat no grains = remove the exceptional glycemic potential of amylopectin A.

2) Add no sugars, avoid high-fructose corn syrup

This should be pretty obvious, but note that the majority of processed foods contain sweeteners such as sucrose or high-fructose corn syrup, tailored to please the increased desire for sweetness among grain-consuming people. While fructose does not raise blood sugar acutely, it does so in delayed fashion, along with triggering other metabolic distortions such as increased triglycerides and fatty liver.

3) Vitamin D

Because vitamin D restores the body’s normal responsiveness to insulin, getting vitamin D right helps reduce blood sugar naturally while providing a range of other health benefits.

4) Restore bowel flora

As cultivation of several Lactobacillus and Bifidobacteria species in bowel flora yields fatty acids that restore insulin responsiveness, this leads to reductions in blood sugar over time. Minus the bowel flora-disrupting effects of grains and sugars, a purposeful program of bowel flora restoration is required (discussed at length in the Cureality Digestive Health section.)

5) Exercise

Blood sugar is reduced during and immediately following exercise, with the effect continuing for many hours afterwards, even into the next day.

Note that, aside from exercise, none of these powerful strategies are advocated by the American Diabetes Association or any other “official” agency purporting to provide dietary advice. As is happening more and more often as the tide of health information rises and is accessible to all, the best advice on health does not come from such agencies nor from your doctor but from your efforts to better understand the truths in health. This is our core mission in Cureality. A nice side benefit: information from Cureality is not accompanied by advertisements from Merck, Pfizer, Kelloggs, Kraft, or Cadbury Schweppes.

Cureality App Review: Breathe Sync



Biofeedback is a wonderful, natural way to gain control over multiple physiological phenomena, a means of tapping into your body’s internal resources. You can, for instance, use biofeedback to reduce anxiety, heart rate, and blood pressure, and achieve a sense of well-being that does not involve drugs, side-effects, or even much cost.

Biofeedback simply means that you are tracking some observable physiologic phenomenon—heart rate, skin temperature, blood pressure—and trying to consciously access control over it. One very successful method is that of bringing the beat-to-beat variation in heart rate into synchrony with the respiratory cycle. In day-to-day life, the heart beat is usually completely out of sync with respiration. Bring it into synchrony and interesting things happen: you experience a feeling of peace and calm, while many healthy phenomena develop.

A company called HeartMath has applied this principle through their personal computer-driven device that plugs into the USB port of your computer and monitors your heart rate with a device clipped on your earlobe. You then regulate breathing and follow the instructions provided and feedback is obtained on whether you are achieving synchrony, or what they call “coherence.” As the user becomes more effective in achieving coherence over time, positive physiological and emotional effects develop. HeartMath has been shown, for instance, to reduce systolic and diastolic blood pressure, morning cortisol levels (a stress hormone), and helps people deal with chronic pain. Downside of the HeartMath process: a $249 price tag for the earlobe-USB device.

But this is the age of emerging smartphone apps, including those applied to health. Smartphone apps are perfect for health monitoring. They are especially changing how we engage in biofeedback. An app called Breathe Sync is available that tracks heart rate using the camera’s flash on the phone. By tracking heart rate and providing visual instruction on breathing pattern, the program generates a Wellness Quotient, WQ, similar to HeartMath’s coherence scoring system. Difference: Breathe Sync is portable and a heck of a lot less costly. I paid $9.99, more than I’ve paid for any other mainstream smartphone application, but a bargain compared to the HeartMath device cost.

One glitch is that you need to not be running any other programs in the background, such as your GPS, else you will have pauses in the Breathe Sync program, negating the value of your WQ. Beyond this, the app functions reliably and can help you achieve the health goals of biofeedback with so much less hassle and greater effectiveness than the older methods.

If you are looking for a biofeedback system that provides advantage in gaining control over metabolic health, while also providing a wonderful method of relaxation, Breathe Sync, I believe, is the go-to app right now.

Amber’s Top 35 Health and Fitness Tips

This year I joined the 35 club!  And in honor of being fabulous and 35, I want to share 35 health and fitness tips with you! 

1.  Foam rolling is for everyone and should be done daily. 
2.  Cold showers are the best way to wake up and burn more body fat. 
3.  Stop locking your knees.  This will lead to lower back pain. 
4.  Avoid eating gluten at all costs. 
5.  Breath deep so that you can feel the sides or your lower back expand. 
6.  Swing a kettlebell for a stronger and great looking backside. 
7.  Fat is where it’s at!  Enjoy butter, ghee, coconut oil, palm oil, duck fat and many other fabulous saturated fats. 
8.  Don’t let your grip strength fade with age.  Farmer carries, kettlebells and hanging from a bar will help with that. 
9.  Runners, keep your long runs slow and easy and keep your interval runs hard.  Don’t fall in the chronic cardio range. 
10.  Drink high quality spring or reverse osmosis water. 
11.  Use high quality sea salt season food and as a mineral supplement. 
12.  Work your squat so that your butt can get down to the ground.  Can you sit in this position? How long?
13.  Lift heavy weights!  We were made for manual work,.   Simulate heavy labor in the weight room. 
14.  Meditate daily.  If you don’t go within, you will go with out.  We need quiet restorative time to balance the stress in our life. 
15.  Stand up and move for 10 minutes for every hour your sit at your computer. 
16. Eat a variety of whole, real foods. 
17.  Sleep 7 to 9 hours every night. 
18.  Pull ups are my favorite exercise.  Get a home pull up bar to practice. 
19.  Get out and spend a few minutes in nature.  Appreciate the world around you while taking in fresh air and natural beauty. 
20.  We all need to pull more in our workouts.  Add more pulling movements horizontally and vertically. 
21. Surround yourself with health minded people. 
22. Keep your room dark for deep sound sleep.  A sleep mask is great for that! 
23. Use chemical free cosmetics.  Your skin is the largest organ of your body and all chemicals will absorb into your blood stream. 
24. Unilateral movements will help improve symmetrical strength. 
25. Become more playful.  We take life too seriously, becoming stress and overwhelmed.  How can you play, smile and laugh more often?
26.  Choose foods that have one ingredient.  Keep your diet simple and clean. 
27.  Keep your joints mobile as you age.  Do exercises that take joints through a full range of motion. 
28. Go to sleep no later than 10:30pm.  This allows your body and brain to repair through the night. 
29. Take care of your health and needs before others.  This allows you to be the best spouse, parent, coworker, and person on the planet. 
30.  Always start your daily with a high fat, high protein meal.  This will encourage less sugar cravings later in the day. 
31. Approach the day with positive thinking!  Stinkin’ thinkin’ only leads to more stress and frustration. 
32. You are never “too old” to do something.  Stay young at heart and keep fitness a priority as the years go by. 
33. Dream big and go for it. 
34.  Lift weights 2 to 4 times every week.  Strong is the new sexy. 
35.  Love.  Love yourself unconditionally.  Love your life and live it to the fullest.  Love others compassionately. 

Amber B.
Cureality Exercise and Fitness Coach

To Change, You Need to Get Uncomfortable

Sitting on the couch is comfortable.  Going through the drive thru to pick up dinner is comfortable.  But when you notice that you’re out-of-shape, tired, sick and your clothes no longer fit, you realize that what makes you comfortable is not in align with what would make you happy.   

You want to see something different when you look in the mirror.  You want to fit into a certain size of jeans or just experience your day with more energy and excitement.  The current condition of your life causes you pain, be it physical, mental or emotional.  To escape the pain you are feeling, you know that you need to make changes to your habits that keep you stuck in your current state.  But why is it so hard to make the changes you know that will help you achieve what you want?  

I want to lose weight but….

I want a six pack but…

I want more energy but….

The statement that follows the “but” is often a situation or habit you are comfortable with.  You want to lose weight but don’t have time to cook healthy meals.  So it’s much more comfortable to go through the drive thru instead of trying some new recipes.   New habits often require a learning curve and a bit of extra time in the beginning.  It also takes courage and energy to establish new routines or seek out help.  

Setting out to achieve your goals requires change.  Making changes to establish new habits that support your goals and dreams can be uncomfortable.  Life, as you know it, will be different.  Knowing that fact can be scary, but so can staying in your current condition.  So I’m asking you to take a risk and get uncomfortable so that you can achieve your goals.  

Realize that it takes 21 days to develop a new habit.  I believe it takes triple that amount of time to really make a new habit stick for the long haul.  So for 21 days, you’ll experience some discomfort while you make changes to your old routine and habits.  Depending on what you are changing, discomfort could mean feeling tired, moody, or even withdrawal symptoms.  However, the longer you stick to your new habits the less uncomfortable you start to feel.  The first week is always the worst, but then it gets easier.

Making it through the uncomfortable times requires staying focused on your goals and not caving to your immediate feelings or desires.  I encourage clients to focus on why their goals important to them.  This reason or burning desire to change will help when old habits, cravings, or situations call you back to your old ways.
Use a tracking and a reward system to stay on track.  Grab a calendar, journal or index card to check off or note your daily successes.  Shoot for consistency and not perfection when trying to make changes.  I encourage my clients to use the 90/10 principle of change and apply that to their goal tracking system.  New clothes, a massage, or a day me-retreat are just a few examples of rewards you can use to sticking to your tracking system.  Pick something that really gets you excited.  

Getting support system in place can help you feel more comfortable with being uncomfortable.  Hiring a coach, joining an online support group, or recruiting family and friends can be very helpful when making big changes.  With a support system in place you are not alone in your discomfort.  You’re network is there for you to reach out for help, knowledge, accountability or camaraderie when you feel frustrated and isolated.  

I’ve helped hundreds of people change their bodies, health and lives of the eleven years I’ve worked as a trainer and coach.  I know it’s hard, but I also know that if they can do it, so can you.  You just need to step outside of your comfort zone and take a risk. Don’t let fear create uncomfortable feelings that keep you stuck in your old ways.  Take that first step and enjoy the journey of reaching your goals and dreams.  

Amber Budahn, B.S., CSCS, ACE PT, USATF 1, CHEK HLC 1, REIKI 1
Cureality Exercise Specialist

The 3 Best Grain Free Food Swaps to Boost Fat Burning

You can join others enjoying substantial improvements in their health, energy and pant size by making a few key, delicious substitutions to your eating habits.  This is possible with the Cureality nutrition approach, which rejects the idea that grains should form the cornerstone of the human diet.  

Grain products, which are seeds of grasses, are incompatible with human digestion.  Contrary to what we have been told for years, eating healthy whole grain is not the answer to whittle away our waists.  Consumption of all grain-based carbohydrates results in increased production of the fat storage hormone insulin.  Increased insulin levels create the perfect recipe for weight gain. By swapping out high carbohydrate grain foods that cause spikes in insulin with much lower carbohydrate foods, insulin release is subdued and allows the body to release fat.

1. Swap wheat-based flour with almond flour/meal

  • One of the most dubious grain offenders is modern wheat. Replace wheat flour with naturally wheat-free, lower carbohydrate almond flour.  
  • Almond flour contains a mere 12 net carbs per cup (carbohydrate minus the fiber) with 50% more filling protein than all-purpose flour.
  • Almond flour and almond meal also offer vitamin E, an important antioxidant to support immune function.

2. Swap potatoes and rice for cauliflower

  • Replace high carb potatoes and pasta with vitamin C packed cauliflower, which has an inconsequential 3 carbs per cup.  
  • Try this food swap: blend raw cauliflower in food processor to make “rice”. (A hand held grater can also be used).  Sautee the “riced” cauliflower in olive or coconut oil for 5 minutes with seasoning to taste.
  • Another food swap: enjoy mashed cauliflower in place of potatoes.  Cook cauliflower. Place in food processor with ½ a stick organic, grass-fed butter, ½ a package full-fat cream cheese and blend until smooth. Add optional minced garlic, chives or other herbs such as rosemary.
3. Swap pasta for shirataki noodles and zucchini

  • Swap out carb-rich white pasta containing 43 carbs per cup with Shirataki noodles that contain a few carbs per package. Shirataki noodles are made from konjac or yam root and are found in refrigerated section of supermarkets.
  • Another swap: zucchini contains about 4 carbs per cup. Make your own grain free, low-carb noodles from zucchini using a julienne peeler, mandolin or one of the various noodle tools on the market.  

Lisa Grudzielanek, MS,RDN,CD,CDE
Cureality Nutrition Specialist

Not so fast. Don’t make this mistake when going gluten free!

Beginning last month, the Food and Drug Administration began implementing its definition of “gluten-free” on packaged food labels.  The FDA determined that packaged food labeled gluten free (or similar claims such as "free of gluten") cannot contain more than 20 parts per million of gluten.

It has been years in the making for the FDA to define what “gluten free” means and hold food manufactures accountable, with respect to food labeling.  However, the story does not end there.

Yes, finding gluten-free food, that is now properly labeled, has become easier. So much so the market for gluten-free foods tops $6 billion last year.   However, finding truly healthy, commercially prepared, grain-free foods is still challenging.

A very common mistake made when jumping into the gluten-free lifestyle is piling everything labeled gluten-free in the shopping cart.  We don’t want to replace a problem: wheat, with another problem: gluten free products.

Typically gluten free products are made with rice flour (and brown rice flour), tapioca starch, cornstarch, and potato flour.  Of the few foods that raise blood sugar higher than wheat, these dried, powdered starches top the list.

 They provide a large surface area for digestion, thereby leading to sky-high blood sugar and all the consequences such as diabetes, hypertension, cataracts, arthritis, and heart disease. These products should be consumed very rarely consumed, if at all.  As Dr. Davis has stated, “100% gluten-free usually means 100% awful!”

There is an ugly side to the gluten-free boom taking place.  The Cureality approach to wellness recommends selecting gluten-free products wisely.  Do not making this misguided mistake and instead aim for elimination of ALL grains, as all seeds of grasses are related to wheat and therefore overlap in many effects.

Lisa Grudzielanek MS, RDN, CD, CDE
Cureality Health & Nutrition Coach

3 Foods to Add to Your Next Grocery List

Looking for some new foods to add to your diet? Look no further. Reach for these three mealtime superstars to encourage a leaner, healthier body.

Microgreens

Microgreens are simply the shoots of salad greens and herbs that are harvested just after the first leaves have developed, or in about 2 weeks.  Microgreen are not sprouts. Sprouts are germinated, in other words, sprouted seeds produced entirely in water. Microgreens are grown in soil, thereby absorbing the nutrients from the soil.

The nutritional profile of each microgreen depends greatly on the type of microgreen you are eating. Researchers found red cabbage microgreens had 40 times more vitamin E and six times more vitamin C than mature red cabbage. Cilantro microgreens had three times more beta-carotene than mature cilantro.

A few popular varieties of microgreens are arugula, kale, radish, pea, and watercress. Flavor can vary from mild to a more intense or spicy mix depending on the microgreens.  They can be added to salads, soup, omelets, stir fry and in place of lettuce.  

Cacao Powder

Cocoa and cacao are close enough in flavor not to make any difference. However, raw cacao powder has 3.6 times the antioxidant activity of roasted cocoa powder.  In short, raw cacao powder is definitely the healthiest, most beneficial of the powders, followed by 100% unsweetened cocoa.

Cacao has more antioxidant flavonoids than blueberries, red wine and black and green teas.  Cacao is one of the highest sources of magnesium, a great source of iron and vitamin C, as well as a good source of fiber for healthy bowel function.
Add cacao powder to milk for chocolate milk or real hot chocolate.  Consider adding to coffee for a little mocha magic or sprinkle on berries and yogurt.




Shallots


Shallots have a better nutrition profile than onions. On a weight per weight basis, they have more anti-oxidants, minerals, and vitamins than onions. Shallots have a milder, less pungent taste than onions, so people who do not care for onions may enjoy shallots.

Like onions, sulfur compounds in shallot are necessary for liver detoxification pathways.  The sulfur compound, allicin has been shown to be beneficial in reducing cholesterol.  Allicin is also noted to have anti-bacterial, anti-viral, and anti-fungal activities.

Diced then up and add to salads, on top of a bun less hamburger, soups, stews, or sauces.  Toss in an omelet or sauté to enhance a piece of chicken or steak, really the possibilities are endless.  

Lisa Grudzielanek,MS,RDN,CD,CDE
Cureality Nutrition & Health Coach

3 Band Exercises for Great Glutes

Bands and buns are a great combination.  (When I talk about glutes or a butt, I use the word buns)  When it comes to sculpting better buns, grab a band.   Bands are great for home workouts, at gym or when you travel.  Check out these 3 amazing exercises that will have your buns burning. 

Band Step Out

Grab a band and place it under the arch of each foot.  Then cross the band and rest your hands in your hip sockets.  The exercise starts with your feet hip width apart and weight in the heels.  Slightly bend the knees and step your right foot out to the side.  Step back in so that your foot is back in the starting position.  With each step, make sure your toes point straight ahead.  The tighter you pull the band, the more resistance you will have.    You will feel this exercise on the outside of your hips. 

Start with one set of 15 repetitions with each foot.  Work on increasing to 25 repetitions on each side and doing two to three sets.



Band Kick Back

This exercise is performed in the quadruped position with your knees under hips and hands under your shoulders.    Take the loop end of the band and put it around your right foot and place the two handles or ends of the band under your hands.  Without moving your body, kick your right leg straight back.  Return to the starting quadruped position.  Adjust the tension of the band to increase or decrease the difficulty of this exercise. 

Start with one set of 10 repetitions with each foot.  Work on increasing to 20 repetitions on each side and doing two to three sets. 



Band Resisted Hip Bridge

Start lying on your back with feet hip distance apart and knees bent at about a 45-degree angle.  Adjust your hips to a neutral position to alleviate any arching in your lower back.  Place the band across your hipbones.  Hold the band down with hands along the sides of your body.  Contract your abs and squeeze your glutes to lift your hips up off the ground.  Stop when your thighs, hips and stomach are in a straight line.  Lower you hips back down to the ground. 

Start with one set of 15 repetitions.  Work on increasing to 25 repetitions and doing two to three.  Another variation of this exercise is to hold the hip bridge position.  Start with a 30 second hold and work up to holding for 60 seconds.

Diet is superior to drugs

Diet is superior to drugs

Might-o’chondri-AL left this wonderful record of his lipoprotein experience in the comments to the last Heart Scan Blog post. It is a great example of what is achievable with diet and a few supplements . . . without drugs.


(A) Jan. 2011 1st ever NMR lipo-protein analysis was done after 4 months of consistent home food prep of pretty low fat (only olive oil and 1 tablespoon coconut oil daily) but plenty of whole wheat and half potatoes:
* LDL # of particles (P) = 1,676 in nmol/L————being a LDL cholesterol (C) reading of 139 mg/dL
* small LDL # P = 1,021 nmol/L —————yikes! you advise smLDL be less than 117 nmol/L
* HDL # of particles = 28.8 umol/L ————–being a HDL C reading of 45 mg/dL
* Triglycerides = 90 mg/dL ————– true, I never struggled with my weight

(B) May 2011 2nd NMR after another 4 months but added in more fat (1 teaspoon highly concentrated fish oil daily, 90% chocolate, handfulls of nuts, more olive oil and kept coconut oil at 1 tablespoon daily for a controlled experiment), added 500 mg Niacin 3 times a day (in stages up to1,500 mg. total daily), 6000 IU daily vitamin D, deliberately cut out all grains except for social politeness and substituted in daily Koji fermented brown rice (rustic Amazake):
** LDL # P……………= 976 nmol/L ——————————– being LDL C of 100 mg/dL
** small LDL # P …. = 96 nmol/L ——————————– nice surprise
** HDL # P ………… = 27.3 umol/L ——————————being an increase to HDL C of 64 mg/dL
** Triglycerides …… = 42 mg/dL ——————————– despite daily carbs over 150 gr. daily

(C) Dec. 2011 3rd NMR after another 7 more months thinking Doc’s advice is worthwhile I added in yet more fat (mainly daily 2 tablespoons of coconut oil, more 90% chocolate), bumped Niacin up to 1,000 mg twice a day (2,000 mg. total daily), cut out the Amazake, kept up the vitamin D adding daily vitamin K & daily ate main mid-day meal out as lunch on spicy Thai & Chinese fish/shrimp/soup/rice meals (my next control):
*** LDL # P ………. = 764 nmol/L ————— being LDL C of 107 mg/dL ( 2x coconut’s saturated fat)
***small LDL # P… = less than 90 nmol/L ——–surprised me NMR can’t count lower
***HDL # P ……… = 41.4 umol/L ——————– being an increase to HDL C of 88 mg/dL
*** Triglycerides ….= 43 mg/dL ——————- daily carbs below ~ 120 gr. & lost too much weight

Isn't that great? Spectacular job, Might!

MIght achieved values that are superior to that achievable with, say, a high-dose statin strategy. Statins only reduce total LDL particles, reducing small LDL in a non-selective way. And, of course, this diet does not cause muscle aches, memory loss, nor liver problems.

Something to consider: As the diet has become so effective, we can reduce our reliance on niacin. In fact, the benefits of niacin diminish substantially, as small LDL is reduced, HDL increased, triglycerides decreased, and postprandial lipoproteins subdued with the diet only.

Comments (27) -

  • Janknitz

    1/7/2012 6:24:17 PM |

    7 months ago I was dying. I was (still am) morbidly obese. I have GERD, hypertension,  sleep apnea, PCOS/insulin resistance, asthma, chronic back and skeletal pain. I could not walk across the room without severe pain and shortness of breath. I was afraid to do any testing or discuss this with my doctor because I knew that I would be prescribed a bunch of meds (statins, diuretics and BP meds) and sent to kaiser's group nutritional counseling to learn all about how six servings of whole grains and daily exercise would fix everything if I was "compliant".   I am not a compliant person . . .

    I had amazing success with low carb 12 years ago--so successful that I conceived my second child despite PCOS (our first daughter was an in vitro).  But having a baby, working two jobs, and attending a doctoral program at night was a lot to handle, and gradually my diet fell by the wayside.

    Returning to low carb was not as difficult as I imagined. I was still eating wheat and other grains, albeit in very small amounts within my 20 to 30 grams of carbs daily. While I felt better, I was still in a lot of pain and discomfort, still could not exercise.

    I was reading everything I could get my hands on and eventually stumbled upon your blogs and Paleo and primal blogs to.   I decided to cut out grains, even my beloved oats. Even though I love baking bread, I was never a great bread eater, so wheat was actually easier to give up. And since I was already in low carb ketosis, it wasn't physically difficult at all.

    I feel like a 1 ton cement jacket has been removed from my body!  My weightloss has stalled (looks like thyroid or IR is the culprit so I'm working on it) but I feel so energetic that on days I don't have time to exercise I feel restless to get moving. I can walk 2 1/2 miles and all of my chronic pain is gone. GERD is gone, I  haven't had an asthma exacerbation in since last winter, BP is normal. My post prandial blood sugars are good.

    Most of all, LOOK AT THESE LABS!
    Cholesterol  235  
    Triglyceride  71  
    HDL  79  
    Low density lipoprotein calculated  142  

    I know there's more work to be done (I'm going to get those triglycerides below 60!), but this is amazing to me considering I eat all the butter, cream, whole eggs,  animal fat, coconut oil, and olive oil I want.   I eat no grains or sugar, very occasional starchy vegetables, and a small serving of berries daily.  I feel like I have my life back. Thank you, thank you, thank you!

  • Jan

    1/7/2012 6:52:31 PM |

    Very interesting stats and the controlled elements show their significance to the lipid profile. Wondering what the rest of your diet looks like. Are you primal or paleo, vegetarian, vegan? Do you drink fresh green juice daily?  Just curious....one concern I would have, in light of all the great things you are doing, eating out everyday with Asian-style foods leaves freshness, preparation, ingredients to someone else. I have found no matter how careful we are in our choice of a restaurant, eating out means eating off! I couldn't do it everyday.  It will be interesting to follow your diet changes and see what happens!  Happy 2012!

  • Might-o'chondri-AL

    1/7/2012 11:46:08 PM |

    Hi Jan,
    Context first:  my results may not translate to everyone, since weight is never a real problem as the 1st NMR results coincided with laboratory measured fasting serum blood glucose = 83 mg/dL & HbA1c = 5.4 (for comparison after 3rd NMR  HbA1c = 5.3 & then serum glucose = 88 mg/dL, probably a mild side effect from added high dose fish oil).
    Asian restaurant lunch "specials" were chosen for  offering me a variety of affordable places &  menu variation to eat 7 days a week. It was to deliberately try to determine how well my lab results might hold up when have to partly yield responsibility &  dine in the world at large.
    I  arranged all other meals to be one's that were nutritious,  yet  whose regularity could become factored around if the lab results from 1/2 year of  cheap lunches played havoc with my NMR  (or  glycation indicator HbA1c).  I  precisely wanted to avoid trying to micro-manage an unknown assortment of cooks who might be using a  bit of sugar, cheap cooking oil, starch for thickening &  flour to sometimes crust fish. The lunch meal's standard full cup of cooked white/brown rice was eaten to see if it made any difference to my metabolism (ie: fasting serum glucose).
    I stuck with seafood dishes because I haven't eaten meat/chicken in over 40 years & have always had robust fortitude without those proteins. My breakfast & desert/snack protein preference is low/non-fat dairy casein (fermented milk solids with reduced whey - consistency of a pudding I can add anything to).
    To establish a standard evening meal I found a olive oil based brand hummus to measure out as a known portion to make up into a nightly mixed vegetable salad (no additional bread/rice) that didn't whack my post-prandial blood sugar (tested once every 15 min. like Doc suggests & after 1 hour blood sugar just 2 units higher than pre-meal, with just 1 unit higher after 2nd hour of meal).
    Green juice was not a part of these trials , so can't say if would affect NMR results. My budget for lab tests is empty so I am not experimenting to determine any other diet nuances now.

  • Andrew

    1/9/2012 1:04:15 PM |

    While Niacin is not a drug, 500 mg 3 times a day is excessive.

    Recommend reducing Niacin supplementation to reasonable levels taking with everything else taken into consideration.

  • Jim

    1/9/2012 5:54:03 PM |

    Mit:

    So happy for you. I have recently found this site and been reading the info for a couple months now. Is the NMR that you get from ineedlabs the full NMR (beyond standards lipid test from local doctor) or is it a truncated version? Thank you for mentioning the site! Jim

  • Might-o'chondri-AL

    1/9/2012 6:30:07 PM |

    Hi Andrew,
    ? How do  you attribute the rise in HDL those NMR demonstrated ?
    My assessment of my carbohydrate intake during last 1/2 year was certainly not very low carb, but more like moderate . I tried to calculate daily carbs & figure a minimum of  100  to more commonly over 120 gr./day . But ,quite frankly , often as not  more likely at least 150 gr./day since ate couple lunches weekly of spicy asian food that chef's told me they  use some sugar as an ingredient (schechwan fish, 3 flavors fish, half a fortune cookie), starch for  cup of soup thickening& wheat for breading (outer fish crispy)  .
    If I was moderate & not low carb I am at a loss to surmise how  that  made my HDL genetics  now re-programmed to going forward be able to provide me with (say) at least 60 mg/dL  if I cut back to 1,000 mg daily niacin.
    Allow me to recapitulate this data:
    NMR   with  zero (0)  niacin   HDL=45 mg/dL
    next    taking     1,500 mg/d  HDL = 64 mg/dL
    or   lastly           2,000 niacin HDL = 88 mg/dL  ( with no increase in fish oil, nor inc. in vit D supplement)
    You echo Doc in cutting back the niacin & presumably this is to avoid over-taxing the liver - am I correct?
    If  this orientates you opinion after 4 months on 1,500 mg daily Niacin I deliberately tested the standard liver enzymes;  showed  SGOT (AST) =  20 Iu/L & SGPT(ALT) = 17 IU/.  And, let me specify I think liver enzymes should  be checked by anyone regularly taking high  Niacin .
    ? Doesn't it seem that at least 1,500 mg/d Niacin is my individual safe dose ?

  • Jacob

    1/9/2012 10:37:21 PM |

    I'm a 38yo white male who experienced a nearly identical change to Mitochondri'Al's without reducing my carbs at all or changing my exercise routine. I'm taking 2,500mg/day of niacin with no side-effects apart from the flush (which I enjoy). My liver enzymes have remained stable and there has been no appreciable increase in homocysteine. Obviously Dr. Davis has infinitely more experience in this realm, but my suggestion would be to continue with the niacin. 1,500 is definitely a safe dose. Intuitively (and I STRESS "intuitively") I feel that it's better for me to take niacin and eat a moderately low-carb diet than to reduce my carb intake to the vanishingly small amount that Dr. Davis recommends. I have cut out wheat though and most grains. Really would love to reincorporate quinoa Smile

    September 2010
    HDL 39
    LDL 135
    Triglycerides 149
    These values had remained stable for 5 years, remaining unchanged in spite of diet and exercise changes. I won't go into all the VAP and NMR nuances (I've had both tests several times), but all the measures improved VERY dramatically...shifted from pattern B -->A LDL, more than quadrupled the "helpful" form of HDL (8 to 35), essentially eliminated IDL. CRP and Fibrinogen were fine to begin with and remained so after a year.

    November 2011
    HDL 87
    LDL 89
    LDL-P 700
    sdLDL <90
    Triglycerdes 40

    My regime included:
    * 2,500 mg/day nicotinic acid
    * Vitamin K2
    * Lovaza, 2 caps/day (I know Dr. Davis hates Lovaza because of the exorbitant price, but my insurance pays for it and I'm not going to shell out $$$ for a nonprescription fish oil of equivalent dosage)
    * Metformin, 500 mg/day (I'm not remotely diabetic. My NMR IR score was 4. However, I wanted to take it as a general antiaging drug and to offset any possible blood sugar increases from the niacin.)
    * D-3, 4000 mcg (or is it IU?)/day
    * Deplin, 7.5 mg/day (to methylate any extra homocysteine from the niacin and metformin and to provide precursors for monoamine neurotransmitters)
    * TMG (same reason as Deplin)
    * Methyl B12 (same as Deplin and TMG; also I'm vegan and don't get much from my diet)
    * 1 tablespoon extra virgin coconut oil / day
    * I purchased a blood glucose meter and test strips. There's more postprandial fluctuation than I would like to see, but my glycated hemoglobin remains at a respectable 5.1. I'd like to get that down to 4.9.
    * Had the battery of cardiovascular-related genetic tests. I'll only mention one: I'm an ApoE 2/3, meaning that moderate fat intake is indicated (versus low fat for 3/4s and 4/4s).

  • Might-o'chondri-AL

    1/9/2012 10:42:21 PM |

    Hi Jim,
    I think  ineedlabs authorized NMR is now sent through the  Labcorp system & so I got whatever Labcorp's NMR details; namely: "LDL-P,  LDL-C,  HDL-P , HDL-C, Triglycerride, Total Cholesterol, small-LDL, LDL size" & also some suggested interpretations Doc says he ignores. Standard old type of lipid test is not  the same as NMR lipo-protein profile , nor  is the  VAP type of lipid test some get.

  • Jacob

    1/9/2012 11:00:15 PM |

    @ Mitochondri'Al

    I had my liver enzymes tested pre-niacin and have repeated the test 7 times. There has been no change. From what I've read it's people taking the extended- and sustained-release formulations who develop liver issues. Immediate-release niacin doesn't seem to affect the liver much.

  • Might-o'chondri-AL

    1/10/2012 1:20:11 AM |

    Hi Jacob,
    I daily eat a good cooked handful  (trying to get beyond need to micro-manage all  portions of ingredients)  of low salt canned red beets into my night time hummus salad.  So, maybe that betaine has been enough to neutralize the homocysteine  you just informed me arises from high dose niacin. I have split niacin in 1,000 mg with morning dairy quark & 1,000mg  with evening meal; flushing has long been minor, aside from reddened face I splash with cold water if think anyone will freak out.

    Since you are the first to suggest blood sugar may elevate from taking high dose niacin this is also intriguingly new to me. My understanding is that it is high dose fish oil that Doc's protocol leads to higher blood sugar. When I introduced high dose EPA/DHA fasting serum glucose went from 1st 83 mg/dL  without fish oil after 4 months on fish oil to 88 mg/dL. Of course I  did start fish oil at the same time as  the niacin, but when I kept fish oil constant and varied upward the niacin (from 1,550 to 2,000 daily) for that last 1/2 year  experimentation my fasting serum glucose stayed at 88 mg/dL. Which  implicates fish oil is the controlled factor provoking 3 mg/dL more fasting blood sugar.

    Doc recently trashed the NMR's derivative chat; but  if  other's have noticed the category "IR score" I'll mention lab 1st gave me an "Insulin Resistance Score " (IR) of 45, 2nd test rated an IR score of 4 and then last NMR put me at 1.  But I am inclined to think many other readers may be more prone to overweight & they  may find it extremely helpful to go with Doc's  "very" low carb to see  lab results he aims for them to achieve if their genetics of blood glucose and lipo-protein are not as favorably responsive as mine seem to be.

  • Jacob

    1/10/2012 3:33:50 AM |

    @Mitochondri'Al...

    The hyperglycemic effect of high-dose niacin is very well documented, though in my case I don't think it had much of an effect. Even in diabetics, the consensus seems to be that the benefits of niacin outweight any associated blood sugar increase. Like you, I didn't go into this with a weight issue. I'm ~5 pounds lighter than when I began this regimen (5'10'' 152 pounds now), a change attributable entirely to the Metformin.

    The rise in homocysteine from high-dose niacin has something to with niacin's action depleting the available methyl donors. I don't think beets will provide anything approaching the amount of TMG necessary to methylate excess homocysteine back to methionine (which is a SAM-E precursor...oh happy day). I take about 3,000 mg/day of TMG. It's an inexpensive supplement, and I'd rather be safe than sorry, as homocysteine can make some major mischief over time in the vascular endothelium.

    I didn't know about the fish oil / blood sugar connection.

    FYI, I don't know if you're familiar with the study in which participants taking vitamins A and C with niacin showed a much-reduced--in fact, practically negated--effect of niacin on blood lipis versus those not taking A and C. No further investigation took place, and the mechanism (assuming this finding is valid) remains unknown. As a precautionary measure, I drink my vitamin A - rich green juices and take my C supplements at least a few hours before or after taking niacin.

    BTW, I've read in several places that effects of niacin can become MORE robust over time, which squares with the steady increase in HDL and the HDL-2 subfraction I've observed over the last year, as well as a decreasing LDL value and increase in mean LDL size.

    One anomalous thing I've noticed is that my lp(a) reading on VAP tests has increased from 4 to 17, but the test for lp(a) alone has remained at the minimum value. I had a VAP today and will be getting the lp(a) monoassay on Wednesday. If this strange discrepancy shows up again, I'm going to call Atherotech and LabCorp and ask them what's up. I did recently read a study in which blood samples from one or more patients were sent to Atherotech, Liposcience, Berkeley Heartlab, and one other company; there were striking discrepancies among the reported results from the four labs. Interestingly, of the four, Atherotech's VAP test was the least likely to characterize a patient as having Pattern A LDL; although, now that I think about it, Liposcience (NMR) doesn't even use the Pattern A, AB, B terminology, do they? Anyway, it's fun to share these observations with a group that actually is thinking about this stuff! I've posted all my blood panels to my facebook account along with what I did to achieve the dramatic changes reflected in the data. My friends found it all very interesting but only one has initiated a similar experiment.

  • Jacob

    1/10/2012 3:34:45 AM |

    outweight = outweigh

  • Might-o'chondri-AL

    1/10/2012 7:59:56 AM |

    Why Doc's low carb may be more important for some more than others is these after meal events. He's pointed out that high after meal (post-prandial) blood sugar (glucose) are a problem because the liver will make that excess glucose into triglycerides (trigs). Some of us may also trend toward low trigs, despite any  post-prandial  glucose spikes, because of our constellation of genetic quirks in how the sequential triglyceride synthesizing enzymes play out their essential esterifying and hydrolyzing ( enzymes = glycerol-3 phosphate acyl-transferase1, 1-acyl-glycerol-3-phosphate-O-acyl-transfe​rase5 & 9, plus di-acyl-glycerol acyl-transferase2). I should stress that my non-low carb lunches were always followed by me walking around extensively on errands - so any contradiction inferred from my lab results (above)  with Doc's low carb preference may be explained by my immediate use of the post-prandial glucose in real time skeletal muscle activity  & not just my genetics.

    Doc insists excess post-prandial trigs should be avoided because those trigs get cobbled into VLDL cholesterol and sent out from the liver. It is when the VLDL comes back to the liver without giving up most of it's trigs that confuses many people. This is because, in the specific context of post-prandial  VLDL, the molecule that brokers recycling entry into the  liver of that VLDL (whatever it's residual trig load) does so in accord with ApoE. (note: it is  not the same type of dynamic that happens with clearing our LDL.)

    Curiously, it is the isoform variant of ApoE4 which can help get the most VLDL quickest into the liver cells; so ApoE4 individuals are shunting plenty of  VLDL in, for recycling, but at the same time plenty of  ApoE4 is also coming into that liver cell. Conversely, ApoE3 will be relatively slower clearing VLDL out of circulation & ApoE2 conformation is slowest in helping get returning VLDL into liver cells; which means, for ApoE2 there's more of a backlog going on in the blood stream of VLDL (& any of those post-prandial trigs our skeletal muscles didn't take up when trigs circulated by).

    Once an individual VLDL complex is inside a liver cell it is subjected to an initial processing in a specialized compartment  (endo-some) of the cell that naturally lowers the pH in that intra-cellular compartment to break the VLDL complex apart for recycling. In response to that normal processing pH drop the ApoE4 molecule (as opposed to other ApoE isoforms) becomes more fickle; basicly  it's (ApoE4) molecular configuration is vulnerable to undergo changes like become globular gel, truncated in some sectors and open up it's hydro-phobic surfaces. In simple terms this means that re-cycling truncated ApoE4 won't move well in the liver cell's interior fluid matrix and hug the lipids it finds closest there more so than recylcled ApoE3 & ApoE2 does.

    VLDL, thus will shed it's ApoE  and that ApoE will ideally move to another compartment inside the same liver cell to tag up with an HDL that has been taken up by that liver cell. One of the things this does for us is hold that ApoE molecule nearby, but where pH isn't going to drop. In this phase until the ApoE gets incorporated, as a component, into on of two cholesterol components. One is to put the recycled ApoE into fledgeling HDL that then becomes "mature" HDL sent out of the liver into circulation.. The other, less understood function (and purpose of this long explanation) is of stashing our VLDL recycled ApoE temporarily bound close by to an HDL (inside the liver cell) is to take & re-use it  (ApoE) reformulated with a VLDL molecule when the liver needs to send out any post-prandial trigs.

    Doc's paradigm is preventative, meaning avoid lingering high blood glucose (hyper-glycemia) due to excessive single meal carbs and thus put less demand for ApoE to be cycled into trig loaded VLDL that might just come back again & again demanding the liver engage in futility. For those with degrees of ApoE4 variants there is slower teaming up of it to that helpful HDL inside the liver cell that normally pulls ApoE away from the cell's low pH compartment. Explicitly it is HDL itself that activates this key stage; it is an additional specialized function of HDL. I don't know if one aspect of having low blood level's of HDL is from when a person's stuck with high trigs driving them to cobble it (trigs) into VLDL  with ApoE and this stalls too much HDL inside liver cells performing an HDL function in there & not out as circulating.HDL.

    Some theorize that by diverting so much ApoE  into post-prandial trig loaded  VLDL there is then going to be "mature" HDL going out of the liver that doesn't carry the ideal amount of  ApoE  to fully perform a cholesterol pick-up function for the HDL molecule while HDL is out in circulation. And  if one has ApoE4 being recycled, which is relatively slower to get over to any HDL in the liver cell, then the "mature" HDL will also go out with less ApoE to snatch back cholesterol.

    Lost? ....We essentially don't want "fat" (lipid, like trigs) we may have made to build up in the liver. So,  if we can't get all the "fat" lipids we made out of our excess blood sugar (glucose) get sent out  of the liver as trigs tied to VLDL there is a backlog of trigs always hanging around in the liver . And then, because the process of  us making trigs potentially stalls at a transitional molecule involved called di-acyl-glycerol (please note, don't let this long word make you confused now: this is just being two "fats", since "di" =2 in a formation that is one step short of the well known  tri =3 "fats"  formation  of tri-acyl-glycerol , that everybody  calls tri-glyceride for short & I  lazily type as  "trigs" ). Anyway ending simply,  it is this intermediate "fat" lipid of di-acyl-glycerol  subsequently building up in the liver that triggers a cascade  (for geeks: protein kinase C ), which ends up involving  the receptor for insulin in that liver cell. This unwanted downstream phase of bonding to that insulin receptor blunts the next cascade (4 geeks: tyrosine kinase) and  then that step is more directly what contributes to liver insulin resistance over time (ie: insulin comes to liver cell but more & more insulin receptors being kept too busy) . This is the problem played out by  our "fat" lipids in a chain of events that individuals with excessive trigs risk getting stuck with. Doc warns us to  beware of carbs making you synthesize lots of after meal trigs from prolonged high blood glucose which then forces you to put out VLDL (ie: to try to reliably take trig load off your liver). Elsewhere he stated, in accord with current science, that it is post-prandial trigs that are the most insidious trigs.

  • Jacob

    1/10/2012 8:58:03 AM |

    Interesting about the postprandial trigs. I was unaware of their significance. Makes sense, though, given the relatively greater importance of the magnitude of postprandial blood glucose excursions versus fasting levels.

    Your post conjured up images from long-ago courses on enzyme mechanisms, except without the fun electron pushing.

  • Might-o'chondri-AL

    1/11/2012 3:44:15 AM |

    2011 Post-prandial trigs relation to cardio-vascular details at the link below will give abstract but click at box where says "The full text is free" in pdf. if inclined.
    http://www.ingentaconnect.com/content/ben/cvp/2011/00000009/00000003/art00001
    (titled) "Free Content Assessment and Clinical Relevance of Non-Fasting and Postprandial Triglycerides: An Expert Panel Statement"
    Current Vascular Pharmacology, Volume 9, Number 3, May 2011 , pp. 258-270(13)

  • Taking Charge

    1/11/2012 3:55:46 PM |

    While not directly related to this thread I wanted to get this request out there. I am hoping that  some one can help me find a doctor that is following a similar or the same protocol wtih vitamin K2 etc. and diet as Dr. Davis'.
    I was recently diagnosed with aortic stenosis and am looking for an alternative to valve replacement. I am looking for a cardiologist in the Greater Toronto ON  - Buffalo NY area.
    Thanks in advance for any suggestions given.

  • Galina L.

    1/11/2012 7:14:38 PM |

    @ Might
    Sorry, it my comment is out of tangent, but as a long-time fan of you, I want to share a Russian recipe of a beet salad with you. It contains cooked (or canned) chopped beets, chopped raw onion, chopped  fermented pickles or sauerkraut, some potatoes cooked and cut in small cubes (it is possible to skip), salad is seasoned with mix of brine and olive oil (in Russia an unrefined sunflower oil is used).  Other things may be added like cooked cubed or shredded raw carrots, fresh cucumber ,celery, some herbs, maybe garlic.  It is often consumed instead of a potatoes salad, especially at winter time..

  • Jacob

    1/13/2012 4:50:46 AM |

    The lp(a)  measurement truly puzzles me. When I get the lp(a) monoassay it always comes back <2 (the minimum measurable) , but the VAP is all over the place (up to 17).

  • Might-o'chondri-AL

    1/13/2012 3:31:55 PM |

    Hi GalinaL,
    Thank you. Beets' nitrate are converted into nitrite in us to do all kinds of good things, as medical news reports.

  • Gene K

    1/13/2012 6:15:53 PM |

    Galina,
    How about a Russian borscht (a beet soup, for those who are not familiar with it)? We had it at home recently, but I neglected to take my BG after eating, so will do it next time. It is hard to give up beets, but Might's comment about it is encouraging. I also surprised Dr Davis that such dish existed, when I saw him not long ago.

  • Galina L

    1/14/2012 3:32:19 AM |

    Borscht is a cabbage soup , with two main features - first of all it contains beets(obviously), second, very important  secret difference,  that it is seasoned , when it is almost ready,  with the bacon (fatty part) crashed together with some salt and couple garlic gloves. I use mortar and pestle, but it is possible to do crashing between wax paper sheets, plastic sheets, just make sure it looks more or less like a paste. There several recipes,
    here is an example - use broth or  water, may be 3 - 4 cups, bring it to a boil, while water is getting into a  boiling, make sauteed veggies , fist put on a pan chopped carrots (1 big or 2 small) and parsley , then bell pepper, then chopped onions, when onions are ready - add  1 -2 tomatoes. Prepare garlic+bacon paste. Put 1/2 head of shredded cabbage into boiling salted water, when cabbage is almost ready, add sauteed veggies, let is quickly boil, add  the chopped content of one can of beets(beets must be added only after sour ingredient - tomato in that recipe) with the liquid and the paste, then  take it  from the heat, close with a lid.. Taste is better next day. I didn't mention herbs, possible vegetables to add, when to put salt. It taste very good with sour cream, chopped chives, even slice of a lemon in your plate..

    There many variations, important thing - don't let it boil again after it  isready - it will change color and flavor.

  • Might-o'chondri-AL

    1/14/2012 4:39:38 AM |

    Hi Jacob,
    Lp(a) is a molecule with an Apo-lipo-protein B100 core like an LDL with protein ApoA bonded on it. The gene LPA encodes for the Apo-lipo-protein A & there are many genetic variations of LPA.

    When the LPA copy # if greater the amount of gene driven expression going on is less. This is apart from  any SNP (polymorphism) of LPA & involves the number of reating domain(s), called  "kringles" (kringle IV domain). Basicly the more kringles the less genetic induced protein to build up into a full Apo-lipo-protein A. In Europeans +/- 60% of the variation in circulating Lp(a) is due to the peculiarity of kringle copy #.

    The SNP variants (of LPA) have more relationship to the way that particular conformation of  Lp(a) might uniquely degrade and give off metabolic by-products that potentially can act against organ tissue promoting enough new blood supply (angio-genesis). If the heart can readily make new blood supply routes that is ideal & thus a specific genetic Lp(a) variant that doesn't stymie angio-genesis is not a cardio-vascular problem  - irregardless of that Lp(a) level.

    You take supplements to restore homocysteine back into methionine. There is a specific LPA polymorphism giving one a SNP allele 4399 methionine (in substitution for the standard isoleucine amino) inclining those people to make +/- 6 times more Lp(a) than otherwise. I don't know if you carry that particular SNP, but if your rise in Lp(a) coincides with your protocol against homocysteine you may (?) be feeding  into
    the LPA4399Met hand . Admittedly far fetched, yet methionine boosting is not always benign for longevity according to some investigators.

    Vitamin A converts to retinoic acid in the body & this may ( ?) be more relevant. The Retinoic acid-related orphan receptor alpha (RORalpha) has 4 different variant iso-forms. It (RORalpha) is found in the nucleus of liver cells and responds to melatonin if you supplement with  melatonin as well.

    Your RORalpha iso-form may also be prone to receiving activation when there is  excess vitamin A's retinoic acid reaching the liver. RORalpha activation gets it's  nuclear response element ( Rev-erba) to bind to DNA & this engages several genes. In other words liver RORalpha up-regulation greatly influences Apo-lipo-proteins A, as well as A"V"(5), & C"III" (3) put out by the liver - among other things (ex: carb processes).

    Which, coincidentally, leads back to heart as per 3rd paragraph above....Hypoxia (oxygen low) also activates RORalpha, and thus Lp(a);  but one's LPA variant iso-form can give an Lp(a) degradation that acts anti(against)-angio-geneic. Then that heart's ability to get alternate blood supply  of oxygen to fall back on is limited; meaning the degree of  hypoxia damage done to any of that heart's cells becomes more problematic. Hypoxia isn't an all at once state of an all over or nothing organ-wide event.

    Cardio-vascular problems are said to be an "inflammation" problem & the more pro-inflammatory Il-6 (interleukin 6) the greater upregulation of Lp(a) going into circulation. Doc expounds his low carb protocol cuts down inflammation marker CRP (C-reactive protein) & Il-6 is a big part of CRP dynamic.  By blunting  Il-6 (or if  fortunately genetically don't make or even receptor  much) there is less Apo-lipo-protein B being made that is an important part of  liver's VLDL formation. Consider, as an example,  that the drug "Mipomersin" acts to block ApoB synthesis with a side effect of lowering Lp(a).

    Unfortunately too, high Il-6 is associated with lots of  triglycerides being made in the liver .  Having high Il-6 instigating lots of ApoB to cobble the excess trigs it (Il-6) provoked into VLDL  favors getting those Il-6 hyped trigs get sent out into circulation. Then too high Il-6 makes for lower rates of liver trig clearance from the trigs brought back by various lipo-proteins. D ue to the inflammatory  settting when the VLDL (with it's remaining load of trigs) comes back to a liver cell for VLDL re-cycling (detailed in earlier comment here)  it can't unload  & clear it's trigs  due to the co-existing high levels of Lp(a).

    In other words,  induced to make lots of Lp(a) overactivated LPA gene means excessive ApoA. Since ApoA can also go where ApoE  can , the  molecule of ApoE that is normally designed to get free from the VLDL risks getting out-competed. Then HDL inside that liver cell doesn't mediate the movement of  stale VLDL's  ApoE as much (because busy with ApoA),  which creates a backlog of  freed ApoE in that  cell's endosome  forcing other returning VLDL ( with it's trigs & ApoE) stalled in a traffic jam.  And that HDL doesn't rush to leave the liver cell because it isn't getting normal ApoE chain of events making it a "mature" HDL; so circulating HDL level is paradoxically lessened despite plenty of  ApoA  around.

  • Might-o'chondri-AL

    1/14/2012 6:23:11 AM |

    IL-6 meant by Il-6 (among other proof reading  mistakes )

  • Gene K

    1/14/2012 9:32:24 PM |

    Galina,
    Thank you for this extensive recipe. I am tempted to continue, but it is not my blog. Maybe Dr Davis will find these Russian recipes good for the TYP program...

  • Jacob

    1/16/2012 1:52:02 AM |

    ". There is a specific LPA polymorphism giving one a SNP allele 4399 methionine (in substitution for the standard isoleucine amino) inclining those people to make +/- 6 times more Lp(a) than otherwise. I don’t know if you carry that particular SNP..."

    I don't. I'm 4399 Ile/Ile homozygous.

  • Jacob

    1/16/2012 1:58:50 AM |

    Also LPA-Intron 25: tt homozygous.
    KIF6: 719 Trp/Arg heterozygous :-(  [[I don't want to take statins though]]
    9p21: ag heterozygous at rs10757278 and gc heterozygous at rs1222049 [[I read a recent study indicating that a diet primarily composed of vegetables and fruits (and maybe nuts) almost negates the associated risk here, and that's how I eat. So, fingers crossed.]]

  • Dennis

    1/23/2012 6:47:58 PM |

    While Dr. Davis' website & blogs got me started on the path of getting off the statins, etc (thank you 1000 times!!!)...I believe we are over-thinking this and making it way too complicated.
    Look at it from an evolutionary biology perspective (I just finished Food and Western Disease by Staffan Lindeberg, http://www.amazon.com/Food-Western-Disease-evolutionary-perspective/dp/1405197714) Our metabolic processes developed over the course of millions of years, being optimized by evolution all along the way. We ate meat, eggs, fruit, veges, nuts and did just fine. Then about 10,000 years ago we figured out we could stay put, not follow the wild herds and dig up food as much, and grow our food where we lived. Big problem...the food we decided to grow makes us sick (wheat, corn, rice). Not falling down, vomiting sick, but just a little at a time sick. We get fat, have strokes, heartattacks, high BP, diabetes, cancer, etc... aka Western Disease. But don't all the experts tell us to eat whole grain, and drink milk, and eat cheese, and use olive oil??? That's where the next problem arises...we don't know what we don't know. All the "science" behind good nutrition today is based on studies with many, many flaws. And, our metabolic systems are so enourmously complex, that we don't really understand how it works. If you look at people today, who still maintain a paleolithic diet (hunter / gatherer) you find that they do not suffer from Western Diseases. When they move from their ancestral ways to "modern" diets, they suffer like we do.
    I've gone from a Mediterranean diet to a Paleo diet, lost 15 lbs in 7 wks without changing my exercise routine, stopped taking my statin, am eating less, sleeping better, and feel really good. And this coming from a lifelong semi-hardcore athlete, who at 45 got a stent in a coronary artery, and prescriptions for Plavix and Simvastatin. Two years later i felt like crap and decided it was time to do something different. First stop was DR. Davis' sites, then others. The blood work is coming in mid Feb to establish the first real data points.
    Bottom line...eat what the cave man ate, get plenty of sleep, go outside in the sun, do some strenuous excercise, and quit letting your doctor feed you the Big Pharma line of BS. It's not easy. Nothing worth while is. But, as your body changes, so will your resolve to save your own life!
    //DM9

Loading