Diabetes is Track Your Plaque's Kryptonite!


If there's one thing I truly fear from a heart scan score reduction/coronary plaque regression standpoint, it's diabetes.

I saw a graphic illustration of this today. Roy came into the office after his 2nd heart scan. His first scan 14 months ago showed a score of 162. Roy started out weighing well over 300 lbs and with newly-diagnosed adult diabetes.

Roy put extraordinary effort into his program. He lost nearly 70 lbs by walking; cutting processed carbohydrates, greasy foods, and slashing overall calories. His lipoproteins, disastrous in the beginning, were falling into line, though HDL was still lagging in the low 40s, as Roy remains around 60 lbs overweight, even after the initial 70 lb loss.

Unfortunately, despite the huge loss in weight, Roy remains diabetic. On a drug called Actos, which enhances sensitivity to insulin, along with vitamin D to also enhance insulin response, his blood sugars remained in the overtly diabetic range.

Roy's repeat heart scan showed a score of 482--a tripling of his original score.

Obviously, major changes in Roy's program are going to be required to keep this rate of growth from continuing. But I tell Roy's story to illustrate the frightening power of diabetes to trigger coronary plaque growth.

Like Kryptonite to Superman (remember George Reeves crumbling and falling to his knees when the bad guys got a hold of some?), diabetes is the one thing I fear greatly when it comes to reducing your heart scan score. As you see with Roy's case, diabetes can be responsible for explosive plaque growth, more than anything else I know.

The best protection from diabetes is to never get it in the first place. (See my earlier Blog, "Diabetes is a choice you make".)
Loading
The Great Low-Carb Connector

The Great Low-Carb Connector

The effusive Jimmy Moore of Livin' La Vida Low-Carb asked me to help get the word out about his new podcast subscription service, The Livin' La Vida Low-Carb Show Fan Club.

Jimmy has been The Great Connector for the low-carb discussion, from his ubiquitous online and social media presence, to his annual low-carb cruise. He has also broadcast first class interviews of nutritional notables like Gary Taubes, Dr. Robert Lustig, and blogger Stephan Guyenet. His Fan Club expands listener involvement in the podcast process and, potentially, greater access to his guests:

My faithful listeners have long been asking me about how they can become even more engaged in the behind-the-scenes workings of the show to get the inside scoop about what’s coming next. I’ve heard people ask specifically for access to transcripts of the most popular podcasts, a listing of the interviews I’m currently working on with the ability to ask questions of those guests, to have sneak peek of audio from not-yet-released interviews and more. My amazing podcast producer, Kevin Kennedy-Spaein, and I have been discussing how to best do this for a while in an effort to meet the demands of our biggest fans and we think we’ve got just the answer for you. Introducing The Livin’ La Vida Low-Carb Show Fan Club!

This is for all intents and purposes the quintessential destination for people who can’t get enough of this podcast that goes much deeper than discussion about the low-carb lifestyle. Yes, I speak with a lot of people who are supporters of carbohydrate-restricted diets, but I also talk with fitness gurus, people who support alternative eating plans, those who have interesting theories and beliefs regarding health and much more. Wouldn’t you love to have a chance to know who’s coming up in my schedule to be able to ask them questions BEFORE I interview them? Keep in mind that my interviews are pre-recorded and air sometimes as much as 5-6 months afterwards. Members of the “fan club” would know all about who’s coming and likely will have their question asked on the air just for signing up to be a part of this exciting new addition to “The Livin’ La Vida Low-Carb Show.”


Jimmy is the guy who is bringing this disparate and widely-spread community together. He's the guy we all know, he knows "everybody." I'm looking forward to seeing how this new project makes a more involved, personal delivery of interaction possible.

Comments (15) -

  • Anonymous

    10/28/2010 12:54:06 PM |

    Is Jimmy still eating eggs for every meal in order to lose weight?

  • kris

    10/28/2010 2:37:00 PM |

    Dr. Davis, How true is this statement?
    "before resorting to muscle tissue, the body will burn fat. If you have no body fat, (or even very little of it), then eating carbohydrates is a good idea. If there is fat to burn, it will be burned first. Our entire body runs on sugar, but you can turn fat into sugar and sugar into fat, depending on the current needs of the body"

  • Anonymous

    10/28/2010 4:02:20 PM |

    No - he is off the eggs, but somewhere up around 282lbs.  Jimmy is indeed a great connector and does well with podcasts and interviews but his own diet - and as a consequence his weight - remains a problem.  He remains obese and as such is not a great advert for low carb.

  • Jimmy Moore

    10/28/2010 6:04:17 PM |

    THANKS for the plug for my new "Fan Club" associated with my podcast, Dr. Davis.  I certainly hope to indeed connect fans of "The Livin' La Vida Low-Carb Show" with more of the behind-the-scenes happenings to get them involved in the interview process, share transcripts of past episodes, and even let them hear sneak peak audio of not-yet-aired podcasts.  I'm excited to make this little something extra available to those who want more.

    As for the the anonymous criticism about my weight, yes I weigh more than I would like to at this moment.  This is not a secret and I've been quite candid about this publicly because there are many who face the same frustrations of doing everything right and yet seeing very little progress on the scale.  While I'm seeking to rectify those issues by lowering my calories to 1800/daily and engaging in regular exercise, the fact remains my health is immaculate.

    High HDL, low triglycerides, low percentage of Small LDL particles, stable blood sugar, normal blood pressure, a heart scan score of ZERO, abundant energy and so much more.  While the focus tends to be on weight as the key measurement in someone being healthy, I think that's as shortsighted as telling someone a low-fat, high-carb diet is the only way to lose weight and be healthy.  Again, I'd like to weigh less than I do now but it's difficult to argue that the way I'm eating isn't making me healthier than when I weighed 400+ pounds in 2004 on three prescription medications.

  • Jamie Scott

    10/29/2010 12:17:43 AM |

    Re: Jimmy's weight - it's Jimmy's business!  The guy does a massive amount of work, as highlighted by Dr Davis' post, promoting the many and varied strains of low carb eating, and he does so because he has first-hand experience of the benefits of doing so.  Sure HE might not want to be where HE wants to be with HIS weight, but it isn't like he is ht eonly guy pushing the low carb mantra and peddling snack oil is it?

    Jimmy, I'd have no doubt you could get to where you wanted to be (or closer to it at least), if you gave up on the stuff that you do.  But the rest of us would be poorer for it.  A run a very small and very much part-time blog in this field and if I put in the amount of time Jimmy does with all his work, I doubt I would be able to maintain the other aspects of my life that I enjoy so much.  It is a sacrifice Jimmy makes.

    One last thing, and Jimmy may disagree with me on this... At one point in time, Jimmy's lifestyle lead him down the obesity pathway.  One aspect of this, and one that I try to promote in my line of work, is if you go down that road, there is no guarantee you can come back out of it.  Things like the consumption of industrial seed oils can lead to fat cell hypertrophy & hyperplasia... size AND number of fat cells increase.  Stay in this state long enough, and there is high chance you will never fully undo the damage done.  You can certainly imporve your health biomarkers as Jimmy has obviously done.  But you might not necessarily be able to return to an ultrathin body, no matter how much you desire it.  There is a degree of ingorance from people who just automatically assume that because one is eating low carb, they should look like a Crossfitter all the time and failure to do so means that low carbing is a failure also.

  • Jimmy Moore

    10/29/2010 2:16:34 AM |

    Well said Jamie!  I totally agree.

  • Lori Miller

    10/29/2010 4:29:01 AM |

    Nothing measures up when compared to perfection. It's better to compare real-life choices and their likely consequences whenever possible.

    If someone was 400+ pounds and on medications on their old diet, and 120 pounds lighter, energetic and off the medications on a different diet, the different diet must have some benefits. I prefer to think in terms of progress, not perfection.

  • Susan

    10/29/2010 5:24:31 AM |

    Jimmy, Jamie and Lori


    AMEN !!!!


    Sue

  • Dr. William Davis

    10/29/2010 12:01:08 PM |

    I know Jimmy personally and he is a sincere, hard-working nice guy.

    We are all learning new lessons in nutrition and how to manage diet, navigating all the landmines in the commercial food that we are sold.

    Jimmy's unquestioned role in this has been to facilitate the discussion, bringing differing viewpoints from interesting people like Gary Taubes and Jeff Volek.

    Personally, I am grateful that we have someone like Jimmy Moore who acts as amiable host to our discussions.

  • ben

    10/29/2010 1:20:41 PM |

    i love Jimmy's podcasts. In fact i subscribe via itunes. He never fails to have intelligent guests. Especially in the last year or two he has had many paleo people which is great. I like to see the focus on good-health-all-around entering into his lowcarb world, rather than the sole goal of weightloss that i feel many atkinsers etc have. Anyway, he's doing a great job. and he has been for quite some time now. His weight? Who cares. Jimmy, dont sweat it! you've lost all that, your health numbers look great and you are leading a life that benefits many. I think you can be satisfied.

  • Anonymous

    10/29/2010 6:20:42 PM |

    Train wreck/drama queen. Needs to lift free weights or join a cross fit gym…quit making excuses..

  • Anonymous

    10/30/2010 1:22:10 AM |

    "Train wreck/drama queen...quit making excuses..."

    You got that right!

  • Anonymous

    10/30/2010 4:28:00 PM |

    Thank you so much Jimmy for the help you provide to all of us.
    I am an uruguayan and follow your podcast from Uruguay LA.
    Thanks again.
    Jose.

  • Anonymous

    10/30/2010 9:37:25 PM |

    If not for Jimmy Moore I would never have heard of Dr Davis, Mark Sisson, Stephan Guyenet, Robb Wolf, Dr Briffa, Fred Hahn and so many others.  I would never in a million years have thought to include strength training in my lifestyle.  I wouldn't have learned about the impact of sleep on health and mood.  Without the information Jimmy Moore brought into my life, I'd still be Vitamin D deficient, undermuscled, underslept and unhealthy.  Instead I've grown strength and muscle, ditched lifelong allergies and have had only one cold in the last three years.  (I work in healthcare and get coughed/sneezed upon constantly, so this is no insignificant fact.)

    Jimmy is humble, funny, candid and generous.  Sure, we'd all like to include "stunning physique" in our list of personal qualities, but some of us just have to be satisfied with excellent health and an ongoing commitment to pursue optimal body composition.

    For me, Jimmy Moore is a treasure.

  • e4e

    11/1/2010 6:16:54 PM |

    Kudos to Jimmy for all his good work. I completely agree with Jamie above.

    Anonymous trolls, just go away, or at least show a little spine and put your name.

    Tony K

Loading
Name that food

Name that food

What common food can:

• Cause destructive intestinal damage that, if unrecognized, can lead to disability and death?
• Increase blood sugar higher and faster than table sugar?
• Trigger an autoimmune inflammatory condition in the thyroid (Hashimoto’s thyroiditis)?
• Create intestinal bloating, cramps, and alternating diarrhea and constipation, often labeled irritable bowel syndrome?
• Trigger schizophrenia in susceptible individuals?
• Cause behavioral outbursts in children with autism?
• Cause various inflammatory diseases such as rheumatoid arthritis, ulcerative colitis, dermatitis herpetiformis, systemic lupus, pancreatic destruction, and increase measures of inflammation like c-reactive protein?
• Cause unexplained anemia, mood swings, fatigue, fibromyalgia, eczema, and osteoporosis?


The food is wheat. Yes, the ubiquitous grain we are urged to eat more and more of by the USDA (8-11 servings per day, according to the USDA food pyramid), American Heart Association, American Dietetic Association, and the American Diabetes Association. Wheat is among the most destructive ingredients in the modern diet, worse than sugar, worse than high-fructose corn syrup, worse than any fat.

What other common food can result in such an extensive list of diseases, even death?

Celiac disease alone, a severe intestinal inflammatory condition from wheat gluten, affects an estimated 3 million Americans (Celiac Disease Foundation). The medical literature is filled with case reports of deaths from this disease, often after many years of struggle with incapacitating intestinal dysfunction and the sufferer's last days plagued by encephalopathy (brain inflammation).

What happens when you remove wheat from the diet?

The majority of people quickly shed 20-30 lbs in the first few weeks, selectively lost from the abdomen (what I call “wheat belly”); blood sugar plummets; triglycerides drop up to several hundred milligrams, HDL increases, LDL drops (yes, wheat elimination is a means of achieving marked reduction in LDL cholesterol, especially the small, heart disease-causing variety); c-reactive protein plummets. In addition to this, intestinal complaints improve or disappear, rashes improve, inflammatory conditions like rheumatoid arthritis improve, diabetes can improve or be cured, and behavioral disorders and mood improve.

Along with the ill-fated low-fat dietary advice of the last 40 years, the advice to eat plenty of "healthy whole grains" is responsible for untold disease and suffering. Yes, if you start with a fast food and junk diet and replace some of the calories with whole grains, you will be better off. (That was the logic--the Nutritional Syllogism--of the studies that established the benefits of whole grains over processed, "white" grains.)

But eliminate wheat grains and health takes a huge leap forward. And, no, there is no such thing as wheat deficiency--B vitamins, insoluble fiber, some protein--can easily be replaced by other foods.

Comments (30) -

  • Peter

    10/13/2009 12:40:15 PM |

    I stopped eating wheat when I read Gary Taubes's book Good Calories, Bad Calories.  However, I haven't noticed any changes.  My blood sugar is still a little high, and my weight is about the same.  Could you cite a study that shows that blood sugar and weight often go down when you stop eating wheat.

  • Anonymous

    10/13/2009 1:12:56 PM |

    Yes, yes!  Great post!  However, I think there is a huge mssing link here, and that is the source of wheat.  Sure, wheat (or gluten in many cases) causes problems.  I totally agree.  But my theory is that people who drop weight and improve their health by eliminating wheat were not eating the ocassional slice of home-made sourdough.  Nope.  I'd be willing to bet that most of the "wheat" elimination that leads to a better lipid profile and decreased body fat is from the elimination of packaged and processed foods like cereals, bars, crackers, store breads and buns, and other snack foods.

    Avoiding wheat due to a sensitivity or allergy is one thing.  But gorging oneself on processed foods and so-called healthy whole grain products only to later marvel at the results of a "wheat" elimination diet is a bit ridiculous.

    Eat from the earth.  And if for you that means no wheat, then great!  Just don't go eating all that "gluten free" stuff.  One can still eat a ton of junk without eating wheat.

  • Allison

    10/13/2009 1:58:16 PM |

    I love that you're pursuing this matter. Smile  It's not just wheat, though.  It's all the gluten grains related to wheat: barley, rye, spelt, kamut, etc.  In those of us sensitive to gluten, even the tiny bits of gluten in most processed foods cause problems.  So do oats, even gluten-free oats, in some Celiacs.

    Keep up the anti-wheat campaign, but please add the other gluten grains to your target.

  • Catherine (Santa Fe)

    10/13/2009 5:55:01 PM |

    Dr. Davis,
    I started the gluten-free diet 2 months ago after reading all your blogs. The one thing I did not think it would influence is thyroid. You stated so confidently that it influences Hashimotos, I wondered how you came to that knowledge---articles, research, personal observation?
    For 8 years my TPO antibodies have been very high in 700-800 range even with meds and good T4, T3 numbers. All tests came back negative for celiac although with high IGA. I have never been able to get Hashimotos numbers down, so would love to know how/where you heard about this. I will report back if after being wheat free my IGA and TPO numbers go down.
    Warmly,  Catherine

  • I Pull 400 Watts

    10/13/2009 6:40:50 PM |

    Fantastic post.


    I have been looking into a lower wheat (or gluten?) diet for a bit now, and recently purchased The Paleo Diet for Athletes. As soon as a finish In Defense of Food, that is next on my list.

    A quick question if you have a second. Maybe you can simply directly me to a page with the answer, as I have not been able to clearly find it.

    Is the key avoiding grains as a group, or would eating gluten free products be partially sufficient?

  • woly

    10/13/2009 8:47:33 PM |

    Do you have any references you could post for those claims?

  • Dr. William Davis

    10/14/2009 1:15:19 AM |

    In answer to several questions to clarify what I mean by "wheat":

    1) For celiac disease or marked wheat sensitivity, including "wheat addiction," all grains that immunologically cross-react with wheat should be eliminated--barley, spelt, oats.

    2) For those with extreme carbohydrate sensitivity--meaning diabetics, pre-diabetics, or marked small LDL, then even spelt, bulghur, sorghum, quinoa, barley, etc. can present excessive carbohydrate loads.

    For everyone else, I believe that these whole grains can play a role.

    Re: references. Just go to Pubmed.gov and enter your relevant search terms. It's quite easy.

  • Peter

    10/14/2009 10:07:13 AM |

    It's hard for me to separate out the effects of wheat, gluten, flour, grains, carbs.  

    Probably, nobody really knows yet., which is what it's like in 2009: lots of clues but nothing definitve.

  • Jonathan Byron

    10/14/2009 2:40:16 PM |

    My wife has hashimoto's thyroiditis, and cutting out the gluten has led to tremendous improvements. Her T3 and T4 levels are back to normal, and her anti-thyroid antibodies dropped significantly, to nearly undetectable. And she feels normal, not cold and lethargic.

    I am not convinced that all people with Hashimoto's benefit from cutting out gluten - some studies showed only about 30% to 50% of the group improved (but many people show amazing improvement). A change of diet should be the first thing tried IMO. It was not something the endocrinologist discussed. When my wife asked if there were any dietary or lifestyle changes that might help, she was told there were none.

  • Dr. William Davis

    10/14/2009 4:47:40 PM |

    Hi, Jonathan--

    Yes, wheat exposure probably requires years to trigger the Hashimoto's reaction. Unfortunately, to my knowledge, the precise trigger and "dose" or duration required is not well sorted out.

  • Christine Anderson

    10/14/2009 5:19:18 PM |

    I find the statement “don’t go eating all that ‘gluten free’ stuff” rather silly – the implication being that it’s full of junk.  Most of the gluten free food I’ve found is wonderfully free of the usual high-fructose corn syrup and the like.  It’s a real blessing, to be quite frank.  And by the way, all my food comes from Earth.

  • Anonymous

    10/15/2009 12:58:54 AM |

    Dr. D, correct me if I am wrong but quinoa is not a grain (it's a seed) and should not be grouped with wheat, spelt, barley, etc.

    My understanding is that its impact on the body is significantly more positive compared to grains.

  • Anne

    10/15/2009 1:06:24 AM |

    I have both gluten sensitivity and insulin resistance. Gluten free means I avoid wheat(includes spelt, kamut and other related grains), barley and rye. Oats are available that are certified gluten free. Removing gluten eliminated my GERD, gas and bloating, improved my neuropathy, lifted my depression, stopped my joint pain and the list goes on.

    When I discovered my blood sugar issues, I dropped all the gluten free grains that caused spikes in blood glucose. OK, I have not found a grain that does not spike my blood sugar so I am now grain free. The only problem I noticed when eating the GF grains was the blood sugar effect.

    Gluten/wheat and carbs/sugar are two separate issues for me.

  • Sue

    10/15/2009 11:01:24 AM |

    Is it full of soy?  That's junk.

    Peter, you probably have to reduce your carbs to see improvement in your blood sugar levels.

  • Anonymous

    10/15/2009 2:39:19 PM |

    To clarify: My point was that most products tha are labeled as "gluten free" are processed, and largely a part of the food industry's marketing tactics.  They are not there for your health, but rather to make profits.

    You can buy gluten free cookies, cereal, and other snack foods.  These foods are far from being close to the earth, and IMHO, not to be a regular part of a healthful diet.

  • Anonymous

    10/15/2009 3:15:27 PM |

    The sentiment is valuable, but I worry about hyperbole.  If an individual cuts out 1000 calories a day of wheat-related foods (a generous estimate), and doesn't replace those calories with any other foods, then they would lose about 2 pounds a weeks, not 10 or 15.

  • Anonymous

    10/19/2009 2:50:23 AM |

    I agree with Anon., who on the 15th wrote it's about reducing calories.

    1lb fat = 3,500 cals; hence 2lbs/week is practical weight loss. Getting fat does not happen overnight, or a week for that matter so why would anyone expect to loose weight magically within a week.

    If by not eating wheat you get there, I say go for it. For me, I feel much better since doing mega-dose K2/D3/B3/C which I learned here on the Heatscanblog and I will be forever grateful for those who aid Dr Davis in sharing their knowledge such as Ted Hutchinson who takes the time to post links to scientific papers supporting the cause of improved heart health.

  • Caballaria

    10/29/2009 10:43:40 PM |

    Question - how about rice? Is it just as bad?

  • Michael

    12/6/2009 12:32:14 AM |

    I take wheat grass tablets from Pines.  I have stopped eating wheat and reduced all grain consumption dramatically.  However, I still take the wheat grass tablets.  Is wheat grass a problem, like wheat?

  • Anonymous

    12/28/2009 4:27:15 AM |

    Well I acquiesce in but I contemplate the list inform should have more info then it has.

  • Anonymous

    12/31/2009 5:08:59 AM |

    Again a gentle post. Thanks your also pen-friend

  • Term Papers

    1/29/2010 7:49:30 AM |

    I think there is a huge missing link here, and that is the source of wheat.

  • Term papers

    6/8/2010 1:59:54 PM |

    I just bookmarked your blog and will come back in the future. Keep up your great job, I hope you have a nice day!

  • Anonymous

    3/26/2011 3:12:34 PM |

    Pretty good post. I just stumbled upon your blog and wanted to say that I have really enjoyed reading your blog posts. Any way I'll be subscribing to your feed and I hope you post again soon.



    Web Design

  • auto insurance quotes

    3/28/2011 8:22:55 PM |

    I study carried out in China proved conclusively that wheat was the major cause of heart attacks. I am quite sad to read these reports because I love bread. The question is that do I love it to death?

  • Study in UK

    5/9/2011 6:14:45 AM |

    This is generally a wonderful website i should say,I enjoyed reading your articles. This is truly a great read for me. I have bookmarked it and I am looking forward to reading new articles. Keep up the good work.


    Education

  • Julie

    10/20/2011 1:01:55 AM |

    I'm new here but looking for answers on systemic inflammation.
    Can eliminating wheat or gluten reduce the inflammation in my system?

  • Jaime M

    12/27/2011 7:34:37 PM |

    Hey Dr. Williams,
    My mom stumbled across this article a year ago in attempt to help me explain some unusal blood work and severe contipation issues that the gastro doc called IBS after a negative celiac test. At the time my c-reactive protein was elevated, my T4 was elevated, I was chronically tired, cold intolerant, constant constipation, stabbing pain in my abdomen (hurt to touch my toes and put shoes on),had eczema, and mood swings. More then ten years ago I had thought I was a celiac and had gone wheat free, went to a gastro doc but was told it was just IBS and now looking back my symptoms were worse after I began to eat wheat again.
    So, I have now been wheat free for a year now because of your article!.... my constipation has been reduced dramatically (no more miralax everyday) and my eczema only flares when I have accidently eaten something with wheat in it!
    Here's my delima now.. I thought that being wheat free for a year would change the unusal blood work, but I just got results back and my c-reactive protein has elevated slightly more, my T4 has elevated more, but the strange thing is my TSH is on the higher end too. Hashimoto's usually has high T4 and low TSH, plus all my symptoms are that of someone with a hypothyroid.  I'm still chronically tired, cold, and getting more moody. Any ideas?

Loading
Diabetes is a choice you make

Diabetes is a choice you make

Tim had heart disease identified as a young man. He had his first heart attack followed by a quadruple bypass surgery at age 38. Recurrent anginal chest pain and another small heart attack led to several stents over three procedures in the first four years after bypass.

Tim finally came to us, interested in improving his prevention program. You name it, he had it: small LDL, low HDL (28 mg/dl), lipoprotein(a), etc. The problem was that Tim was also clearly pre-diabetic. At 5 ft 10 inches, he weighed 272 lbs--easily 80 or more pounds overweight.

Tim was willing to make the medication and nutritional supplement changes to gain control over his seeminglly relentless disease. He even turned up his exercise program and lost 28 lbs in the beginning. But as time passed and no symptoms recurred, he became lax.

Tim regained all the weight he'd lost and some more. Now Tim was diabetic.

"I don't get it. I eat good foods that shouldn't raise my insulin. I almost never eat sweets."

I stressed to Tim that diabetes and pre-diabetes, while provoked acutely by sugar-equivalent foods (wheat products, breads, breakfast cereals, crackers, etc.), is caused chronically by excess weight. If Tim wants to regain control over his heart disease, he needed to lost the weight.

Unlike, say, leukemia, an unfortunate disease that has little to do with lifestyle choices, diabetes is a choice you make over 90% of the time. In other words, if you become diabetic (adult variety, not children's variety) as an adult, that's because you've chosen to follow that path. You've neglected physical activity, or indulged in too many calories or poor food choices, or simply allowed weight to balloon out of control.

But diabetes is also a path most people can choose not to take. And it is a painfully common choice: Nearly two-thirds of the adults in my office have patterns of pre-diabetes or diabetes when I first meet them.

Let me stress this: For the vast majority of adults, diabetes is a choice, not an inevitability.
Loading
The case against vitamin D2

The case against vitamin D2

Why would vitamin D be prescribed when vitamin D3 is available over-the-counter?

Let's review the known differences between vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol):

--D3 is the human form; D2 is the non-human form found in plants.

--Dose for dose, D3 is more effective at raising blood levels of 25-hydroxy vitamin D than D2. It requires roughly twice to 250% of the dose of D2 to match that of D3 (Trang H et al 1998).

--D2 blood levels don't yield long-term sustained levels of 25-hydroxy vitamin D as does D3. When examined as a 28-day area under the curve (AUC--a superior measure of biologic exposure), D3 yields better than a 300% increased potency compared to D2. This means that it requires around 50,000 units D2 to match the effects of 15,000 units D3 (Armas LA et al 2004).

--D2 has lower binding affinity for vitamin D-binding protein, compared to D3

--Mitochondrial vitamin D 25-hydroxylase converts D3 to the 25-hydroxylated form five times more rapidly than D2.

--As we age, the ability to metabolize D2 is dramatically reduced, while D3 is not subject to this phenomenon (Harris SS et al 2002).




From Armas LA, Hollis BW, Heaney RP 2004


While there are dissenters on this view, the bulk of evidence suggests that D2 is an inferior form of D3.

Then why is D2 prescribed by many doctors when the natural, human, and superior D3 is available over-the-counter?

You already know the answer: Much of your doctor's education did not come from scientific lectures nor from reading scientific studies. It came from the pretty drug representative in the waiting room who hands the doctor reprints of the "studies" performed by the drug industry to support the use of their drugs. There is no such nutritional supplement representative in the waiting room. This preference for the "drug" D2 over the supplement D3 also stems from the inherent preference of physicians for things they can control, whether or not there is proof of superiority.

In my view, there is absolutely no reason to take vitamin D2 over D3 except to enrich the drug industry.

Comments (40) -

  • Barkeater

    8/11/2009 1:08:02 PM |

    I recently had a discussion with a relative who got a prescription for Vitamin D.  (This after I bought her a Vitamin D test from Grassroots showing a level of 19.)  I told her the prescription was a bad idea as it was surely Vitamin D2.  She looked into it and came back and told me, no, it was D3.  I have not seen it, but I am asking now - is it really true that prescriptions are invariably D2?  She claimed it was 50k IU of D3, once a week.

    Separately, I see it stated here and there that the Vitamin D added to milk is D2.  Most milk labels I see show it as D3.

  • Anne

    8/11/2009 2:41:22 PM |

    A bit of information that the drug reps don't tell the physician is people need to be on a maintenance dose. I have seen so many people who were prescribed D2 for a few months. Once the vitamin D level rose to over 30, they were told they could discontinue taking the D2.

    One person told me that she had started and stopped D2 three times. She said her doctor could not figure out why her vitamin D level keeps dropping when the D is stopped. At least she was retested. The other people who were told to stop taking D2, were never retested once their D hit "normal".  

    I have a friend who told her doctor she would get her vitamin D as D3 OTC. She said he expressed surprise that it could be bought without a prescription.

  • Richard A.

    8/11/2009 5:06:19 PM |

    The study you site appears to use the dry form of vitamin D3.

  • Tony Kenck

    8/11/2009 5:06:41 PM |

    So is D2 a prescription medicine?

  • TedHutchinson

    8/11/2009 5:13:14 PM |

    Here is an abstract providing an example of the total lack of effect of D2 in a patient.
    The lack of vitamin D toxicity with megadose of daily ergocalciferol (D2) therapy:
    The maximum daily dose of vitamin D currently recommended is 2000 IU. Ergocalciferol (D2) 50,000 IU orally weekly for 8-12 weeks is often used to treat vitamin D deficient patients (25(OH) vitamin D <20 ng/mL).
    The lack of vitamin D toxicity after massive doses of ergocalciferol has yet to be reported in the literature.
    We report a case of a 56-year-old woman who received supratherapeutic doses of ergocalciferol (150,000 IU orally daily) for 28 years without toxicity. We discuss the possible mechanisms which may account for a lack of toxicity despite intake of massive daily doses of ergocalciferol in this patient.


    The sad aspect to this story is that as Vitamin D2 at that ridiculously high intake didn't do her harm, it's also probable that her body did not recognise it at all, so it probably didn't do her any good either. As there have been other accounts of people taking large (but not as huge as this case) amounts of D2 and it not having any noticeable effect on Vitamin d deficiency symptoms it seems just pointless to risk using it, when there is a cheaper, more reliable, alternative readily available.

  • billye

    8/11/2009 8:23:28 PM |

    I think it is up to the patient who is tuned in to this fine blog and several other like minded blogs who preach as you do, such  as "nephropal.blogspot.com" to bring your information to their primary doctors.  My primary doctor still takes a Staten drug even though he knows and marvels at the health gains that I have achieved through supplementation with high dose vitamin D3 and high dose omega 3fish oil, along with a cave man like diet.  I asked him why he take a Staten drug when they work by increasing his vitamin D level? I said just take vitamin D3 instead of the Staten drug.  His answer was that he only takes a little Staten drug.  When he found my wife to be vitamin D deficient, he in fact ordered a script for vitamin D2.  I insisted that she take OTC vitamin D3 and after a tussle he gave in.  

    I am sorry to say that only we the patients can change the system.  I don't blame the very over worked primary care physicians who have no time to read the necessary science.  We the patients have to bring the relevant data to them.  After all it's our health that is being impacted.

  • Dr. William Davis

    8/11/2009 10:53:05 PM |

    Bark--

    There is indeed a prescription D3.

    Now, why a prescription form is necessary is beyond me. I suppose we could make prescription vitamin C, too, and charge $120 per month.

  • Dr. William Davis

    8/11/2009 10:53:51 PM |

    Hi, Anne-

    Yes, I also see this incredible blunder occuring around me.

    I'm not sure what they're thinking.

  • Anonymous

    8/12/2009 12:28:05 AM |

    Vitamin D3 1000 IU 240 tablets per bottle x 2 bottles purchased from Costco is dirt cheap.  $5.20 Cdn.  Very cheap $ U.S. dollars.

    I take 3,000 to 5,000 IU daily and associate it with stopping hot flashes.

    Inadvertently 'experiments' by running out of D3 for several weeks at a time resulted in really terrific hot flashes. Nothing is quite as unpleasant as having a hot flash as soon as I wake up, for example. Clearly I have not done double blind studies.  I am (sort of) menopausal.  No periods from September 2008 to June 2009.  Now, back. Frown

    No vitamin D3 intake during summer of 2008:  terrible terrible hot flahses. Then started taking D3 3000 IU in August 2008. Ran out of D3 sometime in Januray.  Hot flashes started up sometime later.  However, no hot flashes since end of March 2009.  No hot flashes from September to January.  Stopped taking D3 because too lazy to go to Costco to buy more.  Then started taking D3 and then stopped with the hot flashes and have not had another one in months even though obviously the hormones are fluctuating.

    I used to think that HRT would stop hot flashes.  HRT does nothing for the hot flashes.  Vitamin D3 appears to work much more effectively.  

    Dr. G. Kadar
    Toronto, Canada

  • Dr. William Davis

    8/12/2009 1:58:52 AM |

    Dr. Kadar--

    Fascinating observation!

    Any other ladies who've made similar observations? Or perhaps taken vitamin D yet continued to experience hot flashes?

  • Anne

    8/12/2009 2:31:35 AM |

    Tony ~ D2 can be bought as an OTC too.

    Dr. Kader ~ I have a co-worker who says her hot flashes disappear when she takes vitamin D.
    Anne

  • Peter

    8/12/2009 9:58:46 AM |

    I wonder if there is any research on your view that the tablets don't work, only the gelcaps, for raising vitamin D levles.  It seems like it would be very easy to show whether or not this is true, and very important since lots of people take the tablets.

  • Dr. William Davis

    8/12/2009 12:15:34 PM |

    Hi, Peter-

    To my knowledge, there is no research on this topic. However, having tested vitamin D blood levels thousands of times, I can say with confidence that the tablets are inconsistently absorbed--sometimes they work, often they don't, or they increase blood levels less effectively. Levels also vary widely, due to inconsistent absorption.

    Gelcaps--i.e.,oil-based--are absorbed consistently.

  • Anonymous

    8/12/2009 1:59:08 PM |

    What are some good brands of OTC D3?  I see the Costco mentioned, but has it been independently tested?  I know the Costco brand fish oil is supposedly decent, so it would make since that the D3 is as well.

    I usually order online (vitacost.com) and I like the NSI brands.  Are they good?

  • billye

    8/12/2009 4:24:24 PM |

    Dr. Kadar

    Thanks for sharing about your success with vitamin D3 bringing relief for your hot flashes.  I have a daughter who was suffering with hot flashes and refused to take the dangerous medically recommended hormones to alleviate the problem.  Instead she started to take black cohosh. when I pulled a negative study from Pub Med she stopped. She continued to suffer and not in silence.  In the meantime, understanding the health benefits, I convinced her to start taking 6000 IU of vitamin D3 soft gels.  It never dawned on me that this could be so positive relative to hot flashes.  This morning I asked her how come I don't hear any hot flash complaints and she answered that she hasn't had an episode in a very very long time.  It seems likely that we now can put a face on the reason why.  Yet another use for the miracle health supporting hormone vitamin D3.  

    It truly is a fascinating observation,as Dr. Davis remarked.  Thanks for solving this mystery.

  • Nameless

    8/12/2009 5:19:25 PM |

    It's just a guess, but the inconsistent absorption of dry  D3 sounds like it's due to fats (or lack of fats) consumed when dosing. So if patients take it with fish oil, or right after a fatty meal, it may work.

    But I see no reason to stay on dry anyway as gels are very cheap. There are also liquid drops (usually with a fat carrier) for those who dislike pills.

    I'm just waiting for a company to put out a D3/K2 gel next. They seem like logical partners.

  • Diana

    8/12/2009 6:54:38 PM |

    I have a blogsite where I am tracking successes regarding the usage of vitamin D.  Will you tell your success story?  I am an advocate and educator for using Vitamin D3.  I personally take 6000-8000 to keep my levels of D3 at the appropriate level.  

    I will never stop!  It manages the SAD disorder that I had without knowing for over 25 years.  It has changed my life.  My sense of wellbeing has increased to 100%.  Before, it was always a struggle to shake off the feeling that something always felt off, or wrong. It never felt like depression, and my outlook has always been upbeat.  But I still carried around, what I only know how to discribe as almost a sadness, or a feeling that something was wrong but I couldn't put my finger on it.  After taking the Vitamin D3, it just disappeared.  So, now I am an advocate, and believe firmly that this information must be disemminated out into the communities.  

    If you have a story to tell I would appreciate it if you would add it to my blog site:

    http://dactionhealth.ning.com/

    Best~Diana~

  • Diana

    8/12/2009 7:02:19 PM |

    There are also D3 available in liquid form.  It is great for those who can't swallow pills.  I believe it is through Biotics Research.  It is 2000U a drop.  I put 3 to 4 on my finger, and it is done. Nice to have the option and works better for children.

  • Anonymous

    8/12/2009 10:22:05 PM |

    I recently discovered while shopping for my D3 that there is also a D3 version made from sheep lanolin.  Is this as effective as the D3 from fish oil?  Is there any reason why one would be preferred over the other?  I go for the fish oil source because I just don't know anything about the other.

    I've been taking anywhere from 4,000 iu to 10,000 iu per day since February 2009 when my test revealed a level of 27 ng/dl. Last month I asked my dr for another test and he said they normally don't test again, which I just don't understand!(kaiser insurance). I still have my hot flashes but now that I think about it they are few and far between and less intense.
    Nancy

  • Anonymous

    8/12/2009 10:41:32 PM |

    Probably taking vitamin D3 tablets with a meal containing fat helps with absorption.

    I've got patients using the drops.  They butter their toast and add the relevent number of drops of D3 1000 IU per drop to their buttered toast. (I recommend 100% rye sourdough bread for those patients who must eat their bread.)

    I am now asking female patients experiencing intrusive hot flashes to take vitamin D3.  I'll wait for feedback from them.  Also for perimenopausal mood fluctuations.

    Looked at another way:  D3 is a hormone replacement therapy.  

    I do also tell patients about vitamin K2 and how it is also necessary for bone metabolism.  If they take therapeutic doses of
    vitamin D3, then they also must eat eggs (and cheese, liver, etc.)  But minimally, they must eat egg yolks.  In Canada, K2 is not available in any serious way as a supplement.  

    Dr. G. Kadar
    Toronto, Canada

  • Sue

    8/13/2009 2:35:08 PM |

    I would love to take my D3 in gelcap form, but have thus far been unable to find any here in Canada.  I sometimes take the liquid, but get hung up on what constitutes 'a drop,'  so usually settle for tablets along with fish or krill oil.  Anyone know of a Canadian source for gelcaps?

  • Neonomide

    8/13/2009 10:22:50 PM |

    Dr. William Davis said...

    "I can say with confidence that the tablets are inconsistently absorbed--sometimes they work, often they don't, or they increase blood levels less effectively. Levels also vary widely, due to inconsistent absorption.

    Gelcaps--i.e.,oil-based--are absorbed consistently."


    I cannot say anything about hot flashes since I'm a man (but can and will tell these interesting observations to PMP women I know), yet I have something to say about tablet versus powder versus gelcaps issue that may be of interest.

    I have moderate level Crohn's disease and got great help from D3 supplements for over 7 months now. I started with gelcaps (dosage 25-75 µg/d), then abruptly moved into powder form (Vit D Max, dosage 125 µg/d) and observed GREAT improvement in a couple of weeks. Even my BP dropped so much - from 145/95 to 115/75 and I even got dizzy during daytime. (I also took some melatonin to be fair).

    Then - after about 4 months - I changed back to gelcap form and kept the dosage and experienced somewhat more symptoms - if only for a while.

    Is it possible that powder form may work more quickly, or did my powder D3 contain more D3 than mentioned? I honestly don't know.

    I wrote for Dr B G about my Crohn improvement a while ago but she seems to be on holiday as we're speaking? Smile

    - Neo

  • Anonymous

    8/13/2009 11:18:11 PM |

    I buy small easy to dissolve capsules of D3 (dry powder, not oil) made by Bio-Tech from Dr. Eades' Protein Power site (no affliation other than as a reader).  The cost for the dose is very, very good ($8 for 100 capsules) and the bottles are small.  I was able to buy 11 bottles for the same shipping price as 1 bottle, so I stocked up and shared with family members (my experience is that middle aged adults need at least 5000iu per day year round to keep 25 (OH)D levels above 50 ng/mL).  I test at least twice a year, so I know that the D3 is absorbing.  

    I also usually take the D3 around the same time I am consuming some fat, which probably helps with absorption.  Other family members take Carlson's oil capsules with good results.  We avoid hard tablets.

    Bio-tech also makes a non-prescription D3 in a 50,000iU dose, 12 capsules for about $18 (plus shipping), which is a very competitive price compared to high dose Rx D2.

  • rendev

    8/14/2009 5:07:29 AM |

    Hi
    Really a nice blog!
    Needs stuff to to!

  • TedHutchinson

    8/15/2009 6:29:52 PM |

    Readers who are using Vitamin D3 for cancer prevention may be interested in this new paper from Vieth
    How to Optimize Vitamin D Supplementation
    to Prevent Cancer, Based on Cellular
    Adaptation and Hydroxylase Enzymology

    The hypothesis seeks to answer some of the Dilemmas that challenge the vitamin D/Cancer hypothesis regarding prostate/pancreatic cancers.
    1)How can the vitamin D hypothesis explain the U-shaped risk curve for prostate cancer when the data suggest that the average 25(OH)D
    concentrations in countries with relatively high rates of prostate cancer are apparently the optimal concentrations for preventing prostate
    cancer?
    2 What plausible mechanism, other than vitamin D, could account for the association between greater lifetime sun exposure and diminished risk of prostate cancer ?
    3 How can latitude and environmental ultraviolet light be associated with increased risk of prostate cancer, and pancreatic cancer, yet not be a significant contributor to the lower average 25(OH)D concentrations theorized to be the key component of the mechanism that relates latitude to cancer risk?
    4 Why is summer season of diagnosis, or a higher serum 25(OH)D associated with better prognosis of prostate cancer?
    5 If vitamin D is adverse for prostate cancer, then why is the rate of rise in prostate-specific antigen (PSA) slower in summer  than in other seasons and why would vitamin D supplementation slow the rate of rise in PSA ?
    6 Why, in regions of the United States where environmental UVB is low, is there a positive association between pancreatic cancer versus serum 25(OH)D, while at the same time, in regions where UVB is high (presumably providing even higher serum 25(OH)D levels), is there no relationship with 25(OH)D ?
    7 If 25(OH)D is antiproliferative in cell cultures of prostate cells in vitro  and pancreatic cells, then why would it contribute to the development of cancer in vivo?

    Vieth suggests that as circulating 25(OH)D levels rise and fall, 1,25-dihydroxyvitamin D  concentrations  need to be adjusted and the balance between 25(OH)D-1-hydroxylase [CYP27B1](tumor surpressing) and the catabolic enzyme, 1,25(OH)2D-24-hydroxylase [CYP24](oncogene) may for a while become disrupted.

    Any time there is a delay in cellular adaptation, or lag time in the fine tuning of  1,25(OH)2D  in response to fluctuating 25(OH)d concentrations there is the potential for too little of the tumor suppressor enzyme and too much of the oncogene CYP24.

    Regular daily supplementation with D3 keeps levels high.
    Regular 25(OH)D testing will enable you to see your levels are remaining steady.
    It may be  sensible for people living further North to have a lower summer intake and higher winter amount in order to reduce the amplitude between summer highs and winter low 25(OH)D levels.

    Those who go for Winter sunshine breaks may want to think about increasing D3 intakes before they fly off, reducing supplement intake while under the tropical sunshine and resuming supplementing immediately on returning home to prevent sudden changes in status and limit the extent of gains/losses.

    25(OH)D levels need to be both high and stable.

    The graph Dr Davis shows how D2 levels dropped steeply (indeed levels at the end of the month were  lower than before supplementing started) so the fact that D2 increases the rate at which 25(OH)D depletes making the fluctuation in level more acute, is a further reason to avoid it.

  • Sabio Lantz

    8/16/2009 11:33:35 AM |

    Dr. Davis,
    I just got my labs back after 7 months on low-carb, high-fat diet.  Chol was 337 (my labs are here).
    I was wondering if you or readers could point me to 5 or 6 links that would help educate me on this issue so I can see if I need to make any changes in the next 7 months.  Thank you for your time.

  • epistemology

    10/27/2009 1:43:39 AM |

    Why do doctors prescribe Vitamin D2?
    They don't very often. Calcitriol (most common brand, Rocaltrol) is the most often prescribed Vitamin D around here (near Philadelphia).

    Why do we need a prescription Vitamin D when OTC Vitamin D is just as good?
    Two reasons:
    1. Without a prescription, patients take medicine less reliably,
    2. More importantly, many of my patients are poor, and OTC meds are not paid for, but prescriptions are.

  • Anonymous

    10/29/2009 11:35:25 PM |

    I take D2 (and get as much midday sun as is safe) because of the horrible way the sheep are treated.

    http://www.savethesheep.com/animals.asp

  • Jim

    12/2/2009 5:38:41 AM |

    I know a nurse practitioner who practices in Phoenix, Arizona. She has done hundreds of blood draws for nutrient levels and has noted that some 99% of people were vitamin D deficient.

    She went on to explain that a lot of these people were construction workers and did not even wear sunscreen. Again, this is in Phoenix where the sun shines intensely nearly every single day of the year. If those people are not getting enough D, I think it's pretty safe to say that you are at least at risk.

  • Anonymous

    12/7/2009 4:38:54 PM |

    D2 comes from plant sources. D3 comes from animal sources, primarily animal skins. If you are vegetarian you would not want to take D3.

    The primary reason the prescription form is D2 is because D2 is much safer. Too much vitamin D is worse than too little. The standard prescription dose is very high, 50,000 units. High doses like that of D3 would be extremely dangerous. Your body is much better able to regulate it's absorbtion of D2.

    I would never take D3. It might take a bit higher dose of D2  to achieve the same result (studies do not agree on this) but I am never going to poison myself. I expect sereous negative health consequences in the future as a result of the marketing of D3. D3 is pretty much all you can find over the counter these days. I assume that it is more about promoting animal agriculture than human health.

  • Dr. J.

    12/16/2009 8:24:54 PM |

    It is true that the pharmaceutical industry has at times had undue sway over the medical profession.  To say that physicians are educated by "pretty representatives" is insulting and undermines the credibility of the author.  I agree that vitamin D3 is more "natural" and technically more potent.  The reason why vitamin D2 is more often prescribed is at least three-fold.
    1. Vitamin D2 is available in a prescription strength that allows for a more rapid repletion of vitamin D levels.  (It is hard to find a prescription vitamin D3)  In other words, it would take longer to replete vitamin D with over-the-counter doses of vitamin D3.  So why not just take a bunch of D3 capsules?  The dosing schedule for repletion of vitamin D with D3 is not as well worked out as it is with vitamin D2.  As soon as someone does a large scale study using vitamin D3, we will all be willing to switch.  Doctors are hesitant to make up regimens where effective ones already exist (re: risk of patient harm/legal liabilities)  
    2. Vitamin D2 has been prescribed for decades. We as physicians are more familiar with its effect on patients.  
    3.  Finally, vitamin D3 used to be more expensive--another reason D2 was preferred over D3.  Doctors, like everyone else, are often resistant to change.
    One thing is certain.  The author's assertion that physicians are not guided by science is false.  What we need is large scale clinical trial with vitamin D3.  The problem here is funding.  Who will pay for it?  Until then, the most we can say is that vitamin D3 is more "natural" and more potent.  Vitamin D2 however is effective and has not been shown to be injurious.

  • Dr. William Davis

    12/17/2009 12:22:06 AM |

    Dr. J--

    Allow me to insult you again: It has been my experience that many of our colleagues are miserably susceptible to the smile of a pretty representative. Perhaps you are not, but I see it all the time.

    I'm afraid that I believe you are way off base on the D2. I recommend that you read the existing literature. I believe that there's only one conclusion: D2 is markedly inferior. While better than nothing, why would anyone take a non-human form over a human form?

    Having replaced vitamin D in approximately 2000 patients using D3, I can tell you it is safe and reliable. In the handful of patients taking D2, I've seen everything from modest increases in blood level so 25-hydroxy vitamin D to no increase at all.

  • Deana

    3/20/2010 4:14:53 PM |

    Twice I have been on prescription strength Vit d2(50,000 units first for 8 weeks since my level was 30  and then rose to 66 with RxI took good quality Vit D3 in between 2000 units daily faithfully,eat a good diet (also take ERT age 65) and after serveral months^ my level again fell to 33 now have beenplaced on Vit D2 for 12 weeks, blood level 64 and will repeat test in 6 months.I am now taking 4000 units of D3. I DO NOT seem to be absorbing Vit D3 and wonder why or if I need even more daily

  • Gypsy Boheme

    7/14/2010 1:09:54 AM |

    Why wouldn't you just obtain your Vit D through food sources? sardines, salmon, tuna, liver, egg yolk, cod liver oil, fatty fish, dairy

  • Mary

    10/16/2010 1:27:55 AM |

    I HAVE to say something.  There are some valid health related reasons why some people/children have to take D2.  My daughter has to take D2 (her levels are at 33) so her DAN doc wants her D supplemented.  She also has some gastritis/EE he is hoping to heal in her tummy w it.  He wishes and we all wish she could take D3--I know its way better than D2.  BUT--she can't take D3--she is allergic to both fish and lanolin . . . so . . . therefore she has to take D2 right?  No other D3 option out there for her right--please answer if there is another option for her.  She is allergic to all the natural foods with D3 as well--egg etc.  D2 is all thats left.  I PRAY its helping her a little. We use a local company in WI called Cty Line Pharmaceuticals--the D2 is liquid, its D2 dissolved in propylene gycol with NOTHING else added.  Its a bit spicy but my daughter "Gags" it down as she  surely be allergic to anything added to flavor it.

  • buy jeans

    11/3/2010 3:44:48 PM |

    There is no such nutritional supplement representative in the waiting room. This preference for the "drug" D2 over the supplement D3 also stems from the inherent preference of physicians for things they can control, whether or not there is proof of superiority.

  • Anonymous

    12/13/2010 4:25:32 PM |

    I was vit D deficient at a level 12. I was told to take over the counter D3 1,000 a day for 5 mths, retest. It raised to only 23. I was told to take Vit D 3 at 2,000 a day for another 4 mths and the result was I went back down to 18. Finally took the presciption D2 at 50,000 a wk and I am mid normal. My 2 daughters were recently diagnosed with D deficiency as well. I walk a dog daily yet my 85 yr old mother who does not really see the sun and when does wears sunscreen takes no Vit D and is not deficient. Go figure.

    P.S. Yes Vit D did reduce hot flashes as well.

  • Sidney Lohr, Ph.D.

    12/16/2010 4:43:10 AM |

    In 1972, one year after starting my Medical Education {Psychology}, I attended the yearly "National Health Federation" {Monrovia, California} Convention. I was already prescribing High Doses of Vitamin D, and I attended a lecture by a  Physician who was already known as THE EXPERT in Vitamin D research!! To this day, I don't remember his Name. The Subject of this particular presentation,  was that Vitamin D2 was toxic to the Kidneys & caused Kidney Damage; Primarily Kidney Stones! His Research was solid and alarming! I bought the 90-minute Tape of his entire Presentation, but misplaced it approximately 5 years later. His presentation  was a Classic, and I'd pay $50.00 to $100.00 for a copy of the Tape today! If anyone has this tape, PLEASE contact me!!
    Meanwhile, NEVER take any amount of Vitamin D2. He proved that Vitamin D3 was safe, and that Vitamin D2 should never be ingested!

  • Provillus

    5/2/2011 5:43:57 AM |

    I find this very interesting because on the one hand they are giving up control over what their advertisement says, but on the other hand the ads that people come up with are probably even more relevant to the readers.

  • sex pills

    7/26/2011 7:31:33 PM |

    Very good blog, support, only the future health!

Loading
Jelly beans and ice cream

Jelly beans and ice cream

What if I said: "Eliminate all wheat from your diet and replace it with all the jelly beans and ice cream you want."

That would be stupid, wouldn't it? Eliminate one rotten thing in diet--modern high-yield, semi-dwarf wheat products that stimulate appetite (via gliadin), send blood sugar through the roof (via amylopectin A), and disrupt the normal intestinal barriers to foreign substances (via the lectin, wheat germ agglutinin)--and replace it with something else that has its own set of problems, in this case sugary foods. How about a few other stupid replacements: Replace your drunken, foul-mouthed binges with wife beating? Replace cigarette smoking with excessive bourbon?

Sugary carbohydrate-rich foods like jelly beans and ice cream are not good for us because:

1) High blood sugar causes endogenous glycation, i.e, glucose modification of long-lived proteins in the body. Glycate the proteins in the lenses of your eyes, you get cataracts. Glycate cartilage proteins in the cartilage of your hips and knees, you get brittle cartilage that erodes and causes arthritis. Glycate structural proteins in your arteries and you get hypertension (stiff arteries) and atherosclerosis. Small LDL particles--the #1 cause of heart disease in the U.S. today--are both triggered by blood sugar rises and are 8-fold more prone to glycation (and thereby oxidation).

2) High blood sugar is inevitably accompanied by high blood insulin. Repetitive surges in insulin lead to <em>insulin resistance</em>, i.e., muscles, liver, and fat cells unresponsive to insulin. This forces your poor tired pancreas to produce even more insulin, which causes even more insulin resistance, and round and round in a vicious cycle. This leads to visceral fat accumulation (Jelly Bean Belly!), which is highly inflammatory, further worsening insulin resistance via various inflammatory mediators like tumor necrosis factor.

3) Sugary foods, i.e., sucrose- or high-fructose corn syrup-sweetened, are sources of fructose, a truly very, very bad sugar that is metabolized via a completely separate pathway from glucose. Fructose is 10-fold more likely to induce glycation of proteins than glucose. It also provokes a (delayed) rise in insulin resistance, accumulation of triglycerides, marked increase in formation of small LDL particles, and delayed postprandial (after-eating) clearance of the lipoprotein byproducts of meals, all of which leads to diabetes, hypertension, and atherosclerosis.

I think we can all agree that replacing wheat with jelly beans and ice cream is not a good solution. And, no, we shouldn't have drunken binges, wife beating, smoking or bourbon to excess. So why does the "gluten-free" community advocate replacing wheat with products made with:

rice starch, tapioca starch, potato starch, and cornstarch?

These powdered starches are among the few foods that increase blood sugar (and thereby provoke glycation and insulin) higher than even the amylopectin A of wheat! For instance, two slices of whole wheat bread typically increase blood sugar in a slender, non-diabetic person to around 170 mg/dl. Two slices of gluten-free, multigrain bread will increase blood sugar typically to 180-190 mg/dl.

The fatal flaw in thinking surrounding gluten-free junk carbohydrates is this: If a food lacks some undesirable ingredient, then it must be good. This is the same fatally flawed thinking that led people to believe, for instance, that Snack Well low-fat cookies were healthy: because they lacked fat. Or processed foods made with hydrogenated oils were healthy because they lacked saturated fat.

So gluten-free foods made with junk carbohydrates are good because they lack gluten? No. Gluten-free foods made with rice starch, tapioca starch, potato starch, and cornstarch are destructive foods that NOBODY should be eating.

This is why the recipes for muffins, cupcakes, cookies, etc. in this blog, the Track Your Plaque website, and the Track Your Plaque Cookbook are wheat- and gluten-free and free of gluten-free junk carbohydrates. And put that bottle of Jim Beam down!

Comments (6) -

  • April 9th | CrossFit-HR

    4/8/2012 6:02:59 PM |

    [...] all wheat from your diet and replace it with all the jelly beans and ice cream you [...]

  • [...] Here’s an interesting post by Dr. Davis. He makes a good argument for sticking to more natural foods when getting rid of sugars and wheat from our diets. Great info on additives that we see in so many “healthy” processed foods nowdays.   Like this:LikeBe the first to like this post.   This entry was posted in Uncategorized. Bookmark the permalink.    ← Thursday May 3, 2012 [...]

  • [...] Here’s an interesting post by Dr. Davis. He makes a good argument for sticking to more natural foods when getting rid of sugars and wheat from our diets. Great info on additives that we see in so many “healthy” processed foods nowdays.   Like this:LikeBe the first to like this post.   This entry was posted in Uncategorized. Bookmark the permalink.    ← Sunday May 13, 2012 [...]

  • Chris

    5/22/2012 6:22:22 PM |

    What about arrowroot powder?

  • jpatti

    5/25/2012 7:14:44 PM |

    Ice cream is not bad for bg.  

    Sure, INDUSTRIAL ice cream is bad, cause it's full of junk.

    But... I've made ice cream a lot, several years in a manual machine, then the past few years in a Vitamix.  

    My ice cream is something like... frozen sliced peaches and heavy cream (from pastured cows).  Or frozen blueberries and cream.  Basically, any frozen fruit and some cream, blend until it turns to ice cream.  Honestly, when frozen, you lose sweetness, so sometimes I need to add a bit of stevia even if the fruit tasted sweet before freezing.  

    I don't do bananas cause they're too carby for me plus I don't like them.  ;)  But a couple frozen bananas and a few TB unsweetened cocoa also makes a decent "ice cream" for hubby (without needing any cream).

    My fruit and cream ice cream actually raises bg LESS than the fruit by itself, cause fat slows the absorption of the sugar from the fruit.  Well, it does for me, dunno how it would work for a nondiabetic.  

    I'm not suggesting people should eat even my ice cream daily or anything.   Heavy cream is some SERIOUS fat.  And really, it's too rich to eat and eat anyways.  A small serving will really do you as it's VERY rich stuff.  

    We go through about a quart of cream a month, much less than butter.  Dunno why butter is easier to eat than cream, since really it's the same stuff, but I never feel like putting cream on my veggies or eggs!  ;)

    But... since the cream is from pastured animals, it's full of vitamins A, D3 and K2 - so not exactly like industrial ice cream, which rarely even has actual cream as an ingredient, and any dairy it does contain will be from feedlot animals with little nutrition anyways.

Loading
Erectile dysfunction and coronary plaque

Erectile dysfunction and coronary plaque

Erectile dysfunction (ED), previously known as "impotence," and coronary atherosclerotic plaque go hand in hand.

A recent study in men with advanced coronary disease showed that 93% experienced ED. The participants in the Track Your Plaque program, for the most part, do not have advanced coronary atherosclerosis, but have an earlier form detected by a CT heart scan.

What proportion of men with asymptomatic coronary plaque as measured by a CT heart scan have ED? Around 50%. In other words, it's not a rare occurrence.

The conversation about ED (and even its renaming from impotence) really gained momentum with the development of ED-drugs like Viagra and Cialis. The drugs are reasonably effective and safe. However, you will hear little about all the strategies that can either precede your need for these drugs and/or enhance your response to these drugs if the response is partial. That part of the conversation, of course, doesn't yield loads of drug company revenues.

One of the most helpful and specific nutritional supplements available that can partially restore the nitric oxide-deficiency of ED is l-arginine. L-arginine is the body's source of nitric oxide (NO), the master dilator (relaxing agent) for all arteries of the body. NO dilates penile arteries, it dilates coronary arteries. Lack of NO disables the penile capacity for erection and encourages growth of coronary atherosclerotic plaque. Track Your Plaque Members are already familiar with l-arginine as a facilitator of coronary plaque regression.

We will detail the supplements that you can use safely in your Track Your Plaque program to both enhance erectile function if you suffer ED, as well as impact positively on coronary health, in an upcoming and detailed Special Report on the www.cureality.com website.

Comments (5) -

  • Raoul

    4/30/2008 3:28:00 PM |

    Ah !

    Erectile dysfunction is a reality.

  • Madona

    10/13/2008 6:15:00 AM |

    One of the best ways to the cure of ED is to see the disease in its correct light. It should merely be seen as a disease, and disease it is, that has affected the male sex organ. Correct and proper ED assessment is necessary to do away the disease from one’s life. People attach a lot of other factors like shame, embarrassment, fear, low self-esteem etc and these make the treatment of erectile dysfunction all the more complex and difficult. http://www.besthealthmed.com/ed_assessment.html

  • kevin

    11/28/2008 5:52:00 AM |

    Just after its launch in the market, viagra has created a niche for itself as the most effective medication for treating male erectile dysfunction across the world but alongside, the effectives of herbal Viagra products in dealing with male sexual problems cannot be ignored. Herbs and plants are, however, extensively used as sex stimulants worldwide and details present at http://www.pill-care.com inform you that the highly utilized sex boosters collectively known as herbal Viagra are namely, gingko biloba, yohimbe, horny goat weed and muira puama.

  • viagra online

    8/30/2010 6:11:53 AM |

    Both can be treated safely by generic Viagra medication which is safe and secure for all men suffering from Erectile dysfunction.
    buy cheap edegra

  • Buy Kamagra

    2/22/2011 2:23:50 PM |

    Kamagra is a real good choice if you're looking for a generic version. There are different forms of Kamagra if men find it difficult to take tablets, including soft tabs, jelly & soluble form.

Loading
Why do morphine-blocking drugs make you lose weight?

Why do morphine-blocking drugs make you lose weight?

Naloxone (IV) and naltrexone (oral) are drugs that block the action of morphine.

If you were an inner city heroine addict and got knifed during a drug deal, you'd be dragged into the local emergency room. You're high, irrational, and combative. The ER staff restrain you, inject you with naloxone and you are instantly not high. Or, if you overdosed on morphine and stopped breathing, an injection of naloxone would reverse the effect immediately, making you sit bolt upright and wondering what the heck was going on.

So what do morphine-blocking drugs have to do with weight loss?

An odd series of clinical studies conducted over the past 40 years has demonstrated that foods can have opiate-like properties. Opiate blockers, like naloxone, can thereby block appetite. One such study demonstrated 28% reduction in caloric intake after naloxone administration. But opiate blocking drugs don't block desire for all foods, just some.

What food is known to be broken down into opiate-like polypeptides?

Wheat. On digestion in the gastrointestinal tract, wheat gluten is broken down into a collection of polypeptides that are released into the bloodstream. These gluten-derived polypeptides are able to cross the blood-brain barrier and enter the brain. Their binding to brain cells can be blocked by naloxone or naltrexone administration. These polypeptides have been named exorphins, since they exert morphine-like activity on the brain. While you may not be "high," many people experience a subtle reward, a low-grade pleasure or euphoria.

For the same reasons, 30% of people who stop consuming wheat experience withdrawal, i.e., sadness, mental fog, and fatigue.

Wouldn't you know that the pharmaceutical industry would eventually catch on? Drug company startup, Orexigen, will be making FDA application for its drug, Contrave, a combination of naltrexone and the antidepressant, buproprion. It is billed as a blocker of the "mesolimbic reward system" that enhances weight loss.

Step back a moment and think about this: We are urged by the USDA and other "official" sources of nutritional advice to eat more "healthy whole grains." Such advice creates a nation of obese Americans, many the unwitting victims of the new generation of exorphin-generating, high-yield dwarf mutant wheat. A desperate, obese public now turns to the drug industry to provide drugs that can turn off the addictive behavior of the USDA-endorsed food.

There is no question that wheat has addictive properties. You will soon be able to take a drug to block its effects. That way, the food industry profits, the drug industry profits, and you pay for it all.

Comments (24) -

  • praguestepchild

    11/10/2010 3:49:28 PM |

    A doctor friend of mine was telling me about this, junkies hate it because it makes them instantly sober. Interesting that it would block the same receptors involved in wheat addiction.

  • Anonymous

    11/10/2010 4:29:57 PM |

    Thank you for explaining/exposing this.  For years I've wondered how food addictions work, especially wheat.  That our representative government is serving profit seeking corporate interests no longer surprises me though.

  • Anonymous

    11/10/2010 4:30:30 PM |

    Thesis + antithesis = synthesis.

  • arnoud

    11/10/2010 7:12:13 PM |

    Thank you for these interesting insights.  

    Now I also know why I couldn't just eat one cookie - - had to continue and eat the whole box.

    Now, without that first cookie, I totally don't care about them at all.

  • Anonymous

    11/10/2010 7:32:04 PM |

    BTW, naltrexone is also used to treat alcoholism in protocol known as The Sinclair Method.  You take the naltrexone an hour before drinking and then drink normally.  The naltrexone blocks the opoid receptors in the brain and the endorphins released by the drinking find no room at the inn.  Over time, the addiction is extinguished.

  • terrence

    11/10/2010 7:35:08 PM |

    I do not think I could have made up something like this! If I could I would be very rich, and maybe own a Big Pharma company or two.

    BTW, awhile ago, I read about a clinical study done in the UK. It had three groups of heron addicts - one group stayed on heroin, another was given methadone, the third was given a placebo (that they were told was methadone).

    Not surprisingly, the first group remained addicted to heroin, and the second group remained addicted to Methadone. The third group ALL got over their previous addiction to heroin, and with NO withdrawal symptoms, NONE, not one of them.

    Some commentators pointed out that The Heroin Establishment has a very large financial interest in keeping the story alive that heroin is hard to stop.

    I also know someone who was addicted to heroin. But, he realized that he was messing up his life (lost his wife, kids, etc). So, just stopped taking it - NO withdrawal issues, NONE.

  • Steve Cooksey

    11/10/2010 7:59:52 PM |

    Smile

    I love it when you rant against the MACHINE!!!  (in a dignified manner of course) Smile

    I'm a Type 2 Diabetic, with normal blood sugar and I take -0- drugs , -0- insulin.

    I follow a Very Low Carb, Gluten Free "Primal" meal plan....and I LOVE IT!

  • Dr. William Davis

    11/10/2010 11:04:21 PM |

    It's not clear to me how much of this is intentional, i.e., is wheat now a ubiquitous component of processed food precisely because of its addictive potential?

    Regardless, wheat stands apart from all other foods for this effect on humans.

  • mrfreddy

    11/11/2010 12:41:41 PM |

    interesting!

    and to think, the Ornishes, Furhmans, and Campbells of the world would have us believe that meat is addictive. Ha!

  • Anonymous

    11/11/2010 2:52:43 PM |

    Naltrexone..really?  Do some research on this drug and you will find that used over a long period of time it will cause changes to the receptors so that we feel no euphoria ever!  Bad Bad news.

  • Chet

    11/11/2010 6:13:47 PM |

    Eating wheat bread by itself is not very addicting but if sugar is thrown in the mix, you can get a nice mood lift.  This is because sugar(along with the wheat) spike insulin which drives tryptophan into the brain, where it converts to serotonin, the feel good neurotransmitter.

  • Kevin

    11/11/2010 9:58:03 PM |

    I may experiment.  I have some naltrexone that is about to expire.  I might give myself an injection and see if it makes me less interested in bread.  At the most I might eat two slices of whole wheat once or twice a week.  Would it work for other carbs like potatoes?

  • Dr. William Davis

    11/12/2010 1:32:06 AM |

    HI, Kevin--

    I'm impressed that you've got naltrexone! Please let us know what becomes of the experiment.

    Wheat stands apart for this effect. The only other foods that have been shown to exert a morphine-like effect are dairy products ("caseomorphin"), though the potency is many times less than that exerted by wheat.

  • Anonymous

    11/12/2010 3:09:49 AM |

    I eliminated grains, switched to Almond milk, cut out coffee and all artificial sweeteners.

    I started LDN in June and have easily lost 23 pounds, a feat almost unheard of in a Hashimoto's patient.

    Just a small amount of some protein and veggies will satisfy me but so could a handful of unsalted nuts.
    My appetite is no longer an issue.
    I would say I don't really have an interest in food anymore.
    I no longer have any blood sugar swings but those disappeared when I eliminated grains. I just feel LDN was helping in the appetite area, now your post confirms what I had been feeling.

    Now that my thyroid medication has been switched ( Armour to Synthroid due to manufacturing issues) and adding Cytomel plus LDN, I feel better.

    I am waiting of lab results to see where my Vit. D level is ( was at 42 aiming for 60) and to see what impact 6 months of no grains has done to my cholesterol.
    I am hopeful!  And that's another thing about LDN, depression is a thing of the past.
      
    My holistic MD thinks because the dosage is so small, LDN is acting in a homeopathic manner.  
    Many Hashimoto's patients have to decrease the amount of hormone they take because of LDN's effect on the thyroid.  
    I should know if my thyroid is happier by the end of the month. It might even be too happy.

  • Anne

    11/12/2010 3:28:40 AM |

    Chet - you say wheat is not addicting. My experience is not proof but when I gave up wheat I had about 3 days of withdrawal symptoms.  I felt really terrible and I was still eating sugar and high carb foods. A few years later I gave up the sugars. Although it took a while to lose the cravings for sweets, I did not have a period of feeling ill like I did when I gave up wheat.  

    Giving up wheat eliminated my depression. The tiniest amount of accidental wheat causes my mood to drop for a few days.

  • Anonymous

    11/12/2010 6:22:05 AM |

    Wrong explanation. By antagonizing opioid receptors, naltrexone disrupts flow in reward circuit. Which we know is central to the development of addiction. Wheat or no wheat. The weight loss appears to be at least in part something else. In combination with buproprion (AKA Zyban, an effective quit smoking drug) it significantly reduces food intake (by blocking hunger signal and reducing cravings). Again, wheat or no wheat.

  • Peter

    11/12/2010 5:40:16 PM |

    I'm trying to understand trade-offs.  Since quitting meat my weight hasn't changed, my blood sugar has improved, and my LDL is worse.

  • Kevin

    11/12/2010 7:35:40 PM |

    I took a closer look.  It's naloxone, not naltrexone.  Very rarely I see a dog that's ingested opiates.  That's why I have it but as I said, the dozen vials have reached the expiration date.

    kevin

  • Sue

    11/13/2010 3:22:52 AM |

    Sorry, completely off topic but did you see the article in HeartWire re reducing LDL even more.
    http://www.theheart.org/article/1145175.do

  • ilaçlama

    11/13/2010 11:03:45 AM |

    Thanx For subject

  • Anonymous

    11/13/2010 1:55:04 PM |

    ANNE
    I suffer from depression and would like to know more about how giving up wheat has helped you. Do u mind emailing me? If you don't scooby43215@yahoo.com. Thanks in advance.

  • Denny Barnes

    11/17/2010 8:50:40 AM |

    The diabetes guru Dr. Bernstein has written about low dose naltrexone therapy (LDN) to help diabetics lose weight.  Have you used LDN with your patients?  I understand that a low dose of naltrexone taken at night at first inhibits endorphin release and then stimulates it.  Presumably, increased endorphins eliminates the need for addictive foods and lowers inflammation.  Your thoughts?

  • elpi

    11/18/2010 1:30:57 AM |

    I just need to exercise and a healthy diet for me to lose weight. .That's all

  • Rene Sugar

    11/29/2010 6:25:35 PM |

    There is a Scientific American article that says negative emotions and pain-induced negative emotion are processed in the same brain areas so pain medication also relieves emotional pain.

    If wheat has opiate like effects, it might explain "emotional eating".

    http://www.scientificamerican.com/article.cfm?id=how-pain-can-make-you-fee

Loading