Top Doctor

Dr. Robert Connors is the hospital’s most prized cardiologist.

Practically a fixture in the cath lab, he generates more revenues for the hospital than any of his colleagues. Last year alone, he performed over 1500 procedures, bringing in $18 million dollars to the cath lab, $27 million to the hospital. Dr. Connors is very good at what he does: 55-years old, he has been involved in high-tech heart care since the “early days,” 25 years ago, when hospital procedures really took off.

During his career, he has personally performed over 25,000 heart procedures and has built a reputation as a skilled operator of complex coronary procedures. Because of his skills, he enjoys a vigorous flow of referrals for procedures from dozens of primary care physicians. His skill has also earned him referrals from cardiologist colleagues who seek his abilities for difficult cases.

On any day, Dr. Connors typically schedules up to 12 procedures. His entire day is spent in the cath lab, usually from 7 am until 6 pm. He meets many patients for the first time on the catheterization laboratory table as staff shave their groin, preparing for the procedure. Much of the procedure itself is not even performed by Dr. Connors, but by one or another cardiologists-in-training, a “fellow,” or member of the fellowship the hospital proudly maintains as a clinical teaching institution. Nor will Dr. Connors talk to most patients at the close of the procedure. He leaves that to either the fellow or a nurse. Dr. Connors views himself as a procedural specialist, not someone who has to take care of patients. He gave up seeing patients in his office over 10 years ago.

Dr. Connors’ procedural enthusiasm gained him the attention of drug and medical device manufacturers. Because Dr. Connors lectures widely and advises colleagues, his comments can dramatically alter perceptions of the value of a technology. He has, on many occasions, catapulted an unpopular device to most-asked-for among colleagues, bringing millions in revenues to the manufacturer. One particularly lucrative arrangement he made around 10 years ago involved a “closure” device, a $400 single-use plug used to close the access site made during heart catheterizations. By swaying his colleagues at St. Matthews Hospital, 50 orders per day (one per procedure) tallied $20,000 every day, $7.1 million dollars per year for the manufacturer. Although he’d used other devices on the market, the 5,000 shares of stock he was offered encouraged him to issue glowing comments to colleagues on the superiority of this specific brand of closure device. Now over 90% of all catheterizations at St. Matthews conclude with the device manufactured by the company in which Dr. Connors maintains partial ownership.

Negative comments, on the other hand, topple other products when Dr. Connors sees fit to pan them. For this reason, device and drug manufacturers run straight to Dr. Connors to gain his good graces as soon as possible after a product is released into the market. Because the competition is just as likely to do the same, it has often come down to a bidding war, the company providing the most lucrative arrangement most likely to win.

Thus, Dr. Connors proudly boasts of how many times he has flown to Hawaii, Europe, and other exotic locations at industry expense. He also boasts of how, for $100,000 paid to him for a “consulting fee,” he can overturn the choice of products lining hospital shelves. As the hospital’s annual budget for coronary devices will top $84,000,000 this year, device manufacturers regard the sum paid Connors as a profitable investment.

Despite his lofty status in the hospital, Dr. Connors has long expressed a love-hate relationship with St. Matthews. While he enjoys his work and has made a more than comfortable income, he has long felt that the hospital administration didn’t truly appreciate his contributions. Five years ago, he therefore demanded that he be made “Director of Research.” After all, he had hired a nurse to help him coordinate enrollment of patients into several device trials brought to him by medical device manufacturers. When he encountered an initial lukewarm response from hospital administrators, he threatened to take his “business” elsewhere to a competing hospital. St. Matthews’ administrators gave in. They provided him with the title he wanted, along with $100,000 annual “stipend.”

True story, though names have been changed to protect the guilty.

Is Dr. Connors just an “outlier” among colleagues who toe a more conservative line? Or does his brand of commercial enterprise in hospital heart care represent the ideal that they seek, brazenly and ambitiously seeking to expand the procedural solution to heart disease to the exclusion of patient care and real human interaction?

Comments (2) -

  • Anonymous

    10/23/2008 2:30:00 AM |

    Chilling.

    American medicine is really just organized crime by guys with better SAT scores.

  • pooti

    11/6/2008 12:37:00 PM |

    Yeah, so you really ought to don your lone ranger mask and go in cognito and start writing a book about this. I'd buy it.

    A growing segment of American's who seek medical care/advice believe in the "big pharma/big medicine" conspiracy theory. You write engagingly and persuasively along these lines. In just two posts, you've drawn me into reading your blog!

    I can't help but ask if your practice or referral business from fellow docs is suffering because of these types of posts, though. Because they are definitely counter to the mainstream physician's "fraternity" order of business.

    I believe you write of truth and as your other commenter said, "Chilling".

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Near-death experience with nattokinase

Near-death experience with nattokinase

This is a true story that I personally witnessed.

A 60-some year old man heard that nattokinase "thinned the blood." So he had been taking it for the past 6 months.

One week before he came to see me, he abruptly became quite breathless. He was unable to walk more than 20 feet or bend over to tie his shoes due to the breathlessness.

He came to see me in the office. I was alarmed by how breathless he was without signs of heart failure or other obvious explanation. I sent him for an immediate CT pulmonary angiogram. Within 30 minutes, we had the diagnosis: a large "saddle" pulmonary embolus, meaning a large blood clot that straddled the right and left main pulmonary arteries. One wrong move and . . . bang! He would have been dead within a couple of minutes, since a large clot can completely occlude the large arteries feeding the lung, essentially corking any blood circuiting through the lungs and back to the left side of the heart. (Causing, incidentally, electromechanical dissociation, in which the heart keeps beating for a few minutes but no blood is being pumped. CPR can keep you alive for a few minutes, then it's over.)

When I advised the patient of the diagnosis (after initiating the REAL anticoagulants), he said, "But I was taking nattokinase!"

Exactly. Blood clots are no laughing matter. They are potentially fatal events. Betting your life on some company's advertisement is nothing short of foolish.

Anyone who reads The Heart Scan Blog knows that I am an avid supporter of nutritional supplements. I even write articles and consult for the supplement industry. But I truly despise hearing unfounded marketing claims that some supplement companies will make in the pursuit of a fast buck.

There is no doubt that we need better, safer methods to deal with dangerous blood clots, whether in the lung, pelvis, or other areas. But, before anyone takes a leap based on the extravagant marketing claims made by a supplement manufacturer, you want to be damn sure there are real data--not marketing claims, REAL data--before you use something like nattokinase in place of a proven therapy.

Don't confuse the very interesting, though unpalatable, natto with nattokinase. Natto contains vitamin K2 and some other interesting compounds, including nattokinase.

Comments (22) -

  • Anonymous

    5/15/2010 10:41:58 PM |

    Interesting that your warning about nattokinese is FOLLOWED immediately by an advertisement for.... nattokinase extracts!

  • mongander

    5/16/2010 1:29:07 AM |

    Actually most nattokinase does not contain vitamin K2.  When nattokinase is extracted from natto, the K2 is separated and sold as another profitable byproduct.

  • Anonymous

    5/16/2010 1:29:07 AM |

    Wait a minute though! Was there any indication that he needed a real blood thinner before his clot? Maybe he was just taking it like a daily aspirin to "thin the blood" not for therapeutic blood anticoagulation. His clot was unfortunate but probably could have occurred with a cardiologist sactioned baby aspirin.

  • Dr. William Davis

    5/16/2010 1:07:24 PM |

    Anon--

    He was taking aspirin, as well.

    However, aspirin does NOT prevent deep vein thromboses that lead to pulmonary emboli, regardless of dose. Aspirin is a platelet-inhibitor, not a true "blood thinner" that works by way of clotting proteins.

  • sfr

    5/16/2010 2:18:50 PM |

    Was he using nattokinase as an excuse not to take his warfarin, or something like that? Otherwise it seems very unlikely that the nattokinase had anything to do with the clot. If anything, I'd worry about nattokinase causing bleeds, not clots.

  • Anonymous

    5/16/2010 5:58:24 PM |

    Curious if you ever recommend pycnogenol in cases where there is a risk of DVT? I believe there is at least one study showing a reduced risk of DVT in those who took pycnogenol.

    I'm not saying it's better than anti-coagulants, but it may be better than aspirin.

  • Myron

    5/16/2010 6:08:01 PM |

    Real anti-coagulants?  Like the red clover extract coumadin?  Patients on coumadin even with careful control often suffer excessive bleeding or more clots and strokes.    
    I guess the point is that clotting control is very difficult and that the number one drug is a natural medicine, herbal extract.

  • Anonymous

    5/16/2010 11:25:24 PM |

    One time, I was at a local vitamin shop when I saw that the supplement I was thinking about buying contained nattokinase.  Having read your blog and knowing what you think of nattokinase, I put the product back on the shelf.  The proprietor of the shop asked me why I did not want that supplement, because in his opinon it was a very good product.  I said that I did not want to take anything with nattokinase in it, and he said, "What do you have against nattokinase?"  I didn't bother to explain myself to him, figuring that I would just be wasting my breath.

  • Eric

    5/17/2010 1:37:14 AM |

    What is your opinion about doing higher dose mixed tocopherols, which do work on the clotting cascade. Or garlic and omegas which decrease platelet aggregation. What is your stand on normalizing your vitamin K content and then titrating your dosage of coumadin up to theraputic INR. As far as the nattokinase is concerned, do you like any of that style of enzyme? lumbokinase, serrapeptase. Although they don't have any effect on INR they should have an affect on FDPs

  • Paul

    5/17/2010 3:40:36 AM |

    That title is misleading.  People have been known to have near death cardiac events while taking fish oil, vitamin D3, and high dose niacin too.

    As well, on rare occasion, people have been known to have a recurrent DVT and/or PE while on warfarin therapy, even with an INR as high as 2.5.  Therefore, does that mean warfarin is an ineffective anticoagulant?  Of course not.

    This whole blog is about how we as individuals need to take control of our own health.  That just because we're taking a therapeutic medication or supplement, it does not therefore absolve ourselves from further investing in a life style that is proven to lower risk factors that may cause catastrophic health events.  

    I totally agree that some of the marketing claims made concerning nattokinase are inflated and frankly, unbelievable - particularly about its capabilities as a thrombolysis.  And I agree that if your doctor advices that you need heprin or warfarin therapy in order to prevent a catastrophic health event, you certainly need to heed that advice.

    But, count me down as someone who has extensively studied this subject and is still open to the possibility that nattokinase may contain some attributes in the prevention of venus thrombosis from a novel approach that needs further clinical investigation.

  • Dave

    5/17/2010 3:57:54 PM |

    Dr. Davis,

    I wouldn't be so quick to blast nattokinase because of this isolated incident or lack of research.

    Nattokinase is a "mild" blood thinner. Taking it once a day will not do more than relieve inflammation and slightly improve a person's circulation.

    A person would have to take it every 4 times a day (800 IU) on an empty stomach for if he desires a therapeutic effect. I would be curious if this patient of yours even took 200 IU per day (because a lot of products don't even contain that much).

    I have personally witnessed an improvement in circulation after taking nattokinase.

  • Dave

    5/17/2010 4:03:09 PM |

    I would like to add one more thing...

    I'm sure you have had experience with patients who took 400 IU of vitamin D in tablet form, and did not see any results after six months either. Was it because vitamin D is a worthless supplement, and should not be used?

  • Dave

    5/17/2010 4:42:33 PM |

    Sorry, I was misspoke about the dosage. Nattokinase is measured in fibrinolysis units (FU), not IU, and the effective dose ranges anywhere from 2,000-8000 FU per day.

    Also, here's actual scientific research (albeit small), not marketing hype, on nattokinase.

    http://www.ncbi.nlm.nih.gov/pubmed/19358933

    http://www.ncbi.nlm.nih.gov/pubmed/18971533

  • StephenB

    5/17/2010 6:40:37 PM |

    I've like the taste of natto from the moment I tried it. I am, however, a bit weird. ;)

  • Aaron

    5/17/2010 8:19:54 PM |

    Dr. Davis -- my question here is, could the nattokinase cause the blood clot (doesn't seem the be the case)?  Are you saying that it didn't matter that he was taking nattokinese because it doesn't reach the bloodstream to clear clots (so he would of had the clot anyway)

    Secondly, if he was taking nattokinese that had vitamin K2 <--- is it possible that increases in K2 might cause abnormal blood cloting?

  • Dr. William Davis

    5/17/2010 9:44:34 PM |

    Vitamin K2 does not cause blood clotting any more than topping up your gas tank makes your car go faster.

    Whether nattokinase has other effects is not my point. My concern is that people frequently ask if they should treat their DVT or pulmonary embolus with nattokinase. This is a death sentence. It should NOT be used for a such a purpose unless there were a large treatment trial proving equivalence or superiority to existing therapies.

  • Paul

    5/18/2010 12:50:58 AM |

    Eric,

    High dose mixed tocopherols use the same mechanisms as Wafarin/Coumadin.  They block the reabsorption of vitamin-K in the liver.  Vitamin-K is necessary for the liver to synthesize and release clotting proteins in the blood.  Warfarin/Coumadin is much, much more consistent than tocopherols in maintaining vitamin-K malabsorption and a safely prescribed INR range.  

    Titrating a Warfarin/Coumadin dosage never made sense to me. It is not toxic other than causing vitamin-K deficiency. What difference does it make if the dosage is 20 mg or 20 mcg to maintain a therapeutic INR?  Your liver will need to be equally deficient in vitamin-K no matter how you caused the deficiency.

    Garlic, ginger, ginkgo, curcumin, n-3, aspirin, N-acetylcysteine, Plavix, and yes tocopherols too all are anti-platelet agents.   They are effective at preventing arterial thrombosis, where anticoagulants have little effect. Conversely, anticoagulants are effective at preventing venous thrombosis, where anti-platelet agents (unfortunately) have little effect.

  • Michaela

    5/18/2010 7:36:40 AM |

    I'm giving my son nattokinase, one tablet daily and he also takes Vitamin K2. He has not been prescribed blood thinners, only aspirin which I stopped many months ago.
    Are you warning of not replacing prescribed blood thinners with natural therapies?
    If blood thinners have not been prescribed, is it of benefit to supplement with nattokinase?

  • rob_scheuneman

    5/18/2010 11:31:00 PM |

    Hi Dr. Davis

    I was wondering if you could help me with something.

    I've been monitoring my blood glucose recently with a basic monitor, and my readings would suggest that I am on the verge of impaired glucose tolerance, but not quite there yet.

    I was reading about continuous glucose monitoring systems. I would love to have on if these to more thoroughly monitor my blood glucose, but every model out there requires a prescription to obtain one. I don't understand this, because they are not dangerous in any way.

    Do you know of any way a non diabetic can purchase one of these?

    Any information you can give me would be greatly appreciated. Thank you.

    Rob

  • Anonymous

    9/25/2010 9:36:39 PM |

    Dr. Davis, i am a 45 year old female who recently started taking Lovasa for high triglycerides , i am also on garlic tabs and one baby asprin per day . Is is safe to replace the garlic and asprin with one tab of Natto- K per day and is it safe to take with Lovasa? I am about 20 lbs overweight do not drink or smoke and swim and or walk 3 days per week. i am genetically predisposed to high triglycerides but never had a problem until i gained the weight. Until i get the weight off i am trying a more natural approach. Help!

  • Kelly D

    8/10/2013 3:24:08 AM |

    Acta Haematol. 2010;124(4):218-24. doi: 10.1159/000321518. Epub 2010 Nov 13.

    In vivo evaluation method of the effect of nattokinase on carrageenan-induced tail thrombosis in a rat model.
    Kamiya S, Hagimori M, Ogasawara M, Arakawa M.
    Source
    Nagasaki International University, Sasebo, Japan. kamiya@niu.ac.jp

    Abstract
    Thrombosis is characterized by congenital and acquired procatarxis. Nattokinase inhibits thrombus formation in vitro. However, in vivo evaluation of the therapeutic efficacy of nattokinase against thrombosis remains to be conducted. Subcutaneous nattokinase injections of 1 or 2 mg/ml were administered to the tails of rats. Subsequently, κ-carrageenan was intravenously administered to the tails at 12 h after nattokinase injections. The mean length of the infarcted regions in the tails of rats was significantly shorter in rats administered 2 mg/ml of nattokinase than those in control rats. Nattokinase exhibited significant prophylactic antithrombotic effects. Previously, the in vitro efficacy of nattokinase against thrombosis had been reported; now our study has revealed the in vivo efficacy of nattokinase against thrombosis.

    PMID: 21071931

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Chocolate peanut butter cup smoothie

Chocolate peanut butter cup smoothie

Here's a simple recipe for chocolate peanut butter cup smoothie.

The coconut milk, nut butter, and flaxseed make this smoothie exceptionally filling. If you are a fan of cocoa flavonoids for reducing blood pressure, then this provides a wallop. Approximately 10% of cocoa by weight consists of the various cocoa flavonoids, like procyanidins (polymers of catechin and epicatechin) and quercetin, the components like responsible for many of the health benefits of cocoa.


Ingredients:
1/2 cup coconut milk
1 cup unsweetened almond milk
2 tablespoons cocoa powder (without alkali)
2 tablespoons shredded coconut (unsweetened)
1 tablespoon ground flaxseed
1 teaspoon almond extract
1 1/2 tablespoons natural peanut, almond, or sunflower seed butter
Non-nutritive sweetener to taste (stevia, Truvia, sucralose, xylitol, erythritol)
4 ice cubes

Combine ingredients in blender. Blend and serve.

If you plan to set any of the smoothie aside, then leave out the flaxseed, as it absorbs water and will expand and solidify if left to stand.

For an easy variation, try adding vanilla extract or 1/4 cup of sugar-free (sucralose) vanilla or coconut syrup from Torani or DaVinci and leave out the added sweetener.

The compromise I draw here is the use of non-nutritive sweeteners. Beware that they can increase appetite, since they likely trigger insulin release. However, this smoothie is so filling that I don't believe you will experience this effect with this recipe.

Comments (18) -

  • Anonymous

    3/18/2011 11:28:11 PM |

    This is very good - just mixed up a large glass full (minus the flaxseed).  And, that's my question, do you use finely ground flax seed?  I also tossed in a fist-full of blueberries - should be able to tolerate them well; I just had a very intense resistance training session

    I'd love to see more recipes for some ideas.  I disagree with those who wrote in on the earlier post, characterizing smoothies as "not real food."  I'm a big fan for time-challenged mornings and post-workout nourishment.

    Bill

  • praguestepchild

    3/19/2011 12:11:34 AM |

    I can't believe you passed up a perfectly good opportunity to embed a cheesy 80's Reese's commercial in this post.

    http://www.youtube.com/watch?v=DJLDF6qZUX0

  • Dr. William Davis

    3/19/2011 1:36:19 PM |

    Anon--

    Yes, I used a finely-ground flaxseed.

    The berries are a great idea, provided quantity is small.

  • Kathryn

    3/19/2011 6:33:41 PM |

    Just a cautionary note -

    Sucralose/Splenda can have severe reactions.

    I seem to respond/react to things severely.  Sucralose has caused both allergic reaction (swollen mucus membranes) and severe migraine for me.  In fact, as a frequent migraine sufferer (tho much less now that i've removed gluten and sulfites), the migraine i got from sucralose was by far the worst i've ever had.  

    Personally, i am of the belief that if it effects me so strongly, it is probably not good for anyone, but the damage it does is much less pronounced in other people.

    I stick to stevia for a no-calorie sweetener.

  • Geoffrey Levens

    3/19/2011 8:43:16 PM |

    http://jstevens.wordpress.com/2008/02/20/how-sucralose-aka-splenda-is-made-and-why-you-want-to-avoid-it/

    "How Sucralose (aka Splenda) Is Made And Why You Want To Avoid It

    ...I wanted to comment on Splenda.  Splenda, also known as sucralose, was created accidentally when some chemists were trying to produce an insecticide.  Here is the process by which they produce the formula sold in stores:

    “1.  Sucrose is tritylated with trityl chloride in the presence of dimethylformamide and 4-methylmorpholine, and the tritylated sucrose is then acetylated with acetic anhydride.

    2.  The resulting sucrose molecule TRISPA is chlorinated with hydrogen chlorine in the presence of tolulene.

    3.  The resulting 4-PAS is heated in the presence of methyl isobutyl ketone and acetic acid.

    4.  The resulting 6-PAS is chlorinated with thionyl chloride in the presence of toluene and benzyltriethylammonium chloride.

    5.  The resulting TOSPA is treated with methanol in the presence of sodium methoxide to produce sucralose.”  (Note that methanol, wood alcohol aka paint remover,  is one of the questionable ingredients in aspartame.)

    In addition, the bags and packets of Splenda commercially available are not pure sucralose.  They also contain bulking agents.  All artificial sweeteners use bulking agents.  Do you know what they use?  Sugar.  Dextrose, sucrose, and maltodextrin.  (Maltodextrin is corn syrup solids composed primarily from fructose and glucose in a starch form.)   All sweetener packets are at least 96 percent sugar.  Splenda is 99% sugar.

    The packets are labelled calorie free as a result of manipulating a loophole in the food labeling laws.  The product can be described as sugar free if a serving contains less than 5 grams of sugar, and calorie free if a serving is less than 5 calories.  So they set the serving size on bags at .5 grams  and the packets contain a serving of 1 gram.  A one gram packet contains 4 calories.   This can be confirmed on the manufacturer’s website in the FAQ section:  â€œLike many no and low calorie sweeteners, each serving of SPLENDA® No Calorie Sweetener contains a very small amount of common food ingredients, e.g., dextrose and/or maltodextrin, for volume. Because the amount of these ingredients is so small, SPLENDA® No Calorie Sweetener still has an insignificant calorie value per serving and meets FDA’s standards for “no calorie” sweeteners. “

    To make matters worse, when sucralose was shown to not raise blood sugars, it was the pure substance that was tested, not the mixture that is sold to the public.  Dextrose, sucrose, and/or maltodextrin are definitely going to raise a diabetic’s blood sugar.  There is also a great deal of evidence that artificial sweeteners actually cause an increase in appetite, causing people who consume them to take in more calories than they would otherwise.

    Stevia, on the other hand, lowers blood sugar, making it a much better choice.  If you have tried stevia in the past and did not like the flavor, you might want to try another brand. ..."

  • Brandon Nolte

    3/19/2011 10:38:51 PM |

    If your looking for a more nutritious "sweetner" you should try adding half a cup of coconut water. Delicious!

    Ps. I love your blog. Keep up the great work!

  • bob412

    3/19/2011 11:34:59 PM |

    Tapioca starch in the almond milk, but not enough to hurt you.

  • Dr. John

    3/20/2011 2:49:18 AM |

    I enjoy your blog. You have a good thread about the hazards of hyperglycemia.
    However, this recipe is not one I would recommend to patients attempting to reverse metabolic syndrome, T2D, or IR.
    Their main concern is the inflammation caused by the above listed disorders. The omega 6 content of the peanut butter, sunflower seed, and to an extent, almond butter would exacerbate the inflammation mitigated by the hyperglycemia.
    In addition, sugar alcohols (xylitol, erythritol) tend to cause GI upset (gas, diarrhea). Also the hazards of Sucralose are intuitively obvious....it contains chlorine molecules....commonly found in many household cleaners, and of course used in WWI as a pulmonary choking agent.
    I would only use macadamia nuts/nut butter, and Stevia to sweeten.
    Dr. John

  • Dr. William Davis

    3/20/2011 1:28:28 PM |

    Thanks, Dr. John.

    I hear you on the sucralose issue. I've actually been having positive experiences with stevia, xylitol, and erythritol. The important thing is that people have some good choices nowadays, unlike 20 years ago when we had saccharine . . . period.

    There is no question that mannitol and sorbitol have greater potential for both GI distress (diarrhea) as well as increases in blood glucose, so these are clearly on the no-no list (unless you need a quick laxative).

  • Gabriella Kadar

    3/20/2011 7:23:42 PM |

    Sucralose is not metabolized.  Most of it is excreted unchanged in the feces.  A small percentage is absorbed and excreted unchanged in urine.  

    Sodium in food is more of a concern for a person who experiences migraine headaches.  Over-activity of muscles activated by the Trigeminal nerve due to airway resistance secondary to water retention is a greater concern.  Various factors are present both anatomically and physiologically in people who experience migraine.  The only way to determine if sucralose is actually the cause of a migraine is to consume sucralose on its own.

    What concerns me is what happens to the sucralose in the environment.  The addition of a chlorine atom, (not a molecule, Dr. John) results in a molecule which cannot be metabolized by bacteria.  If environmental degradation is possible, then sucralose excreted by human beings is not an issue.  But if it persists in the environment, then it is a pollutant.

  • Anonymous

    3/21/2011 3:22:42 AM |

    I am practically a fruitarian, so much of what I like would be off limits.
    Is there an article here on what IS recommended?

  • Dr. John

    3/21/2011 3:29:27 PM |

    Yes, atoms, not molecules...ie. precisely 3 atoms of chlorine/molecule of sucrose...

    An interesting thing about this selective halogenation of sucrose, is the fact that sucralose (being 600 times as sweet as sucrose), increases the HbA1c numbers in my patients. This demonstrates a lessening of diabetic control. Thus, hemoglobin gets glycated and fasting blood sugar increases....with the attendant hyperglycemia issues as mentioned, and this excellent blog site.

    For this reason I do not recommend sucralose for diabetics nor anyone wanting to keep blood sugar levels within normal limits. The current cost and future costs for diabetes will cripple our healthcare structure. Here are ADA numbers:

    $174 billion: Total costs of diagnosed diabetes in the United States in 2007
    $116 billion for direct medical costs
    $58 billion for indirect costs (disability, work loss, premature mortality)

    Dr. John

  • Gabriella Kadar

    3/22/2011 1:42:51 AM |

    Dr. John, is it possible that other factors contribute to higher H1ac levels in your type 2 diabetic patients?  

    Since sucrolose is not metabolically active and does not act as a laxative, then there could be other endocrinological and neurological reasons for higher glucose levels.

    Here's an abstract on sucralose and Type 2 diabetes:

    Grotz VL, Henry RR, McGill JB, Prince MJ, Shamoon H, Trout JR, Pi-Sunyer FX. Lack of effect of sucralose on glucose homeostasis in subjects with type 2 diabetes. J Am Diet Assoc. 2003 Dec;103(12):1607-12.

    OBJECTIVE: To investigate the effect of 3-months' daily administration of high doses of sucralose, a non-nutritive sweetener, on glycemic control in subjects with type 2 diabetes. DESIGN: A multicenter, double-blind, placebo-controlled, randomized study, consisting of a 6-week screening phase, a 13-week test phase, and a 4-week follow-up phase. SUBJECTS/SETTING: Subjects with type 2 diabetes (age range 31 to 70 years) entered the test phase of this study; 128 subjects completed the study. The subjects were recruited from 5 medical centers across the United States and were, on average, obese. INTERVENTION: Subjects were randomly assigned to receive either placebo (cellulose) capsules (n=69) or 667 mg encapsulated sucralose (n=67) daily for the 13-week test phase. All subjects blindly received placebo capsules during the last 4 weeks of the screening phase and for the entire 4-week follow-up phase. MAIN OUTCOME MEASURES: Glycated hemoglobin (HbA1c), fasting plasma glucose, and fasting serum C-peptide were measured approximately every 2 weeks to evaluate blood glucose homeostasis. Data were analyzed by analysis of variance using repeated measures. RESULTS: There were no significant differences between the sucralose and placebo groups in HbA1c, fasting plasma glucose, or fasting serum C-peptide changes from baseline. There were no clinically meaningful differences between the groups in any safety measure. CONCLUSIONS: This study demonstrated that, similar to cellulose, sucralose consumption for 3 months at doses of 7.5 mg/kg/day, which is approximately three times the estimated maximum intake, had no effect on glucose homeostasis in individuals with type 2 diabetes. Additionally, this study showed that sucralose was as well-tolerated by the study subjects as was the placebo.

    PMID: 14647086 [PubMed - indexed for MEDLINE]

    Now, I can understand how sugar alcohols taken in large quantities might have some effect on blood sugar because they are laxative and increase gut motility and cause discofort or pain, both of which will spike blood sugar values. the liver dumps glucose into the bloodstream when the body is under stress like this.  And of course, the pancreas reacts very sluggishly to endogenous glucose.

    I think type 2 diabetics should have routine sleep study screening to determine whether breathing issues during sleep may be upramping the sympathetic nervous system and causing high sugar levels during sleep. We can't just help these people improve their life quality by looking at only one parameter.

    They need otolaryngological evaluation for anything from deviated nasal septa to chronic allergies, enlarged adenoids and tonsils.  The size of their jaws, how they function and tongue posture also factors in.

    Not to mention, anyone with pulmonary issues would have increased effort on breathing...asthma, pulmonary hypertension etc.  The existance of chronic pain and anxiety conditions also influence how the body produces its own glucose.  

    Patient's require a multi-disciplinary workup to determine the multiple factors that result in the development of type 2 diabetes.  It's not merely diet because these people have an awfully hard time changing their diets without having other problems addressed.

  • Anonymous

    3/24/2011 7:01:46 PM |

    Excellent! Dr. Davis, you have had many posts of what not to eat but very few on what we should eat. Taking something out of our diet means we have to replace it with something. This post seems to be in the right spirit. I am going to try this soon. Now if only you can post a similar substitute for Keva Juice's Oreo Speedwagon smoothie! Yes, I know they are hazardous to your health but they are wickedly good!

    -- Boris

  • Dr. John

    3/25/2011 5:50:15 AM |

    I'm not totally convinced why sucralose, a chloro-carbon, similar to DDT and PCBs, would elevate the HgA1c levels. My guess would be a neurological response to an ingested poison. Sucralose does kill intestinal beneficial bacteria...lactobacillus, bifidobacteria, and bacteroides...of varying amounts of 37-67%...and the enteric nervous system would react by elevating cortisol/adrenaline/glucagon: while at the same time not delaying gastric emptying.
    Body perception is stress....glycation of RBCs result, with CVD and sudden cardiac death.

    Studies that use diabetic, and obese subjects in the assessment of A1c elevation are biased from the start. These individuals have already lost glycemic control and as a result would not have normal A1c levels to begin with...let alone studying their response 13 weeks later.

    McNeil Nutritionals, maker of SPLENDA® Brand products, stated it has provided the American Diabetes Association (ADA) with a sponsorship to support the Association's efforts to fund research, information and advocacy programs on behalf of people with diabetes.
    And McNeil Nuts. are owned by Johnson and Johnson, who are large contributors to the ADA...the journal of the previously listed biased study showing the sucralose doesn't affect A1c levels...in spite of the fact in clinical results showing the opposite.

    Anything, sucrose or sucralose, that elevates A1c levels is cardio-lethal...and is best avoided.

  • reikime

    4/2/2011 5:07:29 PM |

    Dr. D,
    Do you use regular coconut milk or the lite? Does it make a difference, except calorically?

    Thanks!

    Jeanne

  • Anonymous

    4/8/2011 1:09:56 AM |

    I am allergic to the artificial sweeteners. Thought I could tolerate sucralose but it just took a little time for a reaction. My mouth and throat became inflamed and I had sore bumps all over the inside of my throat and back of my mouth after about a week.

    I don't like stevia or the other natural no calorie sweeteners either...they just don't taste sweet to me or have odd flavors.

    But I found something.  It is not calorie free, but it has low glycemic index and tastes just like sugar.  It is "Organic Blue Agave". What are a few calories in exchange for some actual taste.

    I bought it at Costco.

  • Geoffrey Levens

    4/8/2011 1:30:13 AM |

    ""Organic Blue Agave". What are a few calories in exchange for some actual taste."

    High fructose corn syrup (HFCS) is about 55% fructose and cause inflammation, insulin resistance, and elevates triglycerides.  Agave syrup is often 70% or higher (possibly as high as 90%) fructose!  Marketing scam...

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Vitamin D toxicity

Vitamin D toxicity

It is the craziest thing.

The notion of vitamin D being easily and readily toxic has grabbed hold of many people, including my colleagues who were taught that vitamin D was toxic in medical school based on the skimpiest (and often misinterpreted) observations in a handful of unusual cases.

In my practice and in the Track Your Plaque program, we routinely use doses of 2000-10,000 units per day, occasionally more. We are guided by blood levels of 25(OH) vitamin D3. I have personally never witnessed vitamin D toxicity.

Here's an interesting graph from Dr. Reinhold Vieth. Those of you familiar with the vitamin D argument know that Dr. Vieth is among the few genuine gurus in the vitamin D world.



















From Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr 1999;69:842-856. (Full text is available without charge.)

In the graph, the X's represent toxicity; circles fall within the non-toxic range. (Toxicity is generally defined as a level sufficient to raise blood calcium levels, "hypercalcemia.") Note that the 25(OH) vitamin D3 levels are given in nmol/L; to convert to ng/ml units that are customary in the U.S., divide the nmol/L value by a factor of 2.5.

You will notice that toxicity is virtually unheard of until the dose exceeds 10,000 units per day. Beyond 10,000 units per day, the curve heads upward sharply and toxicity does become a possibility, though not an absolute (since there are circles above 10,000 units).

You may also notice that the curve is relatively flat from vitamin D doses between 200 units and 10,000 units (log scale on x axis; arithmetic scale on y), the range of most common doses for vitamin D supplementation.

Another perspective on vitamin D blood levels is to examine the blood levels of people who are young and obtain plentiful sun exposure. Lifeguards, for instance, have blood levels of 84 ng/ml (210 nmol/L) without ill-effect. (Sun exposure cannot generate vitamin D toxicity, because of a feedback safety mechanism in skin.) While this may not represent an ideal level since they represent an extreme, it does provide reassurance that such levels are non-toxic. I also point out these levels occur in the youthful since most people lose 75% or more of vitamin D activating capacity in the skin by their 70s. Most of us over 40 are kidding ourselves if we think that a suntan provides sufficient vitamin D.

Keep in mind that it is not necessarily the dose of vitamin D that is toxic, but the blood level it generates. I take 10,000 units of vitamin D as a gelcap per day to maintain my blood level between 50-60 ng/ml (125-150 nmol/L). This strategy helps me keep my HDL in the 70-80 mg/dl range, my blood sugar around 90 mg/dl, my blood pressure <120/80, and I no longer experience colds nor winter "blues."


Copyright 2008 William Davis, MD

Comments (26) -

  • mike V

    2/6/2008 5:19:00 PM |

    Dr D:
    I take up to 4000 IU per day depending on season and have recently had a zero CTA scan, so I personally have high confidence in vitamin D3.
    From time to time I see references to the possibility that excessive D can produce soft tissue/arterial calcification in some people. I understand of course that Vitamin K2 menaquinone is an essential partner in proper calcium homeostasis.
    Are you completely without concern at the blood levels discussed?, or should people with marginal kidney performance or other moderate metabolic conditions be cautious?
    Would appreciate your thoughts.
    MikeV

  • mtflight

    2/6/2008 5:31:00 PM |

    Where does one get 10,000 IU caps?

    I take 4000 IU capsules from Carlson Labs (called "Solar Gems")--the oil in the caps is fish oil, so that's a plus, and my multivitamin has 1,000 IUs.


    P.S. Thanks for the blog, I'm a big fan!

  • Dr. Davis

    2/6/2008 9:33:00 PM |

    There are clearly groups of people who should work with their doctor when it comes to vitamin D, particularly people with kidney disease or dysfunction; history of kidney stones; glandular diseases like hyperparathyroidism; a history of high calcium.

  • MrSardonicus

    2/6/2008 9:58:00 PM |

    If taking 4,000 IU of Vitamin D a day increases one's HDL by a relatively small number -- say, 10 -- but it's still low, what do you think is the likelihood hiking the amount will further increase HDL?

    Also, do you take calcium with your Vitamin D?

  • Dr. Davis

    2/6/2008 10:01:00 PM |

    I have never seen 10,000 capsules. I'm hoping somebody comes out with such a preparation. I wasn't aware of the 4000 unit capsules. Thanks for the tip!

  • Dr. Davis

    2/6/2008 10:04:00 PM |

    I would not advise taking more vit D just to raise HDL.

    Blood level of vit D is the parameter to assess vit D adequacy. I would regard a rise in HDL as a fortuitous side phenomenon.

  • Brandon

    2/6/2008 11:00:00 PM |

    “…and I no longer experience colds nor winter "blues."

    Careful, this sort of personal testimonial lends to sounding more like a “nutritional guru” instead of medical professional examining scientific evidence.

    I’m not saying you’re incorrect, it may be your experience and it may be absolutely true, but a stick to the clinical facts. You’re talents are better suited to being a “medical watchdog” than a “dietary duck.”

  • Anonymous

    2/7/2008 12:19:00 AM |

    Dear Dr. Davis,
    I would love your opinion of my doctor's protocol regarding my recent diagnosis of osteopenia in my hips (t-scores -1.1 and -1.2 femoral neck, my spine was normal, -0.2).  I'm a 56 year old woman, 115 pounds, just went through menopause, taking Zocor and Lotrel (high cholesterol and hypertension both run in my family), I exercise regularly.  My doctor said he wanted to see how well I absorb Vit D, so he ordered a blood test, however, he ordered the D1,25 test (results 35 pg/mL), NOT D25 which I understand is a truer biomarker.  He prescribed Vitamin D, Calcitriol, one 0.025 capsule per day for one month, with no restrictions on my Calcium/Vit D intake through supplements, after which he said to return for another Vitamind D blood test (another D1,25).  I've read that Calcitriol can cause hypercalcemia.  I've also read that D1,25 will not tell you how well you're absorbing Vitamin D.  Based on that, I felt I was wasting my time and risking hypercalcemia, so I stopped taking the Calcitriol.  Should I tell my doctor that he ordered the wrong blood test?  Also, which prescription Vit D should I be taking? I have no other health issues.  Thank you, Dr. Davis.
    Ruthie

  • Dr. Davis

    2/7/2008 12:58:00 AM |

    Thank you, but I disagree.

    I add my experiences to that of probably over 1000 patients in the last two years who have shared similar effects.

  • Dr. Davis

    2/7/2008 1:00:00 AM |

    Hi, Ruthie-

    Lots of issues. However, it sounds like your doctor is simply toeing the conventional line of prescription drugs. It may be time to either prod your doctor to get up to date on vitamin D, or to find a doctor willing to engage in the discussion.

  • Anonymous

    2/7/2008 1:27:00 AM |

    Do you know if any one is making or developing an at home vitamin D3 testing product?

  • Dr. Davis

    2/7/2008 2:55:00 AM |

    Wouldn't that be wonderful?!

    Unfortunately, I do not know of any such commercially available product. However, it would be a tremendous boon to this movement of self-empowerment in health care that I see coming for the future.

  • Anonymous

    2/7/2008 5:36:00 AM |

    I am taking vitamin D3 two softgels of 2000 IU each daily, one in the morning and one in the evening. I want to know if I get the same effect if I take two softgels together instead of taking one twice a day. Thanks.

  • Anne

    2/7/2008 9:12:00 AM |

    Hi Ruthie,

    I'm 54 and diagnosed with osteoporosis (T scores -3.7 in hips and -3.1 lumbar spine). I've been prescribed calcium supplements (as well as Strontium Ranelate) but I've found that I'm very intolerant to the calcium, no matter whether I try calcium citrate, calcium carbonate or calcium amino acid chelate, so since Christmas I've stopped all calcium supplements and upped my vitamin D3 intake to 4000iu per day (not prescription, I wish it was then it wouldn't be so expensive...vitamin D costs a lot in the UK, much more than the US) so that I absorb my dietary calcium as well as possible. I feel very confident that this will work, especially in view of a previous blog from Dr Davis about calcium:http://heartscanblog.blogspot.com/2008/01/calcium-chaos_22.html

    Plus logic tells me that it is not lack of calcium that causes osteoporosis but other factors. People in third world countries such as Africa on suboptimal diets have very low levels of dietary calcium but they don't usually get osteoporosis...they get more sunshine (vitamin D) and do much more physical work. I'm doing plenty of weight resistance exercise now !

    bw's
    Anne

  • Dr. Davis

    2/7/2008 1:03:00 PM |

    Yes, no difference.

  • moblogs

    2/7/2008 2:25:00 PM |

    bio-tech-pharm.com supply D3 in 1k, 5k and 50k capsules, and with delivery rates that are reasonable for those out of the US.
    I've been taking 5k for the past 2 weeks and don't feel bad on it, but will be getting blood levels checked within a season to see if I'm personally responding correctly.
    The 400IU average was just based on preventing rickets.

  • hoosierville

    2/7/2008 7:03:00 PM |

    Dr. Davis,
    I've had great results from increasing my vitamin D intake with regards to my lung capacity. I'm a recovering smoker with moderate copd and, after being hospitalized for pneumonia, am finally recovering to a point where I can almost run up and down steps. I attribute this to my "D" supplements which I began taking about a month ago. I can take deep breaths for the first time in years.

    My question is about the supplements themselves. I see very expensive D3 tablets and then I see the regular vitamin D. Is one better than the other? Is there a great deal of difference? Thanks.

  • jabs28

    2/8/2008 6:05:00 PM |

    I am surprised to see how many people are gettingtheir their Vitamin D requirements with supplements.  Go out into the sun WITHOUT sunscreen for 10-15 minutes a day and then supplement the rest.  Remember it also takes about 40 glasses of milk to equal 4000 iu's of Vitamin D.  You can get that from about 15 minutes of sun exposure depending on your age and ethnicity.  The more melanin in your skin, the longer you need to expose it.

  • Anonymous

    2/8/2008 6:10:00 PM |

    The capsules I take (the Solar Gems) are 6 cents a 4000 IU softgel:

    http://www.vitacost.com/Carlson-Solar-D-Gems-Vitamin-D

  • hoosierville

    2/9/2008 2:25:00 PM |

    Jabs,
    I live in Indiana. It's going to be 6 degrees out in just a few minutes. We haven't seen the sun in weeks. What do you suggest, tanning beds? I'll do it but not until I hear that they're safe. Be reasonable, not everyone lives where they can get natural sunlight. I think that's part of the Vitamin D deficiency problem.

  • TedHutchinson

    2/10/2008 9:08:00 PM |

    I have been taking the same 5000iu Biotech capsules Moblogs uses.
    I was 147.5nmol - 59ng when tested at the end of summer (UK latitude 53) although I did not take a D3 on days when I knew I would be able to get near full body sun exposure at midday.

    As others have reported, I also have not had a cold or flu over the winter (so far and still touching wood) others I am regularly in contact with have been unlucky.
    (I also did not need to get my SADLIGHT down from the attic this winter)

  • MattWheeler

    2/11/2008 3:26:00 AM |

    Something in the my 7 month TYP program (6000iu D3 gelcap, Slo-Niacin 1.5g, 3g+ fishoil, low wheat-suger) has really helped with joint pain I have had for 8 years.  This has allowed me to lift weights 3 times per week and thus reduced my bodyfat from 27 to 19 percent.  I look and feel much better.  I am 51, male at 215 lbs.

  • Anonymous

    2/11/2008 10:00:00 PM |

    Oh, is it because I take vitamin D3 that even with people dropping like flies around me (with colds, flu, etc) I never get sick? I have always thought it surprising that I tend not to get these things, given that I do have a number of autoimmune conditions. I have only ever used tablets (1000IU 1/day) and my vitamin D3 (250H) level is 52ng/mL.

    However, my vitamin D2 (250H) level is <4ng/mL and my vitamin D (1,25) level is only 24pg/mL (normal range 22-67). Should I (and is it possible to?) do anything to increase those levels?

  • Anonymous

    12/3/2008 2:51:00 PM |

    * * D2 v. D3 * *
    http://www.medicalnewstoday.com/articles/92952.php

    * * D2 vs. lupus vulgaris * *
    ("administered in alcoholic solution is key" to success of therapy)
    http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1583253&blobtype=pdf

  • George Mclaughlin

    10/9/2010 12:37:54 AM |

    Very interesting article. I find myself concerned about the side effects of vitamin D supplements, as opposed to sunlight-derived vitamin D.

    I'd love to hear your thoughts on this article, which appears to be quite well cited:

    http://www.raw-food-health.net/Vitamin-D-Toxicity.html

  • buy jeans

    11/2/2010 8:39:57 PM |

    In my practice and in the Track Your Plaque program, we routinely use doses of 2000-10,000 units per day, occasionally more. We are guided by blood levels of 25(OH) vitamin D3. I have personally never witnessed vitamin D toxicity.

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