Is pomegranate juice healthy?


Pomegranate juice, 8 oz:

Sugars, total 31.50 g

Sucrose 0.00 g

Glucose (dextrose) 15.64 g

Fructose 15.86 g




In your quest to increase the flavonoids in your diet, do you overexpose yourself to fructose?

Remember: Fructose increases LDL cholesterol, apoprotein B, small LDL, triglycerides, and substantially increases deposition of visceral fat (fructose belly?). How about a slice of whole grain bread with that glass of pomegranate juice? The Heart Association says it's all low-fat!


(Coming on the Track Your Plaque website: A full in-depth Special Report on fructose in all its glorious forms and whether this is truly an issue for your health. Fructose tables and the scientific data to establish a safe "threshold" value will be included.)

Image courtesy Wikipedia

Comments (20) -

  • Anonymous

    7/19/2009 1:45:42 PM |

    all should keep in mind that 4 grams of sugar is equal to one teaspoon.  31 grams is 7 teaspoons plus; not exactly what one would think in what is promoted to be a healthful product!

  • John

    7/19/2009 2:15:04 PM |

    Like most juices, pomegranate juice just has too much sugar.  There is a reason why a juice glass is very small!

    I don't buy pomgrante juice anymore, and when I did I would water it down.  100% is very expensive too.

    Another thing about pomegranate juice, people might be surprised to find that many of them are not 100% pomegranate, but a blend of several juices.

  • Andrew

    7/19/2009 3:59:34 PM |

    At what point do the positive health benefits of pomegranate outweigh the bad parts of fructose?

  • Tom

    7/19/2009 4:20:58 PM |

    Thanks for your great blog! Your information on wheat and sugar is a must read for anyone serious about their health. I like your blog so much, I added a link to it at my blog at http://eatingandfasting.blogspot.com/

  • Anonymous

    7/19/2009 6:07:12 PM |

    Dr. Davis,

    Are you implying that there is no difference between a glass of Kool-ade and a glass of fresh Orange Juice?

    IMO, the problem is not fructose. The problem is highly refined sugar sources that are isolated from their highly complex natural matrix of fiber, vitamins, minerals, flavanoids, antioxidants, enzymes, amino acids--all which act in synergy together.

    That's why PJ reduced atherosclerosis by 35% compared to control group, lowered BP by 20%, increased antioxidant status, and did not raise blood sugar.

    (FYI, I happen to have heterozygous FH and drink daily one full glass of PJ along with one full glass of concord grape juice, and 97% of my LDL particle size remains large, my blood sugar is perfect, and my apo B is not too high. I do avoid refined sugars and carbs, however.)

    So please, Dr. Davis, don't compare an apple with a candy bar.

  • AJ

    7/20/2009 4:52:14 AM |

    Guava juice used to be my particular poison - literally speaking. But it's just not worth the hit to my metabolism. It's been awhile since I last drank any fruit juice and it will be never before I drink it again.

    It's an uphill battle to get people to realise the dangers of fructose, particularly when food manufacturers are allowed to put "No sugar added" on the label. Have them put the grammes of sugars the whole bottle contains on the front of the container in large bright type. It won't stop everyone, but it may help a few people make healthier choices.

  • JC

    7/20/2009 10:55:48 AM |

    Pomegranate juice more than triples PSA doubling time.Is that significant?

  • Peter

    7/20/2009 1:56:43 PM |

    I like to dilute the pomegranate juice with vodka.  That way I only use a couple of ounces of juice at a time, minimizing the fructose but still getting some flavanoids.  Of course once the long term study on this regimen comes out I may have to revise my view.

  • Dr. William Davis

    7/21/2009 3:28:52 AM |

    It's the same flawed logic of "healthy whole grains": If it contains something good (B vitamins, fiber), then it must be good. And it must be even better when consumed in greater quantities.

    Just because it contains one or two desirable ingredients doesn't mean that the entire "package" is desirable,

  • niner

    7/21/2009 5:00:09 AM |

    There's always pomegranate extracts.  You can get the polyphenols in a pill without all the sugar.  I'd be interested in what Dr. D thinks about this form of "sugar-free pomegranate".

  • JC

    7/21/2009 11:19:40 AM |

    Dr Davis,What about the research on pomegranate juice and PSA doubling time?

    Can you also comment on the reported benefits of cranberry juice in preventing urinary infection?

    Thanks,JC

  • Jonathan Byron

    7/21/2009 3:12:18 PM |

    You are absolutely right that fruit can contain large amounts of fruit sugar, and that large amounts of fructose can have serious consequences. The idea that fruit juice must be good (in any quantity) is not supported by the evidence.

    But fruits are more than sugar and moderate amounts of fruits and fructose are not inherently bad - the question is what is reasonable. For those of us with fatty liver, certain patterns of dyslipidemia, or a GI fructose intolerance, the ideal amount is very low. For those who don't fall into that category, the ideal amount of fruit is somewhat greater (but probably less than most people assume).

  • Anna

    7/22/2009 10:22:04 PM |

    I can't remember the last time I saw someone outside my household drink juice from a small juice glass.  Most people I see drinking juice are consuming quantities of juice that practically rival a 7-Eleven Big Gulp.

    Many days I squeeze a half orange to make a couple ounces of OJ to mix with cod liver oil to make the CLO palatable for my young son.  

    To fill a 4 oz juice glass (with about 3-3.5 oz juice), it takes 1-2 oranges, which means that larger glasses of OJ contain the sugar of a whole lot of oranges!  Who would ever eat that many whole oranges in one sitting?

    Also, I know from using a glucose meter that OJ sugar is nearly instantly into my blood stream (and that isn't even measuring the affect of the fructose portion of sugars.  The glucose spikes an insulin response and later a nasty feeling low BG.  So I approach fruit juices with extreme caution and limitations on both quantity and frequency.  I eat whole lower sugar fruits in extreme moderation (avoiding higher sugar tropical fruits).  I focus more on non-starchy veggies rather than fruit, anyway, because veggies are high in the nutrients I want without the excess sugar that fruit has.        

    Not long ago I was in waiting in line at a Starbucks to order an Americano (lack of local coffee shops at that particular suburban area) and right next to me a dad was reading aloud to his young daughter the number of grams of sugar from her “fresh-squeezed 100% fruit juice” bottle label. He noted incredulously there were 30-something grams of sugars per serving and there were 2.5 servings per bottle. He said  â€œwow, that’s a lot of sugar in that bottle”. I thought to myself, wow, here’s a dad who is “getting it”, so I said to him, “there’s 4 grams of sugar to a teaspoon, so that’s at least 7-9 teaspoons of sugar per serving, very nearly the sugar content in soda.”

    His response was, “but it’s fruit sugar, and she doesn’t eat enough fruits and vegetables, so I guess that’s ok.” Sigh. I let it go, and ordered my Americano (unsweetened).

    I've had many interesting conversations with a glycobiologist colleague of my husband's.  He has confirmed I'd be wise to keep all sources of fructose intake to a minimum, as well as being especially wary of concentrated sources of fructose.    I'm sure he follows his own advice; he's looks at least 15 years younger than his 60 years - lack of AGEing, I guess.

  • trinkwasser

    7/29/2009 6:04:30 PM |

    Tell this stuff to a dietician and they won't believe you "but it's low fat!"

    My BG meter tells me fruit juice is an exceedingly toxic substance, and most of my once favourite fruits aren't much better.

    Fortunately it permits me to eat a few berries, but I'd rather get my bioflavinoids etc. from vegetables.

    IMO there's a balancing point between the beneficial and non-beneficial properties of many foods, we probably evolved to deal with small acute doses of toxins but fall apart with chronic exposure to high levels of the same stuff, and all the bioflavinoids and vitamins don't outweigh the damage.

    I just stuffed some strawberries in my face following my lamb chops and runner beans, but only a few, and I washed them down with a fine Bordeaux, that'll about achieve a balance.

  • Barrry

    2/22/2010 12:58:33 PM |

    i have been using Pomegranate juice for 3 years every day after i had 2 stents placed. i also had type 2 diabetes. It has worked very well for me and has not effected my A1c in the least. My cardilogical nuclear studies have been perfect. i am a believer my opinion this stuff can save your life.

  • EMR

    2/24/2010 1:33:43 PM |

    ink it should be avoided by sugar patients.It contains almost a spoon of sugar...though with wheat bread the whole effect of the meal is balanced.

  • Anonymous

    3/8/2010 3:03:37 PM |

    http://www.nutraingredients-usa.com/Research/Pomegranate-juice-shows-possible-diabetes-benefits

    Quit being sugar paranoid.

  • buy jeans

    11/3/2010 3:09:20 PM |

    Remember: Fructose increases LDL cholesterol, apoprotein B, small LDL, triglycerides, and substantially increases deposition of visceral fat (fructose belly?). How about a slice of whole grain bread with that glass of pomegranate juice? The Heart Association says it's all low-fat!

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Carbohydrate-LDL double whammy

Carbohydrate-LDL double whammy

Carbohydrates in the diet trigger formation of small LDL particles. Because carbohydrates, such as products made from wheat, increase triglycerides and triglyceride-containing lipoproteins (chylomicrons, chylomicron remnants, VLDL, and IDL), LDL particles (NOT LDL cholesterol) become triglyceride-enriched. Triglyceride-enriched LDL particles are "remodeled" by the enzyme, hepatic lipase, into triglyceride-depleted, small LDL particles.

The list of reasons why small LDL particles are more atherogenic, i.e., plaque-causing, is long:

--Small LDL particles, being smaller, more readily penetrate the endothelial barrier of the arterial wall.
--Small LDL particles are more adherent to glycosaminoglycans in the artery wall.
--Small LDL particles are poorly taken up by the liver LDL receptor, but enthusiastically taken up by macrophage receptors of the sort in your artery walls.
--Because of their poor liver clearance, small LDL persists in the bloodstream far longer than large LDL.
--Small LDL particles are more oxidation-prone. Oxidized LDL are more likely to trigger inflammatory phenomena and be taken up by macrophages in the artery wall.

Let me add another reason why small LDL particles are more likely to cause plaque: They are more likely to undergo glycation. (More on glycation here.)

Glycation occurs when glucose (sugar) molecules in the blood or tissue modify proteins, usually irreversibly. Small LDL particles are uniquely glycation-prone. (This is likely due to a conformational change of the apoprotein B in the small LDL particle, exposing lysine residues along apo B that become glycated.)

Here's a great demonstration of this phenomenon by Younis et al:


"LDL3" is the small type. Note that small LDL particles are 4-5 times more glycated than large LDL. That's a big difference.

Once glycated, small LDL is especially resistant to being taken up by the liver. Like annoying in-laws, they hang around and hang around and . . . The longer they hang around, they more opportunity they have to contribute to plaque formation.

So, carbohydrates trigger formation of small LDL particles. Once formed, small LDL particles are glycated when blood sugar increases. While LDL can be glycated even when blood sugars are in the normal range (90 mg/dl or less), glycation goes berserk when blood sugars go higher, such as a blood sugar of 155 mg/dl after a bowl of steel-cut oatmeal.

Comments (14) -

  • Tony

    7/9/2010 4:06:01 PM |

    I used diet and supplements instead of a statin to control my cholesterol, and my recent VAP test indicated I had "large buoyant" LDL. We know statins reduce LDL and inflammation, but do they affect particle size?

  • Red Sphynx

    7/9/2010 4:26:18 PM |

    Does increasing dietary fiber have a significant effect on the abundance of of LDL3, or its oxidation or glycation?

    My reasoning is that the gut reabsorbs cholesterol and returns it to the gall bladder.  The gall bladder taps the liver for the make-up cholesterol.  The liver draws LDL out of the blood when it needs cholesterol.  Sooo... fiber decreases re-absorption of cholesterol  This  ought to, eventually, decrease the time that LDL3 particles circulate before the liver grabs them.

    But I don't know if it works out that way, or if the effect is negligible.  Can you say?

  • Hans Keer

    7/9/2010 5:09:58 PM |

    As far as I'm concerned, you cannot say enough bad things about carbohydrates, but unfortunately they are not responsible for the formation of chylomicrons and chylomicron remnants. Chylomicrons consist mainly of dietary fat.

  • Anonymous

    7/9/2010 10:49:58 PM |

    Assuming you can't measure your LDL particle sizes, would a low (<2) Triglicerides  ratio to HDL be a good indicator whether you have predominately Pattern A (awesome) or B (bad)?

  • MADBOB

    7/10/2010 12:18:03 AM |

    Hi Can someone please tell me if
    ALL BRAN cereal being all bran and insoluble fiber is the same as eating wheat products?  

    Thanks

  • Randy

    7/10/2010 8:51:13 AM |

    Hi Doctor Davis,

    I have two questions.

    1. How would you compare rice (unpolished but non brown) to other carbohydrates (non gluten based)?

    2. How far does the fermenting/sourdough making process make wheat or other gluten containing carbs a healthier choice?

    Thanks.

  • Anonymous

    7/10/2010 1:58:31 PM |

    A question for Dr Davis: Do you screen for pregnenolone deficiency?  If so, do you recommend pregnenolone supplements, in addition or in lieu of dhea?

    As a male, age 60+, I read TYP and  got the calcium scoring exam, which fortunately was zero percent.  Also had the carotid artery ultrasound which said no plaque (visual inspection).

    Got me to wondering why I (apparently) have no plaque.

    Well, twenty years ago when I was suffering arthritis joint pain I read Dr. Regelson's book the Super-Hormone Promise. (Still available on Amazon.) He discussed using pregnenlone as an arthritis treatment. So, I got the blood test and I discovered that I had a 100% deficiency of pregnenolone!

    I've been taking 500 mg a day of LEF's pregnenolone ever since. Blood levels back to normal immediately and no joint pain. (Re hormones, I also take 25 mg dhea and about 10 mg of melatonin at night.)

    My speculation is that perhaps supplementing my hormones at an earlier age, when serious deficiencies were starting to develop, helped keep my arteries healthy. On the other hand, it could be something else of course. Just my two cents!

  • Anonymous

    7/10/2010 4:27:18 PM |

    I got a good chuckle from the in-laws reference.  Thanks!

    Char

  • Anna

    7/10/2010 6:52:39 PM |

    Madrob:

    Yes.

    If you are consuming All Bran cereal, you are consuming wheat, though the bran doesn't have the starchiness that refined wheat and whole wheat flour have.  But the bran presents other problematic properties.  

    If you must supplement with a refined fiber product (for regularity, belief that high fiber diets are healthful, etc.), consider instead soluble fiber such as inulin and/or pectin (and whole foods which contain soluble fiber, such as onions, leeks, apples, sunchokes, etc.).  

    See Dr. Art Ayer's (Ph.D. researcher, not an MD) blog Cooling Inflammation  for fascinating discussions on feeding and promoting healthy gut bacteria populations ("inner gardens") with soluble fiber.

  • Anonymous

    7/11/2010 5:36:05 PM |

    happy to see denise mingers study featured here. Smile

    wheat asides, milk pasteurised or uht causes a pretty massive immune system flare up for me.

  • Anonymous

    7/13/2010 4:06:07 PM |

    Dr. Davis, I emailed you on this but figured I'd post this study in response to this.

    Can you comment on the following study ?

    4) Schaefer EJ.  Body weight and low-density lipoprotein cholesterol changes after consumption of a low-fat ad libitum diet. JAMA. 1995 Nov 8;274(18):1450-5.

  • Adult Diaper

    7/15/2010 3:48:53 PM |

    Eversures incontinence underwear that fits your lifestyle. The best selling, patented, washable and reusable bladder control garments.  More products can be view at Adult Diaper

  • Anonymous

    7/22/2010 11:36:58 AM |

    can you decipher this new research for us? older women with low HDL are nore likely to be depressed, as well as more likely to have heart problems. Older men (over 65)with low LDL are more likely to be depressed, especially if their serotonin transport gene doesn't work efficiently.
    http://www.alphagalileo.org/ViewItem.aspx?ItemId=81683&CultureCode=en
    Research from ESPRIT study in Biological Psychiatry Journal (sobp.org/journal)

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