How far wrong can cholesterol be?

Conventional thinking is that high LDL cholesterol causes heart disease. In this line of thinking, reducing cholesterol by cutting fat and taking statin drugs thereby reduces or eliminates risk for heart disease.

Here's an (extreme) example of just how far wrong this simpleminded way of thinking can take you. At age 63, Michael had been told for the last 20 years that he was in great health, including "perfect" cholesterol values of LDL 73 mg/dl, HDL 61 mg/dl, triglycerides 102 mg/dl, total cholesterol 144 mg/dl. "Your [total] cholesterol is way below 200. You're in great shape!" his doctor told him.

Being skeptical because of the heart disease in his family, had a CT heart scan. His coronary calcium score: 4390. Needless to say, this is high . . . extremely high.

Extremely high coronary calcium scores like this carry high likelihood of death and heart attack, as high as 15-20% per year. So Michael was on borrowed time. It was damn lucky he hadn't yet experienced any cardiovascular events.

That's when Michael found our Track Your Plaque program that showed him how to 1) identify the causes of the extensive coronary atherosclerosis signified by his high calcium score, then 2) correct the causes.

The solutions, Michael learned, are relatively simple:

--Omega-3 fatty acid supplementation at a dose sufficient to yield substantial reductions in heart attack.
--"Normalization" of vitamin D blood levels (We aim for a 25-hydroxy vitamin D level of 60-70 ng/ml)
--Iodine supplementation and thyroid normalization
--A diet in which all wheat products are eliminated--whole wheat, white, it makes no difference--followed by carbohydrate restriction.
--Identification and correction of all hidden causes of coronary plaque such as small LDL particles and lipoprotein(a)

Yes, indeed: The information and online tools for health can handily exceed the limited "wisdom" dispensed by John Q. Primary Care doctor.

Comments (32) -

  • Jan

    8/17/2011 6:36:25 PM |

    Time to stop bashing primary care docs, doc. Online sites are full of B.S.
    Show me the evidence that testing with CAC improves outcomes (Sure it predicts risks, not the same as actually preventing disease, especially in those at lower risk of CAD.)

  • Might-o'chondri-AL

    8/17/2011 8:11:19 PM |

    Hi Jan,
    Since you accept plaque showing up as being a cardio-vascular risk factor then if Doc reports he has treated some patients whose measurement of plaque has diminished using his protocol would you also accept the proposition that those patients have reduced one of their cardio-vascular risk factors?
    If Doc has patient records showing diminished plaque and therefore one less risk might that not be considered preventative due to his patient following his protocol ?
    As for those individuals with hypothetically lower risk of CAD (ex: the 63 year old low cholesterol example Doc gave) are they not going to undergo changes as they age ?  
    A primary care physician is valuable and yet older westerners are increasingly engaging specialists for good reasons.  Doc has a self-professed specialty tracking plaque  that he wants to impart; sure, his blogging tone may not always be mellow.

  • Jan

    8/18/2011 2:52:13 AM |

    Dear Might,
    Your comment is akin to those who report the association of statin use with lowered risk of MI. A correlation does not prove causation until valid  scientific research confirms.
    How do we know treating CAC lowers risk of MI until a study proves this? Docs have been wild to accept the association of statin use lowering cholesterol components as the mechanism of effectiveness for prevention of MI, ignoring studies in which dietary measures that did the same were ineffective. Just pointing out the need for caution in going so far as to treat a test without evidence that the intervention is working on the test findings (rather than something else).
    Perhaps there are studies that are underway or perhaps the evidence, er association, is just considered too strong, (Bradford-Hill criteria) to ethically justify a trial. My concern is for individuals who score in the lower range of abnormal. At what cost do we label and treat those?

  • joel oosterlinck M.D.

    8/18/2011 9:21:42 AM |

    just remembret the lyon heart study, by  Renaud & de Lorgeril demonstrating the efficacy  of mediterranean diet in lowering the risk of recurrent MI in French patients. although cholesterol levels were higher with diet than with statins. Dietary measures seem there to demonstrate  efficacy

  • Dr. William Davis

    8/18/2011 12:15:43 PM |

    Not only is it NOT time to stop bashing primary care docs, but it's time to begin accepting that their role is outdated. In fact, an average nurse practitioner or physician's assistant can do an equal, if not better, job than most primary care physicians. How health care is dispensed is going to undergo dramatic transformation, just as the business of travel agents and real estate have been transformed by rapid information exchange.

    In our program, we see virtually NO heart attacks. Not a randomized clinical trial, but watching heart attacks drop from a weekly event to almost never is good enough for me to not accept the status quo and continue to work along a path that, from every indication, works exceptionally well.

  • JC

    8/18/2011 12:49:19 PM |

    If high crab diets are considered unhealthy then why do some cultures like the rural Chinese live long healthy lives on nearly 100% crabs,mostly rice and vegetables?

  • majkinetor

    8/18/2011 2:16:50 PM |

    Isn't the best thing for calcium on wrong places vitamin K2 ?
    In my country doctors even prescribe it for calcification issues.
    Dose is around 100mcg/day for 6-12 mo.

  • Marlene

    8/18/2011 4:06:07 PM |

    Read Gary Taubes' "Good Calories, Bad Calories" to find several instances of other cultures eating the typicial high carb food yet seemingly stay within the healthy range.

  • Jan

    8/18/2011 4:22:12 PM |

    Trust my care (or a family members care) to a NP or PA who does not have the capability of complex medical decision making - no thanks. NP's actually are complimentary to physicians with different skill sets. So glad to know your level of knowledge about them. PA's are nothing but junior medical students with enormous salaries. Working 9 to 5 - oh, yeah!

    I'm certain your referral network of primary care docs would be interested in your belief system.

  • Joe

    8/18/2011 4:49:51 PM |

    Dr. Davis:
    I don't know if you've seen this new video yet, but I think you'll want to.
    http://www.youtube.com/watch?v=3vr-c8GeT34&feature=player_embedded
    If you do watch it, I have a question. This doctor thinks sugar (by itself) plays a huge role in causing plaque to rupture and cause heart attacks, etc. If after watching the video you agree with him, would you please tell me how (biologically) it does this?
    Thanks!

    Joe

  • Might-o'chondri-AL

    8/18/2011 8:51:08 PM |

    Hi Jan,
    True correlation does not necessarily equate to causation. As for statins, it seems that statins act to lessen inflammatory processes; and it is this dynamic, rather than numerically lowering cholesterol, that is a crucial way that statins correlate with reduced risk. Which, to me,  seems to further support Doc's contention here in this posting that  low cholesterol levels doesn't  tell one if they have abnormal plaque (ex: patient above with "exceedingly high" score) .

    I will accept Doc's data, as given ,that very high plaque is a 15-20% risk factor since many other published sources cite even carotid plaque as a risk factor . As far as who to test for what, and when, I am not qualified to make recommendations. I do know that time can remodel some cellular dynamics and the aging cardio-vascular system is vulnerable to alterations.  Doc's got my attention because no one at all in my paternal male ancestral line lived past their late 50's due to heart problems and I am 60; while my 61 year old brother already was hospitalized from transient ischemic attack  .

  • Might-o'chondri-AL

    8/18/2011 9:33:17 PM |

    Mediterranean diet's efficacy for heart health is probably due to the % of poly-amines per calorie consumed and of course isn't in keeping with Doc Davis' detestation of modern wheat (among other protocols). As we age our poly-amine levels decrease and Mediterranean diet supplies lots of poly-amines.

    Poly-amines ( molecules inelegantly named spermine, spermadine and putrescine) are all anti-inflammatory, especially spermine; in our body we synthesize poly-amines from arginine. Mediterranean diet's high poly-amine levels spares the amount of arginine our body uses in synthesizing poly-amines; and thus we can more readily produce the vaso-dilator signalling molecule NO (nitric oxide) from body's arginine. NO is valuable to keep oxygenated blood reaching the heart muscle cells; NO keeps vessels from constricting dangerously.

    Poly-amines lower inflammation and in the context of age associated problems the less low grade inflammation the better.  Inflammation leads to defectively functioning cells and molecular processes; with time the  over stimulation of immunological responses (both innate and adaptive immunity) leaves the body burdened with unknown clones of T cells (both memory and effector types). Eventually the build up of  T cell clones limits new variants and what occurs is more macrophages circulating; once an over abundant macrophage stage reins the body is essentially always in low grade inflammation , and prone to various age associated pathology (including cardio-vascular).

  • Dr. Johns

    8/19/2011 12:25:40 AM |

    @jan....
    A vast majority of primary care doctors are extremely limited in their abilities to treat/advise patients for CVD risks. They don't understand nutrition, effects of supplements upon serum biomarkers, nor effective diagnostic testing for heart disease.
    CAC is a much better biomarker for who is at greater risk of CVD than serum markers:
    http://www.eurekalert.org/pub_releases/2011-08/jhmi-sfc081611.php

    I seriously doubt even 1:100 primary care docs see studies like the aforementioned one.
    And I seriously doubt the one doc would understand it....
    Dr. John

  • Gene K

    8/19/2011 1:48:19 AM |

    An interpretation of the same study for a broader audience just appeared at http://www.webmd.com/heart-disease/news/20110818/is-calcium-test-the-best-way-to-check-for-heart-risk.

  • Thomas White

    8/19/2011 2:09:49 AM |

    I'd accept a bashing of physicians in general.   But to single out primary care physicians - overwhelmed with paperwork and patients with multiple problems, and vastly underpaid and underappreciated, and continually put down by "Partialists" - Really ? Cardiologists are superior? Really ?

    Forget my support and admiration henceforth.

  • Might-o'chondri-AL

    8/19/2011 5:43:43 AM |

    CRP (C-reactive protein), an inflammation marker surrogate, does not directly correlate with whether there is coronary artery calcium (CAC), or the degree of CAC severity. CRP is also subject to variables of race and age, so it loses some potential as a predictive marker. Yet looking at CAC along with CRP is considered useful for complex insight into a patients pathology.

    Analysis of the Multi-Ethnic Study  of Atherosclerosis (MESA) involving 6,800 men & women seems to indicate that inflammatory markers (ex: CRP) relate to the physiology of pathological processes other than CAC laid down; possibly because plaque undergoes morphological changes over time. The CRP level is proposed, by some, to relate more to the stability of plaque from rupturing and the incidence of blood clotting in a thrombosis.

    The inflammatory marker of Interleukin-6 (IL-6) anti-bodies seems to be better than CRP and fibrinogen for correlating an individual's trend toward CAC. Thus the cytokine IL-6 is a better indicator of sub-clinical atherosclerosis; Doc likes to cut to the chase, eyeball the plaque and track it with current technology ( that is not available worldwide).

  • David

    8/19/2011 6:16:33 AM |

    Is it typical for someone with such low ldl and high hdl to have such a high CAC score? Had he previously had a higher LDL and then been placed on a statin?

  • TT

    8/19/2011 12:36:37 PM |

    The energy expenditure of the rural Chinese is very high.  They don't drive, they walk, or ride bicycles.  They don't sit in office from 9am to 5pm, they work hard in the rice field from 5am to 9pm.  They can eat anything without gaining weight.
    For the urban Chinese, it is a different story.  They have the same life sytle as ours, and they are getting heavier every year.  More and more people become diabetic, even young kids.

  • Dr. William Davis

    8/19/2011 1:51:32 PM |

    K2 is indeed a fascinating nutrient. There are extensive discussions about it on the Track Your Plaque website.

  • Dr. William Davis

    8/19/2011 1:53:33 PM |

    Thanks, Joe. I watched the entire thing and was impressed with Dr. Diamond's grasp of the issues.

    I'm going to post this on the main page because I think his overview was extremely effective.

  • Dr. William Davis

    8/19/2011 1:55:24 PM |

    Sorry you see it that way. This was a comment directed at the system of primary care in general.

    I reread the post and I didn't see the name "Dr. Thomas White" mentioned anywhere. If you choose to feel slighted in some way, that's your choice.

  • Kent

    8/19/2011 3:20:32 PM |

    Jan, I would certainly trust my care (or a family members care) to a NP or PA who looks outside just the pharma driven medical journals which primarily support a diagnose & drug philosophy.  And I'll take an NP or PA who actually uses some common sence rather than being a puppet given to the pushy drug rep.

    I live in a family of MD's, and they have made it clear as to their terribly limited training and knowledge they gain from med school on the level of building and supporting the body from within.  Example, I have an Aunt that is currently suffering from stage 4 cancer. Due to the chemo treatment that she's instructed to not spend time in the Sun. Her Dr. has not even checked her for vitamin D levels. This is not the exception, but the norm when it comes to common sence treatment, pathetic.

  • Joe

    8/19/2011 6:56:14 PM |

    Okay, Dr. Davis.  I'll be looking for it. When you do, please take a moment and explain how you think that sugar might be responsible for plaque rupture.
    Thanks again!

    Joe

  • steve

    8/19/2011 7:06:59 PM |

    Sugar is just one part of the equation.  As Dr. Davis has covered on this website, small LDL is also a villian and needs to be minimized as much as possible.

  • Might-o'chondri-AL

    8/19/2011 8:05:24 PM |

    Hi Joe,
    Thanx for the video ... maybe the following answers you.

    Regarding sugar: see 59:33 into presentation, where diagram shows "sugar" blurb  - lecturer is using compact word sugar to represent how glucose's glycation end products alter the artery and make the artery vulnerable. It is not a molecule of sugar acting all by itself; lecturer explains slide when talks of how glycation is a problem (another of  Doc Davis'  peeves).

    Follow up at 1:01 into presentation: see diagram's top left  where the various adverse influences on artery  are specified as "modified lipoprotein", "hemodynamic insult" (includes, but is not limited to blood sugar's  glycation end products affect on artery), "reactive oxygen species" (ROS) and "infectious agents".

  • Thomas White

    8/20/2011 12:22:15 PM |

    Thank you for all your hard work and dedication to your web site and education.

    I apologize for cluttering up the discussion with a personal statement.

    TRW

  • Joe

    8/20/2011 4:13:56 PM |

    Thank you, Might. I guess I'm going to have to do some research on glycation before I can fully understand what you're saying above.

    I didn't even notice the PowerPoint Presentation that was included with Dr. Diamond's video presentation.  Sigh.

    Thanks again!

    Joe

  • Jim

    8/20/2011 7:55:03 PM |

    AMEN! Right on target.

  • Louis

    8/23/2011 2:05:01 PM |

    I don't know if you're aware of the differences between calculated test that most doctors use and NMR that Dr. Davis uses. When your diet consists of mostly carbohydrates leading to chronic high blood sugar level, it tends to raise your SMALL DENSE LDL level but calculated cannot measure it accurately. It often greatly underestimate it.  Dr. Davis has covered it many times. Dig through his website for it.

  • Louis

    8/23/2011 2:16:27 PM |

    Optimal vitamin D level helps lower IL-6. It can be a big problem with black people as they tend to have the lowest vitamin D level of any races. Dr. Cannell mentioned that in his new book called Athlete's Edge Faster Quicker Stronger with vitamin D with the hope that the word about vitamin D would spread out faster if more and more professional athletes started using it to gain some advantage over opponents much like what East Germany and formerly USSR used to do in 1960 and 1970s at the Olympic games and other world events.

  • live-healthcare

    8/27/2011 4:31:48 AM |

    Yes Joe i have seen the video you linked. That's right i also think the same.

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You're at the cutting edge

You're at the cutting edge

If you're a participant in the Track Your Plaque program for atherosclerotic plaque regression, you are at the cutting edge of health.

Few physicians give this issue any thought. Chances are, for instance, that if you were to bring up the subject of reversal of heart disease to your primary care physician, you'd get a dismissive "it's not possible," or " Yeah, it's possible but it's rare."

Ask a cardiologist and you might make a little more progress. He/she might tell you that Lipitor 80 mg per day or Crestor 40 mg per day might achieve a halt in plaque growth or a modest reduction of up to 5-6%. If they've tried this strategy, they would likely also tell you that hardly anybody can tolerate these doses for long due to muscle aches. I'd estimate that 1 of 10 of my colleagues would even be aware of these studies.

Both groups are, however, reasonably adept at diagnosing chest pain, an everyday occurrence in hospitals and offices. Chest pain, for them, is a whole lot more interesting. It holds the promise of acute catastrophe and all its excitement. It also holds the key to lots of hospital revenues. Did you know that 80% of all internal medicine physicians are now employees of hospitals? They're also commonly paid on an incentive basis. More revenues, more money.

Ask Drs. Dean Ornish or Caldwell Esselstyn about reversal of heart disease and they will tell you that a very low-fat diet (<10% of calories)can do it. That's true if you use a flawed test of coronary disease like heart catheterization (angiograms) or nuclear stress tests (Ornish calls them "SPECT"). It would be like judging the health of the plumbing in your house by the volume of water flowing out the spigot. It flows even when the pipes are loaded with rust.

In the Track Your Plaque experience, extreme low-fat diets (i.e., high wheat, corn, and rice diets) grotesquely exagerrate the small LDL particle size pattern, among the most potent triggers for coronary plaque growth. This approach also makes your abdomen get fatter and fatter and inches you closer to diabetes. Triglycerides go up, inflammation increases.

If you were able to measure the rust in the pipes, that would be a superior test. You can measure the "rust" in your "pipes," the atherosclerotic plaque in your coronary arteries, using two methods: CT heart scans or intracoronary ultrasound. Take your pick. I'd choose a heart scan. It's safe, accurate, inexpensive. I've performed many intracoronary ultrasounds for people in the midst of heart attacks or some other reason to go to the catheterization laboratory. But for well people, without symptoms, who are interested in identifying and tracking plaque? That's the place for heart scans.

In our program, 18-30% reductions in heart scan scores are common.

Comments (3) -

  • farseas

    12/6/2011 5:01:54 PM |

    Dr. Eselstyn claims that animal protein damages the endothelium.  Dr. Weil says that a high fat meal lowers artery function.   But I had a heart attack and have a stent and have been following your diet for about a year.  If I start eating significant quantities of carbs, I used to get chest pains.  Since then I have went from 305 to 235 and want to get to 175.  I got the stent three years ago.

    Is there any truth to either Weil's or Esselstyn's claims?

    Now I take no medication except a daily 325mg aspirin and a bunch of supplements, including hawthorne and of course, fish oil.  I control my blood pressure with medical MJ and it works great to lower my blood pressure.

    Do I need to worry about saturated fat and high blood pressure?  I used to be on Plavix, blood pressure medication, and statins.  I tried three different statins and they all caused me leg pains.  In fact I seem to have chronic but intermittent leg pain since the statins.

  • Dr. William Davis

    12/6/2011 5:28:45 PM |

    I don't think so.

    They understand this disease incompletely. I can't blame an ENT surgeon for not fully understanding a disease he has never treated.

  • bob stanton

    12/13/2011 3:39:07 PM |

    Esselstyn says this based on the fact that animal protein has higher levels of methionine.  But this study,  Toxicity of Methionine in Humans, by Peter J. Garlick, refutes this claim:
    ----------------------------------------------------------------------------------------------------------
    Conclusions. Although methionine was labeled as being the most toxic amino acid in relation to growth in animals (1), the evidence in humans does not point to serious toxicity, except at very high levels of intake. Despite the function of methionine as a precursor of homocysteine, and the role of homocysteine in vascular damage and cardiovascular disease, there is no evidence that dietary intake of methionine within reasonable limits will cause cardiovascular damage. A single dose of 100 mg/kg body weight has been shown to be safe, but this dose is about 7 times the daily requirement for sulfur amino acids, and repeated consumption for 1 wk was shown to result in increased homocysteine levels (37,42). Daily doses of 250 mg (i.e., 4 mg/kg per day) are only 25% of the daily requirement and have been shown to be safe. Overall, the literature suggests that the single dose which is typically given in the methionine loading test (100mg/kg/d) does not cause any serious complications, except in the extreme case when a 10-fold excess of methionine appears to have been given, and in patients who have schizophrenia or inborn errors of sulfur amino acid metabolism, such as hypermethioninemia.
    ----------------------------------------------------------------------------------------------------------

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Extreme carbohydrate intolerance

Extreme carbohydrate intolerance

Here's an interesting example of what you might call "extreme carbohydrate intolerance."

May is a 44-year woman who has now had her 7th stent placed in her coronary arteries. She lives on a diet dominated by breads, breakfast cereals, muffins, rice, corn products, along with some real foods.

Her conventional lipid panel and other lab values:

Total cholesterol 346 mg/dl
Triglycerides: 877 mg/dl
HDL cholesterol: 22 mg/dl
LDL cholesterol: incalculable
(Recall that LDL cholesterol is usually a calculated, not a measured value. The excessively high triglycerides make the standard calculation invalid--more invalid than usual.)

Fasting blood glucose: 210 mg/dl
HbA1c (a reflection of previous 60-90 days average glucose): 7.2% (desirable 4.5% or less)
ALT (a "liver enzyme"): 438 (about five-fold normal)


At 5 ft even and 138 lbs (BMI 27.0), May appears small. But the modest excess weight is all concentrated in her abdomen, i.e., in visceral fat.

By lipoprotein analysis via NMR (Liposcience), May's LDL particle number was 2912 nmol/L, or what I would call a "true" LDL of 291 mg/dl. (Drop the last digit.) Of the 2912 nmol/L LDL particles, 2678 nmol/L, or 92%, were small.

The bad news: This pattern of extremely high triglycerides, extremely high LDL particle number, low HDL, predominant small LDL, and diabetes poses high-risk for heart disease--no surprise. It earned her 7 stents so far. (Unfortunately, she has made no effort whatsoever to correct these patterns, despite repeated advice to do so.)

The good news: This collection is wonderfully responsive to diet. LDL particle number, small LDL, triglycerides, blood glucose, and HbA1c drop dramatically, while HDL increases. Heart disease will at least slow, if not stop.

It's amazing how far off human metabolism can go while indulging in carbohydrates, particularly a genetically carbohydrate-intolerance person. (Actually, I wouldn't be surprised if May's diet, as bad as it seems to you and me, still fits within the dictates of the USDA food pyramid.) The crucial step in diet to correct this smorgasbord of disaster is elimination of carbohydrates, especially that from wheat, cornstarch, and sugars.

Comments (26) -

  • john

    8/24/2010 9:57:22 PM |

    Wow, these numbers are wild.  It'd be great to see where they are in six months, assuming a change in diet.

  • Tuck

    8/24/2010 10:03:12 PM |

    Did you see the WSJ article today?

    "Giving Up Gluten to Lose Weight? Not So Fast"

    The last sentence is priceless:

    “Also, for dieters, going back to gluten after avoiding it can lead to stomach cramps, bloating, diarrhea and other symptoms, at least temporarily.”

    If an egg had that effect on you, they'd do a recall.

    http://online.wsj.com/article/SB10001424052748703846604575447413874799110.html

  • qualia

    8/24/2010 10:59:36 PM |

    great post! would be cool if you could pipe the links to your posts into your twitter account as well (there are online services), so that it can easier be forwarded by followers of you.

  • Anonymous

    8/24/2010 11:06:26 PM |

    The WSJ should give up the diet reporting and stick to what they (supposedly) know - financial news.  

    There's giving up gluten and then there's giving up gluten but maintaining a high starch alternative grain  GF diet.   Of course replacing one starch with another won't result in weight loss if one is overweight.  It's even possible to gain weight on such a GF diet.    

    Are people really silly enough to take diet advice from "creaky bones" Gwenyth Paltrow?

  • dan

    8/25/2010 1:01:04 AM |

    I watched the WSJ video.  It wasn't bad.  It was mainly ridiculing "gluten-free" imitation products.  The lady recommended eating natural foods that are gluten free.

  • Tommy

    8/25/2010 1:50:03 AM |

    I am completely baffled by some of the lipid panel numbers I see. She had 7 stents put in but there are many out there seemingly with no problems, with high numbers like that. Meanwhile I have eaten right and exercised seriously for the last 30 years, have never been overweight, always been in shape, had good lipid panel results but suffered a heart attack last year anyway. I just had bloodwork shortly before the attack and once again (as had been the case for years) I was told I was in perfect health. My triglycerides were good as was my CRP and my complete lipid panel. Actually any test I took ever, always produced good results. Even after my heart attack they couldn't get my heart rate up high enough in my stress test unless I ran longer and at the steepest incline. I'm still in great shape.....but I had a heart attack.  I never had a belly or bulge and still don't. 5'10" 169 lbs.  Go  figure.

  • 42

    8/25/2010 4:28:11 AM |

    My results after eight months: http://paleohacks.com/questions/9124/first-post-paleo-blood-work-results

    After 8 months and -50lbs  I can safely say that the std American flour/sugar diet is complete bullshit.

  • Lori Miller

    8/25/2010 4:36:29 AM |

    I bet that poor woman has forgotten what it's like to feel good. She'll surely feel better with an improved diet. I wish her the best.

    Re: WSJ article, I got a stomach ache that lasted two days the last time I ate a chocolate chip cookie made of wheat flour. That's some kind of "temporarily"!

  • Anonymous

    8/25/2010 5:58:01 AM |

    Lipids after two years of high-fat, moderate-protein, very low-carb eating:
    Total Cholesterol: 220, Triglycerides: 69,
    HDL: 98,
    LDL: 108.
    I think I'll carry on that way.

  • Anonymous

    8/25/2010 6:19:42 AM |

    After 7 stents and she still refuses to change her eating habits? I think that got my attention more than anything else in your report of this patient. I guess I am baffled on why people do not take charge of their health especially when expert advice is offered on a "silver platter".

  • Derek

    8/25/2010 2:11:31 PM |

    Tommy,

    Sorry to hear that.  I guess it goes to show nothing is a guarantee.  No matter what we do, the chance is always there.

  • Jonathan

    8/25/2010 3:39:40 PM |

    Tommy, your case only goes to prove that cholesterol doesn't cause heart attacks.  
    There is something else causing CVD.
    Inflammation from Poly fat and grains seem the most plausible to me.

  • Tommy

    8/25/2010 4:04:49 PM |

    "Tommy, your case only goes to prove that cholesterol doesn't cause heart attacks.
    There is something else causing CVD.
    Inflammation from Poly fat and grains seem the most plausible to me."


    I had my CRP checked and it was below 4 just before my HA. After taking care of myself for the last 30 years and always doing well in every aspect I really felt backed against the wall afterward. My numbers are very low now (pretty close to 60's across the board) but all of this is more complexed than just numbers.

  • Dr. William Davis

    8/25/2010 5:05:28 PM |

    Hi, Tuck--

    That's great!

    It reminds me of the USDA's request for public commentary on the food pyramid revision, prefaced by "We don't understand why, after we tell people to increase consumption of whole grains, they keep on gaining weight and becoming diabetic."

  • Dr. William Davis

    8/25/2010 5:07:20 PM |

    42--

    Well said!

  • Jonathan

    8/25/2010 5:20:01 PM |

    "eating right" and "taking care of myself" only tells me you were healthy by your standards or by the governments standards.  Most of the people I hear say "I eat healthy" means they eat lower fat but mostly trans fat when they do.

    There has to be something causing your problem.  I would suspect what ever makes you extra hungry would be a possible cause.  Maybe it's too low cholesterol.  Agreed; very complicated.  Maybe it's just genetics.  Maybe there's something in the past 30 years that was not right but what?  A lot of maybes there.  Have you had a calcium score?

  • David

    8/25/2010 7:46:48 PM |

    Tommy-

    Do you have Lipoprotein(a)? You sound to me like a textbook Lp(a) case. Better get it checked and address it.

  • Tommy

    8/25/2010 8:41:00 PM |

    Trans fat? nooooooooo...lol.
    No refined crap, no processed anything. Damn...I don't even eat ketchup(sugar)!! I consider AMA snobish about food intake. I had a conversation with a "heart healthy" dietitian from the hospital after my heart attack and she wanted me to have less than 50 g of fat per day (impossible). I told her I go by percentages of total calories consumed and explained it to her. She had no clue and didn't understand it in simplest terms. "Ok what if I wanted to consume more fat and just added non fat calories to my total intake....that would lower my percentage right? Uhhh....what? lol

    @ David
    I am thinking I may be LP(a) and I have been taking extra Vitamin D as well as a high dose of fish oil. Next cardiologist visit I will discuss Niacin as well as pattern B possibilities.

  • David

    8/26/2010 7:41:39 AM |

    Tommy, what about stress and sleep?  Stress is a killer...

  • Tommy

    8/26/2010 12:42:21 PM |

    David, that is my suspicion. It's complicated because a lot of things happened at once at that time. Through July and August I was under stress from problems at work combined with personal family issues. In September i went on a cruise an ate up a storm as well as drank more than normal gaining 14 lbs. (my prior good blood labs gave me confidence ..ha ha ha.) Then I came home, worked out hard and lost all the weight in a week. Then my grand daughter got sick and I was very stressed out about it while my work issues were still mounting. In October I had an argument in the morning before leaving work (I had been switched to an overnight shift)and was stewing when I went to sleep. I woke up a few hours later having a heart attack. The rest is history.

  • Ned Kock

    8/26/2010 2:50:39 PM |

    Hi Dr. Davis.

    These numbers are awful, but I think a point must be stressed regarding natural vs. industrial carbohydrate-rich foods. These numbers are not typical for normoglycemic folks who eat natural carbohydrate-rich foods.

    Avoiding natural carbohydrate-rich foods in the absence of compromised glucose metabolism is unnecessary. Those foods do not “tire” the pancreas significantly more than protein-rich foods do.

    Protein elicits an insulin response that is comparable to that of natural carbohydrate-rich foods, on a gram-adjusted basis (but significantly lower than that of refined carbohydrate-rich foods, like doughnuts and bagels).

    http://healthcorrelator.blogspot.com/2010/04/insulin-responses-to-foods-rich-in.html

    And nobody can live without protein. It is an essential nutrient. Usually protein does not lead to a measurable glucose response because glucagon is secreted together with insulin in response to ingestion of protein, preventing hypoglycemia.

  • Anonymous

    8/26/2010 10:33:29 PM |

    I definitely get the whole low-carb thing, but I think you always use the extreme cases to make your point.  Even dietitians would not recommend that much starch.  In fact, many of the "top" dietitians limit starch quite drastically in their meal plans.  They are not as ignorant as you think.  However, because they have clinical experience (which I know you have too), they know that draconian, restrictive diets do not work.  Therefore, they work starches in the diet a bit, so people don't feel "deprived."  Still they choose "better" starch options like beans (OMG LECTINS!!!).

    I do not believe for one second that the majority of people claiming to be eating according to the USDA guidelines are doing so within the correct caloric guidelines.  They are eating far too much and making terrible choices for starches to boot.  Portion control is tough obviously.  I think people who cannot master it may find low-carb useful because they eliminate starches/sugars outright and don't have to worry about serving sizes.  Plus, ketosis gives them a metabolic advantage allowing them to consume more calories and still lose weight.  It definitely is not an end all solution though.

  • Anonymous

    8/26/2010 10:37:29 PM |

    Also, they don't bad mouth carbs in the press because people being people would start avoiding things like vegetables.

    There is nothing inherently wrong with carbs.  We just have to eat them within reason.  Just like calcium for example.  Too much calcium is linked to heart attacks and prostate cancer.  But in moderate amounts, it is helpful.

  • stop smoking help

    8/27/2010 3:47:04 AM |

    Okay, I went my two weeks without wheat carbs. My results are purely non-scientific, but here goes. I lost 4 pounds, down to 156. I wasn't hungry at all. I didn't have any bread cravings like I thought I would. But I did have a hard time sleeping, for whatever reason.

    After my two weeks I had angel hair pasta and a hamburger on a wheat roll. My stomach was slightly upset for a couple of days once I started eating wheat carbs again - probably just a coincidence though.

    So I proved I could do it and I proved to myself that I wouldn't starve or go crazy without my bread. So, I think I'll be more careful about the wheat I put into my system. On the other hand, it looks like May needs to correct things and do it sooner than later.

  • scall0way

    8/29/2010 7:19:55 PM |

    Just goes to show ya. I'd *love* to weigh what Mary weighs - but it seems there is more involved that that. I just had an NMR test recently myself. Total LDL particle count was 2018. My doctor is freaked and says it's a horrible number. Every website I consult says it's a horrible number -though my small LDL is 212, only 10.6% of the total. But all the websites I consult say the total number is far more a risk factor than paticle size.

    But what were the HDL and triglycerides of the people with high particle counts. High like Mary's? My own HDL (measured just last week) is 66 and my triglycerides 49.

    But how do you get the particle number down? I've already been low-carb for four years, gluten-free for 18 months, avoid all sugars, take D3, magenesium, K2, 1500 mg niacin.

    Might it go down if I can get my thyroid normalized? That's one issue I'm still trying to work through with my doctor. Sheesh, the older I get the harder it gets. So many things to consider I sometimes wonder how anyone manages to stay alive for a few weeks - let alone many years for most of us.

  • Tommy

    8/30/2010 1:54:37 PM |

    So for people with existing coronary artery issues and Small particle LDL is it true that increasing fat (especially saturated fat) only makes this worse? If you go low carb you need to also be low fat?
    I read that "low fat" is bad for Pattern A but beneficial to pattern B.

    Dr. Davis?

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What's better than fish oil?

What's better than fish oil?

One of the recent questions on our Track Your Plaque Forum related to what to do about a triglyceride level of 101 mg/dl while on fish oil.

Recall that, contary to conventional thinking like that articulated in the ATP-III cholesterol treatment guidelines, we aim to reduce triglycerides to 60 mg/dl or less. This is important to suppress the formation of abnormal triglyceride-containing lipoprotein particles, especially small LDL, reduced HDL, lack of healthy large HDL, VLDL. ATP-III advises a level of 150 mg/dl or less. Unfortunately, triglyceride levels this high guarantee appearance of all these undesirable particles and an increasing heart scan score.

What's better than 4000 mg of fish oil for its 1200 mg of EPA and DHA (omega-3 fatty acids)? More fish oil. In other words, the 4000 mg fish oil providing 1200 mg EPA + DHA is our minimum. A simple increase to 6000 mg to provide 1800 mg EPA + DHA is usually all that is necessary to reduce triglycerides and put a halt to the cascade of abnormal lipoprotein particles that trigger plaque growth. Occasionally, a somewhat higher dose may be required. Doses are best divided into two, with meals (e.g., three capsules twice a day).

Another important issue: An over-reliance on wheat products can also increase triglycerides. This includes any flour product like breads (regardless of whether it's white, whole wheat, or whole grain--they all raise triglycerides), pretzels, bagels, breakfast cereals, and pasta. A dramatic reduction in wheat-containing products will reduce triglycerides substantially, help you reduce your abdominal fat, reduce blood pressure, raise HDL and reduce small LDL, clear your mind, provide more energy, avoid afternoon "fogginess" . . . Huge benefits.

Comments (1) -

  • Anonymous

    5/22/2007 12:00:00 AM |

    I am taking a yield of 1,000 mg of EPA from fish oil and my numbers still look bleak, so thanks for the encouragement to bump things up. I am also completely off sugar and wheat (not easy) for a year and still have these numbers.

    Total cholesterol - 272
    LDL-177
    HDL -34
    triglycerides- 300
    VLDL- 60

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Life without Lipitor

Life without Lipitor

One of the most common reasons people come to my office is to correct high cholesterol values without Lipitor. (Substitute "Lipitor" with Crestor, simvastatin, Vytorin, or any of the other cholesterol drugs; it's much the same.)

In the world of conventional healthcare, in which you are instructed to follow a diet that increases risk for heart disease and not advised to correct nutrient deficiencies like vitamin D and omega-3 fatty acids, then a drug like Lipitor may indeed provide benefit.

But when you are provided genuinely effective information on diet, along with correction of nutrient deficiencies, then the "need" and apparent benefits of Lipitor largely dissolve. While there are occasional genetic anomalies that can improve with use of Lipitor and other statins, many, perhaps most, people taking these drugs really would not have to if they were just provided the right information.

Anyone following the discussions on these pages knows that wheat elimination is probably one of the most powerful overall health strategies available. Wheat elimination reduces real measured LDL quite dramatically. Provided you limit other carbohydrates, such as those from fruits, as well, LDL can drop like a stone. That's not what your doctor tells you. This approach works because elimination of wheat and limiting other carbohydrates reduces small LDL. Small LDL particles are triggered by carbohydrates, especially wheat; reducing carbohydrates reduces small LDL. Conventional LDL of the sort obtained in your doctor's office will not show this, since it is a calculated value that appears to increase with reduced carbohydrates, a misleading result.

Throw vitamin D normalization and iodine + thyroid normalization into the mix (both are exceptionally common), and you have two additional potent means to reduce (measured) LDL. Not restricting fat but increasing healthy fat intake, such as the fats in lots of raw nuts, olive oil, and flaxseed oil reduce LDL.

While I still prescribe statins now and then, a growing number of people are succeeding without them.

(Note that by "measured" LDL I am referring to the "gold standard," LDL particle number by NMR provided by Liposcience. A second best is measured Apoprotein B available through most conventional labs.)

Comments (17) -

  • Anonymous

    6/25/2010 5:19:20 PM |

    Hi Dr. Davis,

    I follow much of your advice.  On my NMR, I had an LDL of 50 and particle number of "less than 300".  Also, HDL was 82.  My LDL particle size was 21.1.  Large VLDL was 2.6 nmol/L (and the share of large VLDL was above the reference range), but I did the test postprandially.  My small LDL was "less than 90".  Interestingly, last year, my LDL particle number was 530 and small LDL was 120, but LDL size was larger at 22.3.  Is there anything to make of this?

  • Anonymous

    6/25/2010 7:02:42 PM |

    I'd like to see a discussion of what you'd do for a patient who didn't eat wheat, was on a LC diet, ate a lot of fish, had high vitamin D levels, had normal thyroid tests and still had high LDL levels.

  • Dan

    6/25/2010 7:31:34 PM |

    My father takes Lipitor.  He's also suffering from occasional short term memory loss (he's visiting a neurologist often to figure out why).  I'm damn sure it's because of the statins.  I've been on the "no wheat" & high good fat diet for a while and am in great shape.  I Can't get my father to ditch the drug and adopt my diet though (even if he does, I'm not sure if the memory issue will resolve itself).  Going against conventional wisdom is a constant uphill battle.

  • JamesSteeleII

    6/25/2010 9:07:32 PM |

    "...then the "need" and apparent benefits of Lipitor largely dissolve."

    I was unaware that there was any research supporting statin use at all except maybe in one group (men under 65 with pre-existing conditions) which is still questionable. Could you further explain what this 'need' might actually be in abscence of such dietary intervention?

  • mongander

    6/26/2010 1:58:26 AM |

    8 months ago my 91 year old mother was out of her mind in the hospital.  She had no idea where she was and was too weak to walk to the bathroom.  She was falling frequently.

    Now that she's off lipitor she has a new lease on life.  She works in her flower garden and bathes herself.  

    I'm now her caregiver and ensure that she takes 5 to 10 thousand iu of D3, Iodoral, 200 mg Ubiquinol, and a couple of grams of fishoil, but the biggest move, in my opinion, was taking her off Lipitor.

    We have no family history of heart disease.

  • Anonymous

    6/26/2010 10:38:27 AM |

    This advice works!

  • David M Gordon

    6/26/2010 2:08:23 PM |

    I know you intended "Life without Lipitor" to be for all your readers, Dr. Davis, but you might as well have written it for me (because of my earlier importunate and selfish request). Thank you.

    Some things I still do not get, noted as they appear in your post:
    1) Eliminate fruit?! Fruit, rich with nutrients, now is bad because fruit also comes packed with sugar (its complex carbs)? I respect the notion to eliminate carbs, especially wheat and other grains, but this notion seems rather... narrow. HELP!
    2) "Conventional LDL of the sort obtained in your doctor's office": What test is this? Do you mean the phlebotomist (in the doctor's office) who sends the blood sample to Quest or LabCorp to obtain the calculated score?

    Thank you for these, and all future clarifications. And for this site, of course.

    Best wishes,

  • Anonymous

    6/26/2010 3:14:47 PM |

    while you seem to recommend nuts be a part of the diet, what do you tell your patients who are allergic to nuts?  Peanuts ok?

  • D.M.

    6/26/2010 5:05:55 PM |

    Agree with much of the article but not sure about this:

    "increasing healthy fat intake, such as the fats in lots of raw nuts, olive oil, and flaxseed oil reduce LDL."

    All of these will contain unnaturally* large amounts of omega 6 (at least 9g/100g of almonds or olive oil, for example, or 12g/100 for flax oil). This will unquestionably drive up oxidised (atherogenic) LDL cholesterol. (See WholeHealthSource for details). Is there any reason at all to think that natural saturated fat isn't a far safer option (that will drive up HDL)? I can understand why one would worry at saturated fat increasing "cholesterol" back in the day before we could analyse lipid fractions, but what reason do we have to think it would have negative effects now?

  • Hans Keer

    6/26/2010 5:16:20 PM |

    Very good doc. I hope you come to the point that you will no longer subscribe statins at all.

  • Anonymous

    6/27/2010 3:39:41 AM |

    DM Wrote:

    All of these will contain unnaturally* large amounts of omega 6 (at least 9g/100g of almonds or olive oil, for example, or 12g/100 for flax oil). This will unquestionably drive up oxidised (atherogenic) LDL cholesterol. (See WholeHealthSource for details). Is there any reason at all to think that natural saturated fat isn't a far safer option (that will drive up HDL)? I can understand why one would worry at saturated fat increasing "cholesterol" back in the day before we could analyse lipid fractions, but what reason do we have to think it would have negative effects now?

    ----------------

    Hi DM, I was the first anonymous up top.  I follow Dr. Davis' advice and eat lots of omega-6 rich nuts and, as you can see from the numbers above, my LDL and HDL look pretty good.  Also, my crp was .18 mg/L which is quite low and lp(a) was 2, so I doubt I have much inflammation/oxidation etc.

  • Jeff@muscle mass building

    6/28/2010 4:02:55 PM |

    What are lipitors? Is there any substitute for lipitors?

  • Jeff@muscle mass building

    6/28/2010 4:02:55 PM |

    What are lipitors? Is there any substitute for lipitors?

  • Anonymous

    6/28/2010 7:08:43 PM |

    I've been taking off the shelf Red Yeast Rice instead of lipitor. Works great! My LDL cholesterol went down down down.

    -- Boris

  • D.M.

    6/29/2010 6:01:04 PM |

    @ Anonymous-with-pretty-good-cholesterol.

    That's good for you, but the studies show that across large groups, omega-6 will raise the amount of oxidised LDL, which is probably a *bad* thing for cardiovascular health. Stephan discusses this here: http://wholehealthsource.blogspot.com/2009/07/diet-heart-hypothesis-oxidized-ldl-part.html and here http://wholehealthsource.blogspot.com/2009/07/animal-models-of-atherosclerosis-ldl.html

  • Bill Meli

    7/1/2010 6:27:07 PM |

    Does anyone have a sample diet that they follow that is recommended from this website. I have recently eliminated all sugars from my diet and eat 7 small meals a day, but would like some help on seeing a recommended diet that is wheat free, also interested in what supplements people are taking. Thank you!

  • shaheel

    9/27/2010 12:39:49 PM |

    Heart  disease is one of the most  dangerous disease which takes thousands of life every years all over the world. If we know its symptoms and Treatment for heart disease. We can prevent is to large extent.

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Is einkorn the answer?

Is einkorn the answer?

People ask: "What if I would like a piece of bread or other baked product just once in a while? What is safe?"

Eli Rogosa, Director of The Heritage Wheat Conservancy, believes that a return to the wheat of our ancestors in the Fertile Crescent, circa 10,000 years ago, is the answer.

Former science teacher, now organic farmer, farm researcher, and advocate of sustainable agriculture, Eli has been reviving "heritage" crops farmed under organic conditions, some of her research USDA-funded.

In particular, Eli has been cultivating original 14-chromosome ("diploid") einkorn wheat. Although einkorn contains gluten (in lesser quantities despite the higher total protein content), the group of proteins that trigger the immune abnormalities of celiac disease and other immune phenomena, Eli tells me that she has witnessed many people with a variety of wheat intolerances, including celiac disease, tolerate foods made with einkorn wheat. (The variety of glutens in einkorn differ from the glutens of the dwarf mutant that now dominate supermarket shelves.)

Eli travels to Israel every year, returning with "heritage" seeds for wheat and other crops. She formerly worked in the Israel GenBank as Director of the Ancient Wheat Program. She has written a brochure that describes her einkorn wheat.

Eli sent me 2 lb of her einkorn grain that nutritionist, Margaret Pfeiffer, and I ground into bread. Our experience is detailed here. My subsequent blood sugar misadventure, comparing einkorn bread to conventional organic whole wheat bread is detailed here, followed by the odd neurologic effects I experienced here.

Anyone else wishing to try this little ancient wheat experiment with einkorn can also obtain either the unground grain or ground flour through Eli's website, www.growseed.org. Most recently, einkorn pasta is being retailed under the Jovial brand at Whole Foods Market.

If anyone else makes bread or any other food with Eli's einkorn wheat, please let me know:

1) Your blood sugar response (before and 1 hour after consumption)
2) Whether you experienced any evidence of wheat intolerance similar to what you experienced with conventional wheat, e.g., rash, acid reflux, gas and cramping, moodiness, asthma, etc.

But remember: Wheat effects or no, einkorn is still a grain. My belief is that humans do best with little or no grain. The einkorn experience is an effort to identify reasonable compromises so that you and I can have a piece of birthday cake once a year without getting sick.

Comments (14) -

  • JohnR

    1/11/2011 5:39:46 PM |

    Speaking as someone with celiac, I wouldn't go NEAR einkorn and I don't understand why it continues to hold your interest. On the rare occasion that I really need a grain product of some kind, rice and corn are entirely adequate.

  • Anonymous

    1/11/2011 9:07:47 PM |

    Have you heard of that study?  http://informahealthcare.com/doi/abs/10.1080/00365520600699983

  • Travis Culp

    1/11/2011 10:37:38 PM |

    The problem is that even if you mitigated the inflammatory effects of the gluten, you're still eating a (relatively) high glycemic, pre-masticated food. The pulverization and reconstitution of food, especially grain, is going to make the blood glucose response far greater. That then could be addressed, I suppose, with physical activity timed to coincide with the spike. At that point, however, it seems like you're going through great pains to eat something of no great nutritional value just for nostalgia's sake.

    However, if we're talking about getting one's intractable relatives to save their lives through small steps, then this could be a legitimate option.

  • Anonymous

    1/11/2011 10:44:05 PM |

    I have never been tested for celiac but can tell you within an hour if a food had gluten in it. Headache and abdominal pains as digestion starts followed by days near the bathroom. I have had the jovail pasta twice since your post about it. It was very nerve wracking to eat but ended up being very pleasant. The second time I checked my blood sugar before and every 15 min after eating.  89, 96, 109, 116,132, 116, 98, 92

    I'm happy I read about it on your blog. On a side note now if I'm exposed to gluten by accident I take a product called gultenease and it seems to shorten the severity and duration.

  • Martin Levac

    1/12/2011 5:27:44 AM |

    Or declare grains not suitable for human consumption. After all, without fortification, it's not suitable for human consumption.

  • TWF

    1/12/2011 6:28:14 AM |

    I go through periods of eating wheat and not eating it. My habits are very hard to break and I find bread products "comforting".

    I have to say that when I eat a lot of breads, chips, etc., I find myself with a lot of belching, listlessness and bloating. I don't think I'm completely intolerant, just a little.

    Oddly though, I can't eat oats. If I do, I get major cramping and all the fun that comes with that type of GI situation. My parents used to tell me I had a "nervous stomach". It turned out I ate too many Cheerios and granola cereal.

    Can anyone tell me what's so bad about oats? Do they have similar affects as wheat?

  • Kevin

    1/12/2011 6:03:00 PM |

    I get no symptoms subsequent to eating bread or other wheat products.  But I do develop canker sores soon after a high-wheat meal.  That alone is enough motivation to avoid bread, pasta, etc.

    kevin

  • shutchings

    1/13/2011 8:14:59 PM |

    I’m wondering if you’ve ever tried the Zone bread products and then measured your blood sugar with a glucose monitor. They claim that their products won’t raise your blood sugar more than a strawberry would. I couldn’t figure out if they used anything like Einkorn, but they say there’s a lot more protein in their products than normal bread products.

  • Tiffany Jewelry

    1/14/2011 9:52:49 AM |

    I am the first time on this site and am really enthusiastic about and so many good articles. I think it’s just very good.
    Always yours

  • Einkorn Wheat

    1/14/2011 2:49:35 PM |

    Your interest in einkorn as a via ingredient for an birthday cake is interesting.  I'm thinking that whatever is used to sweeten the birthday cake will have a bigger effect on glycemic response than the wheat.  No?

    At any rate, the value of einkorn comes not only in the form of a lower glycemic impact(compared with normal wheat) but also it's nutritional qualities.

  • Larry

    2/3/2011 12:39:23 AM |

    I was able to buy Jovial Einkorn Fusilli at WF.
    My FBG this morning was 82.
    I tested myself right before I ate dinner at 6PM..
    My BG - non fasting - was 90.
    The wife made pasta, with sweet sausage(2) and broccoli rabe.
    I had three ounces of the pasta.
    I also had a small piece - 2"x2" of home made corn bread afterwards.
    My 1 hr BG was 142.
    That's the highest BG reading I've ever had.
    Back to no pasta and primal eating tomorrow.
    For me that's a scary number.
    Even if it's an abberation.

  • mary wier

    10/29/2011 9:09:16 AM |

    Dear Dr. Davis, I just bought your book and my spouse and I are trying gluten free to help with type 2 diabetes and BP-----we already had slashed carbs and sugar, and spouse has normal glucose if he stays on this strict lo carb diet, but we want to lose weight, lower my BP and reverse diabetes. IT is 6 weeks now and we are getting out of the detox.  We are noticing we are leaning toward low sugar foods to fell that 400  calorie gap, but we are wanting to try this way as long as we can, your book is great.  I also saw a new tv show on that frozen mummy from the alps, they did a second thing of exams on it and found einkorn wheat product in his stomach AND also calcification of the arteries, he is said to have been in his forties, this was 5 thousand years ago!  Looks like einkorn was affecting humankind even then???Thanks for your book.
    Bill and Mary Wier in Chattanooga TN,

  • Dr. William Davis

    10/29/2011 10:47:06 PM |

    Hi, Bill and Mary--

    Yes, I fear that, while einkorn is better, it may not be great. We don't want to repeat the flawed logic of the wheat lobby: replace something bad with something less bad, and the less bad thing must be good.

  • Kristi

    2/17/2013 2:33:20 PM |

    We don't have wheat every day, in fact, most days we do not.  Having the Jovial Einkorn makes things bearable for those days when we do have wheat.  We have their pasta about once per month.  I use the flour for baking cookies or other treats where I can't use almond meal or coconut flour.  It's a nice trade-off.  I'm never going to be as die-hard as some of you who never eat anything that isn't raw, or isn't whole, but it certainly makes making the changes better.  We really should try to be more loving about other's food choices, even if you don't find them to be the best for you.

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Are there any alternatives to niacin?

Are there any alternatives to niacin?

In the Track Your Plaque program, we tend to rely a great deal on niacin. When used properly, 90-95% of people will do just fine and achieve their lipid and lipoprotein goals with the help of niacin, along with their other efforts.

Unfortunately, around 5% of people simply can't take niacin without intolerable "hot flush" effects, or occasionally excessive skin sensitivity--itching, burning, etc.

Why does this happen? These 5% tend to be "rapid metabolizers" of niacin, i.e. they convert niacin (nicotinic acid, or vitamin B3) into a metabolite called nicotinuric acid. Nicotinuric acid is the compound responsible for the skin flush. Most people can slow or reduce the effects of nicotinuric acid by:

--Taking niacin with dinner, so that food slow tablet dissolution.

--Taking with plenty of water. Two 8-12 oz glasses usually eliminates the flush entirely in most people.

--Taking with an uncoated 325 mg tablet of aspirin in the first few weeks or months. Eventually, you will need to revert back to a better stomach tolerated dose of 81 mg, preferably enteric coated. But a full 325 mg uncoated can really help in the beginning, or when you have any niacin dose increases, e.g., 500 mg to 1000 mg.

But even with these very effective strategies, some people still struggle. That's when the question arises: Are there any alternatives to niacin?

Well, it depends on why niacin is being used. If you and your doctor are using niacin for:

Raising HDL--Then weight loss to your ideal weight; reduction of processed carbohydrates, especially wheat products; avoidance of hydrogenated ("trans") fats; a glass or two of red wine per day; dark chocolates (make sure first ingredient is chocolate or cocoa, not sugar), 40 gm per day; fish oil; exercise; other prescription agents (fibrates like Tricor; TZD agents for diabetes; cilostazol (Pletal)). Niacin is by far the most effective agent of all, but, if you're intolerant, raising HDL is still possible through a multi-faceted effort.

Reduction of small LDL--The list of effective strategies is the same as for raising HDL, but add raw almonds (1/4-1/2 cup per day), oat bran and other beta-glucan rich foods like oatmeal. Reduction of processed carbohydrates is especially important to reduce small LDL.

Reduction of Lipoprotein(a)--This is a tricky one. For men, testosterone and DHEA are effective alternatives; for women, estrogen and perhaps DHEA. Hormonal preparations of testosterone and estrogen are stricly prescription; DHEA is OTC. I have not seen the outsized benefits on lipoprotein(a) claimed by Rath et al by using high-dose vitamin C, lysine, and profile, unfortunately. We are clearly in need of better alternatives to treat this difficult and high-risk disorder.

Reduction of triglycerides/VLDL/IDL--I lump these three together since they all respond together. If you're niacin intolerant, maximixing your fish oil can be crucial for reduction of these patterns using doses above the usual starting 4000 mg per day (providing 1200 mg EPA+DHA). Reduction of processed carbohydrates, eimination of processed foods that contain high-fructose corn syrup, and weight loss to ideal weight are also very effective. "Soft" strategies with modest effects include green tea (>6 cups per day) or theaflavin 600-900 mg/day; raw nuts like almonds, walnuts, and pecans; exercise; soy protein.

Reduction of LDL--Lots of alternatives here including oat bran (3 tbsp per day), ground flaxseed (3 tbsp per day), soy protein (25 grams per day), Benecol butter substitute (for stanol esters), soluble fibers like pectin, psyllium, glucomannan; raw nuts like almonds, walnuts, and pecans.

In future, should torcetrapib become available (by prescription), this will add to our available tools for these areas when niacin can't be used. Until now, the alternatives to niacin depend on what you and your doctor are trying to achieve. In the vast majority of cases, HDL, small LDL, triglyceride, etc. goals for heart scan score control can be achieved, even when niacin is not well tolerated.
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