One bite or many mouthfuls

A reader brought this beautiful series of food photos to my attention:

http://www.wisegeek.com/what-does-200-calories-look-like.htm

It's simply a graphic display of what 200 calories of various foods look like. You'll note that vegetables and fruits permit large servings to yield 200 calories. Processed foods, on the other hand, require very little to tally up the same calorie load. In particularly, look how little in the way of wheat products are required to match that amount.

Heart scan curiosities #4

Here's an interesting example of a 63-year old man with a heart scan score of 112. However, his aortic valve was also severely calcified (loaded with calcium). In other words, the normally flexible and mobile "leaflets" of the aortic valve were coated with calcium and other tissues that interfere with its free motion. The aortic valve is the starburst white in the center of the heart.








This is what the aortic valve should look like on a CT heart scan--you shouldn't see it at all.

The first man with the calcified valve will unfortunately require a new prosthetic aortic valve sometime in his future. This is usually determined with the help of an ultrasound, or echocardiogram, a better test for assessment of the aortic valve (though useless for detection of coronary plaque).

It's my suspicion that chronic and longstanding deficiency of vitamin D is among the factors that contribute to the abnormal deposition of calcium on the aortic valve. We desperately need more data on this. Nonetheless, perhaps this adds yet another reason to 1)get a CT heart scan, and 2) bring your vitamin D blood level to normal. (We aim for 50 ng/ml year round.)

Fish oil and the perverse logic of hospitals

Hospitals are now starting to carry prescription fish oil, known as Omacor, on their formularies. It's used by some thoracic surgeons after bypass surgery, since fish oil has been shown to reduce the likelihood of atrial fibrillation (a common rhythm after heart surgery).

Why now? The data confirming the benefits of fish oil on atrial fibrillation has been available for several years.

It's now available in hospitals because it's FDA-approved. In other words, when fish oil was just a supplement, it was not available in most hospitals. Whenever I've tried to get fish oil for my patients while in hospital, you'd think I was trying to smuggle Osama Bin Laden into the place. The resistance was incredible.

Now that FDA-approved Omacor is available, costing $130 dollars per month for two capsules, $195 for the three capsule per day dose for after surgery, all of a sudden it becomes available. Why would this irrational state of affairs occur in hospitals?

Several reasons, most of which revolve around the great suspicion my colleagues have towards nutritional supplements. In addition, there's the litigation risk: If something has been approved by the FDA, their stamp of endorsement provides some layer of legal protection.

However, I regard those as pretty weak reasons. I am, indeed, grateful that fish oil is gaining a wider audience. But I think it's absurd that it requires a prescription to get it in many hospitals. Imagine, as the drug companies would love, vitamin C became a prescription agent. Instead of $3, it would cost far more. Does that make it better, safer, more effective?

Of course, no drug sales representative is promoting the nutritional supplement fish oil to physicians nor to hospitals. I now see people adding the extraordinary expense of prescription fish oil to their presription bills.

In my view, it's unnecessary, irrational, and driven more by politics and greed than actual need. Take a look at the website for Omacor (www.omacorrx.com). Among the claims:

"OMACOR is the only omega-3 that, along with diet, has been proven and approved to dramatically reduce very high triglycerides..."

This is a bald lie. Dozens of studies have used nutritional supplement fish oil and shown spectacular triglyceride-reducing effects.

Their argument against fish oil supplements:

"Dietary supplements are not FDA-approved for the treatment of any specific disease or medical condition. Get the Facts: nonprescription, dietary supplement omega-3 is not a substitute for prescription OMACOR."

Does that make any sense to you? Should you buy a GM car because only GM makes genuine GM cars? This is the silly logic being offered by these people to justify their ridiculous pricing.

How about: "The unique manufacturing process for OMACOR helps to eliminate worries about mercury and other pollution from the environment."

Funny...mercury in fish tends to be sequestered in the meat, not the oil. Independent reports by both Consumer Reports and Consumer Lab found no mercury, nor PCB's, in nutritional supplement fish oil. But just suggesting a difference without proving it may be enough to scare some people.

Just because something is used by a hospital does not make it better. The adoption of fish oil is hospitals is a good thing. Too bad it has to add to already bloated health care costs to enrich some drug manufacturer.

Repent for past sins

If the food temptations of the holidays got the best of you, and you're now 5, 10, 15 lbs or more over your pre-holiday weight (our record is 18lbs!), then it's time for serious action.

One easy method to regain the control you may have lost is to pick some period, say, 3 days. During those three days, eat nothing but vegetables--no breads, meats, dairy products, certainly no cookies, cakes, pasta, etc., not even fruit. Follow this routine and weight drops rapidly. Vegetables are wonderful but sometimes boring, so use healthy condiments to spice them up: mustards (hot, brown, yellow, horseradish); healthy salad dressings, which are olive or canola oil-based; salsas, a fabulous garnish with no nutritional downside whatsoever; pesto; tapenades; horseradish added to other condiments or even by itself (wasabi).

Of course, fasting in one of its several variations is another rapid method to regain control. My favorite is to use soy milk in a modified fast, usually 4-6 glasses of a low-fat, low-sugar soy milk per day, along with plenty of water. (Please refer to the precautions detailed in the recent Track Your Plaque Special Report, Fasting: Fast Track to Control Plaque , particularly if you fast 5 days or longer or take blood pressure or diabetic medication.)

Of course, yo-yoing your weight--up during the holidays, down after their conclusion--is not good for you. It does raise the likelihood of diabetes, not to mention cultivate the patterns that contribute to coronary plaque growth, especially small LDL. But if temptation got out of control and you need to regain lost ground, these two strategies work fabulously well for most people.

If you've gained, say, 10 lbs during the holidays, but simply resume your usual habits, chances are you won't lose the weight. Year after year, this can add up to an enormous weight gain. The time to act is now. It's easier to lose the 10 lbs of weight you gained recently, rather than the 50 lbs you've stacked up over the past 5 years.

Wheat-free 2007


Long ago, most of us made the change of reducing saturated fat in our diet. Few people now rely on butter (despite the idiotic butter vs. margarine controversy), full-fat dairy products, fried foods, and greasy meats. That's a healthy change, since saturated fat has conclusively been tied to various cancers, high blood pressure, rise in LDL, and is calorie-dense.

But if there were just one change you were to make beyond a reduction in saturated fat, a change that would translate into dramatic health benefits, it would be a drastic reduction, even elimination, of wheat products.

People do indeed eat enormous quantities of wheat flour-containing products. U.S. per capita consumption of wheat flour was 110 pounds in the early 1970s, and rose to 141 pounds in 1991. It's even higher now. 20% or more of most people's caloric intake every day is provided by wheat flour products.

Wheat containing foods are tasty and convenient. Witness the popularity of bagel shops, the goodie counter at Starbuck's, the proliferation of crackers, breads, and breakfast cereals at the grocery store. Patients are horrified when I suggest that they find a substitute for the sandwiches they eat every day. Even Mom said they were okay!

You're unlikely to hear much about this from the popular press. The wheat industry is enormous and exerts extraordinary clout, just like the drug industry. Texas alone farms 6 million acres of wheat, yielding over $2 billion for the state's economy. The "wheat chain" is complex and far-reaching: growers, processors, food manufacturers, the transportation industry, retailers, chemical producers, and on and on. Wheat futures are traded on the Chicago Board of Trade. Wheat is a major export industry for the U.S.

Of course, these are not evil people, intent on corrupting your health. In fact, most of them are probably working under the perception that they are raising a healthy product. The point is that the notion that wheat is healthy is deeply entrenched in the minds and economy of the U.S. Don't expect to hear unbiased commentary on the health effects of wheat products from most media sources.

What can you expect if you sharply reduce or eliminate wheat? The majority of people:

--Feel like a cloud has been lifted from their thinking.
--Don't experience the afternoon blah or tired feeling after lunch.
--Lose weight, sometimes substantial quantities.
--Raise HDL.
--Reduce small LDL.
--Reduce triglycerides, particularly if they start >100 mg/dl.
--Reduce blood sugar.

The reduction in small LDL can be especially impressive.

For most people, reducing or eliminating wheat is a sacrifice, a major change in food choices and even a loss of convenience. But the health benefits for most people can be dramatic.

Is vitamin D a "vitamin"?

Vitamins are crucial participants in the body's reactions and are obtainable from food. Vitamin C, for example, comes from citrus fruits and vegetables. Vitamin K comes from green vegetables. The B vitamins are found in meats, soy, dairy products, and grains. Vitamin A comes from carrots, squash, and other orange and green colored vegetables.

How about vitamin D? What foods contain vitamin D? The list includes:


Food International Units(IU) vitamin D per serving

Cod liver oil, 1 Tablespoon 1,360
Salmon, cooked, 3½ ounces 360
Mackerel, cooked, 3½ ounces 345
Tuna fish, canned in oil, 3 ounces 200
Sardines, canned in oil, drained, 1¾ ounces 250

Milk, nonfat, reduced fat, and whole, vitamin D fortified, 1 cup 98
Margarine, fortified, 1 Tablespoon 60
Pudding, prepared from mix and made with vitamin D fortified milk, ½ cup 50
Cheese, Swiss, 1 ounce 12

Ready-to-eat cereals fortified with 10% of the DV for vitamin D, ¾ cup to 1 cup servings (servings vary according to the brand) 40

Egg, 1 whole (vitamin D is found in egg yolk) 20
Liver, beef, cooked, 3½ ounces 15

(Modified from the Office of Dietary Supplements, National Institutes of Health)


You'll note that the only naturally-occurring food sources of vitamin D are the modest quantities in fish, egg yolks, and liver. All the other vitamin D-containing foods like cereal, milk, and other dairy products have vitamin D only because humans add it.

It takes me (personally) 6000 units of vitamin D per day to bring my blood level to an acceptable 50 ng/ml. To obtain this from eating salmon, I would have to eat 58 ounces, or 3 1/2 pounds of salmon--every day. Or, I could eat 30 cans of tuna fish.

If I didn't want to eat loads of fish every day, I could drink 60 glasses of milk every day. After I recovered from the diarrhea, my vitamin D might be adequate, provided the milk indeed contained the amount stated on the label (which it often does not when scrutinized by the USDA).

If vitamin D is a vitamin, how are humans supposed to get sufficient quantities? I don't know anybody who can eat 3 1/2 lbs of salmon per day, nor drink 60 glasses of milk per day. But aren't vitamins supposed to come from food?




The problem is that vitamin D is not really a vitamin, it's a hormone. If your thyroid hormone level was low, you'd gain 20, 30, or more pounds in weight, your blood pressure would skyrocket, you'd lose your hair, become constipated, develop blood clots, be terribly fatigued. In other words, you'd suffer profound changes. Likewise, if thyroid hormone levels are corrected by giving you thyroid hormone, you'd experience profound correction of these phenomena.

That's what I'm seeing with vitamin D: restoration of this hormone to normal blood levels (25-OH-vitamin D3 50 ng/ml) yields profound changes in the body.

If there's one thing that I've come across lately that packs extraordinary potential to help us in reducing heart scan scores, it's the vitamin--sorry, the hormone--cholecalciferol, or D3.

Heart scan curiosities 3


Note the shape of the chest in this 64-year old man. The front of his chest (upper portion of scan) is concave. In other words, if you were looking at this man (shirtless, of course) face to face, his chest would bow inward, rather than the usual outward configuration. The official name for this is "pectus excavatum".





Compare this to the normal chest in the second image, in which the chest is convex. Face to face, the chest would bow slightly outward.















What does it matter? The pectus excavatum in and of itself has no importance, just a curiousity. (I personally find this surprising, given the fact that the heart actually appears squashed by the sternum, or chest wall.) However, it is commonly associated with a "floppy" mitral valve (also called mitral valve prolapse), a common congenital disorder of the mitral valve often accompanied by a slender build, loose joints, and even a nervous disposition. Occasionally, in its more severe forms, the aorta is also enlarged. (This man's aorta is not enlarged.)

So, while we can't actually visualize the mitral valve by a CT heart scan, we can surmise that he likely has a floppy mitral valve, is slender, is probably a nervous sort, and has long limbs with loose joints. He probably required braces as a child, since many people have a phenemenon of "crowded teeth". The roof of his mouth, or hard palate, probably unusually high up in the mouth. He probably has a "weak chin", meaning a less prominent protuberance of his chin. His fingers and toes are likely unusually long and slender.

It could mean that some attention and exploration of how floppy his mitral valve might be could be useful, e.g., an ultrasound or echocardiogram. He might even require oral antibiotics at the time of any oral or some gastrointestinal procedures, since floppy valve are more susceptible to blood infections when potentially "dirty" orifices are instrumented.

All that from a heart scan!

Gratitude

The holidays and the end of the year may be a good time to reflect on how grateful we should be for having the freedom to discuss the ideas we share on this Blog, the Track Your Plaque website, online and offline.

Although I rant and rave against the status quo in heart disease, the shameful profiteering of my colleagues and hospitals, the cut-throat marketing practices of drug and device manufacturers, I am truly grateful that, in the U.S., I have the extraordinary freedom to say these things. You have the freedom to agree or disagree and none of us pays a price for truth.

I've been reflecting myself a great deal on this idea of happiness and gratitude being a critical component of coronary plaque regression and dropping your heart scan score. (See The Heart Scan Blog from earlier this week.) The more I think about this, the more I think that it is indeed true: Harboring anger and resentment, regrets, irritability, all those petty emotions that most of us know are not good for us, erode our chances for success in dropping your heart scan score.

We could rationalize it this way: Anger and other negative emotions are adrenaline-driven states, also characterized by activation of the "sympathetic" nervous system. (Despite its name, the sympathetic system is not sympathetic, as in compassionate; its the "fight-or-flight" activator that accelerates heart rate and blood pressure.)

Happiness, contentment, and gratitude are "parasympathetic" states characterized by slower heart rates, deeper respiration, greater variation in beat-to-beat heart rates (a powerful predictor for health and the basis for the HeartMath program of Lew Childre), lower blood pressure, and even a subtle change in brain waves. In other words, happiness is not just a mental and emotional state, it is a constellation of physical phenomena.

Even though I pick on Dr. Dean Ornish for his stubborn adherence to the outdated low-fat mantra, I do agree with him on the value of happiness. His book, Love and Survival, articulates this concept. Ornish has even said on several occasions that it wasn't the diet that was most important but the connection and warmth that was created by the comraderie created by participation in the Ornish Program group sessions.

I am personally grateful that the concepts I promote are gaining a following and that I can say so without fear of prosecution. I am grateful that Track Your Plaque followers are not just sharing our concepts, but obtaining genuine and powerful health advice that will help keep them home and healthy, away from hospitals, procedures, and the dangers of heart disease.

I hope you share in my gratitude and are thankful for all the truly wonderful things that surround us. I wish you all a wonderful holiday and long, healthy life filled with gratitude.

A Track Your Plaque failure

We recently had a man suffer a heart attack after beginning the program. Let me tell you the details.

Jerry's heart scan score 781, age 53. Multiple lipoprotein abnormalities: HDL 32 mg/dl, triglycerides 279 mg/dl, nearly all of his LDL was in small particles with an "effective" LDL (LDL particle number), and very high IDL. So Jerry added fish oil 6000 mg per day, niacin, and vitamin D to the statin drug prescribed by his primary physician. Jerry added oat bran, ground flaxseed, and tried to eat fish at least once per week.

However, Jerry continued to smoke. He'd smoked for 40 years (!), up to 2 packs per day, and just reasoned that it was too late to quit. He also continued to indulge in the packaged, processed foods that were part of his convenience story business.

Jerry's stress test was normal--no chest pain, normal EKG, normal images of blood flow, though he was somewhat breathless, likely from his lung disease from smoking.

Two months into his program, he abruptly experienced severe crushing pain in his chest. Because he was traveling, he ended up in a small local hospital. A failed angioplasty led to urgent coronary bypass surgery.

Jerry's alive. Now he's a non-smoker. He's got the pursed lips and peculiar breathing pattern that smokers get, but he's breathing.

Lesson: In the face of the most powerful program for heart disease known, it can still be overpowered by Twinkies, Hoho's, pretzels, chips--and cigarettes.

The new year is approaching. Be grateful for another year of healthy life and commit to a new year of even greater health. If you're a smoker, there's no choice: you've got to quit.

Are you more like a dog or a rabbit?

Dr. William Roberts, editor of the American Journal of Cardiology and cardiovascular pathologist, is a perennial source of clever ideas on heart disease.
In a recent editorial, Dr. Roberts comments:








"Because humans get atherosclerosis, and atherosclerosis is a disease only of herbivorers, humans also must be herbivores. Most humans, of course, eat flesh, but that act does not make us carnivores. Carnivores and herbivores have different characteristics. (1) The teeth of carnivores are sharp; those of herbivores, flat (humans have some sharp teeth but most are flat for grinding the fruits, vegetables, and grains we are built to eat). (2) The intestinal tract of carnivores is short (about 3 times body length); that of herbivores, long (about 12 times body length). (Since I am 6 feet tall my intestinal tract should be about 60 feet long. As a consequence, if I eat bovine muscle [steak], it could take 5 days to course through those 20 yards.) (3) Body cooling for carnivores is done by panting because they have no ability to seat; although herbivores also can pant, they cool their bodies mainly by sweating. (4) Drinking fluids is by lapping them for the carnivore; it is by sipping them for the herbivore. (5) Vitamin C is made by the carnivore's own body; herbivores obtain their ascorbic acid only from their diet. Thus, although most human beings think we are carnivores or at least conduct their lives as if we were, basically humans are herbivores. If we could decrease our flesh intake to as few as 5 to 7 meals a week our health would improve substantially."



You can always count on Dr. Bill Roberts to come up with some clever observations.

I think he's right. Some of the most unhealthy people I've known have been serious meat eaters. Most of the vegetarians have been among the healthiest. (I say most because if a vegetarian still indulges in plenty of junk foods like chips, crackers, breakfast cereals, breads, etc., then they can be every bit as unhealthy as a meat eater.)

Should you become a vegetarian to gain control over coronary plaque and other aspects of health? I don't believe you have to. However, modern livestock raising practices have substantially modified the composition of meats. A steak in 2006, for instance, is not the same thing as a steak in 1896. The saturated and monounsaturated fat content are different, the pattern of fat "marbling" is different, the lean protein content is different. Meat is less healthy today than 100 years ago.

Take a lesson from Dr. Roberts' tongue-in-cheek but nonetheless provocative thoughts. Pardon me while I chew on some carrots.

Track Your Plaque makes Consumer Reports!

. . . but not in a good way.

The September, 2011 issue of Consumer Reports showcases their Protect Your Heart discussion. Third paragraph: "The website Track Your Plaque warns, 'The old tests for heart disease were wrong--dead wrong.' It says heart scans are 'the most important health test you can get.'"

They go on to expose the overuse of heart procedures like angioplasty and stent implantation and offer their advice on how to manage heart disease risk: lower BP, reduce LDL cholesterol, lose weight, stop smoking, take aspirin. They quote Dr. Paul Ridker who declares heart scans are not useful because the "deposits cardiologists worry about are the less stable plaques that CT scans routinely miss."

I thought I'd been transported back to 1995. Not only is it clear that the Consumer Report writers never looked beyond the homepage of Track Your Plaque, but somehow saw our heart disease prevention and reversal program as promoting heart procedures. Incredible.

Of course, the Track Your Plaque program does the exact opposite: Advocates an approach that virtually eliminates the need for procedures and returns control over heart disease to the participant. That's a critical difference.

And, as I've had to remind my colleagues time and time again, what we are really after is an index of total coronary atherosclerotic plaque. Even in 2011, that index remains the simple coronary calcium score, a gauge of total plaque, not just of "hard," stable plaque. Perhaps in 10 years we will be using a better tool to gauge progression and regression of all the components of coronary atherosclerotic plaque, but today it remains the simple, accessible, mammogram-like coronary calcium score.

Consumer Reports does for the idea of heart disease prevention what food manufacturers do for health and weight loss: Echo conventional wisdom of the sort that generally makes us fatter, more diabetic, leads us to more heart procedures and needless deaths. I might use Consumer Reports to rate MP-3 devices or toasters, but I certainly would not rely on them for insightful health advice.

Paging Dr. Basedow

A 23-year old man came to my office having experienced weeks of extreme anxiety, palpitations, and 19 pounds of weight loss triggered by an overactive thyroid.

It all happened because of a large dose of iodine received during a CT scan using iodine-containing x-ray dye. (X-ray dyes are made visible on x-ray due to the iodine content.) This is a reaction first described in the 19th century by German physician, Karl Adolph von Basedow. (Jod is German for iodine.)[caption id="attachment_4313" align="alignleft" width="217" caption="Dr. von Basedow. Image courtesy Wikipedia"][/caption]

Now, here's the kicker: Jod-Basedow only occurs when there is pre-existing iodine deficiency. Indeed, this young man had an enlarged thyroid, signaling longstanding iodine deficiency (a goiter).

This example is among the more flagrant examples of something I have been witnessing: the return of iodine deficiency. As Americans cut back on their intake of iodized salt and fail to obtain iodine in sufficient quantities from seafood, seaweed, or supplementation, goiters and iodine deficiency are making a return in all its glory, reminiscent of the early 20th century, pre-iodized salt.

This young man's frightening experience is yet another way iodine deficiency can show itself, by the overenthusiastic thyroid response to a large dose of iodine when iodine deficiency has been present for a prolonged period.

Iodine deficiency and goiters have been lost to memory for most people. Even the FDA, in its advice for Americans to reduce salt and sodium intake, have forgotten to remind everyone to obtain iodine from an alternative source. "Those who cannot remember the past are condemned to repeat it."

Get your iodine.

Carb counting

In the recent Heart Scan Blog post, Can I eat quinoa, I discussed how non-wheat carbohydrate sources like quinoa, amaranth, black beans, brown rice, fruit, etc. do not exert the inflammation-provoking, appetite-increasing effects of wheat (since gliadin and gluten are not present), nor do they increase blood glucose as enthusiastically as the amylopectin A of wheat--but non-wheat grains can still increase blood sugar quite substantially.

Of course, any food that triggers blood sugar also trigger hepatic de novo lipogenesis, thereby increasing triglyceride levels and postprandial particles (e.g., chylomicron remnants), which, in turn, triggers formation of small LDL particles.

So these non-wheat carbohydrates, or what I call "intermediate carbohydrates" (for lack of a better term; low-glycemic index is falsely reassuring) still trigger all the carbohydrate phenomena of table sugar. Is it possible to obtain the fiber, B-vitamin, flavonoid benefits of these intermediate carbohydrates without triggering the undesirable carbohydrate consequences?

Yes, by using small portions. Small portions are tolerated by most people without triggering all these phenomena. Problem: Individual sensitivity varies widely. One person's perfectly safe portion size is another person's deadly dose. For instance, I've witnessed many extreme differences, such as 1-hour blood sugar after 6 oz unsweetened yogurt of 250 mg/dl in one person, 105 mg/dl in another. So checking 1-hour blood sugars is a confident means of assessing individual sensitivity to carbs.

Some people don't like the idea of checking blood sugars, however. Or, there might be times when it's inconvenient or unavailable. A useful alternative: Count carbohydrate grams. (Count "net" carbohydrate grams, of course, i.e., carbohydrates minus indigestible fiber grams to yield "net" carbs.) Most people can tolerate around 40-50 grams carbohydrates per day and deal with them effectively, provided they are spaced out throughout the day and not all at once. Only the most sensitive, e.g., diabetics, apo E2 people, those with familial hypertriglyceridemia, are intolerant to even this amount and do better with less than 30 grams per day. Then there are the genetically gifted from a carbohydrate perspective, people who can tolerate 50-60 grams, occasionally somewhat more.

People will sometimes say things like "You don't know what the hell you're talking about because I eat 200 grams carbohydrate per day and I'm normal weight and have perfect blood sugar and lipids." As in many things, the crude measures made are falsely reassuring. Glycation, for instance, from postprandial blood sugars of "only" 140 mg/dl--typical after, say, unsweetened oatmeal--still works its unhealthy magic and will lead long-term to cataracts, arthritis, and other conditions.

Humans were not meant to consume an endless supply of readily-digestible carbohydrates. Counting carbohydrates is another way to "tighten up" a carbohydrate restriction.

One hour blood sugar: Key to carbohydrate control and reversing diabetes

Diabetics are instructed to monitor blood glucose first thing in the morning and two hours after eating. This helps determine whether blood sugar is controlled with medications like metformin, Januvia, Byetta injections, or insulin.

But that's not how you use blood sugar to use to prevent or reverse diabetes. Two-hour blood sugars are also of no help in deciding whether you have halted glycation, or glucose modification of proteins the process that leads to cataracts, brittle cartilage and arthritis, oxidation of small LDL particles, atherosclerosis, kidney disease, etc.

So the key is to check one-hour after-eating (postprandial) blood sugars, a time when blood glucose peaks after consumption of carbohydrates. (It may peak somewhat sooner or later, depending on factors such as how much fluid was in the meal; protein, fat, and fiber content; presence of foods like vinegar that slow gastric emptying; the form of carbohydrate such as amylopectin A vs. amylopectin B, amylose, fructose, along with other factors. Once in a while, you might consider constructing your own postprandial glucose curve by doing fingersticks every 15 minutes to determine when your peak occurs.)

I reject the insane notion that after-eating blood sugars of less than 200 mg/dl are acceptable, the value accepted widely as the cutoff for health. Blood sugars this high occurring with any regularity ensure cataracts, arthritis, and all the other consequences of cumulative glycation. I therefore aim to keep one-hour after-eating glucoses 100 mg/dl or less. If you start in a pre-diabetic or diabetic range of, say, 120 mg/dl, then I advise people to not allow blood glucose to go any higher. A pre-meal blood glucose of 120 mg/dl would therefore be followed by an after-eating blood glucose of no higher than 120 mg/dl.

No doubt: This is strict. But people who do this:

--Lose weight from visceral fat
--Heighten insulin sensitivity
--Drop blood pressure
--Drop HbA1c and fasting glucose over time
--Reduce small LDL and other carbohydrate-sensitive measures

By the way, if you inadvertently trigger a high blood sugar like I did when I took my kids to the all-you-can-eat Indian buffet, go for a walk, bike, or burn the sugar off with a 30-minute or longer physical effort. Check your blood sugar again and it should be back in desirable range. But then learn from your lesson: Eliminate or reduce portion size of the culprit carbohydrate food.

Wheat Belly coming to bookstores!

Anyone following the conversations on these pages know that I have some very serious concerns about this thing being sold to us called "wheat"--cause it ain't wheat! It is the result of incredible genetics shenanigans inflicted on this plant, mostly in the name of increased yield per acre.



I now classify wheat as "Public Enemy #1," the prime nutritional culprit underlying obesity, heart disease, "cholesterol" abnormalities, hypertension, arthritis, psychiatric illness, and on and on. Once you read the full story, I believe that you will agree: Modern Triticum aestivum, the plant that now serves as the source for virtually all the wheat flour products now consumed--organic, whole grain, multigrain, sprouted . . . it makes no difference--does not belong in the human diet. So many people, searching for solutions for their fatigue, weight gain, leg edema, incurable rashes, joint pain, etc., will find their answers here.

Wheat Belly: Lose the wheat, lose the weight and find your path back to health will be on bookstore shelves including Barnes and Noble August 30, 2011 or is available for preorder here at Amazon. Wheat Belly will also be available as a downloadable Kindle book and as unabridged audio CDs.

You can also follow the Wheat Belly conversations on my Wheat Belly Blog. One of my recent posts discusses the herbicide-resistant semi-dwarf wheat strain, Clearfield, that is now making its way to more and more supermarket shelves.

You'll also find more conversation on the Wheat Belly Facebook pages.

The exception to low-carb

I witness spectacular results restricting carbohydrates, both in the office as well as in my online experiences, such as those in Track Your Plaque. Of course, the diet I advocate is not just low-carb; it starts with elimination of wheat (for a long list of reasons). So the diet is wheat-free in the setting of low-carbohydrate.

What does this accomplish? Here's a partial list:

--Weight loss-Specifically, loss of visceral fat, the kind hinted at on the surface as "love handles" or what I call "wheat belly."
--Reduced blood sugar and HbA1c (reflecting prior 60-90 days glucose)
--Marked reduction in small LDL and triglycerides, increased HDL
--Reduced inflammatory measures like c-reactive protein
--Reduced leptin and leptin resistance, increased adiponectin
--Reduced estrogen and prolactin in men, accompanied by shrinkage or loss of enlarged breasts ("man boobs"); reduced estrogen in females accompanied by reduced risk for breast cancer

Pretty impressive. But there's one group of people who can experience unexpected effects with this diet: The 25% of people with apoprotein E4.

Everybody has two genes for apo E; the most common type is apo E 3/3. Around 1 in 4 people have 1, less commonly 2, genes for apo E4.

I hate apo E4. I hate apo E4 because it means I've got to dust off the nonsense I used to tell patients about cutting their fat, cutting their saturated fat. But that's what apo E4 people have to do. But it doesn't end there.

Apo E4 people also typically have plenty of small LDL particles triggered by carbohydrates. Put fats and carbohydrates together and you get an explosion of small LDL particles. Remove fats, small LDL goes down a little bit, if at all. Remove carbohydrates, small LDL goes down but total LDL (mostly large) goes up. The large LDL in apo E4 does seem to be atherogenic (plaque-causing), though the data are fairly skimpy.

So apo E4 creates a nutritional rock and a hard place: To extract full advantage from diet, people with apo E4 have to 1) go wheat-free, low-carb, then 2) not overdo fats, especially saturated fat.

It still gives me the creeps to tell an apo E4 person that they've got to watch their fats, worse than watching Starsky and Hutch reruns.

Can I eat quinoa?

. . . or beans, or brown rice, or sweet potatoes? Or how about amaranth, sorghum, oats, and buckwheat? Surely corn on the cob is okay!

These are, of course, non-wheat carbohydrates. They lack several crucial undesirable ingredients found in our old friend, wheat, including no:

Gliadin--The protein that degrades to exorphins, the compound from wheat digestion that exerts mind effects and stimulates appetite to the tune of 400 additional calories (on average) per day.
Gluten--The family of proteins that trigger immune diseases and neurologic impairment.
Amylopectin A--The highly-digestible "complex" carbohydrate that is no better--worse, in fact--than table sugar.

So why not eat these non-wheat grains all you want? If they don't cause appetite stimulation, behavioral outbursts in children with ADHD, addictive consumption of foods, dementia (i.e., gluten encephalopathy), etc., why not just eat them willy nilly?

Because they still increase blood sugar. Conventional wisdom is that these foods trend towards having a lower glycemic index than, say, table sugar, meaning it raises blood glucose less.

That's true . . . but very misleading. Oats, for instance, with a glycemic index of 55 compared to table sugar's 59, still sends blood sugar through the roof. Likewise, quinoa with a glycemic index of 53, will send blood sugar to, say, 150 mg/dl compared to 158 mg/dl for table sugar--yeah, sure, it's better, but it still stinks. And that's in non-diabetics. It's worse in diabetics.

Of course, John Q. Internist will tell you that, provided your blood sugars after eating don't exceed 200 mg/dl, you'll be okay. What he's really saying is "There's no need for diabetes medication, so you're okay. You will still be exposed to the many adverse health consequences of high blood sugar similar to, though less quickly than, a full diabetic, but that's not my problem."

In reality, most people can get away with consuming some of these non-wheat grains . . . provided portion size is limited. Beyond limiting portion size, there are two ways to better manage your carbohydrate sensitivity to ensure that metabolic distortions, such as high blood sugar, glycation, and small LDL particles, are not triggered.

More on that in the future.


Lipoproteins . . . zero!

With the recent refinements in our approach to correction of the lipoprotein abnormalities that lead to coronary plaque and heart disease risk, I have been witnessing more and more people achieve:

Small LDL particles 0 nmol/L
Lipoprotein(a) 0 nmol/L



For instance, Ted, a 58-year old man I saw in the office today started with:

Small LDL 1673 nmol/L
Lipoprotein(a) 219 nmol/L


In other words, both small LDL particles and lipoprotein(a) are being knocked down to zero values.

Incidentally, the combination of lipoprotein(a) with small LDL is among the most atherogenic (atherosclerotic plaque-causing) patterns known. Despite his athletic, slender build and avoidance of unhealthy habits, Ted's heart scan score was 922--very high.

So Ted followed the diet I advocate, i.e., wheat elimination followed by elimination of cornstarch, oats, and sugars; high-dose fish oil (total daily EPA + DHA of 6000 mg/day); vitamin D supplementation sufficient to achieve a 25-hydroxy vitamin D level of 60-70 ng/ml; iodine supplementation; and thyroid normalization which, in Ted's case, required supplementation with the T3 thyroid hormone, liothyronine, at a small dose.

The result:

Small LDL particles 0 nmol/L
Lipoprotein(a) 0 nmol/L


Not everybody, of course, is achieving these incredible--and previously impossible--results. But the numbers are growing. Ted is the third person to achieve zeroes all around, in fact, over the past 10 days.

Heart disease prevention is getting better and more powerful every day. And it ain't all about Lipitor and low-fat.


Chocolate almond biscotti

Biscotti are twice-baked biscuits or cookies that are perfect for dipping into coffee, latté, or espresso. These wheat-free, low-carb biscotti are rich with the taste of chocolate and almonds.

Yield: approximately 15 biscotti



Ingredients:

2 cups almond meal
½ cup chopped walnuts
1/4 cup cocoa powder (undutched)
½ cup dark chocolate chips
Sweetener equivalent to ½ cup sugar (e.g., liquid stevia, Truvia)
½ cup ricotta cheese, room temperature (replace with coconut milk if lactose intolerant)
4 tablespoons butter, melted (replace with coconut oil if lactose intolerant)
2 large eggs
¼ cup milk, unsweetened almond milk, or soy milk
¼ cup almond, peanut, or sunflower seed butter, room temperature

Preheat oven to 350º F.

Mix almond meal, walnuts, sweetener, cocoa powder, and chocolate chips in bowl. Mix in ricotta, butter, eggs, milk, and nut butter and blend by hand thoroughly.

Pour mix onto baking pan lined with parchment paper or greased with coconut oil or other oil. Shape into loaf approximately 1 inch deep and 3½ to 4 inches in width. Place in oven and bake for 40 minutes.

Remove loaf and allow to cool 15 minutes. Slice into approximately ¾-inch widths and lay each biscotto on its side on baking pan. Put back in oven for 10 minutes.

Remove pan and flip biscotti over. Place back in oven and bake an additional 5 minutes. Remove and cool.

Optional: For a little dark chocolate "icing":
Melt 3-4 oz semisweet or dark chocolate in microwave (in 15 second increments until melted) or in metal bowl placed in heated water. Stir in 1-2 teaspoons butter.
Dip each biscotti into melted chocolate mix or drizzle chocolate mixture over top of each biscotto.

Sun green tea

Here's a great way to enjoy the health benefits of green tea during the summer: sun green tea.


I dropped two green tea bags into approximately one-half gallon of cold water in a clear glass jar. I placed the jar in the sun (with top on) for four hours, then brought it into the kitchen. I served it as iced tea with a slice of lemon and mint leaf.

The sun green tea was a smoother than standard green tea brewed with hot water. Ordinarily, if you brew hot green tea for more than 3-5 minutes, it becomes more bitter or tannic. This sun green tea, despite steeping for four hours, was not the least bit bitter or tannic.

The green tea lasted well for about 48 hours, more than enough to enjoy several glasses per day.

Diabetes: Better than hedge funds

Diabetes is where the action is.

While, for virtually all of history, type 2 diabetes was an uncommon condition of adults, the disease has spread so much to all levels of American society that even kids are now developing the adult form. Researchers from the Center for Disease Control and Prevention predict that, by 2050, one in three adults will be diabetic.

The diabetes market is booming, handily surpassing growth of the oil industry, the housing market, even technology. It makes Bernie Madoff’s billions look like small potatoes. In health, few markets are growing as fast as diabetes—-not osteoporosis, not heart disease, not cancer.

Americans are getting fat from carbohydrate consumption, becoming diabetic along with it. While kids hanging around the convenience store gulp down 26 teaspoons of sugar in 32-ounce sodas and 56-grams-of-sugar in 16-ounce frozen ices, health-minded adults are more likely eating two slices of 6-teaspoons sugar-equivalent “healthy whole grain” bread, wondering why last year’s jeans are too tight.

The U.S. is not the only nation affected. Globally, 2.8% of the world’s population are diabetic, a number expected to double over the next 20 years.

Pharmaceutical companies boast double-digit growth for diabetes drugs, growth rates that keep profit-hungry investors happy. Merck’s Januvia, for instance, introduced in 2006, recently catalogued 30% growth in sales, with annual sales approaching $1 billion. Recently FDA-approved Victoza, requiring once-a-day injection, is expected to reap $4 billion in sales per year for manufacturer Novo Nordisk. Such numbers can only warm a drug company CEO’s heart.

Most diabetics don’t just take one medication, but several. A typical regimen for an adult diabetic after a couple of years of treatment and following the dietary advice of the American Diabetes Association includes metformin, Januvia, and Actos, a triple-drug treatment that costs around $420 per month. Two forms of insulin (slow- and fast-acting), along with two or three oral medications, is not at all uncommon.

“Collateral” revenues from the other health conditions that develop from a diet rich in “healthy whole grains,” such as drugs for hypertension, drugs to slow the progression of kidney disease in diabetes, drugs for “high cholesterol,” and drugs for high triglycerides, and you have a pharmaceutical drug bonanza. You, too, would throw all-expenses-paid, fly-the-entire-sales-force-to-the-Caribbean sales meetings.

The global diabetes market has already topped $25 billion and is growing at double-digit rates. Forget the Internet, gold stocks, or solar energy—-diabetes is where the money is. This fact has not been lost on the very market-savvy pharmaceutical industry. As with any successful business, they have devoted substantial resources to develop and grow this booming business.

270 lb man in diapers

Alex is a big guy: 6 ft 4 inches, 273 lbs.

On 10,000 units per day of vitamin D in gelcap form, his 25-hydroxy vitamin D level was 38.4 ng/ml. One year earlier, his 25-hydroxy vitamin D level, prior to any vitamin D supplementation was 9.8 ng/ml.

According to the latest assessment offered by the Institute of Medicine (IOM):

Vitamin D need for a 13-month old infant: 600 units per day

Vitamin D need for a 6 ft 4 in, 273 lb male: 600 units per day

I paint this picture to highlight some of the absurdity built into the smug assumptions of the IOM's report. It would be like trying to fit a large, full-grown man into the diapers of a 13-month old. Few nutrients or hormones (in fact, I can't think of a single one) are required in similar quantity by an infant or toddler and a full grown adult. However, according to the IOM's logic, their vitamin D needs are identical, regardless of age, body size, skin color, genetics, etc. One size fits all.

Just as the original RDA assessment by the Institute of Medicine kept thinking about vitamin D somewhere in the Stone Age, so does this most recent assessment.

90% small LDL: Good news, bad news

Chris has 90% small LDL particles.

On his (NMR) lipoprotein panel, of the total 2432 nmol/L LDL particles ("LDL particle number"), 2157 nmol/L are small, approximately 90% (2157/2432).

Bad news: Having this severe excess of small LDL particles virtually guarantees heart attack and stroke in Chris' future.

Good news: It means that Chris potentially has spectacular control over his lipoprotein and lipid values, achieving statin-like values without statin drugs.

Typically, extravagant quantities of small LDL particles are accompanied by low HDL, high triglycerides, and pre-diabetes or diabetes. Chris' HDL is 26 mg/dl, triglycerides 204 mg/dl; HbA1c 5.9% (a reflection of prior 60-90 days average blood glucose; desirable 4.8% or less), fitting neatly into the expected pattern.

Chris' pattern tells me several things:

1) He overconsumes carbohydrates, since carbohydrates trigger this pattern.
2) He likely has a genetic susceptibility to this effect (e.g., a variant of the gene for cholesteryl ester transfer protein, perhaps hepatic lipase). Only the most gluttonous and overweight carbohydrate consumers can generate this high a percentage small LDL without an underlying genetic susceptibility.
3) Provided he follows the diet advised, i.e., elimination of all wheat, cornstarch, oats, and sugars, he is likely to have an extavagant drop in LDL particle number. Should he achieve the goal I set of small LDL of 300 nmol/L or less, his LDL particle number will likely be around 500 nmol/L. This translates to an LDL cholesterol of 50 mg/dl . . . 50 mg/dl.

In many people, this notion of taking statin drugs for "high cholesterol" is an absurd oversimplification. But it is a situation that, for many, is wonderfully controllable with the right diet.

The American Heart Association has a PR problem

The results of the latest Heart Scan Blog poll are in. The poll was prompted by yet another observation that the American Heart Association diet is a destructive diet that, in this case, made a monkey fat.

Because I am skeptical of "official" organizations that purport to provide health advice, particularly nutritional advice, I thought this poll might provide some interesting feedback.

I asked:

The American Heart Association is an organization that:

The responses:
Tries to maintain the procedural and medication status quo to benefit the medical system and pharmaceutical industry for money
240 (64%)

Doesn't know its ass from a hole in the ground
121 (32%)

Is generally helpful but is misguided in some of its advice
79 (21%)

Accomplishes tremendous good and you people are nuts
6 (1%)


Worrisome. Now, perhaps the people reading this blog are a skeptical bunch. Or perhaps they are better informed.

Nonetheless, one thing is clear: The American Heart Association (and possibly other organizations like the American Diabetes Association and USDA) have a serious PR problem. They are facing an increasingly critical and skeptical public.

Just telling people to "cut the fat and cholesterol" is beginning to fall on deaf ears. After all, the advice to cut fat, cut saturated fat, cut cholesterol and increase consumption of "healthy whole grains" in 1985 began the upward ascent of body weight and diabetes in the American public.

Believe it or not, my vote would be for something between choices 1 and 3. I believe that the American Heart Association achieves a lot of good. But I also believe that there are forces within organizations that are there to serve their own agendas. In this case, I believe there is a substantial push to maintain the procedural and medication status quo, the "treatments" that generate the most generous revenues.

I believe that I will forward these poll results to the marketing people at the American Heart Association. That'll be interesting!

The formula for aortic valve disease?

I've discussed this question before:

Can aortic valve stenosis be stopped or reversed using a regimen of nutritional supplements?

I had a striking experience this past week. Don has coronary plaque and began the Track Your Plaque program. However, discovery of a murmur led to an echocardiogram that measured his effective aortic valve area at 1.5 cm2. (Normal is between 2.5-3.0 cm2.)

Because of his aortic valve issue, I suggested that, in addition to the 10,000 units of vitamin D required to increase his 25-hydroxy vitamin D level to 70 ng/ml, he also add vitamin K2, 1000 mcg per day, along with elimination of all calcium supplements. (I asked Don to use a K2 supplement that contained both forms, short-acting MK-4 and long-acting MK-7.)

One year later, another echocardiogram: aortic valve area 2.6 cm2--an incredible increase.

This is not supposed to happen. By conventional thinking, aortic valve stenosis can only get worse, never get better. But I've now witnessed this in approximately 10% of the people with aortic valve stenosis. The majority just stop getting worse, an occasional person gets worse, while a few, like Don, get better.

Aortic valve stenosis is to the aortic valve as degenerative arthritis is to your knees: A form of wear-and-tear that leads to progressive dysfunction. When the aortic valve becomes stiff enough (i.e., "stenotic"), then it leads to chest pains, lightheadedness or losing consciousness, heart failure, and, eventually, death. Bad problem.

Aortic stenosis typically starts in your 50s with calcification of the valve, getting worse and worse until the calcium makes the valve "leaflets" unable to move. The treatment: a new valve, a major undertaking involving an open heart procedure.

What if taking vitamins D and K2 and avoiding calcium do not just reverse or stop aortic valve stenosis once established, but prevents it in the first place? Tantalizing possibility.

Pressures on my time being what they are, I've not had the freedom to put together a prospective study to further examine this fascinating question. But it is definitely worth pursuing.

Blood glucose 160

What happens when blood glucose hits 160 mg/dl?

A blood glucose at this level is typical after, say, a bowl of slow-cooked oatmeal with no added sugar, a small serving of Cheerios, or even an apple in the ultra carb-sensitive. Normal blood sugar with an empty stomach, i.e., fasting; high blood sugars after eating.

Conventional wisdom is that a blood sugar of 160 mg/dl is okay, since your friendly primary care doctor says that any postprandial glucose of 200 mg/dl or less is fine because you don't "need" medication.

But what sort of phenomena occur when blood sugars are in this range? Here's a list:

--Glycation (i.e., glucose modification of proteins) of various tissues, including the lens of your eyes (cataracts), kidney tissue leading to kidney disease, skin leading to wrinkles, cartilage leading to stiffness, degeneration, and arthritis.
--Glycation of LDL particles. Glycated LDL particles are more prone to oxidation.
--VLDL and triglyceride production by the liver, i.e., de novo lipogenesis.
--Small LDL particle formation--The increased VLDL/triglyceride production leads to the CETP-mediated reaction that creates small LDL particles which are, in turn, more glycation- and oxidation-prone.
--Glucotoxicity--i.e., a direct toxic effect of high blood glucose. This is especially an issue for the vulnerable beta cells of the pancreas that produce insulin. Repeated glucotoxic poundings by high glucose levels lead to fewer functional beta cells.

A blood glucose of 160 mg/dl is definitely not okay. While it is not an immediate threat to your health, repeated exposures will lead you down the same path that diabetics tread with all of its health problems.

Indian buffet

I took my family to a local all-you-can-eat Indian buffet. It was delicious.

I confined my food choices mostly to vegetables and soups. Within about 30 minutes, I started to get that odd buzz in my head that usually signals a high blood sugar.

When I got home, my fingerstick blood glucose: 173 mg/dl. Darn it! Must have been cornstarch or other sugars in the sauces.

I got on my supine stationary bike and pedaled for 40 minutes at a moderate pace while I played Modern Warfare on XBox. (A great way, by the way, to fit in some low- to moderate-intensity exercise while occupying your brain. My wife often has to yell at me to get off, it's so much fun.)

Blood glucose at the conclusion of exercise: 93 mg/dl-- a nice 80 mg/dl drop.

This is a useful strategy to use in a pinch when you've either been inadvertently exposed to more carbohydrate than you can tolerate, or if you'd like to blunt the adverse glucose effects of a bowl of ice cream or other carbohydrate indulgence.

Should we explore the idea of a "morning-after" pill, or actually a "meal-after" pill, a supplement pill or liquid that blunts or eliminates the blood glucose rise after a meal? I've considered such an idea, but have been fearful that people would start to use it habitually. Thoughts?

American Heart Association diet makes a monkey out of you

Heart Scan Blog reader, Roger, brought this New York Times article to my attention.

In an effort to develop a better experimental model for obesity than mice, scientists have turned to monkeys and other primates. The emerging observations are eerily reminiscent of what you and I witness just by going to the local grocery store or fast food outlet:

"'It wasn’t until we added those carbs that we got all those other changes, including those changes in body fat,' said Anthony G. Comuzzie, who helped create an obese baboon colony at the Southwest National Primate Research Center in San Antonio."

"Fat Albert, one of her monkeys who she said was at one time the world’s heaviest rhesus, at 70 pounds, ate “nothing but American Heart Association-recommended diet,” she said."

Yes, indeed: The American Heart Association diet makes monkeys fat. Extrapolate this a little higher on the evolutionary ladder and guess what?

This is one of the many reasons why, when I have a patient who is counseled by the hospital dietitian on the American Heart Association diet, I advise them to 1) ignore everything the dietitian told them, and then 2) follow the wheat-free, cornstarch-free, sugar-free, whole food diet I advocate.

Not unexpectedly, much of this primate research is not being devoted to just manipulating diet to achieve weight loss and health, but to develop new drugs to "treat" obesity.

Would you like a banana?

Construct your glucose curve

In a previous Heart Scan Blog post, I discussed how to make use of postprandial (after-meal) blood sugars to reduce triglycerides, reduce small LDL, increase HDL, reduce blood pressure and inflammatory measures, and accelerate weight loss.

In that post, I suggested checking blood glucose one hour after finishing a meal. However, this is a bit of an oversimplification. Let me explain.

A number of factors influence the magnitude of blood glucose rise after a meal:

--Quantity of carbohydrates
--Digestibility of carbohydrates--The amylopectin A of wheat, for example, is among the most digestible of all, increasing blood sugar higher and faster.
--Fat and protein, both of which blunt the glucose rise (though only modestly).
--Inclusion of foods that slow gastric emptying, such as vinegar and fibers.
--Body weight, age, recent exercise

Just to name a few. Even if 10 people are fed identical meals, each person will have a somewhat different blood glucose pattern.

So it can be helpful to not just assume that 60 minutes will be your peak, but to establish your individual peak. It will vary from meal-to-meal, day-to-day, but you can get a pretty good sense of blood glucose behavior by constructing your own postprandial glucose curve.

Say I have a breakfast of oatmeal: slow-cooked, stoneground oatmeal with skim milk, a few walnuts, blueberries. Blood glucose prior: 95 mg/dl. Blood glucose one-hour postprandial: 160 mg/dl.

Rather than taking a one-hour blood glucose, let's instead take it every 15 minutes after you finish eating your oatmeal:


In this instance, the glucose peak occurred at 90-minutes after eating. 90-minute postprandial checks may therefore better reflect postprandial glucose peaks for this theoretical individual.

I previously picked 60-minutes postprandial to approximate the peak. You have the option of going a step better by, at least one time, performing your own every-15-minute glucose check to establish your own curve.

Why is type 1 diabetes on the rise?

Type 1 diabetes, also called "childhood" or "insulin-dependent" diabetes, is on the rise.

Type 2 diabetes, or "adult," diabetes, is also sharply escalating. But the causes for this are easy-to-identify: overconsumption of carbohydrates and resultant weight gain/obesity, inactivity, as well as genetic predisposition. A formerly rare disease is rapidly becoming the scourge of the century, expected to affect 1 in 3 adults within the next several decades.

Type 1 diabetes, on the other hand, generally occurs in young children, not uncommonly age 3 or 4. Type 1 diabetes also shares a genetic basis to some degree. But the genetic predisposition should be a constant. Obviously, lifestyle issues cannot be blamed in young children.
Then why would type 1 diabetes be on the rise?

For instance, this study by Vehik et al from the University of Colorado documents the approximate 3% per year increase in incidence in children with type 1 diabetes between 1978 and 2004:


(From Vehik 2007)

(For an excellent discussion of the increase in type 1 diabetes in the 20th century, see this review.)

This is no small matter. Just ask any parent of a child diagnosed with type 1 diabetes who, after recovering from hearing the devastating diagnosis, then has to stick her child's fingers to check glucose several times per day, mind carefully what he or she eats or doesn't eat, watch carefully for signs of life-threatening hypoglycemic episodes, not to mention worry about her child's long-term health. Type 1 diabetes is a life-changing diagnosis for both child and parents.

Various explanations have been offered to account for this disturbing trend. Some attribute it to the increase in breast feeding since 1980 (highly unlikely), exposure to some unidentified virus, or other exposures.

I'd like to offer another explanation: wheat.

Lest you accuse me of becoming obsessed with this issue, let me point out the four observations that lead me to even consider such an association:

1) Children diagnosed with celiac disease, i.e., the immune disease of wheat gluten exposure, have 10-fold greater likelihood of developing type 1 diabetes.

2) Children diagnosed with type 1 diabetes are 10-fold more likely to have abnormal levels of antibodies (e.g., transglutaminase antibodies) to wheat gluten.

3) Experimental models, such as in these mice genetically susceptible to type 1 diabetes, showed a reduction of type 1 diabetes from 64% to 15% with avoidance of wheat.

4) The increase in type 1 diabetes corresponds to the introduction of new strains of wheat that resulted from the extensive genetics research and hybridizations carried out on this plant in the 1960s. In particular, unique protein antigens (immune-provoking sequences) were introduced with the dwarf variant attributable to alterations in the "D" genome of modern Triticum aestivum.

Proving the point is tough: Would you enroll your newborn in a study of wheat-containing diet versus no wheat, then watch for 10 years to see which group develops more type 1 diabetes? It is a doable study, just a logistical nightmare. Perhaps the point will be settled as more and more people catch onto the fact that modern wheat--or this thing we are being sold called "wheat"--is a corrupt and destructive "foodstuff" and eliminate it from their lives and the lives of their young children from birth onwards. Then a comparison of wheat-consuming versus non-wheat-consuming populations could be made. But it will be many years before this crucial question is settled.

Yet again, however, the footprints in the sand seem to lead back to wheat as potentially underlying an incredible amount of human illness and suffering. Yes, the stuff our USDA puts at the bottom, widest part of the food pyramid.
Dreamfields pasta is wheat

Dreamfields pasta is wheat

An active question on the blogosphere and elsewhere is whether Dreamfields pasta is truly low-carb. Dr. Andreas Eenfeldt of Diet Doctor detailed his high blood glucose experience with it. Jimmy Moore of Livin' La Vida Low Carb had a similar experience, observing virtually no difference when compared to conventional pasta.

The Dreamfields people make the claim that "Dreamfields' patent-pending recipe and manufacturing process protects all but 5 grams of the carbohydrates per serving from being digested and therefore lessens post-meal blood glucose rise as compared to traditional pasta." They call the modified carbohydrates "protected" carbs.



In other words, they are making the claim that they've somehow modified the amylopectin A and amylose molecules in durum wheat flour to inhibit conversion to glucose.

I'd like to add something to the conversation: Dreamfields pasta is wheat. It is a graphic demonstration that, no matter how you cut it, press it, sauce it up, "protect" it, it's all the same thing: wheat. (It reminds me of a bad girlfriend I had in my 20s: She'd put on makeup, a pretty dress, I'd take her out someplace nice . . . She was still an annoying person who whined about everything.)

Wheat is more than a carbohydrate. It is also a collection of over 1000 proteins, including gliadins, glutens, and glutenins. Gliadins, for instance, are degraded to polypeptide exorphins that underlie the addictive potential of wheat, as well as its withdrawal phenomenon on halting consumption. Gliadin-derived exorphins are also the triggers of auditory hallucinations and paranoid delusions in schizophrenia, as well as behavioral outbursts in children with ADHD and autism.

Wheat is a source of lectins that have the curious effect of "unlocking" the proteins of the intestinal lining, the oddly-named "zonulin" proteins, that protect you from ingested foreign molecules. Ingest wheat lectins and all manner of foreign molecules gain entry into your bloodstream. Cholera works by a similar mechanism. (How about a love story: Bread in the time of cholera?)

Glutens, of course, are responsible for triggering celiac disease, the devastating small intestinal disease that now afflicts 3 million Americans, although 2.7 million don't even know it. Glutens are also responsible for neurologic conditions like cerebellar ataxia, peripheral neuropathy, and dementia ("gluten encephalopathy") and the skin condition, dermatitis herpetiformis.

Then there are the conditions for which the active wheat components have not been identified, including acid reflux, irritable bowel syndrome, asthma (excepting "bakers' asthma), rheumatoid arthritis, edema and fluid retention, and a long list of skin conditions from alopecia to gangrene.

My point: Yeah, Dreamfields pastas, from these instructive experiences, acts a lot like conventional durum wheat pasta. But, even if Dreamfields or somebody else perfects the low-carb aspect of it, it's still wheat. Modern wheat is the genetically tarted-up version of Triticum aestivum, the product of genetic shenanigans from the 1960s and 1970s.

Comments (11) -

  • Andrés

    5/28/2011 4:21:50 PM |

    Thanks for your work!

    I am not enrolled yet on track-your-plaque but I have read thoroughly your blog.

    I know you felt a different reaction to einkorn (diploid) to triticum (hexaploid), hence I wonder: have you (or any one around here, by the way) done some check yourself on durum (tetraploid)?

    I confess I am trying to cut back carbohydrates and pumping up fat, focusing specially on reducing triticum to a minimum (I favor a 60%-rye-40%-durum bread, since I "need" something to support my Gorgonsola and hard cheeses)  and am curious about the hardness about other branches of wheat (at least I found a paper about gluten seeming less aggressive on durum).

    Regards.

  • ceara sullivan

    5/29/2011 9:25:24 PM |

    Getting off wheat is very difficult for some of us. When we started a low-carb diet, we also eliminated wheat, rye, barley, and oats. And, of course, sugars in their various forms.

    My husband had no problems just quitting. I had to "step down" slowly or I became quite ill. From food.  Or rather, "food".

    We stil eat (very limitedly) legumes, rice (in the form of poha), and corn (as grits or as tacos). We don't have any of these in combination, however. IOW, on a day we have rice, we don't have the other two.

    If we cut those out entirely we'd lose weight more quickly I'm sure. However, this is working so far. Slow going but doable.

    A striking experience: after 25 years' smoking, being overweight, and a huge family history of vascular blockage in all my parents' sibs, I had the scan done a few years ago. The cardiologist who read my scan gave me a clean bill of health. My chances of a cardiac "incident" in the next five years was two percent. That was at age 65. I'm still amazed.

    So-called 'pre'-diabetes has reared its ugly head. I insisted on an (hb)A1c test last year and it came back at 5.8, much to my doc's surprise (but not mine). The next test, six months later, was 5.6 . I'll be interested to see if my weight loss has made a difference when it's time for the third one.

    It's great to be rid of wheat, but what a crime they have perpetrated on all of us. My grandson died at age 28, "heart problems". He was obese and addicted to wheat.

  • Alec

    5/31/2011 2:37:40 PM |

    This reminds me of the "Molecularly Baked" products they used to sell on the Zone Diet website. Absolute crap- lots of wheat combined with wheat protein (gluten?) and processed soy crap. Blah!

  • Dr. William Davis

    5/31/2011 4:07:29 PM |

    Hi, Andres--

    For all practical purposes, pasta made with durum wheat is still wheat. Semolina, durum, spelt, whole grain, multigrain, etc., it still remains essentially wheat. Pasta from durum, for instance, triggers sustained high blood sugars after consumption with all of the undesirable consequences that brings.

  • Abhi

    5/31/2011 5:45:57 PM |

    Dear Dr Davis,
    I love your blog!
    How do you compare this with the "Einkorn" (Jovial) pasta that you had tried and even blogged about.
    Thanks!

  • Alan D

    5/31/2011 8:42:43 PM |

    My experience with Einkorn pasta was a very small rise in blood sugar tested an hour and two hours after eating. I cooked the spaghetti and also the penne with tomato and garlic and olive oil. With regular wheat pasta my bg is 130-180. With Einkorn Jovial brand  it was barely over 100. I suspect everyone is a bit different though and some may have different results.

  • Dr. William Davis

    5/31/2011 11:17:49 PM |

    Abhi and Alan raise an important point: Einkorn is wheat, but it, I believe, far less destructive than modern Triticum aestivum, especially the dwarf variant product of genetics research.

    Einkorn is not entirely benign. After all, celiac disease was described even in the 1st century A.D. However, given a choice between modern low-carb Triticum aestivum or durum equivalents and einkorn, I would choose the einkorn, hands down.

  • Andrés

    6/2/2011 10:58:01 AM |

    Thanks for your answer!

    Well, I will try to reduce my durum intake also, then. I am now experimenting with breakfast without bread: I do an omelet with two eggs (three was a little too much a company to my white coffee), Gorgonzola and butter (I am still not convinced about the AGE issue).

    Regards.

  • Ingrown Toenail Remedies

    6/2/2011 11:08:07 AM |

    I’m a new reader and have been very impressed with your recent posts and thought to drop a friendly note. It is really a great information indeed. Waiting for more posts, is there a way to subscribe to your blog via email?

  • JT

    6/12/2011 5:12:58 PM |

    just tried a plate full of Dreamfield pasta with chicken cachitori sauce and it raised my BG to only 104 after an hour.

    I wonder it Dreamfield affects people differnetly

  • Nancy

    12/21/2011 9:27:07 PM |

    How the pasta is prepared is important to its effect on BG.  It can't be sitting around very long in a sauce, especially tomato, before the "protective coating" disintegrates.  Boil in water, drain, then put on sauce and eat.  Do not cook the pasta with sauce.  Do not store leftover pasta mixed with sauce.  Or just don't eat it at all.

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The nattokinase scam

The nattokinase scam

A conversation about vitamin K2 commonly leads to confusion. Several people have asked about something called nattokinase.

The scientific data on the potential role of vitamin K2 deficiency in causing both osteoporosis and vascular calcification is fascinating. Along with vitamin D3, vitamin K2 may be an important factor in regulation of calcium metabolism. Supplementation may prove to be a major strategy for inhibition of vascular calcification.

Obtaining K2 in the diet is tricky, since it's present in just a handful of foods: egg yolks, liver, traditional cheeses, and natto. This is where the confusion starts.

Natto is a Japanese fermented soy product. I've had it and it's quite disgusting. Nonetheless, Japanese who eat natto experience less fracture. (A parallel study in heart disease has not been performed.) Natto is also a source of another substance called nattokinase.

Advocates (otherwise often known as supplement distributors) claim that nattokinase is a "fibrinolytic", or blood clot-dissolving, preparation that "improves blood flow, protects from blood clots, and prevents heart attacks and strokes."

Don't you believe it. This is patent nonsense. There are several problems with this rationale:

--Any oral fibrinolytic agent is promptly degraded in the highly acid environment of the stomach. That's why all medically used fibrinolytics are given intravenously. Drug companies have struggled for years to encapsulate, modify, or somehow protect protein (or polypeptide) products taken orally from degrading this way. They've never succeeded. That's why, for instance, growth hormone (a polypeptide) remains an injection, not an oral agent. An oral growth hormone, by the way, would sell like mad, so the drug companies would very much like to figure out how to bypass the degradative effects of stomach acid. One of the "researchers" behind the nattokinase claims boasts that he has single-handedly figured out how to protect the nattokinase molecule in the gastrointestinal tract. However, he won't tell anybody how he does it. Right.

--Fibrinolytic agents are extremely dangerous. In years past, we used to treat heart attacks with intravenous fibrinolytic agents like tissue plasminogen activator, urokinase, streptokinase, and others. They have fallen by the wayside, for the most part, because of limited effectiveness and the unavoidable dangers of their use. Fibrinolytics are "dumb": they dissolve blood clots in both good places and bad. While they might dissolve the blood clot causing your heart attack, they also degrade the tiny clot in your cerebral (brain) circulation that was protective. That's why fatal brain hemorrhages, bleeding stomach ulcers, and blood oozing from strange places can also occur with fibrinolytic administration. Believe me, I've seen it happen, and I've watched people die from them.

The idea that a small dose taken orally is healthy is ridiculous. Even if nattokinase worked, why the heck would you take an agent that has known dangerous and very real consequences?

Don't let this idiocy reflect poorly on the K2 conversation, which, I believe, holds real merit and is backed by legitimate science. This is symptomatic of a larger difficulty with the supplement industry: Insane and unfounded claims about one supplement erodes credibility for the entire industry. It gives regulation-crazed people like the FDA ammunition to go after supplements, something none of us need. You and I have to sift through the nonsense to uncover the real gems in this rockpile, real gems like vitamin D3, omega-3 fatty acids from fish oil, and, perhaps, vitamin K2. But not nattokinase.

Comments (179) -

  • Anonymous

    6/2/2007 6:49:00 PM |

    Before you dismiss Nattokinase, please check out research done by Hiroyuki Sumi from 1987 (original discovery) and 1990, and subsequent research on how the compound has an effect on plasmin and other clot-dissolving agents.

  • Dr. Davis

    6/2/2007 10:12:00 PM |

    I have read his research. I stand by my opinion: Nattokinase is a scam. It is an utterly ridiculous notion that anyone should take oral thrombolytic agents to "prevent blood clots". Thrombolysis is a dangerous strategy, even if it worked in humans by the oral route. An agent that, if it worked, poses serious potential for severe side effects and death needs to be tested thoroughly first. It is plain idiocy to use this agent. It is not fish  oil, it is not a vitamin, it is something entirely different that has no basis for use as a preventive. You're throwing your money away.

  • Anonymous

    9/2/2007 5:33:00 AM |

    I actually don't find natto disgusting at all -- I think I am one of the few non-Japanese who like it.  I didn't realize it was so healthy for you.  Should I consciously add it to my diet?

  • Dr. Davis

    9/2/2007 1:29:00 PM |

    No kidding?

    Natto is an abundant source of vitamin K2, which may have a role in regulating calcium metabolism. Although not as crucial as vit D3, K2 is emerging as a potential addition to our program. See our full Special Report on vitamin K2 on the www.trackyourplaque.com website.

  • Anonymous

    12/18/2007 11:07:00 PM |

    "Fibrinolytics are "dumb": they dissolve blood clots in both good places and bad."

    That's true of anything taken orally, and is not much of a criticism. And there is little difference in risk between fish oils or aspirin, and typical nattokinase intakes. So the only point you're making that makes any sense to me is that nattokinase does not survive stomach acidity, but that is contradicted by studies where nattokinase taken orally did have an effect.

  • Anonymous

    12/19/2007 6:04:00 AM |

    "I believe you are failing to appreciate what fibrinolytics accomplish if they were truly being absorbed through the stomach: They are deadly. You have to be nuts to take an agent like this chronically if it worked."

    Problem is that it's even nuttier to be taking warfarin chronically, considering it's _known_ interaction with vitamin K - but that's exactly what is currently pushed. See www.vitamink2.org for discussion of the evils of warfarin - the surest route to osteoporosis and blood vessel calcification.

    Personally, I take K2-7, fish oil, etc., but am open to the idea that nattokinase may be able to offset the decline in plasmin production that occurs with age. Of course, it would be best if we had a (convenient) blood value to monitor to check dosage (something as simple as a blood glucose or INR meter). Certainly more research is needed.

    If not nattokinase, then how do you suggest that we address the increased risk of clotting with age? And how should the amounts of these alternatives be adapted to individual differences? (As exemplified by the issue of how much fish oil to consume.)

  • Dr. Davis

    12/19/2007 1:32:00 PM |

    I agree with you on the vitmamin K2 issue and certainly with omega-3. However, the whole lytic issue is truly nutty. Lytics are destructive. While warfarin (I'm no fan, either, and I put all interested warfarin-taking patients on K1 and K2 supplements if the warfarin can't be avoided, e.g., chronic pulmonary emboli, left ventricular thrombi, prosthetic heart valve--these people have no choice) prevents propagation of blood clot, it is NOT a blood clot dissolver. Lytic agents ARE. In other words, the little protective blood clot in the tiny defect in your middle cerebral artery that would have healed itself without consequence becomes a cerebral bleed. I know--I've seen it happen several times in the "old days" when lytics were popular. It even happens with the smaller doses used for localized clot dissolution introduced via specific delivery into the thrombus.

    Unfortunately, I don't have an answer on how to manage the acquired disorder of blood coagulation that accompanies aging. However, omega-3s are a big part of the solution.

  • Anonymous

    12/19/2007 2:49:00 PM |

    For the record, here's a summary of the argument for nattokinase, as promoted by Holsworth. If all of this turns out to be true, would you still be against use of nattokinase?

    Dr. Holsworth describes the actions of nattokinase as “Nurturing Nature”. The most therapeutic perspective property of NK is the indirect effect.
    1) inhibits PAI-1 (plasminogen activation inhibitor-1)
    2) upregulates individual’s own tissue plasminogen activator (tPA) anti-clotting mechanism
    3) converts endogenous pro-urokinase to urokinase
    4) has small anti-platelet activity – similar to garlic or onions
    Lyses cross-linked or dysfunctional fibrin. NK is 6 times more efficient than our own plasmin, but does not compete with cleavage of fibrinogen, so doesn’t attack anything that isn’t dysfunctional. Fibrin is the single-most causative agent that makes blood thick.
    -No direct tPA activity – no direct competition in clotting
    -No degradation of albumin by NK
    -Said to act like an Angiotensin Converting Enzyme inhibitor ACEi). Keeps angiotensin II down and in rat studies, thins the neo-intimal layer of inflamed blood vessels. He is not impressed with the clinical studies suggesting the ACEi effect; but clinically, it works as an anti-hypertensive medicine . He does find that people on antihypertensives decrease the amount of high blood pressure medication or eliminate them all together in 7 – 14 days.
    Dr Holsworth cautions that individuals on high blood pressure medicines, closely monitor their blood pressure and notify their primary care physician about any lowering of their blood pressure.
    Dr. Holsworth has seen significant decreases of 10-20 points of systolic and diastolic blood pressures within 7 days of starting nattokinase.
    -Linked to circadian rhythm. PAI-1 inhibits the ability to create plasmin. Clots occur early in the a.m. predominantly and, therefore, increase the stroke or heart attack incidence.
    Breaking down existing clots…
    NK has only slight or limited Pac Man capabilities to “eat away” directlyat existing clots, but rather “nurtures nature” by enhancing our own endogenous pro-fibrinolytic system. Small direct effect of less than 10% efficacy similar to plasmin where it works directly on a clot – Pac Man style. It will not break loose a clot.

    What is an ideal thyrombolyic agent?
    • Rapid – NK is effective within 4 hours PO (oral) administration and has significant fibrinolytic activity in blood vs. tPA which has that 3-hour grace period to initiate…so there is only one hour differential in ischemia situation. Additionally, tPA has short duration of effectiveness and must be taken intravenously..
    • Duration – maintain patency of vasculature – no early reclusions.
    • Sustained duration of action - half-life of NK is 8 – 12 hours. After tPA administration, patients are at an increased risk for the next 14 – 48 hours where patients are susceptible and have an increased thrombophilic state secondary to tPA IV (as in rebound effect).
    • Specific - no shotgun effect of cleaving any and all fibrin in the body… Specific or targeted…that’s what NK does with cross-linked fibrin.
    • Thrombosis–specific…doesn’t adversely affect coagulation factors or the coagulation cascade
    • Upregulates body’s own plasminogen system.
    • Low risk of hemorrhage - isolated cases of epistaxis (nose bleeds) – compounded by 4 – 5 other anti-platelet agents…garlic ginkgo, fish oil. Reduce intake.
    • Absence of systemic side effects.
    • Caution – if on antihypertensives, check blood pressure in 7 – 10 days. NK can quickly correct the body’s Hemorheology. Blood pressure medicines may have to be titrated down so individual is not over-medicated or discontinue use.
    • -Low cost
    • Per oral (P.O.) convenience (as opposed to IV).

  • Anonymous

    12/22/2007 3:24:00 PM |

    I should have mentioned that the above Holsworth summary is from Jackie on the www.afibbers.net forum.

    I guess I'm also interested in what Dr. Davis has to say about the use of nattokinase to treat fibroids, as exemplified by Fibrovan (www.fibrovan.com). Are all the testimonies faked? Or will all the patients soon die of some sort of internal bleeding?

  • Dr. Davis

    12/23/2007 12:31:00 AM |

    The data I've looked at re: nattokinase has been proprietary, generated clearly by a manufacturer. Until some real science emerges, even modest, to support this otherwise counterintuitive strategy, it remains something that has no value for our plaque reducing focus. The disease is not thrombus or clot; the disease is atherosclerosis. Clot develops when heart attack occurs. It makes no sense to take a lytic agent that dissolves clotes continuously. Unless I am missing something here, nattokinase remains squarely in the nonsense column.

  • Anonymous

    2/24/2008 2:38:00 PM |

    My wife has enometriosis with disabling pain and the treaments that the doctors have been giving seems to only make it wrose. I found aFibrovan on the internet stating that it would reduce the symptoms within in weeks with no side effects.

    Is this fibrovan similar to the scams in which you speak or does it have merit for endo an treatment?

  • Anonymous

    3/2/2008 2:33:00 PM |

    Thank you Dr. Davis for your comments re:  nattokinase.  As you know, the testimonials (at the product sites) are pretty amazing.  As my holistic MD is suggesting UFE or myomectomy, I'm thinking about trying one of the fibrovan, neprinol "fibroid dissolvers"!  I'm also taking codliver oil, turmeric and a pile of herbs to support liver function.  are all those testimonials lies?  maybe if we had an economic system based on love and caring instead of profit, we wouldn't be asking this question.  thank you again for your knowledge and care-it's clear that you do. lynn

  • Anonymous

    3/9/2008 12:18:00 AM |

    I don't have a heart problem.  I have had debilitating muculoskeletal pain for over 8 years.  Last week Friday, 3/7/08, I began taking a large dose of nattokinase.  Results were evident in fewer than 4 hours and continue today, 8 days later.  I am able to function without my usual pain medication and the adhesions and hypertone in my muscle tissue continue to decrease daily.  Do you have any ideas why?

    Thanks.

  • Anonymous

    3/19/2008 3:24:00 PM |

    I have spoken with my doctor who states that NK is being used currently in Germany to treat DVT's, clots, etc., and two of her heart patients also take it, one for over two years now (from Germany himself) and another woman for the past six months, both have improved health.  I also have many friends who have used NK to dissolve their DVT's who no issues what so ever, and with doctors involvement watching the progress.  Why is none of this ever talked about?  I haven't heard one report of a person dying from NK.  SH

  • Rett

    4/15/2008 3:31:00 PM |

    I an interested to know why you think, that if nattokinase were dangerous in that it may dissolve clots too quickly or inappropriately, how come users of natto do not report excessive bruising?

  • Anonymous

    4/17/2008 8:04:00 PM |

    As if conventional medicine is so great.  The United States spends more on health care than any other nation, yet as a recent study revealed we are dead last in outcomes.  I went to FIVE (5) physicians (PCP, ortho, GYN, etc.) over a 3.5-month period with left leg pain and swelling, and stated several times with these symptoms and the fact I'm on estrogen I think this is a DVT.  Response?  "Oh, no that's normal as we age.  Our veins become less efficient" (oh, please...what a crock)  The sixth physician, a pulmonologist, ordered an ultrasound that revealed an extensive proximal DVT.  If conventional medicine is so charming, please explain to me why it is so d*** incompetent.  A friend of mine went for a mammogram.  "We see something suspicious."  Pathology after biopsy-indeterminate x3, then "you've got lymphoma".  An oncologist was wanting to start chemo right away.  A PET scan and numerous labs were all NORMAL!!!  No cancer.  How pathetic.  How many people are receiving chemotherapy who never had cancer in the first place?  Perhaps Dr. Davis you need to open your mind!!  Most sincerely!

  • Anonymous

    4/18/2008 1:33:00 PM |

    I started taking Nattokinase for a DVT.  I was initially taking 2,000 FU per day then bumped it to 6,000.  Recent labs and ultrasound show IT IS WORKING!!  Fibrin degradation products are high and the ultrasound shows a resolving clot just weeks after diagnosis.  (Natto was started in the past 3 weeks; the higher dose within the last week.)  We've been using rat poison (Coumadin) since the early 1950s.  The hair thinning/loss, bloating, headache, etc. that accompanies Coumadin are known side effects though most doctors will tell patients they are not.  Are we to believe that in 60 years we can't come up with anything better to offer than Coumadin?  Studies have undeniably shown that after one year of "treatment" with Coumadin, more than 24 percent of people STILL HAVE residual clot.  Coumadin, of course, does not dissolve clots.  It only prevents new ones from forming and impacts the clotting cascade to enable the body to absorb the clot.  Nattokinase is a viable, effective alternative.  The real reason it is not studied in America is because it is a naturally-occurring substance that cannot be patented,i.e., no drug company can profit.  The Japanese people are the healthiest people on the face of the earth.  How thoughtful of Japan Air Lines to include natto in their snacks on their LONG-HAUL flights.  Obviously, they are proactive in their healthcare and attempts to prevent clots.  Just as American medical practitioners laugh at Nattokinase, I recall a time when we laughed at those cars called Toyotas.  No one is laughing now at the quality and high integrity of this company.  Now as then, perhaps we should stop criticizing and start emulating.

  • Anonymous

    4/18/2008 1:37:00 PM |

    Dr. Davis-you should be upfront about the fact that Coumadin is one of the top 10 reasons for emergency room visits in the United States.

  • Anonymous

    6/21/2008 2:39:00 AM |

    I like the saying "If all you have is a hammer, everyting you see is a nail".  I have seen many doctors on various occasions, lost a tooth because the dentist only had a hammer.  Now I have s second tooth that feels funny, and it will not be treated by a dentist.

    I started taking nattokinase a few days ago, 5000FU per pill once a day.  I do feel something different happening, but can't quite put my finger on it.  But it's not a feeling of being better.  As of now, I am feeling a bit numbness in both arms, and a location between the shoulder blades hurts a bit and changes in area now and then.

  • Dr. William Davis

    7/8/2008 3:47:00 AM |

    Looking back over these posts accumulating over the past several months, I note that some readers have interpreted my criticisms of the junk science behind nattokinase as an indirect endorsement of warfarin.

    That is plain wrong.

    I criticize nattokinase for making extravagant claims with virtually no real data in humans. If fibrinolysis truly developed with nattokinase, we would expect several deaths for every 100 people who take it, because that is the experience with any agent causing lysis of clots.

    If I advocate anything, it is truth. Be aware that, whether it's a drug manufacturer, a food manufacturer, or a supplement manufacturer, they are willing takers of your money.

    There are truly effective, powerful supplements out there. Nattokinase is not one of them.

  • Oswald

    7/12/2008 3:04:00 PM |

    This is an interesting debate on a couple of levels:

    (1) The assertion that "all" fibrolytic substances are broken down by the stomach environment. That should be all *known* substances. Just because you have always seen only white swans doesn't mean there aren't any black swans (see the philosopher Karl Popper to learn about being a real scientist).

    (2) Anecdotal evidence from myself. I try to be objective. I can't say anything about the anticoagulant effects of Nattokinase, but so far as I can tell it has some anti-inflammatory effect. I have monitored this in my own health.

    Of course we all need to proceed carefully when new substances are touted as having fabulous effects.
    Snake oil is ever present. We should also remember that most Doctors are not trained to be scientists, they seldom understand how science should proceed. So very often they retreat into dogma and blanket assertions. It wasn't so long ago that saying stomach ulcers were caused by bacteria would have caused a Doctor to be derided as a fool. Science and knowledge proceeds by conjecture and refutation, and while we do have to be careful of Snake oil, we also have to be aware that accepted dogma is often wrong.

  • Anonymous

    8/4/2008 6:07:00 AM |

    "If fibrinolysis truly developed with nattokinase, we would expect several deaths for every 100 people who take it, because that is the experience with any agent causing lysis of clots." - Dr. Davis

    Makes perfect sense, that as a oral thrombolytic agent, nattokinase very likely is a "scam."

    But, nattokinase's efficacy as an oral anticoagulant is not out of the question by the limited empirical evidence that exists.  Nattokinase begs to be studied in that regard, and should be before being totally declared a "scam."

    Would not nattokinase qualify as an important part of the TYP protocol if it does indeed prove to be an effective alternative for all thoughs people taking warfarin?

  • Gene

    8/22/2008 8:50:00 PM |

    I take it you disapprove of NK.
    Thank you for your insights.  It may or may not be that your paradigm colored your opinion, as it does with all of us, I suppose.  
    NK is an over-the-counter substance and, if taken on its face value, according to your analysis, it should be removed from the stores, as it is monkeying with primal forces.
    Therefore, either someone is asleep at the switch or the risk is not as purported (the risk of being ripped off is another department.)
    I think the scientific method is over-used as a sword and shield, yet doctors rely on their own experience all the time, even disagreeing with reports. My view there is no report not telling me to not eat wood screws.
    More real information is needed, but the drug companies, unlike what is suggested, will not be happy to find a cheap, generic solution to anything. though the president may use the solution. It is just the way reality has been organized.
    What is needed is a useful government, but we all know that is a wasted thought.
    Foreign research should not be put aside, not because to do so is some sort of racism, but because it may be balanced.
    Clearly, NK does something. We can't just throw our hands up and deny anecdotal experience, often quoted by intrigued doctors, and call people nuts. That may be sort of true, but it is a meaningless as blatant advocacy. Thus, we must wait and look for research, probably out of Japan.
    In the meantime, natto is OK if you add cinnamon. Forget that soy stuff.  Do this, and it is anti-inflammatory, too.
    Me, I am a fan of Serrapeptase and have not found much to dissuade me.

  • Anonymous

    9/8/2008 6:31:00 PM |

    Hello Dr. Davis

    While your credentials speak for themselves, I would submit that you simply do not have the nutritional background to support many of your claims re: Nattokinase. I base this on the typical Medical curriculum that includes on average a whopping equivalent of a weekend course at best... I suggest you look at the coagulation pathways that Nattokinase acts within and then you might be entitled to having an opinion that comes from reality and not your personal dogma.

  • Ryan W.

    10/5/2008 8:02:00 AM |

    Another fibrinolytic enzyme, serrapeptase, (which is also a serine protease) which is larger than nattokinase and also absorbed by the gut (if coated to pass through the stomach) is capable of breaking up bacterial biofilms, enhancing the effectiveness of antibiotics, and removing persistent bacterial infections.

    Serrapeptase is also used commonly as a painkiller and anti-inflammatory in Germany with no marked ill effects. The fact that it has fibrinolytic activity, is absorbed gastrointestinaly and still is safe makes me question your catagorical statements about nattokinase.

    I don't suppose you can cite any peer reviewed in vitro research that actually supports your view?

    The safety of natto aside for a moment, personally what I wonder is whether Natto's beneficial effects are from nattokinase or from a different serine protease found in natto.

    ----
    Because the control of the invasion of host cells by Listeria could potentially hinder its spread in the infected host, we have examined the effects of a protease treatment on the ability of L. monocytogenes to form biofilms and to invade tissues. We have chosen serratiopeptidase (SPEP), an extracellular metalloprotease produced by Serratia marcescens that is already widely used as an anti-inflammatory agent, and has been shown to modulate adhesin expression and to induce antibiotic sensitivity in other bacteria. Treatment of L. monocytogenes with sublethal concentrations of SPEP reduced their ability to form biofilms and to invade host cells.

    http://www.ncbi.nlm.nih.gov/pubmed/18479885?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

    CONCLUSIONS: Serratiopeptidase was effective for eradicating infection caused by biofilm-forming bacteria in this experimental animal model. The antibiofilm property of the enzyme may enhance antibiotic efficacy in the treatment of staphylococcal infections.

    http://www.ncbi.nlm.nih.gov/pubmed/16757752?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

    Among the different mechanisms of bacterial resistance to antimicrobial agents that have been studied, biofilm formation is one of the most widespread. This mechanism is frequently the cause of failure in the treatment of prosthetic device infections, and several attempts have been made to develop molecules and protocols that are able to inhibit biofilm-embedded bacteria. We present data suggesting the possibility that proteolytic enzymes could significantly enhance the activities of antibiotics against biofilms. Antibiotic susceptibility tests on both planktonic and sessile cultures, studies on the dynamics of colonization of 10 biofilm-forming isolates, and then bioluminescence and scanning electron microscopy under seven different experimental conditions showed that serratiopeptidase greatly enhances the activity of ofloxacin on sessile cultures and can inhibit biofilm formation.


    http://www.ncbi.nlm.nih.gov/pubmed/8109925?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


    These results indicated QK-1 was a plasmin-like serine protease and QK-2 a subtilisin family serine protease.

    http://www.ncbi.nlm.nih.gov/pubmed/14984705?ordinalpos=13&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

  • Dan

    10/8/2008 2:45:00 PM |

    "I don't have a heart problem. I have had debilitating muculoskeletal pain for over 8 years. Last week Friday, 3/7/08, I began taking a large dose of nattokinase. Results were evident in fewer than 4 hours and continue today, 8 days later. I am able to function without my usual pain medication and the adhesions and hypertone in my muscle tissue continue to decrease daily. Do you have any ideas why?"

    Dr. Davis,

    I have been taking NK since I wrote the quote, above.  In the past 6 months I have continued to experience improvement in my condition.

    I am a massage therapist, having worked on 1000's of clients, many with similar, but less severe, symptoms as mine.  I have never seen, nor experienced such a dramatic improvement in tissue health except with one client who began treatment with quinolin(many years ago), an anomoly to me at that time.

    I was a mechanical engineer, before head injury led to my physical dysfunction.  It is common, in every field of knowledge, for us to limit our options for problem solutions due to unfounded beliefs, often out of convenience, fear or ignorance.

    NK has allowed me to end my slow slide into physical pain and oblivion after more than 8 years of extensive, and intensive treatment(s) that had only succeeded in slowing my slide.  It has allowed me to return to massage practice, part time, to begin reconnecting with my family after years of isolation, and has given me reason to think that a return to engineering practice may one day be possible, too.

    That is a big claim, I realize, but it represents a careful evaluation of objective evidence of the beneficial action of NK in the human body, something I haven't found anywhere, to date. I don't know what makes NK work, but for people with hardened myofacsia, it improves their response to therapy, resulting in reduced pain and improved function in a much shorter time than is typical.  It's effects are obvious to palpation in less than 4hours.

    You have reason to question NK for lack of solid evidence. I don't expect my claim to change your position.  But I can tell you that my claim is solidly objective, the results are more repeatable than most medical claims, rising very near the level of empirical certainty.

    I hope this discussion leads others to unexpected solutions, as it has me.

  • Anonymous

    10/14/2008 5:59:00 PM |

    What the good Doctor unfortunately overlooks, is that most serious Nattokinase supplements are enteric coated tablets, and quite easily pass the acid barrier of the stomach, he also fails to mention that not all of Nattokinase, even in a non enteric protected form, is destroyed by stomach acid. For example , a diet rich in Natto, isn't suffering 100% lost to stomach acid, but rather a mere percentage, as with most any strict exclusive diet of one particular thing.

  • rudy

    11/19/2008 8:43:00 PM |

    i am taking natto 100mg primarily to make blood harder to clot, i have observed three things; 1) it is pretty potent, even with 100mg (2000FU), i had a bleeding in the gum is harder to clot, 2) my blood pressure have dropped about 8 points both high and low side, 3) like DAN, my myfascial pain is lessen ever since taking natto, at first i thought it was because of MSM, but actually it was natto that reduced my pain

    however, my father died from cerebal bleeding after he was given thrombolytic in ER for his heart attack, so i certainly do appreciate Dr.Davis point of view that sometimes clots are useful, and if you overdo it and use too much anticongulate agent (such as natto) it may have negative side effects one has to be careful

  • Anonymous

    12/3/2008 11:05:00 AM |

    By calling Nattokinase a "scam", one implies that current medical treatment is superior or less dangerous.  It encourages people on Coumadin to continue this dangerous drug, which has led to untold morbidity and mortality--and we won't go into the manufacturing debacles from China.  We really should not be comparing Coumadin/Warfarin (a product of the laboratory) with Nattokinase.  Coumadin and Warfarin do NOT dissolve blood clots. They simply prevent them from enlarging/prevent new clots, while the clots (hopefully) stabilize and do not embolize.  After stabilization of a clot against the vessel wall, one must exercise to increase plasmin in the blood in order to significantly affect breakdown.  Doctors DO NOT inform patients that Coumadin is not a fibrinolytic.  Most patients on Coumadin believe that Coumadin is breaking down their clots. Nattokinase supports the plasmin realm, working the way the body naturally does, to gradually break down clot constituents--no emboli are created.  ("-ase" indicates enzyme)  Some other enzymes and enzyme products can have anti-inflammatory properties, such as those naturally occuring in foods, those in the famous Wobenzym, and those in a number of digestive enzyme products absorbed through the gut.  Inflammation is a key factor in preventing aberrant clots.  But taking laboratory products, rather than foods or food derivatives, is what gets us in trouble.  We do not have the full knowledge of synergy in foods and conventional doctors tend to dismiss, rather than respect, what is unknown.  Synergy is why eating "live" food is so important.  I will stand by Hippocrates--"Let your food be your medicine and your medicine your food."  Treatments derived from foods (which have been alive) are safer than and, in the long term, superior to isolated, fractionated, or synthetic drugs.  Enzymes decrease inflammation because they allow it to resolve--breaking down the barriers in the circulatory and interstitial spaces, so that waste products can leave and nutrition can enter.  This may be why folks report effects on fibroids, muscle pain, and fatigue with enzymes such as Nattokinase and Wobenzym.  It supports the normal, continuous break-down/re-build process at work in the body.  Synthetic drugs target isolated effects (clots) from a bigger problem (inflammation) and fail to address root causes.  Enzymes have a more comprehensive effect--they also aid digestion, so that food does not putrefy, ferment, become rancid--absorption of which also causes inflammation and other undesirable effects on health.  We have 3 paths in the body that cause blood to clot and just one (plasmin) to break down clots. That speaks to the wisdom of the Creator--given a good, low inflammation diet of fresh foods with enzymes, clotting would not occur abnormally.  Bleeding (from injury), not aberrant clotting, would be the primary concern for us if we followed a healthy lifestyle.  With aging, there is more tendency to clotting--this parallels digestive problems (stomach, liver, gall bladder, pancreas, intestinal tract).  Conventional Doctors give acid preventer drugs, such as the purple pill, and antacids.  Natural doctors address healing of ulcers and leaky gut, if necessary, and give enzymes and hydrochloric acid supplements (HCl production declines by 1/2 by the time we reach 50--it's the lactic acid from food fermentation that typically causes heartburn).  One cannot   knowledgeably discuss whole foods or whole food derived supplements with a medical-style mindset--foods/phytonutrients are far more complex than synthetic drugs, and have  synergistic, protective effects that haven't been duplicated in the laboratory. Nattokinase is currently being researched for use in atrial fibrillation.

  • Anonymous

    12/10/2008 3:20:00 AM |

    I know someone who has essential thrombocytosis and her platelets were on a steady path upward until she started taking nattokinase with doctor supervision of her platelets.  They are now on a steady path downward and have already dropped by almost 400 in the last 2 months.  I'm not sure the risks are any moreso than taking a chemotherapy drug for the rest of your life which was the alternative. Anecdotal evidence should not be ignored.

  • lmontgom

    1/12/2009 4:11:00 AM |

    Nattokinase has been a miracle for me. I could barely walk or sleep because of chronic, pervasive pain in both my legs. My doctor x-rayed hips and knees, recommended replacements. She sent me to an orthopedist who asked if my knees and hips hurt. My "No" caused him to send me away. I asked for physical therapy. That helped little. Reading on the vitacost site, I found a comment on natto kinase that caused me to drive to my local health food store, buy some and take it immediately. By Day 2, my legs hurt much less. by Day 4, they stopped hurting. That was about 2 months ago, and the experience continues. In addition, occasional numbesses in my hands ceased. I urge Dr. Davis to look at the effects we are experiencing and find research telling him why it works. I know nothing about thrombolytics but am grateful that I have nattokinase and can walk!

  • Red Beard

    1/29/2009 5:35:00 PM |

    Everyone seems to be missing the most important argument against the effectiveness of nattokinase:  it is a protein enzyme, and there is not a single protein in this universe that can be taken up by our GI tract in its whole and active form.  Look at it this way:  there are a few rare diseases in which a person is unable to make some important enzyme on their own.  If enzyme replacement therapy is an option, this is always done intravenously, because we've known for a long time that you cannot introduce an enzyme in pill form and have it be functional in the blood stream.  If you could, enzyme replacement pills would be a multi-billion dollar industry!

    Yes, nattokinase may have all the effects that have been described vs. clotting, but this is only if you add it DIRECTLY to the blood.  The research that has been done that everyone quotes was not done by having people take this enzyme orally then examining their clotting function.  They either took blood out of a person and added it, or gave it to animals intravenously.  

    Secondly, even IF it was true that an enzyme like nattokinase could be orally active--which is impossible--its fibrinolytic properties would make it MORE DANGEROUS than aspirin in terms of serious side effects.

  • Karen

    2/10/2009 3:09:00 PM |

    and the alternative is coumadan (warfarin) WHICH IS RAT POISON. You are so wrong doctor.

  • Anonymous

    2/15/2009 1:50:00 PM |

    Nattokinase taken orally works, yoiu can find a lot of research on pubmed.
    Maybe stomach environment transforms it in something different, but what if that something is active against blood clotting?

  • Anonymous

    2/23/2009 6:41:00 PM |

    I have noted that NattoKinase as an oral blood thinner is asserted to be a scam here and the rationalisation for this is that there was no reliable research done to back it for what it is purported to do, right?.

    If I advocate anything, it is truth. Be aware that, whether it's a drug manufacturer, a food manufacturer, or a supplement manufacturer, they are willing takers of your money.

    Quote:
    "There are truly effective, powerful supplements out there. Nattokinase is not one of them."
    Dr.Davis

    Well what do you call asserting a negative (its a scam) without empirical research to back the assertion? Do we have the pot calling the kettle black?

    Apparently the research has proceeded to an empirical stage.
    A research summary can be seen here:
    http://www.xymogen.com/drr/RR-012-1104-07.pdf

    Excerpt from link;

    Research
    Two human trials and 17 other studies have been done
    on nattokinase. In a placebo-controlled study done by
    Dr. Sumi in which dogs were induced to have blood
    clots, oral administration of nattokinase (1 gm nattokinase
    as four 250 mg capsules) resulted in angiograms
    showing normal circulation and dissolution of the clot
    within five hours of treatment. In contrast, blood clots
    in the dogs receiving only a placebo did not show any
    signs of dissolution during the 18 hours following treatment.4
    Japanese researchers who studied nattokinase's ability
    to dissolve a thrombus in the carotid arteries of rats
    found that those given nattokinase regained 62% of
    blood flow, whereas those treated with plasmin regained only 15.8%.5
    Researchers from Oklahoma State University,Miyazaki Medical College and JCR Pharmaceuticals
    conducted a human study on 12 healthy volunteers (6 men and 6 women; ages 21-55 years). Before breakfast,each of the volunteers was given 200 grams of the food natto. Then, through a series of blood tests, the researchers tracked the fibrinolytic activity. On average, the volunteers' ELT (a measure of how long it takes to dissolve a blood clot) dropped by 48% within two hours of treatment. This heightened ability to dissolve blood clots was retained for 2 to 8 hours. In order to provide
    a control for the study, the same amount of boiled soybeans
    (non-fermented)was consumed by
    the volunteers. The same tests for fibrinolytic activity did
    not show any significant changes.6

    In recent years, several clinical trials on animals and humans have confirmed this action. A Wister rat study demonstrated on average a 12.7% decline in systolic blood pressure within two hours of a single administration of test extract directly into the
    peritoneum of the rats. These same researchers also confirmed the presence of angiotensin converting enzyme (ACE) inhibitors within the test extract of natto.7 The same extract was then tested on hypertensive human volunteers who took 30 grams of the extract for four consecutive days. In four out of five volunteers, the systolic blood pressure dropped an average of 10.9% and the diastolic dropped 9.7%.7,8

  • Anonymous

    3/2/2009 8:16:00 PM |

    During my last blood test, my C-Reactive Protein Test came out high (3.6) My doctor suggested nattokinase to see if that would reduce the inflammation.  After taking the nattokinase for a month I retested my CRP and the reading was 1.4.  Also, as a side note, I had continuous problems with a hemmroid which has disappeared.  I don't know if this was the nattokinase or not, but I wasn't taking anything else at the time.

  • FunkOdyssey

    3/3/2009 9:23:00 PM |

    You are incorrect in your assertion that nattokinase cannot be absorbed intact across the gut mucosa, and this is supported by published data in contrast to your opinion.  Its effects in humans after oral administration include a reduction of blood pressure:

    Hypertens Res. 2008 Aug;31(8):1583-8.

        Effects of nattokinase on blood pressure: a randomized, controlled trial.
        Kim JY, Gum SN, Paik JK, Lim HH, Kim KC, Ogasawara K, Inoue K, Park S, Jang Y, Lee JH.

        Yonsei University Research Institute of Science for Aging, Department of Food and Nutrition, College of Human Ecology, Yonsei University, and Department of Family Medicine, Mizmedi Hospital, Seoul, Korea.

        The objective of this study was to examine the effects of nattokinase supplementation on blood pressure in subjects with pre-hypertension or stage 1 hypertension. In a randomized, double-blind, placebo-controlled trial, 86 participants ranging from 20 to 80 years of age with an initial untreated systolic blood pressure (SBP) of 130 to 159 mmHg received nattokinase (2,000 FU/capsule) or a placebo capsule for 8 weeks. Seventy-three subjects completed the protocol. Compared with the control group, the net changes in SBP and diastolic blood pressure (DBP) were -5.55 mmHg (95% confidence interval [CI], -10.5 to -0.57 mmHg; p<0.05) and -2.84 mmHg (CI, -5.33 to -0.33 mmHg; p<0.05), respectively, after the 8-week intervention. The corresponding net change in renin activity was -1.17 ng/mL/h for the nattokinase group compared with the control group (p<0.05). In conclusion, nattokinase supplementation resulted in a reduction in SBP and DBP. These findings suggest that increased intake of nattokinase may play an important role in preventing and treating hypertension.

        PMID: 18971533

    Some evidence of the fact that nattokinase is an orally effective fibrinolytic agent in humans that can be dangerous when used improperly:

    Intern Med. 2008;47(5):467-9. Epub 2008 Mar 3.
        Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds.
        Chang YY, Liu JS, Lai SL, Wu HS, Lan MY.

        Department of Neurology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.

        Nattokinase is used as a health-promoting medicine for preventing thrombosis due to its fibrinolytic activity. Cerebral microbleed is remnant of blood extravasations from the damaged vessels related to cerebral microangiopathies. We report a patient, having used aspirin for secondary stroke prevention, who had an acute cerebellar hemorrhage after taking nattokinase 400 mg daily for 7 consecutive days. In addition to the hemorrhagic lesion, multiple microbleeds were demonstrated on brain MR images. We suggest that nattokinase may increase risk of intracerebral hemorrhage in patients who have bleeding-prone cerebral microangiopathy and are receiving other antithrombotic agent at the same time.

        PMID: 18310985

    It seems nattokinase should be contraindicated in certain high risk populations and should not be combined with other antithrombotic agents.

  • Anonymous

    3/9/2009 9:58:00 PM |

    I am curious about your blanket statement that fibrinolytics are dangerous. Many plants contain significant amounts of proteases that are fibrinolytic; these survive the acid of the stomach, and a portion is absorbed into the blood. Bromelain from pineapple is one prominent example; kiwis also contain a similar protease. These have been used in large doses for decades with few side effects.

  • DVT research

    3/20/2009 8:25:00 PM |

    Sumi's work was a great start, but now there is some momentum and the recent human trials are very interesting.

    Dr. Davis seems to have been a bit prejudicial. Some clinical MDs are very linear thinkers. Dr. Davis, I hope will open his mind.

  • Anonymous

    3/23/2009 5:05:00 PM |

    The nattokinase bottle states not to take it with any type of blood thinning medication or anticoagulant.  Aspirin of itself can cause a brain bleed

  • Jonathan Byron

    4/3/2009 12:59:00 PM |

    Blanket assumptions that proteolytic enzymes simply cannot be absorbed should be reconsidered.

    Here a study that found that orally administered bromelain enzyme is absorbed into the blood intact.

    Intestinal absorption of undegraded proteins in men: presence of bromelain in plasma after oral intake.


    Here are the conclusions of another review on bromelain:
    Bromelain, a standardized complex of proteases from the pineapple plant, is absorbed unchanged from the intestine of animals at a rate of 40%; in animal experiments it was found to have primarily anti-edema, antiinflammatory, and coagulation-inhibiting effects. These effects are due to an enhancement of the serum fibrinolytic activity and inhibition of the fibrinogen synthesis, as well as a direct degradation of fibrin and fibrinogen."

    On the pharmacology of bromelain

  • joker247

    4/5/2009 6:34:00 PM |

    just a comment on surviving stomach acid - I have UC, so I don't take blood thinners (if I started bleeding internally, where would you put the tourniquet?)
    However I do take an anti-inflammatory called ASACOL which has a polymeric coating that only dissolves in an alkaline environment so that the active ingredient gets where it needs to go, the colon. Unless this coating process is patented, it seems that it IS possible to have an active ingredient survive stomach acid. I'm not one to jump on the bandwagon of sensationalized products - as a former chemist I have a bit of wisdom in that regard - but if you really want to get something past the upper digestive tract it seems quite possible.

  • Anonymous

    4/8/2009 6:20:00 PM |

    My opinion is its all about the money  If you are protecting the Drug Companies,than only 3 people know about it. You,.the Drug Companies, and GOD. Every drug made has killed more people than it has cured. Eternity is a very long time I wish you the best

  • Anonymous

    4/14/2009 4:25:00 PM |

    April 14, 2009 Tues. I am 80 year of age, I have been eating fresh made Natto every day for the past 6 years.  My neuclear stress test has shown that I have a 52% blood flow thru my left ventricle of my heart, which I have been told by my doctor is very exceptional and good. Blood pressure rarely above 120/80 Natto is good for you, eat it.  These scientific guys are wrong quite often????

  • Anonymous

    5/3/2009 7:31:00 AM |

    I spent 25 years in medicine. I used to be somewhat close-minded or skeptical to some things so far as natural supplements were concerned.

    I feel that Dr. Davis is obviously close minded and speaks more like someone who is backed by Big Pharma.

    Dr. Davis -- There IS research out there and proven studies advocating the use and effectiveness of nattokinase. You just do not want to hear it for whatever reason.

    Here is a brief article written by pharmacist Dave Foreman who is an RPh, ND and well known author, lecturer and radio host:

    "In 1980, Doctor Hiroyuki Sumi was in the middle of searching for a natural agent that had thrombolytic effects (able to break up blood clots). The enzyme he was looking for would be able to dissolve the clots associated with heart attacks and stroke. After testing over 100 natural foods as potential clot busters, Dr Sumi accidentally found what he was looking for when Natto was dropped onto artificial thrombus (fibrin) in a Petri dish. The thrombus around the Natto dissolved gradually and had completely dissolved within 18 hours. Dr Sumi named the newly discovered enzyme "nattokinase", which means "enzyme in natto".

    To understand the importance of this discovery, let's go back to biology class for a second. Blood clots form when strands of protein called fibrin accumulate in a blood vessel. In the heart, blood clots cause blockage of blood flow to muscle tissue. If blood flow is blocked, the oxygen supply to that tissue is cut off and it eventually dies. This can result in angina and heart attacks. Clots in chambers of the heart can mobilize to the brain. In the brain, blood clots also block blood and oxygen from reaching necessary areas, which can result in senility and/or stroke.

    For many, Nattokinase may be the biggest discovery for natural approaches to cardiovascular health. But what is Nattokinase? Nattokinase is a potent fibrinolytic (breaks down fibrin) enzyme extracted and purified from a traditional Japanese food called Natto. Natto is a cheese-like food and is produced by a specific fermentation process of soybeans. Natto has been used in Japan for over 1,000 years for cardiovascular support and to lower blood pressure. Natto is the only preparation that contains the remarkable nattokinase enzyme with fibrin-dissolving properties.

    Why is Nattokinase so important? The enzyme is capable of breaking down and dissolving blood clots formed in a vessel or heart chamber and can enhance the body's natural ability to fight clotting of the blood. Unlike the class of medications called antithrombin, Nattokinase produces a prolonged action (lasting from 8 - 12 hours) in preventing coagulation of blood and dissolving existing clots.

    As a pharmacist and ND, I think that this discovery is and should be considered a major discovery for those concerned with cardiovascular health issues and general overall health. I come from a family history of cardiovascular disease and have started using Nattokinase personally to help prevent circulatory episodes in the future.

    Beyond the more obvious uses mentioned above, Nattokinase has shown to provide other health benefits. Here is a small list of some of the other potential health benefits of Nattokinase:

    Hemorrhoids and varicose veins
    Diabetes (caused by pancreatic dysfunction)
    Senile dementia
    Fibromyalgia
    Muscle spasms
    Poor healing
    Chronic inflammation

    I believe in using Nattokinase in combination with other enzymes. I believe in using balance and enzymes are no exception to this philosophy. Enzymes support many different facets of health and in this case, Nattokinase is the one to use for cardiovascular health. Regretfully, for those of us who are healthy, it is hard to notice any changes, but with the science behind Nattokinase, you can get piece of mind knowing that you are doing something proactive to help your cardiovascular health.

    Nattokinase is extremely important for circulation and circulatory disorders. If you look at the physiology of the body and understand how Nattokinase works, you can easily understand why this may be a supplement that even the healthiest of people would want to use.

    Finally, the one concern many natural health enthusiasts have is about safety. When looking for a quality Nattokinase, you need to look for one with the vitamin K removed. Natto contains the highest concentration of Vitamin K known in food. Significant amounts of Vitamin K2 are produced during the fermentation process of Nattokinase. By removing most or all of the Vitamin K2 you will eliminate any potential adverse drug interactions with warfarin (Coumadin), a Vitamin K antagonist pharmacological agent typically used an anticoagulant."

    I seriously hope that Dr. Davis will drop the attitude towards nattokinase and open his mind to the PROOF that IS out there supporting the use and  effectiveness of nattokinase.

    Making false statements such as calling nattokinase "a scam" makes people even more leery of doctors in this day and age. Rightfully so.

    Big Pharma has so many Dr's. blinded (or in their hip pockets) in this day and age and I feel that this may also be the case with Dr. Davis.

    I too made mistakes in putting too much faith in alopathic medicine and my own training. That all changed when I developed many significant health issues and was at one time on a dozen different prescription meds daily.

    No longer. I take natural supplements and my health is greatly improved. I'm on only 2 or 3 medications per day. Modern pharmaceutical agents almost cost me my life!

    Let's wake up people. Prescription medications and ignorance are the real killers!

  • Anonymous

    5/3/2009 7:39:00 AM |

    Dr. Davis - I encourage you to do some research on Dr. Stephen Sinatra. He is a board certified Cardiologist and nationally known speaker and best selling author.

    Dr. Sinatra advocates the use of Nattokinase and has switched many of his patients to taking it as opposed to harmful pharmaceuticals.

    Yes, there is the need for coumadin in some cases - but Dr. Sinatra has wondeful success with patients taking nattokinase!

    You owe it to yourself to check out Dr. Sinatra and what he has to say about Natto. There are enough documented studies that promote the safety and effectiveness of nattokinase.

    I hope you too will come to the realization that Nattokinase is not a scam and does in fact work!

  • Anonymous

    5/5/2009 12:10:00 AM |

    I have fibroids and a cyst on my only ovary-I have never had children and I want to. Can Nattokinase help me? What affect will 100 mg 2000 FU do for me or to me? I want real help because I am running out of options that will keep my fertility intact and rid some of these fibroids so they don't take over my uterus. PLEASE HELP!

  • Anonymous

    5/7/2009 5:04:00 PM |

    Anyone wondering if nattokinase can survive the gut and enter the bloodstream has only to search PubMed. Dr. Davis is incorrect in his assertion that nattokinase is rendered ineffective by transit through the gut. There are interesting studies suggesting that nattokinase can lower blood pressure and inhibit restenosis after angioplasty.

  • Anonymous

    5/21/2009 9:40:29 PM |

    Does anyone know, if when taking Nattokinase, a person can remain active in contact sports or does it thin the blood too much?

  • KRyan

    5/22/2009 5:12:44 PM |

    If your worried about stomach acid destroying nattokinase or any other acid sensitive supplement, just make sure your stomach acid is low. Take them on an empty stomach when there is no need for stomach acid. Take them with water to dilute the acid. I think you'll be surprised at how high the ph will go just from the water alone. (I wonder if people drink to many fluids with their meals and it hinders digestion or puts stress on the body to produce greater loads of acid) More info on stomach acid and reactions with food, supplements,enzymes etc http://www.care2.com/news/member/956805373/322081

  • terraoutwest

    5/28/2009 10:25:06 PM |

    Factor Five Leiden is my main problem, not the usual plaque and cholesterol type issues with blood clots. I recently had a minor heart attack where the blood clot developed in the heart itself (they think) and now I'm on warfarin 5mg. I'm an athlete and although I don't intend to "hurt myself, (who does?)the opportunity for bumps, bruises and scrapes is there. I really don't like the other side effects of warfarin either. I would really like to get away from the pharmaceuticals and on to something more natural with less (or no) side effects. Surely there is some other way to manage Factor Five patients who are otherwise quite healthy. And... I miss my leafy greens!  Any research out there on management of Factor Five without Coumadin?

  • Carla B

    6/4/2009 4:52:48 AM |

    To the person who posted anonymously on december 9, 2008. I am desperately looking for a natural way to treat my escalating thrombocytosis. Would love to talk to your friend. If you're still tuned into this post, please reach me at purpledots at pacbell dott net. I would be forever grateful.

  • Anonymous

    6/4/2009 5:18:50 AM |

    To the anonymous person who left the comment on December 9, 2008 with the friend who's thrombocytosis was improved with nattokinase: I'm desperately trying to find something natural to treat mine. If you're still tuned in to this post, please drop me a line at purpledots at pacbell dott net. I would be forever grateful.

  • Anonymous

    6/10/2009 2:39:19 PM |

    I have various fibroids - the biggest is the size of a canteloupe - or was - since taking Natto for 2 weeks - it is shrunk. I cannot say that it was the Natto for sure, but I changed nothing else.  

    Natto was easier for me to find that Nattokinase.  I have heard that Natto is not popular amongst Westerners but I have no problem with it.

    If it helps those willing to try - its texture is like a tin of baked beans mixed into a tablespoon of a beaten egg. While at the Asian supermarket - where I bought the Natto in the chilled storage section - I also bought a bottle of Chili Soy Sauce (from the Chinese section) and the Chili Soy Sauce is yummy with the Natto.  But then I do like Chili Soy Sauce.  Its worth trying. The Natto that is - add a sauce flavor you like, if it makes it more palatable to you.  The real Natto is way cheaper than the supplement, and in my view it is the supplement manufacturer's that are putting us off eating the cheaper, natural Natto by saying things like it is disgusting - but then some people don't like beaten egg.  PS there are many different types of Natto and I am working my way through.  I can't read Japanese - so all I can tell you is so far I like the ones in the Green wrapper and also the ones in the yellow wrapper.  They are stacked as three small trays each and I eat half a tray every 2 days.

  • Anonymous

    6/14/2009 4:33:21 PM |

    My father had a DVT 2 years ago.  He was started on heparin and then switched to coumadin and had complete resolution of his clots.  He didn't like the idea of being on warfarin for the rest of his life and switched to natto instead.  He had not been feeling well over the course of the past 3 weeks but didn't want to see his doctor until he collapsed at home and was rushed to the ED via ambulance.  He had numerous pumlmonary emboli as well as large clots in his pulmonary artery and the veins of both legs.  The doctors told him that he had probably been throwing clots for weeks if not months.  He is set to be released today and is already talking about when he can get off the warfarin and back on the natto.  I think this is clearly a failure of the natto to prevent and/or treat the clots.  I do not know if the warfarin would have prevented them or not, but due to the number of clots in multiple vessels I am pushing for him to continue the warfarin.  Warfarin certainly has side effects but it is the gold standard for preventing blood clots.  Unless there is a study natto is superior to warfarin then I wouldn't recommend using it.  BTW he had been taking natto for several years prior to his first DVT, so it didn't prevent that one either.

  • terraoutwest

    6/15/2009 2:46:58 PM |

    What about the earthworm based lumbrokinase? Anyone out there tried this?

    It sounds more disgusting than Natto, but I believe there have been more/better studies on it and has accepted as a better alternative (at least) by the Naturopathic doctors.

  • Anonymous

    7/6/2009 2:15:22 AM |

    Anonymous, June 14, 2009 :

    What brand name of Nattokinase did your father take? Be assured there are REPUTABLE brands out there, but also MANY FAKES!

    Just because a brand is cheap does not mean it is reputable. Many of the fakes out there claim to be reputable, and even provide you with a 'certificate', but in reality they have no active ingredients!

    A reputable brand would be (as an example) Allergy Research.

  • Anonymous

    7/6/2009 2:22:54 AM |

    terraoutwest  May 28, 2009

    Nattokinase might just be your ticket. It has virtually no side effect;, the 'real' stuff has no vitamin K in it, so it can be used with warfarin, but if you do it w/o warfarin, then you can eat and drink whatever you want to and however much you want to. The only thing you should not do is to take nattokinase together with other enzymes. Wait a couple hours between each.
    I have factor v leiden, and am on nattokinase since about eight years now. No clots.
    Cannot overdose on it either. Make sure you get a reputable brand.

  • Anonymous

    7/11/2009 4:00:19 AM |

    RE:"Everyone seems to be missing the most important argument against the effectiveness of nattokinase: it is a protein enzyme, and there is not a single protein in this universe that can be taken up by our GI tract in its whole and active form."

    Never say never, or should I regret having just violated that rule by saying never.

    Prions are a class of proteins that modify other proteins.  If taken orally, it will cause illness like mad cow disease.  It is believed that the prion modifies other proteins in the brain in a cascading fashion, eventually causing total cns dysfunction by converting increasing number of proteins into more prions.

    My point, saying all proteins can not survive low pH in the stomach is too broad of a statement to make.  I am afraid modern sciences is not yet able to explain all events that can take place in the body.

    Saying one should be skeptical of nattokinase is justifiable, but declaring nattokinase to be a scam is a claim that calls for more evidence, in my opinion.

    If I witness first hand cases in which natto proves to be effective, I will then become skeptical of the claim that nattokinase is a scam.

    I hope the same will be true for Dr. Davis.

  • Anonymous

    7/19/2009 11:49:43 PM |

    Nearly a year ago I could barely function due to endometriosis. I was working from home only a few hours a week because the pain was so bad. I just wanted to lay around and have someone put me out of my misery.

    I then began purchasing Fibrovan which has nattokinase in it. It didn't take long before I started noticing positive results. Little by little I started improving. The pain began lessening. My blood pressure improved.My energy improved. I was able to go for long walks and I'm back working full time outside the home, doing a very physically demanding job working in a hospital.

    A scam is something that is  fraudulent or deceptive. I in no way feel like I have been scammed. My health has improved and for that I am thankful.

  • citizen alan

    7/20/2009 5:08:10 PM |

    I think the work of Linus Pauling definitely indicates that EVERYONE on ANY sort of anti-coagulant should be supplementing with Vitamin C. My dad was taking aspirin (as a preventative) without letting me know and wound up with blood collecting in his eyes.  Permanently half-blind, a condition that I believe would have been totally avoidable had he also supplemented with at least 500 mg/day of Vitamin C.

  • Anonymous

    7/24/2009 6:30:18 PM |

    My husband and I eat natto, and while not Japanese, I have come to like it. We buy several packs and freeze them.

    We think natto tastes good with chopped green onions or chives, and/or some grated daikon radish, along with a bit of soy sauce.

    Sometimes we also mix natto with a bit of soy sauce, a very small amount of grated ginger, finely shredded radish leaves (leaves of the familiar small, red-skinned-white-inside radishes), and some of the dried fish flakes called "katsuobushi," which is available in small packets at Japanese food stores.

    If you eat natto along with rice, it will probably be easier to get down.

  • Anonymous

    8/5/2009 10:33:31 PM |

    Dr. Davis,

    I don't know if you are right or not on this matter.  If the stomach destroys Nattokinase, how then is there any effect, good or bad?  My wife has fibrosis in her bone marrow and we just discovered today that this substance may stop or reverse this activity.  The alternative is a steady downgrade and finally death.  I am concerned that she is on a baby aspirin along with her chemo as that might not be a good thing to take with this; we will be seeing the oncologist next week again and ask.  

    In any case, I appreciate your attempt to warn, and hope that whoever does not agree would be kind in their remarks and suggestions.  Thank you.

  • Anonymous

    8/12/2009 8:01:50 PM |

    My experience is only anecdotal. After going through a triple by-pass I was put on Plavix, aspirin, etc.  I din't experience the blotches (internal bleeding) that a co-worker who had a stent put in did.  

    But when I added NK about 5 months in I did experience them and consequently cut the Plavix rather than the NK.

    That was a couple years ago and still continue the NK. Wouldn't mind trying the Natto though I would have to go up to Tucson to get it.

    So it could have been just a coincidence but as an engineer I don't really believe in them or half the crap the medical community tries to foist off as fact.  No offense, Doc.  Smile

  • lmontgom

    8/19/2009 8:51:51 PM |

    Dr. Davis:
    Why have you been silent on nattokinase for so long?  I continue to derive great benefit from it.  I would not be walking today because of muscle weakness and pain were it not for nattokinase, which I buy from vitacost.com.

  • Anonymous

    9/8/2009 6:58:32 PM |

    VERY TELLING how Dr. Davis has disappeared, stopped replying when confronted with the double-blind studies that show he's wrong.

    I'm disappointed.  I was considering signing up for the Track Your Plaque program, but forget it.

    This guy has shown that if he's not selling it, he's not buying it either.

  • Fran

    9/22/2009 4:13:25 AM |

    I searched your blog for "serrapeptase", another supplement that claims to be a natural Chelation-Anti-Inflammatory. From serrapeptase info website: "Serrapeptase digests non-living tissue, blood clots, cysts, and arterial plaque and inflammation in all forms." Have you written any blogs about this product?

  • Anonymous

    9/26/2009 3:24:59 PM |

    lmontgom said...
    Dr. Davis:
    Why have you been silent on nattokinase for so long? I continue to derive great benefit from it. I would not be walking today because of muscle weakness and pain were it not for nattokinase, which I buy from vitacost.com

    Please tell me what brand name you bought, I want to be sure to get one that someone has experienced success with! i have always experienced heavy bleeding during menstration but 2 yrs ago it got worse, now I have been bleeding for 3 weeks VERY heavy, hemoglobin down (will need blood transfusion soon), i have fibroids and i have an ultra sound scheduled to see if the fibroids have increased in size, but the treatments that my dr has suggested are ablation or hysterectomy (have 2 children and although I don't currently want any more, not sure if i am ready to close that door, still in my 30s).  I've spoke to many women who have experienced this and am just appalled that some dr's i have seen sit so nonchalant while i explain what is happening as if flowing quarts of blood out of you is completly acceptable!!  Although I have read reviews where nattokinase has not worked for some people, I have not read any reviews where people have experienced negative side effects.  I will try nattokinase and post again, but again, what brand do you buy, I want a reputable brand?

  • Anonymous

    9/28/2009 3:54:08 PM |

    I am interested in NK. This forum has been on for over two years initiated by valid criticisms from Dr. Davis. The respondents are all intelligently fluid in their arguments. There is one thing missing.

    Dr. Davies mentioned side affects of good blood clots dissolving. I imagine anyone with these symptoms would be very miserable or dead and the diagnosis of cause very, very difficult. Of the previous respondents how many have suffered these symptoms? How would we ever know? Could everyone who is PRO NK assign a close relative to update this forum if something happens?

  • Anonymous

    10/1/2009 5:03:44 AM |

    As a mother of 3 adult sons, I have a dilemma! My youngest son (25 yrs) was recently diagnosed with a DVT in his leg. While my oldest son (today 34 yrs) had a blood cloth in his brain 6 yrs ago. Doctors then declared to be a "very rare" case and not to worry that it would happen again. Last Sept, he developed a DVT in his leg. He is now on Coumadin for life.

    I had contacted a Naturopath earlier (Feb 09) who told me that he has helped many patients with similar conditions with Nattokinase.
    As my boys are very young in age (tests do not show genes as both parents have no problems) I would really appreciate some feedback.

  • Tom

    10/19/2009 5:46:32 AM |

    To many people with so little grasp of basic physiology.

    1. Proteins are denatured in the stomach, not degraded. Degradation occurs in the small intestine and can not be avoided because this is also the purported  site of absorbtion.

    2. Intact proteins can not be absorbed. If intact proteins could be absorbed, pretty much all food would be 100% fatal.

    3. If Nattokinase did even half of what is claimed, Dr. Davis is quite right, it would kill you.


    I think most of the miracle cures being claimed by other commentors are either placebo, or missattributed. (I might point out that, in most cases described, the symptoms alleviated could have resulted from a severe vitamin K deficiency, and might be alleviated by the fact that these crude isolates of natto CONTAIN VITAMIN K)




    Nattokinase is produced and market heavily by the same guys who sell you trypsin and chymotrypsin pills in the form of wobenzyme with the claim that those enzymes are able to have a systemic effect.  Clearly the naturally occurring enzyme trypsin (which functions to lyse proteins in the small intestine) could not possibly leave the small intestine without killing you.


    I had a dog once that had a intestinal defect that did allow intact proteins be absorbed from its intestine. Obviously this dog didn't live very long. Think massive fluid imbalances and kidney failure.

  • Dr. William Davis

    10/19/2009 10:04:18 PM |

    Hi, Tom--

    Excellent points.

    The fanaticism that surrounds this absurd approach continues to astound.

  • Anonymous

    10/20/2009 10:52:51 PM |

    From one who has taken nattokinase for a couple of years I find your comments while logically consistent - wrong.

    Nattokinase blew out my arteriosclerosis as evidenced by the elasticity of my blood vessels, reduced my BP. and appears to have cleared out my blood debris. It doesn't replace fish oil, so I will take both - intemittently.

  • Anonymous

    10/22/2009 2:51:32 PM |

    So, how do you research the companies, marketing Nattokinase, to know if the ingredients are real or not?

  • Anonymous

    10/26/2009 1:02:17 AM |

    There is research the supports the concept that the human GI tract can absorb intact proteins:

    http://ajpgi.physiology.org/cgi/content/abstract/273/1/G139

    http://arjournals.annualreviews.org/doi/abs/10.1146%2Fannurev.nu.08.070188.001553

  • Tom

    10/26/2009 6:06:40 AM |

    That first link is only pseudo science done on a small scale by scientific guns for hire, (note that the institute La Fey specializing in being contracted by private R&D entities, and also observe that each author has published about 1 dubious article in just about every field).

    The second only involves trace absorption of 2-3 residue peptides, with some exceptions due to the role of erythrocytes as antigen presenting cells.  It is possible that this mechanism would allow an ingested peptide to be presented intact or in fragments to the immune system with immunomodulating effects(as is clearly the case with certain foodborne allergies and conditions). It is possible that these enzyme products might produce a beneficial effect through that or other unknown mechanisms, but the makers of these products do not make that claim, perhaps due to its complexity. Rather, they invariably make simple, easily marketed claims.


    But that is besides the point,
    those who market and promote Nattokinase and other "enzyme" healing products deceptively make claims that are unsupported, contradictory, and physiologically unfeasible.   One should always be wary of any product, natural or otherwise that makes broad unsupported claims as to how and what it does.

  • lmontgom

    10/26/2009 7:15:16 PM |

    Everyone -- users, researchers, docs -- should remember that each human body is unique.  For those of us who have used nattokinase and say it works (meaning it stops the pain, in my case), who are you to say that we should discontinue it?  I will order natto itself just to be sure nothing has happened in the processing of nattokinase that changes its impact in the body.  Until then, I will use what works for me and trust that Dr. Davis and the rest of the nay-sayers would do the same.

  • Anonymous

    10/29/2009 5:30:58 PM |

    Dear Doc -
    if NK is a scam like you say, then how can it be dangerous?  since a scam is afterall a fake.    yet you say the people who eat the food get some kind of benefit and no ill effects?    

    this does not make any sense.

  • Anonymous

    10/29/2009 11:14:55 PM |

    Not sure what you mean by "pseudoscience" in terms of bromelain absorption (the protein in question my posting of 10/25).  

    This would no doubt come as a surprise to Sloan Kettering Cancer Center, who states:  "Orally administered bromelain is absorbed intact through the intestine. Because of its proteolytic activity, about 50% of bromelain is rapidly complexed with an antiproteinase, namely alpha-2-macroglobulin (AMG). Proteolytic activity is maintained within this protective molecule, but reduced. In a recent human study, plasma half-life was determined to be 6-9 hours. Orally administered bromelain is absorbed at a rate of 40% in animal studies."

    I would also remind you that cyclosporine is an 11 polypeptide molecule that is administered orally.


    Thrombolysis is a natural occuring event.  All blood clots secrete thrombolysins. The question is now much, how its mediated, etc.  It's like saying no one should take Coumadin or Lovenox, because they would all become hemophiliacs and bleed to death.

    I would agree that the story on nattokinase is not complete.  But calling it a "scam" is merely the obverse of calling it a "miracle drug."

  • Tom

    10/30/2009 4:09:16 AM |

    Seriously? You refute me refuting your paper by citing a source which cites the same fake research paper? It is pseudoscience because all the names associated with the paper are people are hired to write whatever paper/conclusion you want. BTW, the paper only goes so far as to say that over a 48 hour period 10.8 micrograms were in the ENTIRE plasma. May I offer you a book titled "How To Lie With Statistics"?


    For a much more in depth study of bromelian absorption look for a 1971 study published in the Japanese Journal of Pharmacology titled Gastrointestinal Absorption And Anti Inflammatory Effect of Bromelian. That study was done in dogs, but they found the half life of intravenous bromelian was only about one hour. They also found that less than .052% of a intraduodenal dose of labeled bromelian was absorbed "intact" based on the assumption that radioactive proteins of similar mass and isoelectric point found in the plasma were in fact bromelian. Their immunological assays detected that the actual amount of bromelian was MUCH less.  The absorption you quote, 40%, is absurd.

    Also, cyclosporine is only 11 residues long, cyclic, and composed of D-amino acids not normally encountered in nature.  11 is much smaller than 275 for nattokinase.  Yes some proteins can be absorbed, like botulin toxin (on a nanogram scale), but not the huge amounts claimed by the natto guys.

  • Anonymous

    11/4/2009 1:24:26 PM |

    Why would someone buy supplements? The whole supplement industry kinda' confuses me over all. Nattou is delicious... just eat nattou. There are lots of foods that have vitamins and nutritional value that you can receive if you just eat a varied diet. As long as you're eating a variety of healthy foods, taking supplements is a big fat waste of money!

  • Chris33780

    11/11/2009 9:29:45 AM |

    Dr Davis said: "The data I've looked at re: nattokinase has been proprietary, generated clearly by a manufacturer. Until some real science emerges, even modest, to support this otherwise counterintuitive strategy, it remains something that has no value for our plaque reducing focus."

    Why would the FDA bother with producing real science on something they cannot patent and gain a return on their investment? I am not going to fall for criticism of the effectiveness of a substance just because money cannot be made by the FDA. The people I hear putting nattokinase down want proof by FDA approval, and this would only happen if it could be patentable, which a natural substance cannot be.

  • Dr. William Davis

    11/11/2009 1:07:21 PM |

    Earth to Chris:

    The FDA does NOT generate data to support or refute any drug or supplement. They are only a regulating agency.

  • Anonymous

    11/22/2009 2:39:06 AM |

    I am just starting to look into this issue having recently been diagnosed with a DVT.

    I appreciate that Dr. Davis has taken the time to explain why he refutes certain natto claims.  I am squarely in the camp of proof via empirical evidence; even more so when people stand to profit from a mere suggestion that something benefits you in a particular way.

  • Anonymous

    12/1/2009 4:48:30 AM |

    Here's the problem with blasting nattokinase based on stomach acid acidity or fear of indiscriminate breakdown of "good" clots as an unwanted side effect: this kind of Western, Descartian thinking when applied to the complex human body so often proves to be simply wrong. There are studies that show vitamin B2 promotes cancer growth, for example, but others that show increased vitamin C counteracts that effect. Perhaps the Japanese who ingest more nattokinase and have fewer fractures benefit from it in ways that are similar to users of whole herbs who do better than those who use just the "active ingredient" isolated from the same herbs. "There are more things in heaven and earth, Horatio..." I eat Natto miso and LOVE it. It tastes great in soup or rice and veggies. I've gone out of my way to find it via internet/mail order after our co-op stopped carrying it. I feel great after I eat it. I also tried buying a bottle of nattokinase and found that my trigeminal neuralgia gets worse after taking it, or seems to. I've only tried it a very few times so perhaps it was coincidental. (When you have something this painful you don't play around with trying things that seem to make it worse.) I also notice bromelain makes it worse, and from what I've read that, too, is fibrinolytic, right? And that one has a lot of research showing it somehow survives the stomach acid, doesn't it? I'm going from memory of quickly scanned articles, there, so may be all wrong. A final thought: I've heard that vegans have substantially less stomach acid than meat eaters. Have there been any studies on this? My intuition is there is probably something to this, and the difference may be quite significant. My wife and I often think our desire for sugar after protein is out of a need to generate more acid than we tend to produce normally. Just some thoughts to encourage a less "know-it-all" attitude so common among doctors trained in the USA and other Western cultures. I almost think sometimes it is a personality trait that is a prerequisite for getting through Med schools here, having a mind that quickly closes.

  • Trey

    12/5/2009 7:41:22 PM |

    Dr. Davis...isn't it true that you as a physician are bound by the laws of the medical community and face a severe fine or possibly loss of license for recommending anything out of conventional treatment? The same treatments such as the same thing we have done tirelessly for years for cancer treatment (Chemotherapy) amd that also as a doctor going through medical school Doctors are taught very little about nutrition?

  • Anonymous

    12/14/2009 10:08:31 PM |

    Could the proliferation of various electromagnetic-radiation-producing technologies within the last century (electricity/electrical power lines, radio, radar, cell phone and wifi towers and antennas) be the underlying mechanism behind the increased risk of heart attacks and strokes in industrialized nations, more so than diet?

    I ask because I've read several articles which seem to indicate that calcium metabolism is affected by these exposures to electromagnetic/radiofreqency/microwave radiation. Specifically, calcium's 'efflux' - its movement into and out of cells - is affected by these exposures.

    http://electromagnetichealth.org/electromagnetic-health-blog/the-cell-phone-and-the-role-of-calcium/

  • ron

    12/30/2009 2:49:14 PM |

    I have had two heart attacks, the last one after a quintuple bypass. Unfortunately, no tests are done as to the bodies rejection factor of sutures used in bypass surgery, resulting in two of the bypass grafts failing (disintegrating) and the remaining grafts heavily crusted by the bodies rejection mechanisms. I am still strong and active, plavix and aspirin daily with BP meds. During a recent angiogram, the Dr. tore the saphenous vein graft to my rt. cor. art. causing a large thrombus. Hence the present meds. Anyone used NK in this instance.
    I know it sounds scary, but I have no chest pain, exercise daily BP 120/60 HR 60. Any other input would be appreciated.
    Ron

  • Anonymous

    12/30/2009 6:42:47 PM |

    The real scam is American medicine that has for years led people to believe it is about "health" and "care".  In reality, it is about money.  Follow the money, you'll always find the answer.  Big Pharma is big business, plain and simple.  Most doctors don't give a hoot about their patients.  With Big Pharma rewarding doctors for prescribing their drugs, doctors have lost credibility in favor of montary persuasion.  It's no longer what's best for the patient, but what profits the practitioner.

  • Anonymous

    1/4/2010 2:09:54 AM |

    Dr. Davis, by not publishing one's comments you likely think nattokinase will lose credibility.  Regardless of what Big Pharma-rewarded MDs think in this country, nattokinase works.  However, I understand the tenacles of Big Pharma reach far and wide and why you would be afraid to publish my comment clearly showing NK worked.  U.S. medicine is gravely lacking in many ways.  I dare you to publish my prior comment regarding how four (count 'em 4) MDs couldn't diagnose the obvious >2 ft. clot in my left leg despite my emphatically telling them it was a clot.  Indeed and in fact, many practitioners have egos that arrive 20 minutes before they do!  I suppose you think the American people should have confidence in a system controlled by drug companies.  You have immensely increased my respect for the Japanese where research is not sponsored by Big Pharma.  Instead of criticizing the Japanese and Nattokinase, perhaps you should start emulating!!

  • Holly

    1/10/2010 4:24:46 AM |

    I am a patient who has antiphospholipid syndrome.  I also have low factor VIII levels. Before this was diagnosed, in 2008, I suffered over 5 strokes (only 1 left me with some small permanent damage, luckily) and countless tia's (am in my 50's and there was no other medical reason for me to be having stroke/tia).
    Because of the low factor VIII levels, my hematologist explained I was not a candidate for warfarin, however we tried heparin injections for 4 months.  My body could not tolerate them, it was explained to me that there was nothing which could be done for me.  (yes, I did have a second opinion).  
    Several months later I was introduced to nattokinase at Allergy Research Group.  After much research, started taking 400 mg. daily, divided.  This was 2 years ago.  Since that time I have had one tia.  My hematologist is familiar with nattokinase, but will not support it, so I have had to leave her.  However I am working with my internist who does support it and gives me the proper blood tests; everything is in order.
    Allergy Research Group addresses the question of stomach acid you bring up; they have printed much with the limited research which has been able to be done.  Before closing your book completely on this subject, perhaps you might look a bit further - many people are being helped by this where no other help is available.  
    Natto is not a scam.  It IS important to get quality product and there ARE inferior products out there.  It is always vital to study carefully when one is venturing into any alternative health remedy and remember that someone is ready to take your money all too easily.  It is just as vital to remember that western medicine, as marvelous as it is, does not have all the answers.  All too often doctors can be very closed minded without doing proper research.

  • Anonymous

    1/29/2010 3:39:51 AM |

    A very interesting thread for sure.

    I had Massive PE last year.  It stemmed from walking pneumonia (treated as adult onset asthma)
    PE never showed up on scans as no contrast was used.  
    They even did a heart cath on me while I had massive PE and could hardly breath (they thought I was nervous)  Major Pulmonary HTN and Massive PE found a week later at a University clinic via spiral CT.
    I could not walk 10 feet, they just said "You out of shape" hehe I'm 40 and play singles comp. tennis.  

    I did have very high CRP >10 and high D-dimer but they failed to connect the dots.  

    Anyway after IV abs, heparin then later coumadin (I declined surgery
    ) My CRP went down to near normal levels.   My clots were thought to be from chronic infection and resulting inflammation.

    I don't take natto (yet) but there seems to be quite a bit of anecdotal and some scientific evidence (Airline study)

    The problem I see is
    1. How does it interact with ASA?
    2. How does it interact with warfarin?
    3. How much is enough?
    4. How often?

    I agree with the good Dr. Davis on most of the points.  But its very difficult to call anything "Snake Oil" without knowing the true mechanism of action.  

    There are many medications that have been studied and are currently being prescribed in which the mechanism of actions is "unknown".  The studies show that it had a repeatable effect and that it improved the condition being tested for but the "how it works" is not known.  These are not snake oil because we do not know how it works.  Its because they have been found to show a positive response above what is found with placebo.


    There is enough anecdotal evidence on Natto for scientific studies to be done.  This is how many drugs are finally tested.  Where do you think we got antibiotics?  People have been taking natural things way before we had science.  Many of these have been tested.

    Natto is one that has not been.

    I would love to see some real studies on it.  

    A more interesting question is not if it is or not is snake oil but why has this not been studied?

    The assumption of its destruction in the stomach implies that one knows its mechanism.  After studies are done we will know.  It may be it works but in a totally different way than DR. Davis envisioned.  

    So I am not sure why he is so quick to label it as a scam when he simply does not have enough information to say one way or another.

    It may be true that the drug companies can't make a profit on it but why can't some of these well to do Vitamin companies fund the research?  The money has to come from somewhere.  I don't expect big pharm to foot the bill but someone should.

    From what evidence is available it all points to something more than a placebo effect.  Animal studies and one human study point to something real happening.
    I have yet to read any studies stating that there is no effect.

    Without seeing studies to the contrary I think Dr. Davis is just using his intuition.  Not saying his educated guess is wrong just saying its just a guess with some holes in it.

  • Anonymous

    1/31/2010 3:59:26 AM |

    I've had many a spirited discussion with MDs and PhDs about whether enzymes taken orally can go systemic.  All I can say is that there are a lot of MDs and PhDs who believe that enzymes cannot and do not go systemic.  HOWEVER, there are other MDs and PhDs who vehemently disagree and there are studies from reputable investigators that support the belief that enzymes can enter the blood stream intact or at least in some fashion where they can can be proteolytic or fibrolytic.  

    So, it's easy to stop all argument about the efficacy of an enzyme like nattokinase if you believe it can't work because it can't get into the blood.  I mean, honestly, there is nothing left to discuss, right?  And that seems to be Dr. Davis's basic position and Dr. Davis is clearly with the majority of doctors who hold this position.  

    However, if you accept the possibility that some enzymes CAN enter the blood stream, then you must then discuss what they might accomplish, for good or for bad, while in the blood.  And that leads to a discussion of WHICH enzymes might work best, and WHAT they might accomplish, and WHAT dosages work . . . a whole host of follow on questions that, presently, have few answers.

    That leaves all of us who'd like to know real answers sort of in the dark.  We are left with anecdotal testimonials, some who had good experiences and some who had adverse reactions.  That still doesn't give intellectual warm fuzzies.  However, if does suggest that if something MIGHT work and has few contraindications, that one might want to give it a try.

    As Dr. Davis clearly knows, logic is not controlling in science.  Science is complete with theories that are logically sound and later completely discredited as simply wrong despite the logic.  

    Logically, one has to allow that enzymes may be able to enter the blood system and may have curative effects -- until the theory is totally discredited -- even if you don't really know how it works.

  • stevensgarethb

    2/8/2010 11:57:22 PM |

    300 years ago if you were ill you would go to the local barbers where they would take some blood with an unclean instrument and infect you with a nasty disease. They would then send you home with some medication which did not work and was highly dangerous causing other medical conditions to arise. It is different today. Now the only thing that has changed is that you go to a nice new hospital to get infected and given medication that is dangerous and does not work and causes other medical conditionsSmile

    I am taking Neprinol which contains Nattokinase and Serrapeptase and it worked within several hours taken orally. I  use Neprinol as a replacement for Fragmin which I had already been taking for 6 months.  The alternative would have been Coumadin (Warfarin). It is all very well knocking Nattokinase but what alternative is there?
    I tried to stop taking fragmin but within half a day my symptoms came back.  Since taking Neprinol my symptoms have not returned and I am  experiencing no side effects apart from increased energy. I am cycling uphill 8 gears higher than before and not getting tired. Previously I had been admitted to hospital 5 times with chest pain, the first time I had an MI and the other times were at a different hospital who did not have a clue.  I did not appreciate being given a drug which made my condition worse.  I am from a highly technical background and could tell that the cardiac department had no expertise in understanding how the body works. It is obvious to me that medical staff are "non technical" so they can never work out what is wrong with someone.
    I decided to self diagnose and self prescribe and that was the best decision I ever made. I understand my condition now and how to treat it which is great.  I have also discovered a rare genetic link in my family and hope to connect with a University who are researching this subject.  I hope to start golf again when the weather improves and cycle along some mountain routes to improve my fitness.


    If doctors were paid by results... we would save an awful lot of money!

  • Anonymous

    2/18/2010 10:40:33 PM |

    I had a documented >2 foot long blood clot.  There is no denying the existence of this clot.  (THERE IS ALSO NO DENYING THE RESOLUTION OF THIS CLOT BY CURRENT ULTRASOUND!)  I went on one week of Lovenox and had serial ultrasounds on my left leg for  months.  The clot remained.  I started Nattokinase 15,000 FUs per capsule (4x/day).  Eighteen months later when another ultrasound was done, I was called back to the facility because they thought they had done the wrong leg or the test was done incorrectly by the tech.  Why?  BECAUSE THERE WAS NO CLOT FOUND.  The radiologist repeatedly stated I had to be incorrect in what I was taking, that it had to be Coumadin [note:  Coumadin prevents additional clots--it does not lyse clots].  HE WAS INCORRECT.  I definitely know what I take--it was, is and continues to be Nattokinase.  Nattokinase got rid of my clot, plain and simple.  If conventional providers do not want to believe it, I don't care.  If it can work for a >2 foot long clot, it likely works for other clots.  That said, I am a healthcare professional and fact is conventional medicine cares about nothing other than money.  Healthcare is "sick" care because that's where the money is made.  An epidemic of good health is the last thing Big Pharma wants!  If something can be effective without requiring frequent labs and doctor visits, obviously it would cut into the "take" on the part of MDs and other providers.  The system itself is sick!  Just as we laughed at those "funny-looking" Japanese cars in the 1970s and 1980s, it was those "funny" cars that gained the majority market share.  The Japanese healthcare system is much more efficient than the U.S. system.  Since it is care-driven versus our money-driven system, I believe it has more credibility.  I believe Dr. Sumi's research and will not have confidence in our system until such time research is objective and not controlled by big pharma.

  • Anonymous

    2/21/2010 3:02:13 AM |

    I just read this from Tom's post and found he countradicts himself:
    Tom said:
    It is possible that these enzyme products might produce a beneficial effect through that or other unknown mechanisms, but the makers of these products do not make that claim, perhaps due to its complexity. Rather, they invariably make simple, easily marketed claims.

    One should always be wary of any product, natural or otherwise that makes broad unsupported claims as to how and what it does." end quote

    Does this apply to Avandia too?

    I stated taking NK a month ago because I was having heart pain, nothing terribly serious as doctors never find any problems with my heart. After a few weeks I have not had any heart pains, and feel better, sleep better, etc.  I attribute it to the NK, and will continue to take it. My dad had heart problems so I am aware that I must prevent the same.  Taking anything else would be contrary to what works.  It is clear that Dr. Davis doesn't have a cure for heart disease and therefore can make no claims that NK does not work.  You can't have it both ways chum.
    The scam is the drug cartels, not natural products that work.

  • Dottie

    2/23/2010 10:46:17 PM |

    I haven't seen anything about Nattokinase being used to dissolve scar tissue in the stomach, for which I was referred.  Anyone heard of this?

  • Anonymous

    3/1/2010 12:39:41 AM |

    Please, people, stop falling into the trap of thinking that every study abstracted in PubMed is of good quality, let alone "proof."  I have to constantly caution myself against this, especially when all I am looking at is an abstract (and I would venture to say that less than 1% of the abstract readers bother to obtain the full article, and even if they do they probably don't rally understand much of what they are reading).

    And remember that the "pro supplement" research is just as prone to bias (often economically-motivated) as the pharma studies, and MORE prone to low quality.  Big Pharma and the Supplement industry BOTH have the almighty dollar as their primary motivator, and your health as -- perhaps -- a secondary motivator.  Neither should be demonized any more than the other.

    I use multiple supplements, including some herbs, and multiple drugs.  And I know there are potential risks and benefits (including unknown properties and unknown interactions) with both.  I also knwo that just because something "works" for me and *seems* safe, that it won't necessarily work for everyone, and isn't necessarily safe for everyone.  And that long-term hidden unknown detriments or benefits (again, for both supplements and drugs) may lurk.

    I know this has been rambling, but the main takeaways are:
    (1) Drug vs. "natural" partisans, please wise up
    (2) Don't assume everything you read is accurate (even the relatively unbiased stuff) just because "there are some studies,"  and
    (3) For very serious consitions such as cardiovascular disease, cerebrovascular disease, and cancer, realize that you NEED a doctor.  That doesn't mean you can't shop around for a better one, or that you can't question everything they say.

    Let me finish by saying that I found a "5 star" customer review of nattokinase on a well-known supplement site chilling.  It was to the effect of, "My Dad died of an aneuryism and no one can explain why, so I'm taking nattokinase to make sure the same thing doesn't happen to me!  It's great!"  That's SCARY!!

    (sorry, no time to check for typos right now... -- gotta run)

  • Anonymous

    3/22/2010 9:10:18 PM |

    Dr. Davis. You say Nattokinase supplementation is a scam? Someone with your professional credentials ought to be a little more informed on the subject as well as sensitive to the needs of others.

    Capsules, pills and tablets can't be made to protect their contents in the stomach? Have you ever herd of enteric coated, time release, or sustained release meds and supplements?

    You've personally witnessed bleed out and death that you attribute to use of nattokinase and other such enzymes. Is this due to product abuse by users? Was it because of a combination of other medical factors resulting in complications? Where is the documentation of your findings? Where is the open mindedness and balance in your personal and professional position? I see scare tactics and ignorance in a condecending spirit.

    I have had 5 DVT's and 3 PE's in recent years with no diagnosis for the cause. I have been seen by dozens of doctors, had 4 trips to the emergency room, and racked up enough medical bills to put me in bankruptcy. I've been on a steady diet of low dose rat poisin (warfarin) and am reminded to flex my calves when standing or sitting. Yes, I just have to live with it, I'm told.

    What ar you going to do for me? You all had your shot. I'm saying to you - Don't be afraid to learn something new or investgate the untraditional. Do your homework first. Then maybe there will be more to your position on this subject than emotional reasoning and unsubstantiated events.

    To all those out there exploring the new wave of enzyme therapies, I say carry on. It is an amazing science and a very viable alternative.

  • Anonymous

    3/26/2010 5:28:54 PM |

    Dr. Davis, I am seriously disappointed in your comments that nattokinase is a scam.  You seem to be very misinformed or have not done your research.

    Any scam you mention does not have to do with Nattokinase itself but the way supplement companies are marketing NK as well as how they are packaging and encapsulating NK with other ingredients to make it seem like a multivitamin.  The supplement versions of NK are diluted considerably by supplement companies. I know this first hand as I have personally seen and taken probably the most purest and concentrated form of NK available.

    "Clot develops when heart attack occurs. It makes no sense to take a lytic agent that dissolves clotes continuously. Unless I am missing something here, nattokinase remains squarely in the nonsense column."

    You are definitely misinformed.  It's really sad that you feel this way seeing that many people will now be misinformed about the truth of NK and how it improves human health.  NK does not have to be taken as a hard capsule.  It does survive stomach acid. That being said, I can understand that you may not have access to all of the information or the pure form of Nattokinase as it is not readily available anywhere other than Japan and China.

    I would suggest that you refrain from calling NK a scam until you yourself have definitive proof.  Otherwise your opinion remains squarely in the nonsense-column.

  • Dr. Dawn

    3/29/2010 1:35:15 PM |

    Dr. Davis,
    This reminds me of the initial skepticism about fish oil--you reference it as if it was always accepted and promoted in the medical community. Now there is Lovasa-- $200/mo. vs. $20/mo. for fish oil. (I actually recommend Krill oil.)
    Enzymes, when used against inflammation instead of digestive purposes, are taken on an empty stomach and are  absorbed into the blood stream. The thrombolytic effect is not sudden and works peripheral to central on the clot, posing no risk of embolism. I introduced fish oil to the cardiology department at  University Hospital (Michigan) in 1993 following a patient's M.I.-- at that time they hadn't heard of using omega 3s, but at least they were open to functional foods, eventually making fish oil part of their cardiac protocol. The early days of introducing most functional foods to the medical community is like turning around a locomotive-- until the pharmaceutical companies find a way to patent them-- we can thank them for the high cost of "sickness mgt" instead of health care. Coumadin counters K2, so while people have been guided to prevent clots (it does not break down clots, only prevents new ones and enlargement of those  established), they've also been engineering hypertension and atherosclerosis in their bodies--not to mention the organ repercussions of Coumadin. Humility in the medical community with respect to historical wisdom would be a refreshing change-- and might have gone a long way to prevent the gradual replacement of health care with our costly system of "sickness management", as well as the recent push for a governmental takeover plan. Research continues: Nutrition Research. Volume 29, Issue 3, March 2009, Pages 190-196. The older article by Milner explains the clotting mechanism for laymen. Research shows that Nattokinase can suppress thickening of the intima following damage to the inside of a blood vessel. Nutrition. 2003 Mar;19(3):261-4
    Remember, many doctors have created many health problems over the years   because they made assumptions..... After all, K2 is in egg yolks and helps calcium reach the bones instead of depositing in arteries-- yet for years doctors advised patients to avoid eggs if they had cardiovascular disease-- more mythology debunked. Those same eggs provide choline, key to brain, liver, and who-knows-what-else. Tanning (sun or bed) has been decried, yet Hollick showed women who tan regularly have 25% higher bone density--and not the inferior bone resulting from so-called osteoporosis drugs-- check out the NY Times article from March 25th.   Vitamin D3 deficiency, due to seriously flawed advice, has contributed to untold diseases-- diabetes, MS, cardiovascular disease,  breast, prostate, and colon cancer--to name just a few. Let's remain humble about non-drug methods and not attribute  characteristics and side effects of synthetic pharmaceutical drugs to functional foods. We are still identifying the beneficial synergistic relationships within these foods that do not exist in synthetic, isolated chemical constituents of drugs.

  • Inquisitive

    4/7/2010 5:00:46 PM |

    I am a 49 year old white male with a high stress life.  I am overweight, have sleep apnea, an asymptomatic irregular heartbeat, bouts with depression and anxiety (for which I was prescribed Prozac), supposedly "pre-diabetic" and I have, what a shock, high blood pressure.  I am interested in the potential benefits of Nattokinase as a possible enhancement to or replacement for the precription meds I am taking for hypertension.  I have recently started taking some other supplements such as Vitamins D3, K2, Fish Oil, Resveratrol, CoQ10 etc.  Does anyone out there with an open mind and the intellect to back it up have any personal experience, reccomendations or advice for me?  Please respond if so!  Thank you!  I am intelligent and I spend lots of time reading and researching from various sources on the internet and frankly, I just don't know who to believe anymore.  I just want to be healthier!

  • Anonymous

    4/9/2010 6:15:01 AM |

    I just want to chime in here - I have been on nattokinase for the last 8 years.
    Before that, I was on Coumadin for over two years for a clot that went all the way from my calf to my belly button. I have Factor V Leiden, a genetic clotting condition.
    While on Coumadin, I had numerous side effects, including Post Phlebitic Syndrome (PPS).
    Since starting on nattokinase, I have not been bothered with ANY of the side effects I had with Coumadin. No more Ultram for PPS, no more worrying about (not) eating my greens, no more INRs - NOTHING! My blood pressure is a healthy 115/75 (I am around 60y/o).

    I swear by Nattokinase, but I also know that there are many 'fakes' out there that claim to be nattokinase, but in reality have no active ingredients. Buyer beware!
    Check out reputable brands like Allergy Research, or Pure Prescriptions, or check out Dr. Holsworth, the researcher of nattokinase. Contact him for other reputable brands.

  • madanthony

    4/10/2010 7:04:09 PM |

    There ARE studies showing oral nattokinase IS fibrinolytic (so obviously was absorbed despite stomach acid!).  Here's one.  (I am limitted by your size restrictions)

    Sumi, H. et al. "Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase." Acta haematol 1990, 84: 139-43.
    Abstract
    The existence of a potent fibrinolytic enzyme (nattokinase, NK) in the traditional fermented food called 'natto', was reported by us previously. It was confirmed that oral administration of NK (or natto) produced a mild and frequent enhancement of the fibrinolytic activity in the plasma, as indicated by the fibrinolytic parameters, and the production of tissue plasminogen activator. NK capsules were also administered orally to dogs with experimentally induced thrombosis, and lysis of the thrombi was observed by angiography. The results obtained suggest that NK represents a possible drug for use not only in the treatment of embolism but also in the prevention of the disease, since NK has a proven safety and can be massproduced.

  • Ara

    4/13/2010 6:37:58 PM |

    So if nattokinnasse works for you. You are dismissed as a crazy -fanatic- person. So here I'm another "fanatic" person that has been taking fibrovan for over a year. My horrendous pelvic (menstrual) pain has improved more than half.
    So I guess it is over 12 months of the placebo effect.
    I read somewhere: First they ignore you then the ridicule you and finally they join you!
    Thank you Dr for at least not deleting the "freaks" posts.
    Anna

  • Anonymous

    4/25/2010 2:14:52 PM |

    I am 54 years old and have suffered from multiple fibroids and dangerous haeavy non-stop bleeding with clots in excess of 1 oz each. I started bleeding last July and by November 15 was close to hemmoraging. I was dangerously anemic for months. They wanted to give me a transfusion in the ER but I refused. I ended up with 10 days of fibrovera which did little except the clots decreased in size. My obgyn wanted to do a hysterectomy but I said no. He gave me 14 days more of fibrovera. Still bleeding I went online and ordered Fibrovan. I had previously taken a fibrinolytic mix with a lot of improvement but had stopped due to feeling better and the cost. After a week on Fibrovan I stopped bleeding for 4 months. I am now having  light manageable flow and will continue the Fibrovan. I would not be able to function otherwise. There are many more testimnials of the help it has been to other women who did not want to be cut on.
    Gail age 54 Texas

  • Tom

    4/25/2010 7:32:17 PM |

    That is ridiculous. Fibroids have nothing to do with fibrin, the words just sound similar. Nor would a purported fibrinolytic help to reduce uterine bleeding. In fact, if it did have fibrinolytic properties, it would increase bleeding.

    The makers of fibrovan and fibrovera (which are both practically identical) both make the absurd claim that nattokinase reduces fibroid size. Fibroids are a benign tumor and are effected by hormone levels. It is absurd to add the unsupported claim that nattokinase is able to shrink tumors and reduce bleeding because this would contradict the other unsupported claims made by pronattokinase commenters.


    It is shameful that supplement manufactures will create entire product lines simply because fibroid sounds like fibrin. I suggest we name this new fake medicine Homonymopathy.

  • Anonymous

    5/17/2010 2:56:11 AM |

    Nattokinase worked for me and I am living proof via ultrasounds.  Wake up folks!  If conventional medicine is so blasted great, then why are there currently mass tort actions regarding Avandia, Bextra, Vioxx, pain pumps used after shoulder surgery, Fleet's Phosphosoda used as a prep before colonoscopies that has put a number of people across our nation in renal failure requiring dialysis and transplants, nephrogenic fibrosing dermopathy as a result of gadolinium used for MRIs, etc., etc., etc.  I could go on and list at least 50 actions rights now for products made by Big Pharma and pushed by those who call themselve doctors (aka glorified drug pushers).  Our system is so broken, I wouldn't trust it to take care of a fruitfly!

  • Tom

    5/18/2010 9:39:02 AM |

    Supplements are just big pharm unregulated. That really turned out well for Europe and thalidomide.

    Also, natural does not equal non toxic. I'm acquainted with a patient who absolutely destroyed his liver on vitamin A and E to the point where he required a transplant.

  • ron

    5/18/2010 12:51:42 PM |

    I had bypass surgery 3 years ago after a heart attack. Five bypass grafts were performed. A year ago, I had another heart attack, the cause as indicated on the angiogram was that my body rejected the sutures used. Two of the bypass grafts fell off, and the others are full of crap at the suture that my body has deposited to counter what it feels is a foreign object. The point of this is that if a bypass is necessary, make sure the sutures used are compatible to your body and will not be rejected. there are several suture materials available from silk to propylene and many others. Question if they will work for you.
    All the best
    RB

  • Dave

    5/21/2010 2:51:10 AM |

    Dr. Davis and Tom,

    Fact: Clinical trials support the fact that oral NK mildly, but significantly, increases fibrnolytic activity in humans. I've personally witnessed this with myself.

    Fact: Clinical trials support the fact that NK lowers BP. I've personally witnessed this myself.

    Fact: Nattokinase lowers CRP levels. I've personally witnessed this myself.

    I realize that if any protease enzyme were directly injected into our blood stream, it would turn our veins and arteries into mush. Obviously, very little oral NK is absorbed, but enough to have an affect.

  • Anonymous

    6/1/2010 6:50:30 PM |

    Does anyone know if NK can be helpful in case of Protein C deficiency?
    I have 2 sons who have been diagnosed with 0.62 ratio of Protein C deficiency (genetically predisposed). It should read 0.70 to be normal range.

    In their case, they have to take Coumadin 10mg for life. Trying to avoid by all means.

    Please help.

  • Anonymous

    6/5/2010 11:38:56 AM |

    While barefoot on a ladder I slipped and fell to the next metal step. By the next day the entire arch of my foot was a deep purple with bruise. As witnessed in the office I showed my bruise, ate 100gm of fermented natto food and we watched as the next two days the bruise had cleared entirely. The only remnant was a small wound under the skin that was the source of the bruise/bleeding. It healed in what I would consider a normal period of time.

    Think of all the people on coumadin that would not be walking around with bruised arms or legs...etc

    Someone please explain if a bruise is a form of clotting or not.

    Perhaps in this economy of forced health care the government could spend some of that money on non pharmaceutical research as it might apply to the health of its citizens from eating food.

    I make my own natto, have been eating it weekly for the last 7 years. Soy sauce makes it better so does yogurt...I now am accustomed to eating it by itself. Thank you mother nature.

    A 52 year old believer.

  • Anonymous

    6/5/2010 11:57:24 AM |

    Same 52 year old believer from recent post.

    My wife was hit by an automobile while on her bicycle very recently. The ER sent her home with clean X-Rays for broken bones but advise on future possibility of finding damaged ligaments and or tendons in her leg where the bike frame contacted her.

    The folks at the ER said that day two would have more pain but day three would be the worse. They also advised that she should expect bruising on here entire leg area along with other areas that she was not aware of yet. (she used her arms when falling to protect her head)

    Within a few hours the large area of a bruise was showing. Again, roughly 100g of natto-the food, and the bruising has cleared the same evening. We are on day 4 and still no bruises. We can see an area under the skin where the tissue has been injured, perhaps a tear.....we are not medically trained. Her healing is progressing ahead of schedule as day two and three where better than day one.
    She was struck hard enough for the SUV to have a flat tire from the bicycle.
    I share these experiences to help show that...yes, there is an active ingredient in the natto and yes it gets past the stomach and does have an effect, if only in clearing a bruised area of the body.
    When I have a paper cut or small skin cut the blood is bright red, like I remember when I was very young. The blood also seems to be thinner but will coagulate easily when I apply pressure...as I always have done pre-natto. This from an ongoing, once a week usage.

  • Anonymous

    7/15/2010 4:36:01 PM |

    If what you say is true about stomache acid, then Plavix does not work either, nor does Asprin.

  • Anonymous

    7/17/2010 6:29:52 AM |

    1. If nattokinase worked as argued, then it should increase bruising, not decrease it.

    2. Plavix and asprin are both not enzymes.

  • Anonymous

    7/28/2010 5:09:52 AM |

    from pubmed.gov

    "Effects of nattokinase on blood pressure: a randomized, controlled trial.

    Kim JY, Gum SN, Paik JK, Lim HH, Kim KC, Ogasawara K, Inoue K, Park S, Jang Y, Lee JH.

    Yonsei University Research Institute of Science for Aging, Department of Food and Nutrition, College of Human Ecology, Yonsei University, and Department of Family Medicine, Mizmedi Hospital, Seoul, Korea.
    Abstract

    The objective of this study was to examine the effects of nattokinase supplementation on blood pressure in subjects with pre-hypertension or stage 1 hypertension. In a randomized, double-blind, placebo-controlled trial, 86 participants ranging from 20 to 80 years of age with an initial untreated systolic blood pressure (SBP) of 130 to 159 mmHg received nattokinase (2,000 FU/capsule) or a placebo capsule for 8 weeks. Seventy-three subjects completed the protocol. Compared with the control group, the net changes in SBP and diastolic blood pressure (DBP) were -5.55 mmHg (95% confidence interval [CI], -10.5 to -0.57 mmHg; p<0.05) and -2.84 mmHg (CI, -5.33 to -0.33 mmHg; p<0.05), respectively, after the 8-week intervention. The corresponding net change in renin activity was -1.17 ng/mL/h for the nattokinase group compared with the control group (p<0.05). In conclusion, nattokinase supplementation resulted in a reduction in SBP and DBP. These findings suggest that increased intake of nattokinase may play an important role in preventing and treating hypertension."

    PMID: 18971533 [PubMed - indexed for MEDLINE]"

  • Robert

    8/5/2010 5:43:33 AM |

    Dr. David, check http://www.houston-enzymes.com/learn/articles/doctor-may-not-know.php which says that plant and microbe based enzymes do survive the stomach acid, it is  the animal based or pancreatic enzymes that do not. So please retract your statement on enzymes.

  • Robert

    8/5/2010 6:17:29 AM |

    The bruising anecdotes are interesting, hopefully some medical researchers will look into it. Natto the food supposedly contains vitamin K2 which helps with clotting and may help reduce additional bleeding.  It is not clear what the interplay is between Nattokinase and K2.

  • Knox

    8/7/2010 3:24:15 PM |

    Dr. Davis -
    I would be very interested in your thoughts on SOD and it's action on fibrosis.  Note the following study:
    http://www.ncbi.nlm.nih.gov/pubmed/11134893

  • Anonymous

    8/8/2010 3:10:03 AM |

    I am thoroughly enjoying the debate on Nattokinase on this site, but one thing bothers me about Dr. Davis' claim that it is a scam.  Firstly, and foremost he claims that there is no way that it can survive the acidity of the stomach, even if it is enteric coated.  Secondly, he claims that it's anti-thrombolic properties are dangerous and can cause aneurysms in the brain.  I think he needs to pick a topic and stick with it.  If indeed, this product is a scam and does not survive the digestive process, then how can it be dangerous. Seems there needs to be more medically based research done on this enzyme before the word "scam" can be wholeheartedly used.

  • Anonymous

    8/10/2010 2:32:40 PM |

    I've been taking Nattokinase for 4 days now, I'm only 35 years old, but I can literally feel how it dramatically improves blood circulation in my body. The best way to prove or disprove something is to try. I have undiagnosed headaches which nobody can figure out for 13 years, I have chronic pain for 13 years daily non stop. My own theory (not supported by healthcare proffessionals) is that I had some kind on tiny aneurysm rupture or other kind of minor brain bleeding not big enough to show up in MRI but enough to somehow cause me this terrible chronic pain. It started as sudden worst headache you could possibly imagine, I almost lost consciousness. Something terrible must have happened. In any case if Nattokinase can help me it will be pretty major proof. It seems that it started to improve things already. The pain is not going away completely, but it started to disappear for like half a day ...

  • knox

    8/12/2010 4:27:33 PM |

    Anonymous from Aug 10 -

    I'm curious if you drink diet soft drinks or consume aspartame.  I used to have daily headaches and they stopped instantly when I stopped consuming aspartame.  It's a neurotoxin and it's deadly.

  • Anonymous

    8/30/2010 9:43:04 PM |

    I.m also interested into Nattokinase and fully agree with comment posted last August 10 by Anonimous:

    "... one thing bothers me about Dr. Davis' claim that [Nattokinase]is a scam. Firstly, and foremost he claims that there is no way that it can survive the acidity of the stomach, even if it is enteric coated. Secondly, he claims that it's anti-thrombolic properties are dangerous and can cause aneurysms in the brain. I think he needs to pick a topic and stick with it. If indeed, this product is a scam and does not survive the digestive process, then how can it be dangerous. Seems there needs to be more medically based research done on this enzyme before the word "scam" can be wholeheartedly used."

    Would like to know Dr.Davis answer

  • Anonymous

    9/1/2010 12:11:25 AM |

    Part 1
    For those who are searching for an answer to dissolving blood clots, I would love 2 share my success story.  In Oct 2009 I developed a freak blood clot after knee surgery.  I exercise almost every day and part of the regimen is cardio 5-7 days a week for 40 minutes @ a time. For a 40 year old male I was in peak condition.  My resting heart rate is excellent, blood pressure, cholesterol, weight, & BMI all perfect.  The week before my surgery I developed the H1N1 flu which put me in bed for a week and they had to push my knee surgery back.  So I went from super active to lying in bed for a week then having surgery and lying in bed again 2 recover.  Doctors tested for all diseases and genetic causes of blood clots and I had none of them.  They finally came to a conclusion that going from extreme activity to nothing could have been the only cause.  If I knew then what I know now I would have moved around more etc. but I had no clue?  I actually self diagnosed my own blood clot using web md and called my doctor.  He didn’t believe me so he said take an aspirin and come see him in the morning (3-4 days after surgery)  They put a Doppler on my leg found the blood clots & immediately rushed me to surgery to have a filter placed in my groin 2 prevent the clot from traveling 2 my heart.  They started giving me Heparin and then warfarin (coumidan) when I left the hospital.  They kept increasing my dose of warfarin since they could not get my PT level above 2 (they wanted it between 2-3) my level was 1.5-1.8.  I started getting terrible headaches, pain behind my eyes and after 6 weeks of this I developed horrible heartburn (I never was sensitive to ANY spicy food for my whole life) they wanted me to take 12mg of warfarin “rat poison” a day and I had enough.  None of my doctors wanted to discuss garlic, fish oil, or any of the other natural blood thinning methods.  They just wanted to give me one drug to cover the side effects of the other.  Since I normally eat mostly organic foods and am ultra healthy I had enough and decided to do my own research.  I read that Nattokinase would not only thin my blood, but unlike the “rat poison” it would actually dissolve the clot.  My doctor had told me that I would always have scars from blood clots and thus would need to take a baby aspirin for the rest of my life and go on warfarin whenever I had surgery in the future, because the “rat poison” only prevented future clots, but would not dissolve the clot.  So I found the best pharmaceutical grade Natto made by Allergy Research Group (I believe it is made in Japan) but was able to find in on Amazon.  I started taking 100mg a day and reduced my warfarin to 5mg & added 1 eight hour time released garlic pill.  Since my doctor could not measure my blood level (his devise only measured the amount of warfarin in my blood) I had to do this on my own and lied to my doctor about how much warfarin I was taking.  I had to judge my blood thickness by bruising and blood flow when pricked ( I know this sounds crazy but where I live I could not find a doctor that was willing to help me)  I knew that I had the filter in my leg as a back up, so that took some of the danger out of the equation.  After about a month of this I went to 200mg of Natto (one pill every 12 hours) and three eight hour time released garlic pills and stopped taking warfarin all together.  I did this for another 3 months.  PLEASE NOTE I UNDERSTAND WHAT I DID WAS DANGEROUS, SO I HOPE YOU CAN FIND A DOCTOR TO HELP WITH THIS PROCESS.
    to be continued...

  • Anonymous

    9/1/2010 12:12:50 AM |

    Part 1
    For those who are searching for an answer to dissolving blood clots, I would love 2 share my success story.  In Oct 2009 I developed a freak blood clot after knee surgery.  I exercise almost every day and part of the regimen is cardio 5-7 days a week for 40 minutes @ a time. For a 40 year old male I was in peak condition.  My resting heart rate is excellent, blood pressure, cholesterol, weight, & BMI all perfect.  The week before my surgery I developed the H1N1 flu which put me in bed for a week and they had to push my knee surgery back.  So I went from super active to lying in bed for a week then having surgery and lying in bed again 2 recover.  Doctors tested for all diseases and genetic causes of blood clots and I had none of them.  They finally came to a conclusion that going from extreme activity to nothing could have been the only cause.  If I knew then what I know now I would have moved around more etc. but I had no clue?  I actually self diagnosed my own blood clot using web md and called my doctor.  He didn’t believe me so he said take an aspirin and come see him in the morning (3-4 days after surgery)  They put a Doppler on my leg found the blood clots & immediately rushed me to surgery to have a filter placed in my groin 2 prevent the clot from traveling 2 my heart.  They started giving me Heparin and then warfarin (coumidan) when I left the hospital.  They kept increasing my dose of warfarin since they could not get my PT level above 2 (they wanted it between 2-3) my level was 1.5-1.8.  I started getting terrible headaches, pain behind my eyes and after 6 weeks of this I developed horrible heartburn (I never was sensitive to ANY spicy food for my whole life) they wanted me to take 12mg of warfarin “rat poison” a day and I had enough.  None of my doctors wanted to discuss garlic, fish oil, or any of the other natural blood thinning methods.  They just wanted to give me one drug to cover the side effects of the other.  Since I normally eat mostly organic foods and am ultra healthy I had enough and decided to do my own research.  I read that Nattokinase would not only thin my blood, but unlike the “rat poison” it would actually dissolve the clot.  My doctor had told me that I would always have scars from blood clots and thus would need to take a baby aspirin for the rest of my life and go on warfarin whenever I had surgery in the future, because the “rat poison” only prevented future clots, but would not dissolve the clot.  So I found the best pharmaceutical grade Natto made by Allergy Research Group (I believe it is made in Japan) but was able to find in on Amazon.  I started taking 100mg a day and reduced my warfarin to 5mg & added 1 eight hour time released garlic pill.  Since my doctor could not measure my blood level (his devise only measured the amount of warfarin in my blood) I had to do this on my own and lied to my doctor about how much warfarin I was taking.  I had to judge my blood thickness by bruising and blood flow when pricked ( I know this sounds crazy but where I live I could not find a doctor that was willing to help me)  I knew that I had the filter in my leg as a back up, so that took some of the danger out of the equation.  After about a month of this I went to 200mg of Natto (one pill every 12 hours) and three eight hour time released garlic pills and stopped taking warfarin all together.  I did this for another 3 months.  PLEASE NOTE I UNDERSTAND WHAT I DID WAS DANGEROUS, SO I HOPE YOU CAN FIND A DOCTOR TO HELP WITH THIS PROCESS.
    to be continued...

  • Anonymous

    9/1/2010 12:14:57 AM |

    Part 1
    For those who are searching for an answer to dissolving blood clots, I would love 2 share my success story.  In Oct 2009 I developed a freak blood clot after knee surgery.  I exercise almost every day and part of the regimen is cardio 5-7 days a week for 40 minutes @ a time. For a 40 year old male I was in peak condition.  My resting heart rate is excellent, blood pressure, cholesterol, weight, & BMI all perfect.  The week before my surgery I developed the H1N1 flu which put me in bed for a week and they had to push my knee surgery back.  So I went from super active to lying in bed for a week then having surgery and lying in bed again 2 recover.  Doctors tested for all diseases and genetic causes of blood clots and I had none of them.  They finally came to a conclusion that going from extreme activity to nothing could have been the only cause.  If I knew then what I know now I would have moved around more etc. but I had no clue?  I actually self diagnosed my own blood clot using web md and called my doctor.  He didn’t believe me so he said take an aspirin and come see him in the morning (3-4 days after surgery)  They put a Doppler on my leg found the blood clots & immediately rushed me to surgery to have a filter placed in my groin 2 prevent the clot from traveling 2 my heart.  They started giving me Heparin and then warfarin (coumidan) when I left the hospital.  They kept increasing my dose of warfarin since they could not get my PT level above 2 (they wanted it between 2-3) my level was 1.5-1.8.  I started getting terrible headaches, pain behind my eyes and after 6 weeks of this I developed horrible heartburn (I never was sensitive to ANY spicy food for my whole life) they wanted me to take 12mg of warfarin “rat poison” a day and I had enough.  None of my doctors wanted to discuss garlic, fish oil, or any of the other natural blood thinning methods.  They just wanted to give me one drug to cover the side effects of the other.  Since I normally eat mostly organic foods and am ultra healthy I had enough and decided to do my own research.  I read that Nattokinase would not only thin my blood, but unlike the “rat poison” it would actually dissolve the clot.  My doctor had told me that I would always have scars from blood clots and thus would need to take a baby aspirin for the rest of my life and go on warfarin whenever I had surgery in the future, because the “rat poison” only prevented future clots, but would not dissolve the clot.  So I found the best pharmaceutical grade Natto made by Allergy Research Group (I believe it is made in Japan) but was able to find in on Amazon.  I started taking 100mg a day and reduced my warfarin to 5mg & added 1 eight hour time released garlic pill.  Since my doctor could not measure my blood level (his devise only measured the amount of warfarin in my blood) I had to do this on my own and lied to my doctor about how much warfarin I was taking.  to be continued...

  • Anonymous

    9/1/2010 12:16:39 AM |

    Part 1
    For those who are searching for an answer to dissolving blood clots, I would love 2 share my success story.  In Oct 2009 I developed a freak blood clot after knee surgery.  I exercise almost every day and part of the regimen is cardio 5-7 days a week for 40 minutes @ a time. For a 40 year old male I was in peak condition.  My resting heart rate is excellent, blood pressure, cholesterol, weight, & BMI all perfect.  The week before my surgery I developed the H1N1 flu which put me in bed for a week and they had to push my knee surgery back.  So I went from super active to lying in bed for a week then having surgery and lying in bed again 2 recover.  Doctors tested for all diseases and genetic causes of blood clots and I had none of them.  They finally came to a conclusion that going from extreme activity to nothing could have been the only cause.  If I knew then what I know now I would have moved around more etc. but I had no clue?  I actually self diagnosed my own blood clot using web md and called my doctor.  He didn’t believe me so he said take an aspirin and come see him in the morning (3-4 days after surgery)  They put a Doppler on my leg found the blood clots & immediately rushed me to surgery to have a filter placed in my groin 2 prevent the clot from traveling 2 my heart.  They started giving me Heparin and then warfarin (coumidan) when I left the hospital.  They kept increasing my dose of warfarin since they could not get my PT level above 2 (they wanted it between 2-3) my level was 1.5-1.8.  I started getting terrible headaches, pain behind my eyes and after 6 weeks of this I developed horrible heartburn (I never was sensitive to ANY spicy food for my whole life) they wanted me to take 12mg of warfarin “rat poison” a day and I had enough.  None of my doctors wanted to discuss garlic, fish oil, or any of the other natural blood thinning methods.  They just wanted to give me one drug to cover the side effects of the other.  Since I normally eat mostly organic foods and am ultra healthy I had enough and decided to do my own research.  I read that Nattokinase would not only thin my blood, but unlike the “rat poison” it would actually dissolve the clot.  My doctor had told me that I would always have scars from blood clots and thus would need to take a baby aspirin for the rest of my life and go on warfarin whenever I had surgery in the future, because the “rat poison” only prevented future clots, but would not dissolve the clot.  So I found the best pharmaceutical grade Natto made by Allergy Research Group (I believe it is made in Japan) but was able to find in on Amazon.
    to be continued...

  • Anonymous

    9/1/2010 12:18:58 AM |

    Part 1
    For those who are searching for an answer to dissolving blood clots, I would love 2 share my success story.  In Oct 2009 I developed a freak blood clot after knee surgery.  I exercise almost every day and part of the regimen is cardio 5-7 days a week for 40 minutes @ a time. For a 40 year old male I was in peak condition.  My resting heart rate is excellent, blood pressure, cholesterol, weight, & BMI all perfect.  The week before my surgery I developed the H1N1 flu which put me in bed for a week and they had to push my knee surgery back.  So I went from super active to lying in bed for a week then having surgery and lying in bed again 2 recover.  Doctors tested for all diseases and genetic causes of blood clots and I had none of them.  They finally came to a conclusion that going from extreme activity to nothing could have been the only cause.  If I knew then what I know now I would have moved around more etc. but I had no clue?  I actually self diagnosed my own blood clot using web md and called my doctor.  He didn’t believe me so he said take an aspirin and come see him in the morning (3-4 days after surgery)  They put a Doppler on my leg found the blood clots & immediately rushed me to surgery to have a filter placed in my groin 2 prevent the clot from traveling 2 my heart.  They started giving me Heparin and then warfarin (coumidan) when I left the hospital.  They kept increasing my dose of warfarin since they could not get my PT level above 2 (they wanted it between 2-3) my level was 1.5-1.8.  I started getting terrible headaches, pain behind my eyes and after 6 weeks of this I developed horrible heartburn (I never was sensitive to ANY spicy food for my whole life) they wanted me to take 12mg of warfarin “rat poison” a day and I had enough.  None of my doctors wanted to discuss garlic, fish oil, or any of the other natural blood thinning methods.  They just wanted to give me one drug to cover the side effects of the other.  Since I normally eat mostly organic foods and am ultra healthy I had enough and decided to do my own research.
    to be continued...

  • Anonymous

    9/1/2010 12:24:06 AM |

    PART 2 Sorry for multiple post the server was not working correctly...

    At the 6 month mark my doctor tested my blood clotting abilities and cleared me to stop taking Warfarin (not knowing I had been off it for a couple of months)  two weeks ago my doctor wanted me to get another Doppler on my leg to see how the blood clot scaring looked as I was going to have another surgery on the same knee (he wanted a before and after picture to see if any further clotting would cling to the scar tissue) The Doppler tech looked up and down my entire leg and could not find ANY evidence I ever had a blood clot.  Naturally I was vindicated and wanted to share my success story with my fellow bloggers that are tired of being pumped full of drugs so that big Pharma can make billions of dollars addicting us to pills.  I know traditional medicine needs to be used in some cases, but I am happy the blood thinning and clot removal can be done naturally.  Now I need to find a natural way to heal the heartburn that has been a part of my life, thanks to the “rat poison” my doctor forced down my throat.

  • Anonymous

    9/1/2010 12:25:51 AM |

    Part 3

    ... Sorry Dr. Davis, but I am LIVING PROOF that you are wrong.

  • Anonymous

    9/1/2010 1:52:07 AM |

    The weight of the anecdotal evidence favors natto and nattokinase.  How can Dr. Davis continue to deny it?  To the most recent courageous person who posted in 3 installments, more power to you.  you give us all courage.

  • Anonymous

    9/1/2010 1:55:45 AM |

    Part 2 (sorry for the multiple posts but the server was having problem.)

    At the 6 month mark my doctor tested my blood clotting abilities and cleared me to stop taking Warfarin (not knowing I had been off it for a couple of months)  two weeks ago my doctor wanted me to get another Doppler on my leg to see how the blood clot scaring looked as I was going to have another surgery on the same knee (he wanted a before and after picture to see if any further clotting would cling to the scar tissue) The Doppler tech looked up and down my entire leg and could not find ANY evidence I ever had a blood clot.  Naturally I was vindicated and wanted to share my success story with my fellow bloggers that are tired of being pumped full of drugs so that big Pharma can make billions of dollars addicting us to pills.  I know traditional medicine needs to be used in some cases, but I am happy the blood thinning and clot removal can be done naturally.  Now I need to find a natural way to heal the heartburn that has been a part of my life, thanks to the “rat poison” my doctor forced down my throat.
    2 b continued...closing statement

  • Anonymous

    9/1/2010 3:48:34 AM |

    Part 4 - I need to add something to my story.  When I used the word Natto in my story, I was referring to Nattokinase.  I should have used NK for a shorten version as Natto is obviously a different form. Sorry for that confusion and the fact that my posts came separately, but I wanted to explain my whole story to help others that are tired of watching our health and this world be destroyed by chemicals and greed.  

    I really think the United states will never have an honest government until they stop allowing Big Pharma, Oil companies, etc. to fund the campaigns of our politicians.  There should be no political parties only Americans that want to protect our health & environment.  Also the only religion that should be affiliated with government is the freedom to practice it.  Watching people treat others badly in the name of their God is probable what drives people to not believe in any God.  

    Peace to you all and good healthSmile

  • Anonymous

    9/1/2010 12:27:10 PM |

    Thanks, Anonymous, for the complete five-part story.  I agree with you on all points. I think we like-minded people need to band together to try to impact the upcoming election.  Any ideas?

  • Anonymous

    9/1/2010 3:03:58 PM |

    Thanks for taking interest in my Nattokinase story (i wish I could have used just one post, but it was too long)and it is great to hear others with  a similar mindset.  Unfortunately, I'm really not sure any vote will matter until we have political reform in this country.  It is laughable to think any politician in any party is going to vote for political reform, when you have separate parties that are both controlled by corporations (Big Pharma, Oil companies, Telecommunication,etc.) funding their campaigns.  The only answer I can see is that you have a number of candidates with NO party affiliation that are not allowed to advertise.  A government political site could have a web page for each qualified candidate (where they answer a uniform set of questions so citizens know the type of policies they support) & TV networks could be forced to donate one commercial for each candidate.  NO special interest, NO personal money could be used.  The small cost to set up a webpage would have to come out of our taxes so that it is kept none bias. I know my idea may sound strange, but without political reform our votes are really just a hope that the persons we put in office will not be influenced by the people funding the ridiculous spending they use to advertise themselves and that is not going to happen.

    Take careSmile

  • Anonymous

    9/1/2010 5:59:03 PM |

    I like the idea of a non-partisan, beyond-the-2-party-deadlock  website.  I see no movement toward a real solution to our problems.  On Diane Rehm's show this morning, I heard about something I knew had to exist -- the BigPharma campaign to take control of medical marijuana, including influencing legislation that is outlawing grow-your-own stuff. The per-capita prescription drug use in the US is 11+, while in the poorest states, it's as high as 17.  We are fat, unhealthy and uninformed, so much so that Fox leads viewership.  Amazing that my country could deteriorate so fast. Take a look at this story: http://www.msnbc.msn.com/id/38727236/ns/health-forbescom

  • Anonymous

    9/2/2010 9:06:38 PM |

    One thing bothers me. FDA does not approve NK as a drug since it has not passed the required tests (clinical trials). On the other hand it is well known that going through the whole process of a certified clinical trial is lenghty and quite costly: only big farmaceutical industries could do it, as a long term investment. Since NK is a natural product, the returns out of such investment would represent for that company a net loss. So, there appear to be no solutions, other  than the organization of interested groups exchanging ideas and information in discussions, blogs [as the present one], ets., with moderators competent and sensible to the issues involved.  This in practice corresponds to a 'natural clinical trial' procedure. It may be objected that it might produce some increscious failures. But this is the case also among people accepting to take part in a certified trial. After all, what counts is the overall general outcome.

  • Anonymous

    9/4/2010 10:33:59 AM |

    Looks like Dr. Davis has been schooled here.  NK wins.

  • Anonymous

    9/22/2010 6:21:46 AM |

    Thanks for your 5 part story.  Hope you come back again to see this post.  It may sound counter-intuitive, but taking one tablespoon of Apple Cider Vinegar will get rid of your heartburn almost immediately.  People with heartburn actually need MORE acid in their stomachs.  Good luck.

  • Anonymous

    10/8/2010 1:40:01 PM |

    In the web several people claim urotherapy (drinking your own urine) is a panacea for a number of ailments (see http://en.wikipedia.org/wiki/Urine_therapy ). Scientific literature does not back this claim but agrees that generally this practice is not harmful (97% of urine is water, it is sterile, and its components come out from a filtering process balancing our blood constituents). The low fraction of urea in it, which in large quantities is toxic, has no adverse effect.
    One of the components of urine is urokinase, which is a potent fibrinolytic. This "natural", costless therapy could represent a safe (since merely enhancing an existing physiological process) alternative to nattokinase. At least for those who claim its validity, disregarding Dr. Davis' opinion that it would be destroyed by the acidity of the stomach.
    I practice urotherapy with good results (better digestion, better sleep, no discomfort whatsoever).
    It should be avoided in certain circumstances (see reference above).

  • Anonymous

    10/15/2010 5:54:48 AM |

    I am so glad I found this thread. I have found in life that the truth is usually somewhere in the middle. I am going to try nattokinase. I think nattokinase probably works at least some of the time, probably because if taken properly, SOME of it does survive. But as somebody noted earlier, I also believe some of these people had a severe vitamin K deficiency which was really the problem. Also, I am going to get off of anything that is a blood thinner like Ginkgo, aspirin or anything else and I'm not going to exceed 2,000 FUs a day. The bottom line is, there are too many people claiming to does work and not enough people dying from any adverse effects to keep me from not at least approaching it with caution.

  • Anonymous

    10/30/2010 5:48:32 AM |

    Thanks for the apple cider vinegar suggestion,  I will give it a trySmile  

    Update on my Nattokinase success story;  I had another doppler done on my leg post ACL surgey and all is clearSmile  The Doppler Tech was amazed when he saw the before and after pictures and had me write down the name of my supplement.  He had NEVER seen blood clots completely disappear like the ones in my leg. It feels good 2 prove Dr. Davis WRONG.

  • Anonymous

    10/31/2010 7:04:14 AM |

    Dear Dr. Davis,

    I have read these comments and can tell you from personal experience that Natto is a much safer way to keep blood from becoming sticky and clotting than thinning the blood with strong pharmaceuticals like Coumadin (Warfarin).

    My Dad had heart surgery and a complication that almost killed him post-operatively - a blood clot that traveled to his lung. Thank God, my Mom's intuition and his attentive Heart Specialist for finding it finally.

    Heparin was used for that intense situation. Then he was to go on Coumadin for 6 months.  After 1 month he started to experience blood blotches all over his body after a shower.

    Something was clearly happening to his blood that was not healthy or normal from the medicine - Not to mention having to go for Blood Tests every 3 weeks to see that it's not TOO thin and Not being able to ever eat healthy quantities of Green foods that build the bodies immune and other systems.

    The doctor's took him off of the Coumadin after several months at our  request and put him on daily aspirin - also to thin the blood and prevent future clots.

    It took him almost a full year of being Coumadin free for his post-shower blood splotches to clear up.

    Ten years later, he developed two small clots in his leg below the knee. The doctor wanted to start up a Coumadin again even though my Dad could not tolerate it.

    He warned us the clots could break off and travel at any time. We saw an MD who was also an ND and well versed. He recommended Nattokinase.

    We used it for 3 month and the MRI showed the clots were stationary. We upgraded to Boluoke Lumbrokinase (Many times more effective) and it had been two years and he is healthy.

    No new clots. No aspirin (since it may conflict with Natto or Lumbro). We are down to 1 tablet a day for maintenance with other natural blood thinners like Fish Oil.

    When he skips the Lumbrokinase, he will get leg cramps from the PAD. When he takes it - there is a marked difference.

    Nattokinase and Lumbrokinase are not miracle cures. But they are not derived from what was intended to be a Poision (Coumadin). The liklihood of a deadly side-effect is slim as they are naturally derived and have been used by many people for a number of years in Japan, China and other countries.


    My Dad can eat healthy green vegetables and drink green drinks. People on Coumadin can't and fear they will die without it. He takes the Lumbrokinase (or Natto if we run out of it) in a dose the ND and research has helped us determine works for his condition.

    He doesn't have to have his blood drawn every three weeks. And there are not long-term side effects that we have seen for the past two years.

    In conclusion, with Nattokinase and Lumbrokinase is a viable alternative to medicines that have immediate and possibly serious long term negative effects - even with the positive effects they are prescribed for.

    All I can tell you is that my Dad has a better quality of life  - and isn't that what we see a Doctor for to begin with?

  • Anonymous

    10/31/2010 7:14:50 AM |

    Dr. Davis,

    My Dad has been on Nattokinase, and then Boluoke Lumbrokinase for more than 2 years in response to two small blood clots below his kneee.

    He could not tolerate Coumadin - he had it more than fifteen years ago for a blood clot after heart surgery.  It gave him blood splotches all over his body after showering. He was only on it for 2 months. Instead he was on low dose aspirin and we saw an MD who is also an ND for a strong antioxidant and heart health program.

    We decided against the Coumadin and opted for the Nattokinase (3x day). The MRI showed the clots stayed the same size or were slightly smaller after 3 months. No new clots. We upgraded to Boluoke Lumbrokinase (3x day).

    It has been 2 years and no further clots. We are down to 1x a day on the Lumbrokinase.

    My Dad feels great, can eat greens make healthy green drinks and doesn't need to go for a blood test every 3 weeks for Coumadin.  If he skips the Lumbro, he will get a cramp in his legs from PAD - noticeable difference.

    Quality of Life is what it is about for my Dad. We've been through the surgery, drugs and side-effects.  

    With solid health research, consulting an experienced MD/ND and determination to find a solution that is not a long-term use of a strong pharmaceutical drug, we have a healthy program.

    Natto and Lumbro are not miracle cures. But they are giving my Dad the quality of life in his older years he could never have with the long term use of potent medications that interfere with the body's natural processes rather than work with it to strengthen it.

  • Anonymous

    10/31/2010 9:19:57 PM |

    Dr Davis:  What are your thoughts on enzymes such as Wobenzymor other enzyme products such as bromelein for myalgia pain?

  • buy jeans

    11/2/2010 7:42:31 PM |

    I have read his research. I stand by my opinion: Nattokinase is a scam. It is an utterly ridiculous notion that anyone should take oral thrombolytic agents to "prevent blood clots". Thrombolysis is a dangerous strategy, even if it worked in humans by the oral route. An agent that, if it worked, poses serious potential for severe side effects and death needs to be tested thoroughly first. It is plain idiocy to use this agent. It is not fish oil, it is not a vitamin, it is something entirely different that has no basis for use as a preventive. You're throwing your money away.

  • Bpb

    11/3/2010 11:51:49 AM |

    I posted a lengthy comment on November 1, where is it?  If you are going to have free speech then have it. If the moderator is going to choose what get's posted then let's bring back Hitler and burn all the books

  • xanax

    11/7/2010 1:34:10 PM |

    Problem is that it's even nuttier to be taking warfarin chronically, considering it's _known_ interaction with vitamin K

  • Anonymous

    11/7/2010 6:32:53 PM |

    The whole point of warfarin is in it's interaction with vitamin K, that is how it works. Also, warfarin is a nearly identical synthetic derivative of a naturally occuring myotoxin called dicoumarin, so warfarin is about as natural as most supplements being promoted as such. If you were really concerned, you could get the all natural version, dicoumarin.


    Warfarin is nasty stuff, which is why doctors carefully weigh the risks versus the benefits of it.


    If you only believe in testimonial evidence given on this blog by commenters, you can still prove to yourself nattokinase is a scam because there are people here shilling it here claiming it helped them clot as well as bust clots.

  • ardi

    11/11/2010 4:36:36 AM |

    You recommend vitamin K2 for people with heart disease because of its property to slow or reverse the process of calcification of the arteries.  However, vitamin K2 promotes the ability of blood to clot, which is especially dangerous for people with heart disease.  
    I am confused by this contradiction.

  • Anonymous

    11/27/2010 12:29:14 AM |

    Does he work for the pharma industry? Doctors are trained to prescribe drugs. Patients have become used to Placebo treatments. Hey! it's a win-win situation. For 5+ years, I worked for Pfizer in Groton, Connecticut and I have been deeply involved with their marketing strategies. Even if Natto were to work, or works, they will never allow it to be considered safe to use, unless regulated by the Pharma industry. Too much money to be lost here. Yes. This is the truth. Work in a pharma establishment, get involved with their tactics and assess yourself. The whole industry is like Amway (no doubt, there are absolute good things this industry has brought for humanity though). Food for thought - get the book "The Encyclopedia of Medical Breakthroughs and Forbidden Treatments" http://cancerdefeated.com/DIA/ or just Google it.

  • jack

    12/19/2010 11:21:25 PM |

    I don't see the answer to the question posted on November 10 ( i think) which said, You recommend vitamin K2 for people with heart disease because of its property to slow or reverse the process of calcification of the arteries. However, vitamin K2 promotes the ability of blood to clot, which is especially dangerous for people with heart disease.
    I am confused by this contradiction.

    I am lookin for the same answer.
    Thank you

  • jack

    12/19/2010 11:22:18 PM |

    You recommend vitamin K2 for people with heart disease because of its property to slow or reverse the process of calcification of the arteries. However, vitamin K2 promotes the ability of blood to clot, which is especially dangerous for people with heart disease.
    I am confused by this contradiction.

  • Anonymous

    12/20/2010 4:28:57 PM |

    I have read the 'for'/'against' arguments about using Nattokinase with interest. I was looking for some guidance on using this product, but instead have uncovered a 'minefield' of claim and counter-claim. Just who can you believe? Well, history is littered with disasters brought about by so-called 'safe' drugs, developed by the big pharmaceutical companies. So although, clinical trials do need to be carried out, they offer no guarantee of 100% safety or, the prevention of possible side-effects. I am also sceptical of anyone who dismisses something so readily. Keeping an open mind until proven otherwise seems a much more sensible approach, especially with so much positive anecdotal evidence being posted. There is much about the human body that even the most eminent MD does not fully understand. So discrediting Nattokinase without this complete knowledge is, at best foolish. Most people are simply looking for help at a time of concern over their health. Please remember this all you doctors out there and don't ridicule something until you know for sure. And, unless I've missed something - you don't!

  • Dr. William Davis

    12/21/2010 1:04:41 PM |

    Jack--

    K2 NORMALIZES clotting, it does NOT cause it.


    Anon-

    My thinking does not change on nattokinase. It still remains foolhardy to believe that, based on marketing claims and the flimsiest of evidence, that you would chance taking a "supplement" for a potentially life-threatening condition. It's not that I love the drugs; it's I like not dying to enrich some foolish supplement manufacturer who makes claims without evidence.

  • Harold

    12/26/2010 10:34:46 PM |

    All foods, (excepting undigestible minerals) are composed of CHO or carbohydrates, including protein which differs by carboxyl minerals in the CHO chain. So it was interesting that you point out no proteins nor enzymes pass through the intestine into the blood.

    However, breaking down nattokinase to its amino acids does provide the blocks to rebuild serine protease.

    "Serine proteases are inhibited by a diverse group of inhibitors, including synthetic chemical inhibitors for research or therapeutic purposes, and also natural proteinaceous inhibitors. One family of natural inhibitors called "serpins" (abbreviated from serine protease inhibitors) can form a covalent bond with the serine protease, inhibiting its function. The best-studied serpins are antithrombin and alpha 1-antitrypsin, studied for their role in coagulation/thrombosis and emphysema/A1AT, respectively. "
    http://en.wikipedia.org/wiki/Serine_protease

    It's necessary to eat foods or the enzymes or proteins that can provide the amono acid materials to form enzymes the body uses for repair. The wonder is what other foods could offer the same as natto.

    If the argument is that no proteins or enzymes pass digestion, then it might be assumed that people are wasting time eating them, so fats and sugars are needed.

  • Anonymous

    1/1/2011 12:34:35 AM |

    I'm sure the FDA's sperm finds its way to that nice shiny skin of yours, so why wouldn't nattokinase do the same.

  • Anonymous

    1/11/2011 3:04:46 AM |

    I am done taking Warfarin. I do not want osteoporosis and am using Now Foods Natto-100mg,120 veg cap.

    I feel better than I did on the warfarin. My periods are much better and I do not have the clutching feeling in my chest that I had after being diagnosed with bi-lateral pulmonary embolisms.

    Thank God for Natto. Please research it more. It works.

  • Anonymous

    1/17/2011 5:35:04 AM |

    I had started taking vitamin K2 and notice that my bones are getting stronger (osteopenia) especially my jaw so less problems with my teeth.

    Secondly, I had some "spider veins" popping out on my legs (not severe) and they seem to have disappeared.

    Can someone out there tell me what this phenomena is? I knew about Vit K2 and bones, but spider veins??

  • Anonymous

    1/18/2011 3:31:59 PM |

    Dr. William Davis is either a narrow minded "know-it-all" or he (like many others in his profession) is having his pocket filled with blood money via Big Pharma.  

    I have documented my success story in my several part post and wanted to return to this forum to encourage others that there is hope beyond the rat poison known as Warfarin.  Nattokinase not only prevented further blood clots, but much to my Doctor & his Doppler Tech’s surprise, it COMPLETELY removed the blood clot without even a trace or scar.

    So Dr. Big Pharma can continue showing it’s true colors and bad mouth Nattokinase, & doctors can use medical terms to describe why it’s not possible for this substance to work and those who were willing to risk using a natural alternative to help with blood clots (LIKE MYSELF) can continue 2 prove how ignorant and WRONG they are.

    I will try to check back from time to time and continue my blood clot free success story.

    Good luck to the true believersSmile

  • Anonymous

    1/20/2011 6:45:33 AM |

    My mother who has been chronically ill and misgidanosed for decades began taking nattokinase as well as bolouke, rottozyme (spelling)..and several other supplements in October 2010 under the care of a naturopath physician.  The first in two decades she is showing improvement on multi-system levels!  I find it UTTERLY RIDICULOUS that dr's prescribe dangerous immune suppresents such as Remicade, Enbryl, my mothers were $1200 per pop, 2 hour infusion into her elbow that caused permanent nerve damage, dr's ignoring warning signes that are bioligic and made from mouse and hamster cell protiens, caused lesions in her brain and spinal, and that she was given Celebrex for more than a decade that was black box warned in 2001 and multiple lawsuits for causing strokes.  The proof is in the pudding for me.  My mother's health is improving, she is now walking, talking, showing interest, absolutly no negative side effects.

  • Anonymous

    1/20/2011 7:18:00 AM |

    And, Utterly ridiculous that most people are brainwashed to question natural, mother nature provided us with what we need...and brainwashed to totally trust taking man made synthetic chemicals and invasive surgeries as the only option, thinking them as superior & the only way.  My mother was too frail to endure any more synthetic chemicals that nearly killed her.  Wish I would have known about many of these  alternatives 20 years ago.  Another example, Artemisinin...been around for thousands of years, used to treat malaria and proven cancer cure for many types of cancer, even some strains resistant to chemo.  You won't hear about Artemisinin (the holly grail cure) until the UW professor who currently has a patent and developing a "sythetic version" so Pharma companies can market it. . .puts it on the market. totally true, google it.

  • Anonymous

    1/20/2011 7:39:47 AM |

    And I bet there are many out there who don't believe that parasites, fungus, mold, acidic high fat diet, skeletal structural issues and toxins are the cause for most all disease - and MDs will rarely if ever investigate and treat.  Nor believe that  natural mineral seasalt - the oldest antibiotic known to mankind, oil of oregano - thousands of uses for disease and parasite cures, chlorella, very popular and hightly used in Japan...ionic therapy...personally, I have taken niacin 500 mg every morning for circulation, have since my 20's. I knew somthing was wrong and kept getting poo-pood by dr's...unknown to me, I had congenital lyme, like my mother. For me, kept my blood from turning to syrup & ionic therapy totally helped me to regain my life, health & focus. Everyone is different, exposure, threshold levels..we should all be able to make informed decisions and choices about our health.  Medicare, like many insurance companies, do not pay for alternative medicine at this time...and times need to change. We are so behind the rest of the world.

  • Anonymous

    2/12/2011 6:55:42 PM |

    July 8 you stated there are some truly great supplements but NOT nattokinase. Why did you not name those supplements? Afraid that nattokinase or other healthy supplement would reduce your and big pharmas income?

  • Anonymous

    3/2/2011 5:51:46 PM |

    Fibrovan - I am a 46 yr old from Caddo Mills Tx.  For 2-3 yrs now I have had unbelievable heavy cycles and clots. A sonogram a year earlier revealed I had fibroids. My cycles were so bad, I had a hard time working. The sonogram at the hosp cost $500 w/insurance.  I am a single mom receiving no support and can not afford surgery. I am VERY skeptical and not an easy sell. I decided to try Fibrovan in desperation. I took it faithfully and am amazed at the results!!!! I am having a normal cycle, my stomach feels 'deflated' and I didn't think I was bloated before. I decided to google this product again to see if there were bad side effects.  I never believe these posts that are good and always think they must work for the company.  I AM TELLING YOU so far 100% satisfied !!!!!! Smile

  • Mark UK

    4/19/2011 8:43:40 AM |

    Hi Im Mark 53 years old and live in the UK, I've been in AF since March 2010 I've been on warfarin since June 2010 and have had a good INR of appox 2.5 and Im tested every week.
    2 weeks ago I went for an AF ablation at Harefield Hospital UK after getting myself in the right frame of mind about having the 5 hour ablation operation I was woken after 1 hour to be told they could not see if my LAA (left artial appendage) was clear of clots using an ultrasound device so I was put in a CT scanner only to be told my LAA was full of THROMBUS, so my doctors now want my INR to be 3.00 and I now have to wait 4 to 6 weeks to have another CT scan and hope the Thrombus has gone so I can have the Ablation and pray in the mean time I dont have a stroke or pulmonary embolism. I am concidering that if after the 6 week CT scan the Thrombus is still there that maybe my body needs the help of some nattokinase and less Warfarin if there is a balance to be found I will buy a Blood Testing CoaguChek XS PLUS system kit to test myself daily for my INR of my normal 2.5 level, because I feel to do nothing after my 6 weeks CT scan is maybe waiting time I may not have, I will leave more comments as time goes on and let you read what happens in the weeks to come, Kind regards Mark

  • ggaylmer

    4/26/2011 9:26:22 PM |

    I'm fed up reading opinions from "Anonymous".  Are they all the same person?  Why can't you give your name?  At least Dr Davis is not afraid to give his name.

  • Derek Weiss

    5/26/2011 1:33:05 PM |

    I've worked ER for fifteen years, and while I don't have data, only my observations, I'd have to say your statement is WAY over exaggerated.

  • John Doe

    6/16/2011 6:00:20 AM |

    ggaylmer - I don't know about others but I am the "Anonymous" that posted my multi-part success story and the reason I did not use my name is because I do not trust the power and corruption of Big Pharmaceutical companies.   You may find it hard to believe, but I feel there  is no difference between a multi-billion dollar company protecting it's interests and organized crime syndicates of old.

    I am still 100% clot free and now only use Nattokinase one week a month to make sure I stay that way.  Good Health to allSmile

  • Rick Parker

    7/4/2011 10:56:14 PM |

    I used nattokinase to dissolve some blood clots that I had. It cleared them up with no observed side effects, except that I bruised very easily.

  • John Francis

    7/16/2011 1:09:11 AM |

    Anyone out there have any experiance with using Cardiokinase?

  • Cassondra

    9/9/2011 10:06:12 AM |

    I'm grateful for Nattokinase NSK-SD and Cardiokinase. I had a large DVT stemming from behind my knee to mid-calf in 2006 that went away after taking Nattokinase. I did a blood panel not long after I was diagnosed with the DVT, and was additionally diagnosed with MTHFR (two genes) and Factor 5 Leiden (one gene). My Dr. said I would be a "warfarin-for-lifer" but I was only 23 years old when he said that. I'm not sure I'd be in such good condition today, at 28 years old, if I was still taking warfarin daily. It only took me 4 months of being on warfarin before I decided to educate myself about alternatives. During the 4 months being on warfarin, I felt sick much of the time. After taking Nattokinase for a couple months, I went back to the Dr and I no longer had a DVT. Some might deem me a "guinea pig" to this supplement and I'm okay with that. Nattokinase has helped me stay clot free since 2006, even during my pregnancies. I trust Nattokinase over the prescription options, based on the information I've gathered on all counts. The pros outweigh the cons, and it boils down to what *I* feel comfortable taking based on what I know.

  • Kay G

    10/6/2011 9:57:36 PM |

    Contrary to the negative belief that Nattokinase is only a scam, I must tell you that it SAVED MY life.  I read hoards and hoards of complaints here in the forum that there is NO scientific evidence that if taken oraly that it will be effective.  Well my proof is in MY own experience and that is as follows:  for several months I experienced heaviness in my legs and it became very painful for me to even move out of my drivers seat after my 40 minute drive from work each day.  Each time I pulled into my driveway I'd have to prepare myself for  the pain I knew I was about to endure just moving from my car to my front door.  Not exactly the way one wants to end their work day EVERY day.  But that's only the begining...soon I began experiencing an annoying numbness in my left leg when lying down and that same feeling in my left arm as well.  I would elevate my legs and at times that would help but I knew I had to do something more internally to help.  At the same time I began getting lesions on my legs and began to REALLY become afraid after reading the possible reasons for such on countless sites.  I ran across a site speaking of Natto and its ability to naturally disolve blood clots.  I had NO intention on taking Cumadin or Warifin after reading of its danger AND high costs.  I reseached Natto and decided that to order such from Japan or even CA would NOT be too wise as I had NO interest in worrying about the radiation that has taken place recently.  So I decided to take Nattokinase--its supplemental form.  PLEASE BELIEVE ME WHEN I TELL YOU THAT IN ONE MONTH AND A HALF  after taking it, I have had NOT even ONE of the problems described above.  I'd like to add that I am only 40 which tells me that part of my problem with my circulation had to be genetic...along with my sometimes poor eating habits AND the fact that I STAND for all  8 hours of my work shift there at the PO.  I stand by Nattokinase.  It has help me immensely.

  • vicola65

    3/11/2012 9:52:24 AM |

    I''m commenting on an older post from a woman with heavy menstrual bleeding and fibroids and am hoping that in nearly 3 years since her post she''s found relief but perhaps someone else experiencing the same symptoms may find this helpful. I take Doctors'' Best  serrapeptase and nattokinase, both enteric coated.  Here is how it all started.   I experienced prgressively heavy bleeding which basically took over my life, horrible pelvic pain 24/7, inexplicable bladder infections, constant back pain, borderline aneia and overall debilitating feeling of malaise for years.  My (now former) OBGYN treated individual symptoms as they came up, put me on additional estrogen therapy (!) and prescribed high iron pre-natal vitamins for anemia... basically wrote it off as some of the pain in my head and some attributed to my age (then early 40''s and otherwise appeared healthy).    I found that eliminating all red meat helped a bit but still ate soy-based protein and only wild-caught fish. A week after a ''normal'' annual exam,  in early 2010 I landed in the ER in indescribably agony.  After being pumped full of morphine to allow a scan was told of a ''mass'' on my left ovary.  In the next weeks that follwed it was determined that the mass obscured the ovary and it had to come out asap  to determine if it''s cancer,, given the size.  I was also put on vicodin for pain and for the first time in years had a pain free month .I went in calm just to get the ''thing'' out.   When I came out of surgery, my fantastic oncological surgeon gave me the good and the bad. The good turned out to be that he (laporoscopically) removed my ovary, the fallopian tube .and the tangerine-sized ovarian cyst which apparently grew inside the ovary and had smaller ones forming. The real (ha ha) problem turned out to be a stage iV  (!) endometriosis with ''substantial'' amount of endo scar tissue (YEARS!) which fused my many organs together. It took years t get to that point and the combination of symptoms made me a classic example of this disease.  The hour-lng surgery actually took two hours as my doc attempted to remove as much tissue as possible.  My recovery was great - 1 week back to work vs. 9 if operated old school. I happily waited for the feeling of pelvic ''heartburn'' pain  from before to disappear. Unfortunately, when it did not my new doc explained that I still have endetriosis, the remaining tissue produces exponentially more estrogen and causes it to spread.  She advised  Lupron shots to get that under control and to regulate the pain and avoid further disease advance.   I was devastated especially after learning about the med side effects.  
      Instead, I researched everything I could and decided to start fighting the estrogen attack through a strict ''endo'' diet which was close to how I ate already except no soy at all and, of course, gluten free.  To deal with the existing tissue and help the pain, I''ve been ordering Doctors Best Serrapeptase and Nattokinase and taking both (along with green tea extract) at least 1-2 hrs before food (they are also enteric caps), one nattokinase during the day and both at night.   I have for years taken K2/K1 supplement and 5K Vitamin D3 already.  In less than 2 weeks my pain, including back pain (from Tarlov cyst found during the CT scan pre-op), disappeared. That was about a year ago.  I''ve also added yarrow (hormone regulation) and chaste berry (to control bleeding) and am for the first time in the last decade living pain free and functioning normally.  Based on my experience I bought the same enzymes for my sister in law who suffered horribly from fibroids and she, within a month or two, felt considerably better.  Enteric caps are key. I take mine with a full 12 oz of water with a 1/2 tsp of  aluminum free baking soda.   I also noticed that my 25+ year old tendonitis in my elbows/wrists is completely gone, my knee joints feel as if I were in my 20''s.   I plan to continue my regimen until there is a need for something else. At 5'' 10", 135-140 lbs Imy blood pressure is ideal as is cholesterol. These enzymes and a tweaked diet are the only thing I''''ve changed.  I believe that they work as long as they are taken correctly - enteric caps on an empty stomach, otherwise they just work as potent digestive aids which is not a bad thing.  
    I could not be happier.

  • vicola65

    3/11/2012 10:17:22 AM |

    April, Thank you!   I just (overshared) by story as a response to an earlier post.   Big pharma is not always the answer, no matter how much one''s insurance covers.  In fact, I love having an effective solution or two without the added side-effects or dependency on my insurance in case of job loss.  Tow years ago, if someone told me that taking 400 mg liquid CoQ10 daily would wipe out out my migranes, be totally allergy free by drinking Gypsy Cold Care tea (b''bye $30 month/co-pay) and Serrapeptase/Nattokinase combo  would rid me of chronic pain and is likely dissolving my endo scars... well, I wouldn''t believe it either but there it is.

  • vicola65

    3/11/2012 11:06:31 AM |

    Kay,  I too have read every comment on this forum and vast majority of comments are pro NK SP, not against it.   One person complained about the anonimous posts but, honestly, if he/she does not understand that sharing medical issues on the internet is not a big deal that individual needs to learn a bit more on that topic and that''s not what''s important here.  I am a happy much healthier person having found these enzymes in early 2011. (When I posted I wrote about an ovarian cyst removal in 2011 though accidentally put 2010).  The ONLY point where I would agree with Dr. Davis is that just because something is ''natural'' that it is automatically safe. By the same token, however, just becuase something is natural it does not mean that a Big Pharma solution is more effective.  Curare, for example, is both natural and lethal.  Thankfully, these enzymes bought from reputable vendors (mine are from Doctors Best) are reasonably priced and work great.   Everyone''s bodies are different, many folks suffer from poor absorbtion of nutrients because they''ve spent years eating processed foods, bodies riddled with candida and/or yeast.  We need enzymes to digest properly. Everyone can benefit from these supplements in one way or another.  To get the full clot fight we do have to make a bit of effort but I cannot imagine living without them now.

  • Andrea

    12/11/2012 7:16:01 PM |

    God bless you and I pray Jesus will heal you

  • Bonita

    7/1/2014 11:32:04 PM |

    Due to a short course of Premarin (estrogen) to help with uterine fibroid symptoms in 2009, I ended up with a DVT that spread to my lungs within 2 months with barely any noticeable symptoms until my leg was hurting so bad that I ended up in the ER.  After almost 2 weeks in the hospital on Coumadin and Lovenox I went home and weaned myself off of the Coumadin and started nattokinase.   I took it for about 6 months and went off of it for a brief period until my symptoms returned in my leg.  I restarted it and then took it for another 9 months just to be sure and when I stopped taking it, there were no more symptoms.   So if nattokinase is a scam then why did my clots and symptoms go away and I've had no problems since then?  I would also at times add the serrapetase to the natto as well.   It did also help improve my fibroid symptoms as well.  The enzymes break down any fibrin and dissolves it.  Unlike Coumadin which prevents clotting...not a good thing if you get injured is it?

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And you thought gasoline was expensive

In 1995, the Palmaz coronary stent was introduced, the brainchild of Drs. Julio Palmaz and Richard Schatz. Medical device manufacturer, Johnson & Johnson, priced the device at $2500 per stent.

Let's put this into perspective: At just 0.05 grams per 15 millimeter stent, that put the price of the common stainless steel used to manufacture the stent at $22,650,000 per pound.

Only after several competing stents finally made it to market did J&J reduce its price to its bargain price of $1200, or $10,872,000 per pound. And to think that most of us were shocked to find out that the U.S. military paid $200 for a hammer.

Since 1995, a competitive market for stents has developed, pushing prices down. Now, you can purchase a brand-new coronary stent for as little as $4,000,000 per pound.

Medical device manufacturers have been guilty of a degree of greed that would make many Wall Street bankers blush. That's why I call medical devices "the industry of infinite markups."

"Hey buddy, wanna buy some exorphins?"

Dr. Christine Zioudrou and colleagues at the National Institutes of Mental Health got this conversation going back in 1979 with their paper, Opioid peptides derived from food proteins: The exorphins.

Exorphins are exogenously-derived peptides (i.e., short amino acid sequences obtained from outside the body) that exert morphine-like properties. Mimicking the digestive process that occurs in the gastrointestinal tract using the gastric enzyme, pepsin, and hydrochloric acid (stomach acid), Zioudrou et al isolated peptides from wheat gluten with morphine-like activity. They followed this research path because of the apparent association of wheat and mental illness.

In the bioassays used, wheat-derived exorphins competed successfully with the endogenous opiate, met-enkephalin. Interestingly, casein-derived (i.e., casein milk protein) exorphins were also identified that also displayed opiate-binding activity, though less powerfully. The morphine-like activity was also blocked by the drug, naloxone (the same stuff given to people exposed to morphine overdose).

Among the many devastating effects of celiac disease , the immune disease that develops from wheat gluten exposure, are mental and emotional effects, such as anxiety, fatigue, mental "fog," depression, bipolar illness, and schizophrenia, that disappear with removal of gluten. Many parents of autistic children also advocate wheat-free diets for similar reasons.

Among the many wonderful comments posted on the last Heart Scan Blog post, "I can't do it," was Anne's:

I am not the Anne in your post, but I was addicted to wheat. It was my favorite food. I lived on and for breads. Then I discovered I was gluten sensitive and I did go through a withdrawal of about 4 days. After 4 days I noticed my health problems were disappearing. Depression, brain fog and joint pain are 3 of the many symptoms that disappeared. That was 6 yrs ago.

Tell Anne that I had dreams about bread in the beginning - they will pass. Now the donuts, breads, cookies and cakes in the stores and at work don't even look good. In fact, I don't like the smell of bread anymore. It takes time, but the cravings do pass.



Combine wheat"s exorphin-driven addictive potential with its flagrant blood sugar-increasing properties, and you have a formula that:

1) makes you fat
2) increases likelihood of diabetes, and
3) makes you want to keep on doing it.

Reminds me of nicotine.

My personal view: I have absolutely no remaining doubt that wheat products have no place in the human diet. Not only does the research provide a plausible basis for its adverse health effects, but having asked hundreds of people to remove it from their habits has yielded consistent and remarkable health benefits. Just read the reader comments here and here.

"I can't do it"

Anne sat across from me, bent over and sobbing.

"I can't do it. I just can't do it! I cut out the breads and pasta for two days, then I start dreaming about it!

"And my husband is no help. He knows I'm trying to get off the wheat. But then he brings home a bunch of Danish or something. He knows I can't help myself!"

Having asked hundreds of people to completely remove wheat from their diet, I witness 30% of them go through such emotional and physical turmoil, not uncommonly to the point of tears. For about 10-20% of people who try, it is as hard as quitting cigarettes.

Make no mistake about it: For many people, wheat is addictive. It meets all the criteria for an addictive product: People crave it, consuming it creates a desire for more, lacking it triggers a withdrawal phenomenon. If wheat were illegal, there would surely be an active underground trafficking illicit bagels and pretzels.

Withdrawal consists of fatigue and mental fogginess that usually lasts 5-7 days. Just like quitting smoking, wheat withdrawal is harmless but no less profound in severity.

People who lack an addictive relationship with wheat usually have no idea what I'm talking about. To them, wheat is simply a grain, no different than oats.

But wheat addicts immediately know who they are. They are the ones who can't resist the warm dinner rolls served at the Italian restaurant, need to include something made of wheat at every meal, and crave it every 2 hours (matching the cycle of blood sugar peaks and valleys, the "valley" triggering the craving). When they stop the flow of immediately-released glucose that comes from wheat (with blood sugar peaks that occur higher and faster than table sugar), irresistible cravings kick in. Then watch out: They'll bite your hand off if you reach for that roll before they do.

Break the cycle and the body is confused: Where's the sugar? The body is accustomed to receiving a constant flow of easily-digested sugars.

Once the constant influx of sugars ceases, it takes 5-7 days for metabolism to shift towards fat mobilization as a source of energy. But along with fat mobilization comes a shrinking tummy, reducing the characteristic wheat belly.

If you try to quit smoking, you've got "crutches" like nicotine patches and gum, Zyban, Chantix, hypnosis, and group therapy sessions. If you try and quit wheat, what have you got? Nothing, to my knowledge. Nothing but sheer will power to divorce yourself from this enormously destructive, diabetes-causing, small LDL-increasing, inflammation-provoking, and addictive substance.

Spontaneous combustion, vampires, and goitrogens

What do the following have in common:

Lima beans
Flaxseed
Broccoli
Cabbage
Kale
Soy
Millet
Sorghum?

They are all classified as goitrogens, or foods that have been shown to trigger goiter, or thyroid gland enlargement. Most of them do this either by blocking iodine uptake in the thyroid gland or by blocking the enzyme, thyroid peroxidase. This effect can lead to reduction in thyroid hormone output by the thyroid gland, which then triggers increased thyroid stimulating hormone (TSH) by the pituitary; increased TSH acts as a growth factor on the thyroid, thus goiter.

Add to this list of goitrogens the flavonoid, quercertin, found in abundance in red wine, grapes, apples, capers, tomatoes, cherries, raspberries, teas, and onions. Most of us obtain around 30 mg per day from our diet. Quercetin, often touted as a healthy flavonoid alongside resveratrol (e.g., Yang JY et al 2008), has been shown to be associated with reduced risk for heart disease and cancer. Many people even take quercetin as a nutritional supplement.

Quercetin has also been identified as a goitrogen (Giuliani C et al 2008).

What to make of all this?

Most of these observations have been made in in vitro ("test tube") preparations or in mice. Rabbits who consume a cabbage-only diet can develop goiter.

How about humans? The few trials conducted in humans have shown little or no effect. In most instances, the adverse effects of goitrogens have been eliminated with supplemental iodine. In other words, goitrogens seem to exert their ill thyroid effects when iodine deficiency is present. Restore iodine . . . no more goitrogens (with rare exceptions).

Should we as humans adopt a diet that avoids apples, grapes, tomatoes, red wine, tea, onions, soy etc. on the small chance that we will develop goiter?

I believe that we should avoid these common food-sourced goitrogens with as much enthusiasm as we should be worried about spontaneous combustion of humans or the appearance of vampires on our front porches. We are as likely to suffer low thyroid activity from quercetin or other "goitrogens" as we are to experience the "mitochondrial explosions" that are purported to set innocent people afire.

Magnesium and you-Part II

Blood magnesium levels are a poor barometer for true body (intracellular) magnesium.

Only 1% of the body’s magnesium is in the blood, the remaining 99% stored in various body tissues, particularly bone and muscle. If blood magnesium is low, cellular magnesium levels are indeed low—very low.

If blood magnesium is normal, cellular or tissue levels of magnesium may still be low. Unfortunately, tissue magnesium levels are not easy to obtain in living, breathing humans. In all practicality, a blood magnesium test only helps if it’s low, while normal levels don’t necessarily mean anything and may provide false reassurance.

Short of performing a biopsy to measure tissue magnesium levels, several signs provide a tip-off that magnesium may be low:

• Heart arrhythmias—Having any sort of heart rhythm disorder should cause you to question whether magnesium levels in your body are adequate, since low magnesium levels trigger abnormal heart rhythms. In fact, in the hospital we give intravenous magnesium to quiet down abnormal rhythms.
• Low potassium— Low magnesium commonly accompanies low potassium. Potassium is another electrolyte depleted by diuretic use and is commonly deficient in many conditions (e.g., excessive alcohol use, hypertension, loss from malabsorption or diarrhea). Like magnesium, potassium may not be fully replenished by modern diets.
• Muscle cramps— Magnesium regulates muscle contraction. Leg cramps, or “charlie-horses”, painful vise-like cramps in calves, fingers, or other muscles, are a common symptom of magnesium deficiency. (Leg cramps that occur with physical activity, such as walking, are usually due to atherosclerotic blockages in the leg or abdominal arteries, not low magnesium.)
• Migraine headaches—Reflective of magnesium’s role in regulating blood vessel tone, low magnesium can trigger vascular spasm in the blood vessels of the brain. In some emergency rooms, they will actually administer intravenous magnesium to break a migraine.
• Metabolic syndrome—Magnesium plays a fundamental role in regulating insulin responses. Metabolic syndrome (low HDL, high triglycerides, small LDL, high blood pressure, increased blood sugar, excessive abdominal fat, etc.) is triggered by insulin responses gone awry and is clearly linked to low magnesium levels.

The absence of any of these tell-tale signs does not necessarily mean that tissue levels of magnesium are normal.

Then how do you really know? There really is no easy, available method to gauge body magnesium. As a practical solution, we therefore have aimed for maintaining serum levels of >2.1 mg/dl or RBC magnesium (a surrogate for tissue levels) of >6.0 mg/dl. (Going too high is not good either, so occasional monitoring really helps. However, I've only seen this once in a psychotic woman who drank ungodly amounts of magnesium-containing antacids for no apparent reason; she almost ended up on a respirator due to respiratory suppression by the magnesium level of 11 mg/dl!)

In all practicality, because of magnesium’s crucial role in health, its widespread deficiency in Americans, and the growing depletion of magnesium in water, supplemental magnesium is necessary for nearly everyone to ensure healthy levels.

More on magnesium to come.

Lethal Lipids II

I call the combination of low HDL, small LDL, and lipoprotein(a) "lethal lipids," since the trio is an exceptionally potent predictor for heart disease. Uncorrected, the combination is a virtual guarantee of heart disease.

Ed is a perfect example of someone who came to my office recently with this pattern. His starting values:

HDL: 34 mg/dl

Small LDL: 78% of total LDL
NMR: Small LDL 1655 nmol/L; total LDL particle number 2122 nmol/L)

Lipoprotein(a): 205 nmol/L



The atherogenicity, or plaque-causing potential, of this pattern was reflected in Ed's heart scan score of 2133.

You can readily see that, of this combination, only HDL cholesterol would be adequately identified through conventional lipid testing. Small LDL and lipoprotein(a) need to be specifically measured via lipoprotein testing.

And, contrary to the drug industry's "statin drugs for everybody" motto, this pattern, while improved with statin therapy, is not shut off.

Specific correction of each abnormality is required. For instance, niacin addresses all three: increases HDL, reduces small LDL, and (usually) reduces lipoprotein(a). A standard low-fat diet makes this pattern worse by reducing HDL, increasing small LDL, and (usually) increasing lipoprotein(a).

"You've got 10 minutes"

There's a new trend in office healthcare in Milwaukee: Time-restricted office visits.



I'm told by several physicians who are employed by a major healthcare system here in town that they are peridically watched--physically watched by an administrator--to make sure that they do not exceed the allotted 10 minutes of time. My cardiologist colleagues, I gather, were at first incredulous at such intrusions into their practices, but apparently had no choice: They were employees.



Goiter, goiter everywhere

The results of the recent Heart Scan Blog poll are in.

The question:

Do you used iodized salt?

The responses:

Yes, I use iodized salt every day
94 (28%)

Yes, I use iodized salt occasionally
56 (16%)

No, I do not use any iodized salt
41 (12%)

No, I use a non-iodized salt (sea salt, Kosher)
126 (37%)

No, I use a non- or low-sodium substitute
15 (4%)


Thanks for your responses.

If only 28% of people are regular users of iodized salt, that means that the remainder--72%--are at risk for iodine deficiency if they are not getting iodine from an alternative source, such as a multivitamin or multimineral.

Even the occasional users of salt can be at risk. The common perception is that occasional use is probably sufficient to provide iodine. This is probably not true and not just because of the lower quantity of ingestion. Occasional users of salt tend to have their salt canister on the shelf for extended periods. The iodine is then lost, since iodine is volatile. In fact, iodine is virtually undetectable four weeks after a package is opened.

In my office, now that I'm looking for them much more systematically and carefully, I am finding about 2 people with goiters every day. They are not the obvious grotesque goiters of the early 20th century (when quack therapies like the last post, the Golden Medical Discovery, were popular). The goiters I am detecting are small and spongy. Yesterday alone I found 5 people with goiters, one of them visible to the eye and very distressing to the patient.

It seems to me that iodine deficiency is more prevalent than I ever thought. It is also something that is so simple to remedy, though not by increasing salt intake. Kelp tablets--cheap, available--have been working quite well in the office population. My sense is that the Recommended Daily Allowance of 150 mcg per day for adults is low and that many benefit from greater quantities, e.g., 500 mcg. What is is the ideal dose? To my knowledge, nobody has yet generated that data.

Thyroid issues being relatively new to my thinking, I now find it incredible that endocrinologists and the American Thyroid Association are not broadcasting this problem at the top of their lungs. This issue needs to be brought to the top of everyone's attention, or else we'll have history repeating itself and have goiters and thyroid dysfunction galore.

For more on this topic, see the previous Heart Scan Blog post, "Help keep your family goiter free."

Goiter and the Golden Medical Discovery


Thick neck, or goitre . . . consists of an enlargement of the thyroid gland, which lies over and on each side of the trachea, or windpipe, between the prominence known as "Adam's apple" and the breast bone. The tumor gradually increases in front and laterally, until it produces great deformity, and often interferes with respiration and the act of swallowing. From its pressure on the great blood vessels running to and from the head, there is a constant liability to engorgement of blood in the brain, and to apoplexy, epilepsy, etc.

The causes of the affection are not well understood. The use of snow water, or water impregnated with some particular saline or calcareous matter, has been assigned as a cause. It has also been attributed to the use of water in which there is not a trace of iron, iodine, or bromine. . . The disease is often due to an impeded circulation in the large veins of the neck, from pressure of the clothing, or from the head being bent forward, a position which is often seen in school children.



Treatment

We have obtained excellent results in many cases, not too far advanced, by a method of treatment which consists in the employment of electrolysis. . . Many cases at the present time are operated upon with entire success.

Those who are afflicted with this disease and unable to avail themselves of special treatment cannot do better than to take Doctor Pierce's Alterative Extract, or Golden Medical Discovery, and apply over the skin around the tumor, night and morning, the following, which may be prepared at any drug store:

Resublimed Iodine--One dram
Iodide of Potassium--Four drams
Soft Water--Three ounces 


Apply to the tumor, twice daily, with feather or camel hair pencil.


From The People's Common Sense Medical Adviser by R.V. Pierce, MD; 1918.

Magnesium and you-Part I

If this were 10,000 B.C., you'd get your drinking water from streams, rivers, and lakes, all rich in mineral content. Humans became reliant on obtaining a considerable proportion of daily mineral needs from natural water sources.

21st century: We obtain drinking water from a spigot or plastic bottle. Pesticides and other chemicals seep into the water supply. Municipal water purification facilities have intensified water purification in most communities to remove contaminants like lead, pesticide residues, and nitrates. (For a really neat listing of the water quality of various cities, the University of Cincinnati makes this data available.)

But intensive water treatment also removes minerals like calcium and magnesium.

Many people have added water filters or purifiers to their homes,, like reverse osmosis and distillation, that are efficient at extracting any remaining minerals, converting “hard” into “soft” water. In fact, manufacturers of such devices boast of their power to yield pure water free of any “contaminant,” minerals like magnesium included. The magnesium content of water after passing through most commercial filters is zero.

Modern enthusiasm for bottled water has compounded the problem. Americans consumed a lot of bottled water, nearly 8 billion gallons last year. In the U.S., nearly all bottled water has little or no magnesium.

The result is that we can no longer rely on drinking water to provide magnesium. The Recommended Daily Allowance (RDA)—the amount required to prevent severe deficiency—for magnesium is 420 mg per day for men, 320 mg/day for women. In cities with the highest magnesium water content, only 30% of the RDA can be obtained by drinking two liters of tap water per day. In most cities, only a meager 10–20% of the daily requirement can be obtained. That leaves between 70–90% that needs to come from other sources. As a result, the average American ingests substantially less than the RDA.